Deliverables Documents, reports (2) Publication of trial rationale/design Starting at month 24, a publication is written and submitted to a cardiology journal, describing the rationale and design of the clinical trial; a second publication is written and submitted on month 60, describing the results of the trial. Abstracts presentation at heart failure meetings Starting at month 12, abstracts on the scope, design and implementation of the clinical trial are submitted for presentation at Heart Failure congresses Websites, patent fillings, videos etc. (2) Short presentation of study results to general audience A short oral presentation of the study results is made to general audience through media communication at the ESCHFA Spring meeting Contact with patients' organisations through ad hoc initiative of HFA/ESC Starting at month 24 contacts are established with patients organizations through ad hoc initiatives of the Heart Failure Association of the European Society of Cardiology every 2 years Demonstrators, pilots, prototypes (1) Functional website A public website for the trial is implemented and functional Publications Peer reviewed articles (6) Overexpression of endothelial β 3 ‐adrenergic receptor induces diastolic dysfunction in rats Author(s): Justine Dhot, Marine Ferron, Valentine Prat, Antoine Persello, David Roul, David Stévant, Damien Guijarro, Nicolas Piriou, Virginie Aillerie, Angélique Erraud, Gilles Toumaniantz, Morteza Erfanian, Angela Tesse, Amandine Grabherr, Laurent Tesson, Séverine Menoret, Ignacio Anegon, Jean‐Noël Trochu, Marja Steenman, Michel De Waard, Bertrand Rozec, Benjamin Lauzier, Chantal Gauthier Published in: ESC Heart Failure, Issue 7/6, 2020, Page(s) 4159-4171, ISSN 2055-5822 Publisher: ESC Heat failure DOI: 10.1002/ehf2.13040 Early nebivolol treatment is beneficial in myocardial infarction in rats partly through β3‐adrenoceptor remodelling Author(s): Leslie Audigane, Antoine Persello, Nicolas Piriou, Marine Ferron, Jean‐Noël Trochu, Benjamin Lauzier, Chantal Gauthier, Bertrand Rozec Published in: Clinical and Experimental Pharmacology and Physiology, Issue 48/7, 2021, Page(s) 1007-1015, ISSN 0305-1870 Publisher: Blackwell Publishing Inc. DOI: 10.1111/1440-1681.13447 Beta 3 adrenoreceptors protect from hypertrophic remodelling through AMP‐activated protein kinase and autophagy Author(s): Emilie Dubois‐Deruy, Roselle Gelinas, Christophe Beauloye, Hrag Esfahani, Lauriane Y.M. Michel, Chantal Dessy, Luc Bertrand, Jean‐Luc Balligand Published in: ESC Heart Failure, Issue 7/3, 2020, Page(s) 920-932, ISSN 2055-5822 Publisher: ESC heart failure DOI: 10.1002/ehf2.12648 Phosphatase regulatory subunits in beta-adrenergic signalling: a delicate balancing act Author(s): Jean-Luc Balligand Published in: Cardiovascular Research, Issue 115/3, 2018, Page(s) 477-478, ISSN 0008-6363 Publisher: Elsevier BV DOI: 10.1093/cvr/cvy275 Rationale and design of a multicentre, randomized, placebo-controlled trial of mirabegron, a Beta3-adrenergic receptor agonist on left ventricular mass and diastolic function in patients with structural heart disease Beta3-left ventricular hypertrophy (Be Author(s): Anne-Catherine Pouleur, Stefan Anker, Dulce Brito, Oana Brosteanu, Dirk Hasenclever, Barbara Casadei, Frank Edelmann, Gerasimos Filippatos, Damien Gruson, Ignatios Ikonomidis, Renaud Lhommel, Masliza Mahmod, Stefan Neubauer, Alexandre Persu, Bernhard L. Gerber, Stefan Piechnik, Burkert Pieske, Elisabeth Pieske-Kraigher, Fausto Pinto, Piotr Ponikowski, Michele Senni, Jean-Noël Trochu, Nancy Van Ov Published in: ESC Heart Failure, 2018, ISSN 2055-5822 Publisher: ESC Heart Failure DOI: 10.1002/ehf2.12306 β3-Adrenoceptor redistribution impairs NO/cGMP/PDE2 signalling in failing cardiomyocytes Author(s): Sophie Schobesberger, Peter T Wright, Claire Poulet, Jose L Sanchez Alonso Mardones, Catherine Mansfield, Andreas Friebe, Sian E Harding, Jean-Luc Balligand, Viacheslav O Nikolaev, Julia Gorelik Published in: eLife, Issue 9, 2020, ISSN 2050-084X Publisher: eLife Sciences Publications DOI: 10.7554/elife.52221 Other (9) Seminar: Leçon publique sur l'HFpEF Author(s): Anne-Catherine Pouleur Published in: 2015 Publisher: Anne-Catherine Pouleur Youtube video Author(s): Nancy Van Overstraeten Published in: 2015 Publisher: Youtube seminar Author(s): Jean-Luc Balligand Published in: 2015 Publisher: ESC Vers un nouveau traitement de l'insuffisance cardiaque ? Author(s): Jean-Luc Balligand Published in: 2015 Publisher: UCL Towards a new treatment for cardiac remodeling ? Author(s): Nancy Van Overstraeten Published in: 2015 Publisher: UCL IREC A multi-center randomized, placebo-controlled trial of mirabegron, a new beta3-adrenergic receptor agonist on left ventricular mass and diastolic function in patients with structural heart disease Author(s): EU Published in: 2015 Publisher: EU Une molécule pour soulager le coeur Author(s): Frédéric Soumois Published in: Le Soir, Issue daily, 2015 Publisher: Le Soir Piechnik Group: Myocardial functional T1 mapping – Advanced cardiac magnetic resonance imaging techniques Author(s): S. Piechnik Published in: 2018 Publisher: Radcliffe Department of Medicine On-going EU Projects Author(s): ESC Published in: 2016 Publisher: ESC Book chapters (1) New and Emerging Therapies and Targets: Beta-3 Agonists Author(s): Lauriane Y. M. Michel, Jean-Luc Balligand Published in: 2016, Page(s) 205-223 Publisher: Springer International Publishing DOI: 10.1007/164_2016_88 Searching for OpenAIRE data... There was an error trying to search data from OpenAIRE No results available