The continuum between healthy ageing and idiopathic Parkinson Disease within a propagation perspective of inflammation and damage: the search for new diagnostic, prognostic and therapeutic targets

Resultado final

Plan for Using and Disseminating Foreground

A final Plan for Disseminating and Using of Foreground will be produced at the end of the project (M48).

The structure of the PROPAG-AGEING website will have to be developed in consultation with all Participants: anyway, top-level areas are likely to providing general information, announcements, bulletin boards, and discussion forums, etc.; they will include sub-domains for each WP, with access control options. Once the site has been created, the ongoing work will mainly require maintenance and update of the website server and of its contents, on the one hand, and security operations (protection against attack from hackers and spammers), on the other hand. The website will include a reserved area for the Participants’ access only that will be used to exchange information and documents among the Participants.

Publicaciones

A frailty index for UK Biobank participants

Autores: Hagg, Sara; Pedersen, Nancy; Jylhava, Juulia; Williams, Dylan
Publicado en: The journals of gerontology. Series A, Biological sciences and medical sciences., Edición 2, 2018, ISSN 1758-535X
Editor: Oxford University Press
DOI: 10.1101/233692

Circulating insulin-like growth factors and Alzheimer disease

Autores: Dylan M. Williams, Ida K. Karlsson, Nancy L. Pedersen, Sara Hägg
Publicado en: Neurology, Edición 90/4, 2018, Página(s) e291-e297, ISSN 0028-3878
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1212/WNL.0000000000004854

Immunobiography and the Heterogeneity of Immune Responses in the Elderly: A Focus on Inflammaging and Trained Immunity

Autores: Claudio Franceschi, Stefano Salvioli, Paolo Garagnani, Magda de Eguileor, Daniela Monti, Miriam Capri
Publicado en: Frontiers in Immunology, Edición 8, 2017, ISSN 1664-3224
Editor: Frontiers Research Foundation
DOI: 10.3389/fimmu.2017.00982

"Acceleration of leukocytes’ epigenetic age as an early tumor and sex-specific marker of breast and colorectal cancer"

Autores: Danielle Fernandes Durso, Maria Giulia Bacalini, Claudia Sala, Chiara Pirazzini, Elena Marasco, Massimiliano Bonafé, Ítalo Faria do Valle, Davide Gentilini, Gastone Castellani, Ana Maria Caetano Faria, Claudio Franceschi, Paolo Garagnani, Christine Nardini
Publicado en: Oncotarget, Edición 8/14, 2017, ISSN 1949-2553
Editor: Impact Journals
DOI: 10.18632/oncotarget.15573

Gelified Biofluids for High-Resolution Magic Angle Spinning 1 H NMR Analysis: The Case of Urine

Autores: Panteleimon G. Takis, Leonardo Tenori, Enrico Ravera, Claudio Luchinat
Publicado en: Analytical Chemistry, Edición 89/2, 2016, Página(s) 1054-1058, ISSN 0003-2700
Editor: American Chemical Society
DOI: 10.1021/acs.analchem.6b04318

Systemic Age-Associated DNA Hypermethylation of ELOVL2 Gene: In Vivo and In Vitro Evidences of a Cell Replication Process

Autores: Maria Giulia Bacalini, Joris Deelen, Chiara Pirazzini, Marco De Cecco, Cristina Giuliani, Catia Lanzarini, Francesco Ravaioli, Elena Marasco, Diana van Heemst, H. Eka D. Suchiman, Roderick Slieker, Enrico Giampieri, Rina Recchioni, Fiorella Mercheselli, Stefano Salvioli, Giovanni Vitale, Fabiola Olivieri, Annemieke M. W. Spijkerman, Martijn E. T. Dollé, John M. Sedivy, Gastone Castellani, Claudio
Publicado en: The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 2017, Página(s) glw185, ISSN 1079-5006
Editor: Gerontological Society of America
DOI: 10.1093/gerona/glw185

Deconvoluting interrelationships between concentrations and chemical shifts in urine provides a powerful analysis tool

Autores: Panteleimon G. Takis, Hartmut Schäfer, Manfred Spraul, Claudio Luchinat
Publicado en: Nature Communications, Edición 8/1, 2017, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-017-01587-0

Gut microbiota changes in the extreme decades of human life: a focus on centenarians

Autores: Aurelia Santoro, Rita Ostan, Marco Candela, Elena Biagi, Patrizia Brigidi, Miriam Capri, Claudio Franceschi
Publicado en: Cellular and Molecular Life Sciences, Edición 75/1, 2018, Página(s) 129-148, ISSN 1420-682X
Editor: Birkhauser Verlag
DOI: 10.1007/s00018-017-2674-y

Autores: Francesco Ravaioli, Maria Bacalini, Claudio Franceschi, Paolo Garagnani
Publicado en: Genes, Edición 9/1, 2018, Página(s) 39, ISSN 2073-4425
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/genes9010039

Implementing a method for studying longitudinal DNA methylation variability in association with age

Autores: Yunzhang Wang, Nancy L. Pedersen, Sara Hägg
Publicado en: Epigenetics, Edición 13/8, 2018, Página(s) 866-874, ISSN 1559-2294
Editor: Landes Bioscience
DOI: 10.1080/15592294.2018.1521222

The epigenetic landscape of age-related diseases: the geroscience perspective

Autores: Noémie Gensous, Maria Giulia Bacalini, Chiara Pirazzini, Elena Marasco, Cristina Giuliani, Francesco Ravaioli, Giacomo Mengozzi, Claudia Bertarelli, Maria Giustina Palmas, Claudio Franceschi, Paolo Garagnani
Publicado en: Biogerontology, Edición 18/4, 2017, Página(s) 549-559, ISSN 1389-5729
Editor: Kluwer Academic Publishers
DOI: 10.1007/s10522-017-9695-7

Impact of demography and population dynamics on the genetic architecture of human longevity

Autores: Cristina Giuliani, Marco Sazzini, Chiara Pirazzini, Maria Giulia Bacalini, Elena Marasco, Guido Alberto Gnecchi Ruscone, Fang Fang, Stefania Sarno, Davide Gentilini, Anna Maria Di Blasio, Paolina Crocco, Giuseppe Passarino, Daniela Mari, Daniela Monti, Benedetta Nacmias, Sandro Sorbi, Carlo Salvarani, Mariagrazia Catanoso, Davide Pettener, Donata Luiselli, Svetlana Ukraintseva, Anatoliy Yashin, Cl
Publicado en: Aging, 2018, ISSN 1945-4589
Editor: Impact Journals, LLC
DOI: 10.18632/aging.101515

The REM Sleep Behavior Disorder Screening Questionnaire is not Valid in De Novo Parkinson's Disease

Autores: Claire Halsband, Antonia Zapf, Friederike Sixel-Döring, Claudia Trenkwalder, Brit Mollenhauer
Publicado en: Movement Disorders Clinical Practice, Edición 5/2, 2018, Página(s) 171-176, ISSN 2330-1619
Editor: Wiley
DOI: 10.1002/mdc3.12591

Genome-wide DNA methylation analysis in blood cells from patients with Werner syndrome

Autores: T. Guastafierro, M. G. Bacalini, A. Marcoccia, D. Gentilini, S. Pisoni, A. M. Di Blasio, A. Corsi, C. Franceschi, D. Raimondo, A. Spanò, P. Garagnani, F. Bondanini
Publicado en: Clinical Epigenetics, Edición 9/1, 2017, ISSN 1868-7075
Editor: Springer Verlag
DOI: 10.1186/s13148-017-0389-4

The Continuum of Aging and Age-Related Diseases: Common Mechanisms but Different Rates

Autores: Claudio Franceschi, Paolo Garagnani, Cristina Morsiani, Maria Conte, Aurelia Santoro, Andrea Grignolio, Daniela Monti, Miriam Capri, Stefano Salvioli
Publicado en: Frontiers in Medicine, Edición 5, 2018, ISSN 2296-858X
Editor: Frontiers Media S.A.
DOI: 10.3389/fmed.2018.00061

Decreased epigenetic age of PBMCs from Italian semi-supercentenarians and their offspring

