Innate immune responses to human hepatotropic viral infections

Project Information

HBV1

Grant agreement ID: 637304

DOI

10.3030/637304

Project terminated on 26 September 2019

EC signature date 11 May 2015

Start date 1 June 2015

End date 31 May 2020

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 498 312,00

EU contribution

€ 1 498 312,00

Coordinated by

IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
United Kingdom

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (10)

Immune Evasion Strategies during Chronic Hepatitis B and C Virus Infection

Author(s): Ortega-Prieto AM Dorner M
Published in: Vaccines, Issue 5/3, 2017, Page(s) 24, ISSN 2076-393X
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines5030024

3D microfluidic liver cultures as physiological preclinical tool for hepatitis B virus infection

Author(s): Ortega-Prieto AM Skelton JK Wai SN Large E Lussignol M Vizcay-Barrena G Hughes D Fleck RA Thursz M Catanese MT Dorner M
Published in: Nature Communications, 2018, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-018-02969-8

T cell immunity to Zika virus targets immunodominant epitopes that show cross-reactivity with other Flaviviruses

Author(s): C. J. Reynolds, O. M. Suleyman, A. M. Ortega-Prieto, J. K. Skelton, P. Bonnesoeur, A. Blohm, V. Carregaro, J. S. Silva, E. A. James, B. Maillère, M. Dorner, R. J. Boyton, D. M. Altmann
Published in: Scientific Reports, Issue 8/1, 2018, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-017-18781-1

Modeling Unique Patients in Humanized Mice: Toward a Curative Strategy for HIV

Author(s): Marcus Dorner, Ype P. de Jong
Published in: Molecular Therapy, 2018, ISSN 1525-0016
Publisher: Nature Publishing Group
DOI: 10.1016/j.ymthe.2018.01.003

A Hitchhiker's Guide to Humanized Mice: new pathways to studying viral infections

Author(s): Skelton JK, Ortega-Prieto AM, Dorner M
Published in: Immunology, 2018, ISSN 1365-2567
Publisher: Wiley Online Library
DOI: 10.1111/imm.12906

Kinetics of Early Innate Immune Activation during HIV-1 Infection of Humanized Mice

Author(s): Jessica Katy Skelton, Ana Maria Ortega-Prieto, Steve Kaye, Jose Manuel Jimenez-Guardeño, Jane Turner, Michael H. Malim, Greg J. Towers, Marcus Dorner
Published in: Journal of Virology, Issue 93/11, 2019, ISSN 0022-538X
Publisher: American Society for Microbiology
DOI: 10.1128/JVI.02123-18

Identification of Broad-Spectrum Antiviral Compounds by Targeting Viral Entry

Author(s): Michela Mazzon, Ana Ortega-Prieto, Douglas Imrie, Christin Luft, Lena Hess, Stephanie Czieso, Joe Grove, Jessica Skelton, Laura Farleigh, Joachim Bugert, Edward Wright, Nigel Temperton, Richard Angell, Sally Oxenford, Michael Jacobs, Robin Ketteler, Marcus Dorner, Mark Marsh
Published in: Viruses, Issue 11/2, 2019, Page(s) 176, ISSN 1999-4915
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v11020176

In Vivo Model Systems for Hepatitis B Virus Research

Author(s): Ana Maria Ortega-Prieto, Catherine Cherry, Harry Gunn, Marcus Dorner
Published in: ACS Infectious Diseases, Issue 5/5, 2018, Page(s) 688-702, ISSN 2373-8227
Publisher: ACS Infectious Diseases
DOI: 10.1021/acsinfecdis.8b00223

"""Liver-on-a-Chip"" Cultures of Primary Hepatocytes and Kupffer Cells for Hepatitis B Virus Infection"

Author(s): Ana Maria Ortega-Prieto, Jessica Katy Skelton, Catherine Cherry, Marco Antonio Briones-Orta, Charlotte Alexandra Hateley, Marcus Dorner
Published in: Journal of Visualized Experiments, Issue 144, 2019, ISSN 1940-087X
Publisher: MYJoVE Corporation
DOI: 10.3791/58333

Phosphodiesterase-induced cAMP degradation restricts hepatitis B virus infection

Author(s): Antonia Alexandra Evripioti, Ana Maria Ortega-Prieto, Jessica Katy Skelton, Quentin Bazot, Marcus Dorner
Published in: Philosophical Transactions of the Royal Society B: Biological Sciences, Issue 374/1773, 2019, Page(s) 20180292, ISSN 0962-8436
Publisher: Royal Society of London
DOI: 10.1098/rstb.2018.0292

Intellectual Property Rights

Patent (1)

Liver Infection

Application/Publication number: GB PCT/GB2014/052131
Date: 2014-07-11
Applicant(s): IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE