Individualized treatment planning in chronic back pain patients by advanced imaging and multi-parametric biomechanical models

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

A Vertebral Segmentation Dataset with Fracture Grading

Author(s): Maximilian T. Löffler, Anjany Sekuboyina, Alina Jacob, Anna-Lena Grau, Andreas Scharr, Malek El Husseini, Mareike Kallweit, Claus Zimmer, Thomas Baum, Jan S. Kirschke
Published in: Radiology: Artificial Intelligence, Issue 2/4, 2020, Page(s) e190138, ISSN 2638-6100
Publisher: RSNA
DOI: 10.1148/ryai.2020190138

Labeling Vertebrae with Two-dimensional Reformations of Multidetector CT Images: An Adversarial Approach for Incorporating Prior Knowledge of Spine Anatomy

Author(s): Anjany Sekuboyina, Markus Rempfler, Alexander Valentinitsch, Bjoern H. Menze, Jan S. Kirschke
Published in: Radiology: Artificial Intelligence, Issue 2/2, 2020, Page(s) e190074, ISSN 2638-6100
Publisher: RSNA
DOI: 10.1148/ryai.2020190074

MRI-Based Quantitative Osteoporosis Imaging at the Spine and Femur.

Author(s): Roland Krug; Michael Dieckmeyer; Sophia Kronthaler; Dimitrios C. Karampinos; Jan S. Kirschke; Thomas Baum; Nico Sollmann; Christof Böhm; Maximilian T. Löffler; Julio Carballido-Gamio; Stefan Ruschke
Published in: JMRI, Issue 1, 2020, ISSN 1053-1807
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/jmri.27260

T2 mapping of the distal sciatic nerve in healthy subjects and patients suffering from lumbar disc herniation with nerve compression

Author(s): Nico Sollmann, Dominik Weidlich, Elisabeth Klupp, Barbara Cervantes, Carl Ganter, Claus Zimmer, Ernst J. Rummeny, Thomas Baum, Jan S. Kirschke, Dimitrios C. Karampinos
Published in: Magnetic Resonance Materials in Physics, Biology and Medicine, Issue 33/5, 2020, Page(s) 713-724, ISSN 0968-5243
Publisher: Springer Verlag
DOI: 10.1007/s10334-020-00832-w

Is multidetector CT-based bone mineral density and quantitative bone microstructure assessment at the spine still feasible using ultra-low tube current and sparse sampling?

Author(s): Kai Mei, Felix K. Kopp, Rolf Bippus, Thomas Köhler, Benedikt J. Schwaiger, Alexandra S. Gersing, Andreas Fehringer, Andreas Sauter, Daniela Münzel, Franz Pfeiffer, Ernst J. Rummeny, Jan S. Kirschke, Peter B. Noël, Thomas Baum
Published in: European Radiology, Issue 27/12, 2017, Page(s) 5261-5271, ISSN 0938-7994
Publisher: Springer Verlag
DOI: 10.1007/s00330-017-4904-y

Bone mineral density measurements in vertebral specimens and phantoms using dual-layer spectral computed tomography

Author(s): Kai Mei, Benedikt J. Schwaiger, Felix K. Kopp, Sebastian Ehn, Alexandra S. Gersing, Jan S. Kirschke, Daniela Muenzel, Alexander A. Fingerle, Ernst J. Rummeny, Franz Pfeiffer, Thomas Baum, Peter B. Noël
Published in: Scientific Reports, Issue 7/1, 2017, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-017-17855-4

Multi-level h p -finite cell method for embedded interface problems with application in biomechanics

Author(s): Mohamed Elhaddad, Nils Zander, Tino Bog, László Kudela, Stefan Kollmannsberger, Jan S. Kirschke, Thomas Baum, Martin Ruess, Ernst Rank
Published in: International Journal for Numerical Methods in Biomedical Engineering, 2018, ISSN 2040-7939
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/cnm.2951

Anatomical Variation of Age-Related Changes in Vertebral Bone Marrow Composition Using Chemical Shift Encoding-Based Water–Fat Magnetic Resonance Imaging