Autores: Steve Horvath, Chiara Pirazzini, Maria Giulia Bacalini, Davide Gentilini, Anna Maria Di Blasio, Massimo Delledonne, Daniela Mari, Beatrice Arosio, Daniela Monti, Giuseppe Passarino, Francesco De Rango, Patrizia D'Aquila, Cristina Giuliani, Elena Marasco, Sebastiano Collino, Patrick Descombes, Paolo Garagnani, Claudio Franceschi
Publicado en: Aging, Edición 7/12, 2015, Página(s) 1159-1170, ISSN 1945-4589
Editor: Impact Journals, LLC
DOI: 10.18632/aging.100861

Antemortem Prediction of Braak Stage

Autores: Jesper O.E. Carlson, Margaret Gatz, Nancy L. Pedersen, Caroline Graff, Inger Nennesmo, Anna-Karin Lindström, Lotte Gerritsen
Publicado en: Journal of Neuropathology & Experimental Neurology, Edición 74/11, 2015, Página(s) 1061-1070, ISSN 0022-3069
Editor: American Association of Neuropathologists, Inc.
DOI: 10.1097/NEN.0000000000000251

Aging and Parkinson's Disease: Inflammaging, neuroinflammation and biological remodeling as key factors in pathogenesis

Autores: Vittorio Calabrese, Aurelia Santoro, Daniela Monti, Rosalia Crupi, Rosanna Di Paola, Saverio Latteri, Salvatore Cuzzocrea, Mario Zappia, James Giordano, Edward J. Calabrese, Claudio Franceschi
Publicado en: Free Radical Biology and Medicine, Edición 115, 2018, Página(s) 80-91, ISSN 0891-5849
Editor: Elsevier BV
DOI: 10.1016/j.freeradbiomed.2017.10.379

Molecular Aging of Human Liver: An Epigenetic/Transcriptomic Signature

Autores: Maria Giulia Bacalini, Claudio Franceschi, Davide Gentilini, Francesco Ravaioli, Xiaoyuan Zhou, Daniel Remondini, Chiara Pirazzini, Cristina Giuliani, Elena Marasco, Noémie Gensous, Anna Maria Di Blasio, Ewa Ellis, Roberto Gramignoli, Gastone Castellani, Miriam Capri, Stephen Strom, Christine Nardini, Matteo Cescon, Gian Luca Grazi, Paolo Garagnani
Publicado en: The Journals of Gerontology: Series A, 2018, ISSN 1079-5006
Editor: Gerontological Society of America
DOI: 10.1093/gerona/gly048

Nutrition and Inflammation: Are Centenarians Similar to Individuals on Calorie-Restricted Diets?

Autores: Claudio Franceschi, Rita Ostan, Aurelia Santoro
Publicado en: Annual Review of Nutrition, Edición 38/1, 2018, Página(s) 329-356, ISSN 0199-9885
Editor: Annual Reviews, Inc.
DOI: 10.1146/annurev-nutr-082117-051637

The peculiar aging of human liver: A geroscience perspective within transplant context

Autores: Cristina Morsiani, Maria Giulia Bacalini, Aurelia Santoro, Paolo Garagnani, Salvatore Collura, Antonia D’Errico, Magda de Eguileor, Gian Luca Grazi, Matteo Cescon, Claudio Franceschi, Miriam Capri
Publicado en: Ageing Research Reviews, Edición 51, 2019, Página(s) 24-34, ISSN 1568-1637
Editor: Elsevier BV
DOI: 10.1016/j.arr.2019.02.002

Human Aging and Longevity Are Characterized by High Levels of Mitokines

Autores: Maria Conte, Rita Ostan, Cristina Fabbri, Aurelia Santoro, Giulia Guidarelli, Giovanni Vitale, Daniela Mari, Federica Sevini, Miriam Capri, Marco Sandri, Daniela Monti, Claudio Franceschi, Stefano Salvioli
Publicado en: The Journals of Gerontology: Series A, Edición 74/5, 2018, Página(s) 600-607, ISSN 1079-5006
Editor: Gerontological Society of America
DOI: 10.1093/gerona/gly153

