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Breast Cancer Risk after Diagnostic Gene Sequencing (BRIDGES)

Objective

Breast cancer affects more than 360,000 women per year in the EU and causes more than 90,000 deaths. Identification of women at high risk of the disease can lead to disease prevention through intensive screening, chemoprevention or prophylactic surgery. Breast cancer risk is determined by a combination of genetic and lifestyle risk factors. The advent of next generation sequencing has opened up the opportunity for testing in many disease genes, and diagnostic gene panel testing is being introduced in many EU countries. However, the cancer risks associated with most variants in most genes are unknown. This leads to a major problem in appropriate counselling and management of women undergoing panel testing.
In this project, we aim to build a knowledge base that will allow identification of women at high-risk of breast cancer, in particular through comprehensive evaluation of DNA variants in known and suspected breast cancer genes. We will exploit the huge resources established through the Breast Cancer Association Consortium (BCAC) and ENIGMA (Evidence-based Network for the Interpretation of Germline Mutant Alleles). We will expand the existing datasets by sequencing all known breast cancer susceptibility genes in 20,000 breast cancer cases and 20,000 controls from population-based studies, and 10,000 cases from multiple case families. Sequence data will be integrated with in-silico and functional data, with data on other known risk factors, to generate a comprehensive risk model that can provide personalised risk estimates. We will develop online tools to aid the interpretation of gene variants and provide risk estimates in a user-friendly format, to help genetic counsellors and patients worldwide to make informed clinical decisions. We will evaluate the acceptability and utility of comprehensive gene panel testing in the clinical genetics context.

Field of science

  • /medical and health sciences/basic medicine/medical genetics
  • /medical and health sciences/clinical medicine/oncology/cancer
  • /medical and health sciences/clinical medicine/oncology/cancer/breast cancer

Call for proposal

H2020-PHC-2014-two-stage
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

ACADEMISCH ZIEKENHUIS LEIDEN
Address
Albinusdreef 2
2333 ZA Leiden
Netherlands
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 895 000

Participants (17)

THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE
United Kingdom
EU contribution
€ 2 147 737,50
Address
Trinity Lane The Old Schools
CB2 1TN Cambridge
Activity type
Higher or Secondary Education Establishments
FUNDACION CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III
Spain
EU contribution
€ 859 125
Address
Calle Melchor Fernandez Almagro 3
28029 Madrid
Activity type
Research Organisations
LUNDS UNIVERSITET
Sweden
EU contribution
€ 846 887,50
Address
Paradisgatan 5C
22100 Lund
Activity type
Higher or Secondary Education Establishments
UNIVERSITAET LEIPZIG
Germany
EU contribution
€ 254 375
Address
Ritterstrasse 26
04109 Leipzig
Activity type
Higher or Secondary Education Establishments
SERVICIO MADRILENO DE SALUD
Spain
EU contribution
€ 116 875
Address
Plaza Carlos Trias Bertran 7
28020 Madrid
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
INSTITUT CURIE
France
EU contribution
€ 335 000
Address
Rue D'ulm 26
75231 Paris
Activity type
Research Organisations
KAROLINSKA INSTITUTET
Sweden
EU contribution
€ 29 375
Address
Nobels Vag 5
17177 Stockholm
Activity type
Higher or Secondary Education Establishments
BIO-PRODICT BV
Netherlands
EU contribution
€ 166 875
Address
Nieuwe Marktstraat 54
6511 AA Nijmegen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
INTERACTIVE BIOSOFTWARE SAS
France
EU contribution
€ 79 375
Address
141 Boulevard De L'yser
76000 Rouen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
UNIVERSITY OF MELBOURNE
Australia
EU contribution
€ 0
Address
Parkvilleoffice Of The Vice Chancellor
3010 Melbourne
Activity type
Higher or Secondary Education Establishments
UNIVERSITY OF UTAH
United States
EU contribution
€ 0
Address
E Federal Way 1471
84102 Salt Lake City Utah
Activity type
Higher or Secondary Education Establishments
QUEENSLAND INSTITUTE OF MEDICAL RESEARCH
Australia
EU contribution
€ 0
Address
Herston Road, 300
QLD 4006 Herston
Activity type
Research Organisations
Mayo Clinic
United States
EU contribution
€ 0
Address
First Street Sw 200
55905 Rochester
Activity type
Research Organisations
UNIVERSITE LAVAL
Canada
EU contribution
€ 0
Address
Allee Des Bibliotheques 2345
G1V 0A6 Quebec
Activity type
Higher or Secondary Education Establishments
KLINIKUM DER UNIVERSITAET ZU KOELN
Germany
EU contribution
€ 365 000
Address
Kerpener Strasse 62
50937 Koeln
Activity type
Higher or Secondary Education Establishments
REGION HOVEDSTADEN
Denmark
EU contribution
€ 29 375
Address
Kongens Vaenge 2
3400 Hillerod
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS
Spain
EU contribution
€ 75 000
Address
Calle Serrano 117
28006 Madrid
Activity type
Research Organisations