Gut Microbiota in Nervous System Autoimmunity: Molecular Mechanisms of Disease Initiation and Regulation

Project Information

GAMES

Grant agreement ID: 635617

DOI

10.3030/635617

Project closed

EC signature date 18 May 2015

Start date 1 June 2015

End date 31 May 2022

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 499 946,00

EU contribution

€ 1 499 946,00

Coordinated by

MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (11)

Perturbation of gut microbiota decreases susceptibility but does not modulate ongoing autoimmune neurological disease

Author(s): Clemens Gödel, Birgit Kunkel, Alireza Kashani, Hans Lassmann, Manimozhiyan Arumugam, Gurumoorthy Krishnamoorthy
Published in: Journal of Neuroinflammation, Issue 17/1, 2020, Page(s) 79, ISSN 1742-2094
Publisher: BioMed Central
DOI: 10.1186/s12974-020-01766-9

A novel CD4 knockout mouse strain with a spontaneous frameshift mutation in the CD4 locus.

Author(s): Janakiraman M, Na SY, Krishnamoorthy, G
Published in: PLoS One, Issue 17(4), 2022, Page(s) e0266589, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0266589

Gut microbiota from multiple sclerosis patients enables spontaneous autoimmune encephalomyelitis in mice

Author(s): Kerstin Berer, Lisa Ann Gerdes, Egle Cekanaviciute, Xiaoming Jia, Liang Xiao, Zhongkui Xia, Chuan Liu, Luisa Klotz, Uta Stauffer, Sergio E. Baranzini, Tania Kümpfel, Reinhard Hohlfeld, Gurumoorthy Krishnamoorthy, Hartmut Wekerle
Published in: Proceedings of the National Academy of Sciences, Issue 114/40, 2017, Page(s) 10719-10724, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.1711233114

Dietary non-fermentable fiber prevents autoimmune neurological disease by changing gut metabolic and immune status

Author(s): Kerstin Berer, Inés Martínez, Alesia Walker, Birgit Kunkel, Philippe Schmitt-Kopplin, Jens Walter, Gurumoorthy Krishnamoorthy
Published in: Scientific Reports, Issue 8/1, 2018, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-018-28839-3

B ReDi mouse: A novel transgenic mouse strain to track and deplete B cells

Author(s): Marsilius Mues, Gurumoorthy Krishnamoorthy
Published in: European Journal of Immunology, Issue 49/3, 2019, Page(s) 500-503, ISSN 0014-2980
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/eji.201847930

Emerging Role of Diet and Microbiota Interactions in Neuroinflammation

Author(s): Mathangi Janakiraman, Gurumoorthy Krishnamoorthy
Published in: Frontiers in Immunology, Issue 9, 2018, Page(s) 2067, ISSN 1664-3224
Publisher: Frontiers Media SA
DOI: 10.3389/fimmu.2018.02067

Targeted Expression of Myelin Autoantigen in the Periphery Induces Antigen-Specific T and B Cell Tolerance and Ameliorates Autoimmune Disease

Author(s): Shin-Young Na, Gurumoorthy Krishnamoorthy
Published in: Frontiers in Immunology, Issue 12, 2021, ISSN 1664-3224
Publisher: Frontiers Media
DOI: 10.3389/fimmu.2021.668487

High salt diet does not impact the development of acute myeloid leukemia in mice.

Author(s): Janakiraman M, Salei N, Krishnamoorthy G
Published in: Cancer Immunology, Immunotherapy, 2022, ISSN 1432-0851
Publisher: Springer
DOI: 10.1007/s00262-022-03244-y

Splicing factor YBX1 mediates persistence of JAK2-mutated neoplasms

Author(s): Ashok Kumar Jayavelu, Tina M. Schnöder, Florian Perner, Carolin Herzog, Arno Meiler, Gurumoorthy Krishnamoorthy, Nicolas Huber, Juliane Mohr, Bärbel Edelmann-Stephan, Rebecca Austin, Sabine Brandt, Francesca Palandri, Nicolas Schröder, Berend Isermann, Frank Edlich, Amit U. Sinha, Martin Ungelenk, Christian A. Hübner, Robert Zeiser, Susann Rahmig, Claudia Waskow, Iain Coldham, Thomas Ernst, An
Published in: Nature, Issue 588/7836, 2020, Page(s) 157-163, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-020-2968-3

Gene Expression in Spontaneous Experimental Autoimmune Encephalomyelitis Is Linked to Human Multiple Sclerosis Risk Genes

Author(s): Hans Faber, Dunja Kurtoic, Gurumoorthy Krishnamoorthy, Peter Weber, Benno Pütz, Bertram Müller-Myhsok, Frank Weber, Till F. M. Andlauer
Published in: Frontiers in Immunology, Issue 11, 2020, ISSN 1664-3224
Publisher: Frontiers Media
DOI: 10.3389/fimmu.2020.02165

High-salt diet suppresses autoimmune demyelination by regulating the blood–brain barrier permeability

Author(s): Shin-Young Na, Mathangi Janakiraman, Alexei Leliavski, Gurumoorthy Krishnamoorthy
Published in: Proceedings of the National Academy of Sciences, Issue 118/12, 2021, Page(s) e2025944118, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2025944118