Inflammaging: a new immune–metabolic viewpoint for age-related diseases

Autores: Claudio Franceschi, Paolo Garagnani, Paolo Parini, Cristina Giuliani, Aurelia Santoro
Publicado en: Nature Reviews Endocrinology, Edición 14/10, 2018, Página(s) 576-590, ISSN 1759-5029
Editor: Nature Publishing Group
DOI: 10.1038/s41574-018-0059-4

Hormetic approaches to the treatment of Parkinson's disease: Perspectives and possibilities

Autores: Vittorio Calabrese, Aurelia Santoro, Angela Trovato Salinaro, Sergio Modafferi, Maria Scuto, Ferdaous Albouchi, Daniela Monti, James Giordano, Mario Zappia, Claudio Franceschi, Edward J Calabrese
Publicado en: Journal of Neuroscience Research, Edición 96/10, 2018, Página(s) 1641-1662, ISSN 0360-4012
Editor: John Wiley & Sons Inc.
DOI: 10.1002/jnr.24244

Association of pre-pregnancy body mass index with offspring metabolic profile: Analyses of 3 European prospective birth cohorts

Autores: Diana L. Santos Ferreira, Dylan M. Williams, Antti J. Kangas, Pasi Soininen, Mika Ala-Korpela, George Davey Smith, Marjo-Riitta Jarvelin, Debbie A. Lawlor
Publicado en: PLOS Medicine, Edición 14/8, 2017, Página(s) e1002376, ISSN 1549-1676
Editor: Public Library of Science
DOI: 10.1371/journal.pmed.1002376

The Dual Role of the Pervasive “Fattish” Tissue Remodeling With Age

Autores: Maria Conte, Morena Martucci, Marco Sandri, Claudio Franceschi, Stefano Salvioli
Publicado en: Frontiers in Endocrinology, Edición 10, 2019, ISSN 1664-2392
Editor: Frontiers
DOI: 10.3389/fendo.2019.00114

Accelerated bio‐cognitive aging in Down syndrome: State of the art and possible deceleration strategies

Autores: Claudio Franceschi, Paolo Garagnani, Noémie Gensous, Maria Giulia Bacalini, Maria Conte, Stefano Salvioli
Publicado en: Aging Cell, Edición 18/3, 2019, Página(s) e12903, ISSN 1474-9718
Editor: Blackwell Publishing Inc.
DOI: 10.1111/acel.12903

The Genetic Variability of APOE in Different Human Populations and Its Implications for Longevity

Autores: Paolo Abondio, Marco Sazzini, Paolo Garagnani, Alessio Boattini, Daniela Monti, Claudio Franceschi, Donata Luiselli, Cristina Giuliani
Publicado en: Genes, Edición 10/3, 2019, Página(s) 222, ISSN 2073-4425
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/genes10030222

Genomic stability, anti-inflammatory phenotype, and up-regulation of the RNAseH2 in cells from centenarians

Autores: Gianluca Storci, Sabrina De Carolis, Alessio Papi, Maria Giulia Bacalini, Noémie Gensous, Elena Marasco, Anna Tesei, Francesco Fabbri, Chiara Arienti, Michele Zanoni, Anna Sarnelli, Spartaco Santi, Fabiola Olivieri, Emanuela Mensà, Silvia Latini, Manuela Ferracin, Stefano Salvioli, Paolo Garagnani, Claudio Franceschi, Massimiliano Bonafè
Publicado en: Cell Death & Differentiation, Edición 26/9, 2019, Página(s) 1845-1858, ISSN 1350-9047
Editor: Nature Publishing Group
DOI: 10.1038/s41418-018-0255-8

Plasma and urinary metabolomic profiles of Down syndrome correlate with alteration of mitochondrial metabolism

Autores: Maria Caracausi, Veronica Ghini, Chiara Locatelli, Martina Mericio, Allison Piovesan, Francesca Antonaros, Maria Chiara Pelleri, Lorenza Vitale, Rosa Anna Vacca, Federica Bedetti, Maria Chiara Mimmi, Claudio Luchinat, Paola Turano, Pierluigi Strippoli, Guido Cocchi
Publicado en: Scientific Reports, Edición 8/1, 2018, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-018-20834-y