Author(s): Thomas Baum, Alexander Rohrmeier, Jan Syväri, Maximilian N. Diefenbach, Daniela Franz, Michael Dieckmeyer, Andreas Scharr, Hans Hauner, Stefan Ruschke, Jan S. Kirschke, Dimitrios C. Karampinos
Published in: Frontiers in Endocrinology, Issue 9, 2018, ISSN 1664-2392
Publisher: Frontiers
DOI: 10.3389/fendo.2018.00141

Association of Quadriceps Muscle Fat With Isometric Strength Measurements in Healthy Males Using Chemical Shift Encoding-Based Water-Fat Magnetic Resonance Imaging

Author(s): Thomas Baum, Stephanie Inhuber, Michael Dieckmeyer, Christian Cordes, Stefan Ruschke, Elisabeth Klupp, Pia M. Jungmann, Rosanna Farlock, Holger Eggers, Hendrik Kooijman, Ernst J. Rummeny, Ansgar Schwirtz, Jan S. Kirschke, Dimitrios C. Karampinos
Published in: Journal of Computer Assisted Tomography, Issue 40/3, 2016, Page(s) 447-451, ISSN 0363-8715
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/RCT.0000000000000374

Effect of Low-Dose MDCT and Iterative Reconstruction on Trabecular Bone Microstructure Assessment

Author(s): Felix K. Kopp, Konstantin Holzapfel, Thomas Baum, Radin A. Nasirudin, Kai Mei, Eduardo G. Garcia, Rainer Burgkart, Ernst J. Rummeny, Jan S. Kirschke, Peter B. Noël
Published in: PLOS ONE, Issue 11/7, 2016, Page(s) e0159903, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0159903

Bone Mineral Density Estimations From Routine Multidetector Computed Tomography

Author(s): Johannes Kaesmacher, Hans Liebl, Thomas Baum, Jan Stefan Kirschke
Published in: Journal of Computer Assisted Tomography, 2016, Page(s) 1, ISSN 0363-8715
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/RCT.0000000000000518

Effects of dose reduction on bone strength prediction using finite element analysis

Author(s): D. Anitha, Karupppasamy Subburaj, Kai Mei, Felix K. Kopp, Peter Foehr, Peter B. Noel, Jan S. Kirschke, Thomas Baum
Published in: Scientific Reports, Issue 6, 2016, Page(s) 38441, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/srep38441

Diagnostic Value of CT Arthrography for Evaluation of Osteochondral Lesions at the Ankle

Author(s): Thomas Baum; Christian Holwein; Christoph Schaeffeler; Klaus Woertler; Imhoff, Andreas B; Kirschke, Jan S.; Ernst J Rummeny; Jungmann, Pia M.; Sepp Braun
Published in: BioMed Research International, Vol 2016 (2016), Issue 1, 2017, ISSN 2314-6141
Publisher: Hindawi
DOI: 10.1155/2016/3594253

Robust and parallel scalable iterative solutions for large-scale finite cell analyses

Author(s): J.N. Jomo, F. de Prenter, M. Elhaddad, D. D'Angella, C.V. Verhoosel, S. Kollmannsberger, J.S. Kirschke, V. Nübel, E.H. van Brummelen, E. Rank
Published in: Finite Elements in Analysis and Design, Issue 163, 2019, Page(s) 14-30, ISSN 0168-874X
Publisher: Elsevier BV
DOI: 10.1016/j.finel.2019.01.009

Phase-field boundary conditions for the voxel finite cell method: Surface-free stress analysis of CT-based bone structures

Author(s): Lam Nguyen, Stein Stoter, Thomas Baum, Jan Kirschke, Martin Ruess, Zohar Yosibash, Dominik Schillinger
Published in: International Journal for Numerical Methods in Biomedical Engineering, Issue 33/12, 2017, Page(s) e2880, ISSN 2040-7939
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/cnm.2880

Isotropic resolution diffusion tensor imaging of lumbosacral and sciatic nerves using a phase-corrected diffusion-prepared 3D turbo spin echo

Author(s): Barbara Cervantes, Anh T. Van, Dominik Weidlich, Hendrick Kooijman, Andreas Hock, Ernst J. Rummeny, Alexandra Gersing, Jan S. Kirschke, Dimitrios C. Karampinos
Published in: Magnetic Resonance in Medicine, Issue 80/2, 2018, Page(s) 609-618, ISSN 0740-3194
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/mrm.27072

Paraspinal Muscle DTI Metrics Predict Muscle Strength

Author(s): Elisabeth Klupp, Barbara Cervantes, Sarah Schlaeger, Stephanie Inhuber, Florian Kreuzpointer, Ansgar Schwirtz, Alexander Rohrmeier, Michael Dieckmeyer, Dennis M. Hedderich, Maximilian N. Diefenbach, Friedemann Freitag, Ernst J. Rummeny, Claus Zimmer, Jan S. Kirschke, Dimitrios C. Karampinos, Thomas Baum
Published in: Journal of Magnetic Resonance Imaging, 2019, ISSN 1053-1807
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/jmri.26679

Multi-detector CT imaging: impact of virtual tube current reduction and sparse sampling on detection of vertebral fractures

Author(s): Nico Sollmann, Kai Mei, Dennis M. Hedderich, Christian Maegerlein, Felix K. Kopp, Maximilian T. Löffler, Claus Zimmer, Ernst J. Rummeny, Jan S. Kirschke, Thomas Baum, Peter B. Noël
Published in: European Radiology, Issue 29/7, 2019, Page(s) 3606-3616, ISSN 0938-7994
Publisher: Springer Verlag
DOI: 10.1007/s00330-019-06090-2

Effects of virtual tube current reduction and sparse sampling on MDCT-based femoral BMD measurements

Author(s): N. Sollmann, K. Mei, B.J. Schwaiger, A.S. Gersing, F.K. Kopp, R. Bippus, C. Maegerlein, C. Zimmer, E.J. Rummeny, J.S. Kirschke, P.B. Noël, T. Baum
Published in: Osteoporosis International, Issue 29/12, 2018, Page(s) 2685-2692, ISSN 0937-941X
Publisher: Springer Verlag
DOI: 10.1007/s00198-018-4675-6

Lumbar muscle and vertebral bodies segmentation of chemical shift encoding-based water-fat MRI: the reference database MyoSegmenTUM spine

Author(s): Egon Burian, Alexander Rohrmeier, Sarah Schlaeger, Michael Dieckmeyer, Maximilian N. Diefenbach, Jan Syväri, Elisabeth Klupp, Dominik Weidlich, Claus Zimmer, Ernst J. Rummeny, Dimitrios C. Karampinos, Jan S. Kirschke, Thomas Baum
Published in: BMC Musculoskeletal Disorders, Issue 20/1, 2019, ISSN 1471-2474
Publisher: BioMed Central
DOI: 10.1186/s12891-019-2528-x

Opportunistic osteoporosis screening in multi-detector CT images via local classification of textures

Author(s): A. Valentinitsch, S. Trebeschi, J. Kaesmacher, C. Lorenz, M. T. Löffler, C. Zimmer, T. Baum, J. S. Kirschke
Published in: Osteoporosis International, Issue 30/6, 2019, Page(s) 1275-1285, ISSN 0937-941X
Publisher: Springer Verlag
DOI: 10.1007/s00198-019-04910-1

Improved prediction of incident vertebral fractures using opportunistic QCT compared to DXA

Author(s): Maximilian T. Löffler, Alina Jacob, Alexander Valentinitsch, Anna Rienmüller, Claus Zimmer, Yu-Mi Ryang, Thomas Baum, Jan S. Kirschke
Published in: European Radiology, Issue 29/9, 2019, Page(s) 4980-4989, ISSN 0938-7994
Publisher: Springer Verlag
DOI: 10.1007/s00330-019-06018-w

Automated assessment of paraspinal muscle fat composition based on the segmentation of chemical shift encoding-based water/fat-separated images

Author(s): Thomas Baum, Cristian Lorenz, Christian Buerger, Friedemann Freitag, Michael Dieckmeyer, Holger Eggers, Claus Zimmer, Dimitrios C. Karampinos, Jan S. Kirschke
Published in: European Radiology Experimental, Issue 2/1, 2018, ISSN 2509-9280
Publisher: ESR
DOI: 10.1186/s41747-018-0065-2