NMR-based metabolomics identifies patients at high risk of death within two years after acute myocardial infarction in the AMI-Florence II cohort

Autores: Alessia Vignoli, Leonardo Tenori, Betti Giusti, Panteleimon G. Takis, Serafina Valente, Nazario Carrabba, Daniela Balzi, Alessandro Barchielli, Niccolò Marchionni, Gian Franco Gensini, Rossella Marcucci, Claudio Luchinat, Anna Maria Gori
Publicado en: BMC Medicine, Edición 17/1, 2019, ISSN 1741-7015
Editor: BioMed Central
DOI: 10.1186/s12916-018-1240-2

Uniqueness of the NMR approach to metabolomics

Autores: Panteleimon G. Takis, Veronica Ghini, Leonardo Tenori, Paola Turano, Claudio Luchinat
Publicado en: TrAC Trends in Analytical Chemistry, 2018, Página(s) 115300, ISSN 0165-9936
Editor: Elsevier BV
DOI: 10.1016/j.trac.2018.10.036

High-Throughput Metabolomics by 1D NMR

Autores: Alessia Vignoli, Veronica Ghini, Gaia Meoni, Cristina Licari, Panteleimon G. Takis, Leonardo Tenori, Paola Turano, Claudio Luchinat
Publicado en: Angewandte Chemie International Edition, Edición 58/4, 2019, Página(s) 968-994, ISSN 1433-7851
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201804736

Heterogeneity of Thyroid Function and Impact of Peripheral Thyroxine Deiodination in Centenarians and Semi-Supercentenarians: Association With Functional Status and Mortality

Autores: Rita Ostan, Daniela Monti, Daniela Mari, Beatrice Arosio, Davide Gentilini, Evelyn Ferri, Giuseppe Passarino, Francesco De Rango, Patrizia D’Aquila, Stefano Mariotti, Renato Pasquali, Flaminia Fanelli, Laura Bucci, Claudio Franceschi, Giovanni Vitale
Publicado en: The Journals of Gerontology: Series A, Edición 74/6, 2018, Página(s) 802-810, ISSN 1079-5006
Editor: Gerontological Society of America
DOI: 10.1093/gerona/gly194

First evidence of association between past environmental exposure to dioxin and DNA methylation of CYP1A1 and IGF2 genes in present day Vietnamese population

Autores: Cristina Giuliani, David Biggs, Thanh Tin Nguyen, Elena Marasco, Sara De Fanti, Paolo Garagnani, Minh Triet Le Phan, Viet Nhan Nguyen, Donata Luiselli, Giovanni Romeo
Publicado en: Environmental Pollution, Edición 242, 2018, Página(s) 976-985, ISSN 0269-7491
Editor: Pergamon Press Ltd.
DOI: 10.1016/j.envpol.2018.07.015

The epigenetics of inflammaging: The contribution of age-related heterochromatin loss and locus-specific remodelling and the modulation by environmental stimuli

Autores: Christine Nardini, Jean-Francois Moreau, Noémie Gensous, Francesco Ravaioli, Paolo Garagnani, Maria Giulia Bacalini
Publicado en: Seminars in Immunology, Edición 40, 2018, Página(s) 49-60, ISSN 1044-5323
Editor: Academic Press
DOI: 10.1016/j.smim.2018.10.009

Genetics of Human Longevity Within an Eco-Evolutionary Nature-Nurture Framework

Autores: Cristina Giuliani, Paolo Garagnani, Claudio Franceschi
Publicado en: Circulation Research, Edición 123/7, 2018, Página(s) 745-772, ISSN 0009-7330
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circresaha.118.312562

Deep Graph Infomax

Autores: Veličković, Petar; Fedus, William; Hamilton, William L; Liò, Pietro; Bengio, Yoshua; Hjelm, R Devon
Publicado en: Edición 2, 2019
Editor: University of Cambridge
DOI: 10.17863/CAM.40744

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