Gender- and Age-Related Changes in Trunk Muscle Composition Using Chemical Shift Encoding-Based Water–Fat MRI

Author(s): Egon Burian, Jan Syväri, Christina Holzapfel, Theresa Drabsch, Jan Kirschke, Ernst Rummeny, Claus Zimmer, Hans Hauner, Dimitrios Karampinos, Thomas Baum, Daniela Franz
Published in: Nutrients, Issue 10/12, 2018, Page(s) 1972, ISSN 2072-6643
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nu10121972

Associations Between Lumbar Vertebral Bone Marrow and Paraspinal Muscle Fat Compositions—An Investigation by Chemical Shift Encoding-Based Water-Fat MRI

Author(s): Nico Sollmann, Michael Dieckmeyer, Sarah Schlaeger, Alexander Rohrmeier, Jan Syvaeri, Maximilian N. Diefenbach, Dominik Weidlich, Stefan Ruschke, Elisabeth Klupp, Daniela Franz, Ernst J. Rummeny, Claus Zimmer, Jan S. Kirschke, Dimitrios C. Karampinos, Thomas Baum
Published in: Frontiers in Endocrinology, Issue 9, 2018, ISSN 1664-2392
Publisher: Frontiers
DOI: 10.3389/fendo.2018.00563

Texture analysis of vertebral bone marrow using chemical shift encoding–based water-fat MRI: a feasibility study

Author(s): E. Burian, K. Subburaj, M. R. K. Mookiah, A. Rohrmeier, D. M. Hedderich, M. Dieckmeyer, M. N. Diefenbach, S. Ruschke, E. J. Rummeny, C. Zimmer, J. S. Kirschke, D. C. Karampinos, T. Baum
Published in: Osteoporosis International, Issue 30/6, 2019, Page(s) 1265-1274, ISSN 0937-941X
Publisher: Springer Verlag
DOI: 10.1007/s00198-019-04924-9

High Isotropic Resolution T2 Mapping of the Lumbosacral Plexus with T2-Prepared 3D Turbo Spin Echo

Author(s): Nico Sollmann, Dominik Weidlich, Barbara Cervantes, Elisabeth Klupp, Carl Ganter, Hendrik Kooijman, Ernst J. Rummeny, Claus Zimmer, Jan S. Kirschke, Dimitrios C. Karampinos
Published in: Clinical Neuroradiology, Issue 29/2, 2019, Page(s) 223-230, ISSN 1869-1439
Publisher: Springer
DOI: 10.1007/s00062-017-0658-9

Bone mineral density measurements derived from dual-layer spectral CT enable opportunistic screening for osteoporosis

Author(s): Ferdinand Roski, Johannes Hammel, Kai Mei, Thomas Baum, Jan S. Kirschke, Alexis Laugerette, Felix K. Kopp, Jannis Bodden, Daniela Pfeiffer, Franz Pfeiffer, Ernst J. Rummeny, Peter B. Noël, Alexandra S. Gersing, Benedikt J. Schwaiger
Published in: European Radiology, Issue 29/11, 2019, Page(s) 6355-6363, ISSN 0938-7994
Publisher: Springer Verlag
DOI: 10.1007/s00330-019-06263-z

Water T 2 Mapping in Fatty Infiltrated Thigh Muscles of Patients With Neuromuscular Diseases Using a T 2 ‐Prepared 3D Turbo Spin Echo With SPAIR

Author(s): Sarah Schlaeger, Dominik Weidlich, Elisabeth Klupp, Federica Montagnese, Marcus Deschauer, Benedikt Schoser, Sarah Bublitz, Stefan Ruschke, Claus Zimmer, Ernst J. Rummeny, Jan S. Kirschke, Dimitrios C. Karampinos
Published in: Journal of Magnetic Resonance Imaging, 2019, ISSN 1053-1807
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/jmri.27032

Vertebral bone marrow fat fraction changes in postmenopausal women with breast cancer receiving combined aromatase inhibitor and bisphosphonate therapy

Author(s): Michael Dieckmeyer, Stefan Ruschke, Alexander Rohrmeier, Jan Syväri, Ingo Einspieler, Vanadin Seifert-Klauss, Monika Schmidmayr, Stephan Metz, Jan S. Kirschke, Ernst J. Rummeny, Claus Zimmer, Dimitrios C. Karampinos, Thomas Baum
Published in: BMC Musculoskeletal Disorders, Issue 20/1, 2019, ISSN 1471-2474
Publisher: BioMed Central
DOI: 10.1186/s12891-019-2916-2

Associations of thigh muscle fat infiltration with isometric strength measurements based on chemical shift encoding-based water-fat magnetic resonance imaging

Author(s): Stephanie Inhuber, Nico Sollmann, Sarah Schlaeger, Michael Dieckmeyer, Egon Burian, Caroline Kohlmeyer, Dimitrios C. Karampinos, Jan S. Kirschke, Thomas Baum, Florian Kreuzpointner, Ansgar Schwirtz
Published in: European Radiology Experimental, Issue 3/1, 2019, ISSN 2509-9280
Publisher: SpringerNature
DOI: 10.1186/s41747-019-0123-4

MR-based assessment of body fat distribution and characteristics

Author(s): Thomas Baum, Christian Cordes, Michael Dieckmeyer, Stefan Ruschke, Daniela Franz, Hans Hauner, Jan S. Kirschke, Dimitrios C. Karampinos
Published in: European Journal of Radiology, Issue 85/8, 2016, Page(s) 1512-1518, ISSN 0720-048X
Publisher: Elsevier BV
DOI: 10.1016/j.ejrad.2016.02.013

B1-insensitive T2 mapping of healthy thigh muscles using a T2-prepared 3D TSE sequence

Author(s): Elisabeth Klupp, Dominik Weidlich, Sarah Schlaeger, Thomas Baum, Barbara Cervantes, Marcus Deschauer, Hendrik Kooijman, Ernst J. Rummeny, Claus Zimmer, Jan S. Kirschke, Dimitrios C. Karampinos
Published in: PLOS ONE, Issue 12/2, 2017, Page(s) e0171337, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0171337

Opportunistic osteoporosis screening: contrast-enhanced dual-layer spectral CT provides accurate measurements of vertebral bone mineral density.

Author(s): Thomas Baum; Peter B. Noël; Benedikt J. Schwaiger; Bernhard Haller; Kai Mei; Kai Mei; Jan S. Kirschke; Klaus Woertler; Johannes Hammel; Ferdinand Roski; Daniela Pfeiffer; Alexandra S. Gersing; Franz Pfeiffer
Published in: European Radiology, Issue 1, 2020, ISSN 0938-7994
Publisher: Springer Verlag
DOI: 10.1007/s00330-020-07319-1

Opportunistic Osteoporosis Screening Reveals Low Bone Density in Patients With Screw Loosening After Lumbar Semi-Rigid Instrumentation: A Case-Control Study

Author(s): Maximilian T. Löffler, Nico Sollmann, Egon Burian, Amirhossein Bayat, Kaywan Aftahy, Thomas Baum, Bernhard Meyer, Yu-Mi Ryang, Jan S. Kirschke
Published in: Frontiers in Endocrinology, Issue 11, 2021, ISSN 1664-2392
Publisher: Frontiers
DOI: 10.3389/fendo.2020.552719

Cranial Implant Prediction Using Low-Resolution 3D Shape Completion and High-Resolution 2D Refinement

Author(s): Amirhossein Bayat, Suprosanna Shit, Adrian Kilian, Jürgen T. Liechtenstein, Jan S. Kirschke, Bjoern H. Menze
Published in: Towards the Automatization of Cranial Implant Design in Cranioplasty - First Challenge, AutoImplant 2020, Held in Conjunction with MICCAI 2020, Lima, Peru, October 8, 2020, Proceedings, Issue 12439, 2020, Page(s) 77-84, ISBN 978-3-030-64326-3
Publisher: Springer International Publishing
DOI: 10.1007/978-3-030-64327-0_9

Attention-Driven Deep Learning for Pathological Spine Segmentation

Author(s): Anjany Sekuboyina, Jan Kukačka, Jan S. Kirschke, Bjoern H. Menze, Alexander Valentinitsch
Published in: International Workshop on Computational Methods and Clinical Applications in Musculoskeletal Imaging, Issue MSKI 2017: Computational Methods and Clinical Applications in Musculoskeletal Imaging, 2018, Page(s) 108-119
Publisher: Springer
DOI: 10.1007/978-3-319-74113-0_10

Probabilistic Point Cloud Reconstructions for Vertebral Shape Analysis

Author(s): Anjany Sekuboyina, Markus Rempfler, Alexander Valentinitsch, Maximilian Loeffler, Jan S. Kirschke, Bjoern H. Menze
Published in: Medical Image Computing and Computer Assisted Intervention – MICCAI 2019 - 22nd International Conference, Shenzhen, China, October 13–17, 2019, Proceedings, Part VI, Issue 11769, 2019, Page(s) 375-383, ISBN 978-3-030-32225-0
Publisher: Springer International Publishing
DOI: 10.1007/978-3-030-32226-7_42

Btrfly Net: Vertebrae Labelling with Energy-Based Adversarial Learning of Local Spine Prior

Author(s): Anjany Sekuboyina, Markus Rempfler, Jan Kukačka, Giles Tetteh, Alexander Valentinitsch, Jan S. Kirschke, Bjoern H. Menze
Published in: Medical Image Computing and Computer Assisted Intervention – MICCAI 2018 - 21st International Conference, Granada, Spain, September 16-20, 2018, Proceedings, Part IV, Issue 11073, 2018, Page(s) 649-657, ISBN 978-3-030-00936-6
Publisher: Springer International Publishing
DOI: 10.1007/978-3-030-00937-3_74

Inferring the 3D Standing Spine Posture from 2D Radiographs

Author(s): Amirhossein Bayat, Anjany Sekuboyina, Johannes C. Paetzold, Christian Payer, Darko Stern, Martin Urschler, Jan S. Kirschke, Bjoern H. Menze
Published in: Medical Image Computing and Computer Assisted Intervention – MICCAI 2020 - 23rd International Conference, Lima, Peru, October 4–8, 2020, Proceedings, Part VI, Issue 12266, 2020, Page(s) 775-784, ISBN 978-3-030-59724-5
Publisher: Springer International Publishing
DOI: 10.1007/978-3-030-59725-2_75

A Localisation-Segmentation Approach for Multi-label Annotation of Lumbar Vertebrae using Deep Nets

Author(s): Anjany Sekuboyina, Alexander Valentinitsch, Jan S. Kirschke, Bjoern H. Menze
Published in: arXiv.org, Issue arXiv:1703.04347, 2017
Publisher: Cornell University

VerSe: A Vertebrae Labelling and Segmentation Benchmark for Multi-detector CT Images

Author(s): Anjany Sekuboyina, Amirhossein Bayat, Malek E. Husseini, Maximilian Löffler, Hongwei Li, Giles Tetteh, Jan Kukačka, Christian Payer, Darko Štern, Martin Urschler, Maodong Chen, Dalong Cheng, Nikolas Lessmann, Yujin Hu, Tianfu Wang, Dong Yang, Daguang Xu, Felix Ambellan, Tamaz Amiranashvili, Moritz Ehlke, Hans Lamecker, Sebastian Lehnert, Marilia Lirio, Nicolás Pérez de Olaguer, Heiko Ramm, Ma
Published in: ArXiv, 2020
Publisher: Cornell University

Association of bone mineral density with reoperation rate following instrumented lumbar spinal fusion

Author(s): Anna Rienmüller; Martin Vazan; Johannes Kaesmacher; Niklas Loreck; Jan S. Kirschke; Ehab Shiban; Maximilian T. Löffler; Felix Zibold; Bernhard Meyer; Yu-Mi Ryang
Published in: researchsquare, Issue 1, 2019
Publisher: Research Square LLC
DOI: 10.21203/rs.2.18126/v1

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