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Frontier research in arterial fibre remodelling for vascular disease diagnosis and tissue engineering

Publications

Collagen fibre characterisation in arterial tissue under load using SALS

Author(s): R.T. Gaul, D.R. Nolan, C. Lally
Published in: Journal of the Mechanical Behavior of Biomedical Materials, Issue 75, 2017, Page(s) 359-368, ISSN 1751-6161
DOI: 10.1016/j.jmbbm.2017.07.036

Quantifying the ultrastructure of carotid artery using high-resolution micro-diffusion tensor imaging – comparison of intact vs. open cut tissue

Author(s): Syed Salman Shahid, Robert Gaul, Christian M Kerskens, Vittoria Flamini, Caitriona Lally
Published in: Physics in Medicine and Biology, 2017, ISSN 0031-9155
DOI: 10.1088/1361-6560/aa9159

An investigation into the role of different constituents in damage accumulation in arterial tissue and constitutive model development

Author(s): Milad Ghasemi, David R. Nolan, Caitríona Lally
Published in: Biomechanics and Modeling in Mechanobiology, 2018, ISSN 1617-7959
DOI: 10.1007/s10237-018-1054-3

The use of small angle light scattering in assessing strain induced collagen degradation in arterial tissue ex vivo

Author(s): R.T. Gaul, D.R. Nolan, C. Lally
Published in: Journal of Biomechanics, 2018, ISSN 0021-9290
DOI: 10.1016/j.jbiomech.2018.10.006

Strain mediated enzymatic degradation of arterial tissue: Insights into the role of the non-collagenous tissue matrix and collagen crimp

Author(s): R.T. Gaul, D.R. Nolan, T. Ristori, C.V.C. Bouten, S. Loerakker, C. Lally
Published in: Acta Biomaterialia, Issue 77, 2018, Page(s) 301-310, ISSN 1742-7061
DOI: 10.1016/j.actbio.2018.06.037

Assessment of mechanical indicators of carotid plaque vulnerability: Geometrical curvature metric, plaque stresses and damage in tissue fibres

Author(s): Milad Ghasemi, David R. Nolan, Caitríona Lally
Published in: Journal of the Mechanical Behavior of Biomedical Materials, Issue 103, 2020, Page(s) 103573, ISSN 1751-6161
DOI: 10.1016/j.jmbbm.2019.103573

Pressure-induced collagen degradation in arterial tissue as a potential mechanism for degenerative arterial disease progression

Author(s): R.T. Gaul, D.R. Nolan, T. Ristori, C.V.C. Bouten, S. Loerakker, C. Lally
Published in: Journal of the Mechanical Behavior of Biomedical Materials, 2020, Page(s) 103771, ISSN 1751-6161
DOI: 10.1016/j.jmbbm.2020.103771

Resident multipotent vascular stem cells exhibit amplitude dependent strain avoidance similar to that of vascular smooth muscle cells

Author(s): Pattie S. Mathieu, Emma Fitzpatrick, Mariana Di Luca, Paul A. Cahill, Caitríona Lally
Published in: Biochemical and Biophysical Research Communications, Issue 521/3, 2020, Page(s) 762-768, ISSN 0006-291X
DOI: 10.1016/j.bbrc.2019.10.185

Strain Mediated Enzyme Degradation of Arterial Tissue; Implications in Disease and Medical Device Design

Author(s): Robert Gaul, Caitríona Lally
Published in: Summer Biomechanics, Bioengineering and Biotransport Conference, 2017

Non-Destructive Characterisation of Arterial Structure using High-Resolution Diffusion MRI

Author(s): Caitríona Lally, Syed S. Shahid, Christian Kerskens, Céline Smekens, Robert Johnston,
Published in: Proceedings of the Matrix Biology Ireland Conference 2017, Issue Yearly, 2017

STRAIN MEDIATED ARTERIAL DEGRADATION IS CRITICALLY INFLUENCED BY MATRIX CONTENT AND COLLAGEN CRIMP

Author(s): Gaul, R T; Nolan, D R; Ristori, T; Loerakker, S; Lally, C.
Published in: 24th Bioengineering in Ireland Conference, Issue yearly, 2018

PARAMETRIC MAPPING OF PORCINE CAROTID ARTERY MODELS FOR QUANTIFYING CELLULARITY IN DISEASED MODELS OF ARTERIAL TISSUE

Author(s): Smekens, C J; Shahid, S S; Kerskens, C; Lally C.
Published in: 24th Bioengineering in Ireland Conference, Issue Yearly, 2018

AN IN-VIVO STUDY ON THE IMPACT OF AXIAL RESOLUTION ON PEAK STRESSES AT THE CAROTID BIFURCATION

Author(s): Johnston, R; Nolan, D; Ghasemi, M; Kerskens, C; Lally, C.
Published in: 24th Bioengineering in Ireland Conference, Issue Yearly, 2018

DAMAGE ACCUMULATION IN ARTERIAL TISSUE; EXPERIMENTAL OBSERVATIONS ON THE ROLE OF MATRIX AND FIBRES AND CONSTITUTIVE MODEL DEVELOPMENT

Author(s): Ghasemi, M; Nolan, D R; Lally, C.
Published in: 24th Bioengineering in Ireland Conference, Issue Yearly, 2018

Optimization of Magnetic Resonance Imaging (MRI) based Patient Specific Models with mechanical property estimation from inverse finite element analysis

Author(s): Robert Johnston, David Nolan, Dorian Botella-Barriot, Milad Ghasemi, Christian Kerskens, Caitriona Lally
Published in: Proceedings of the European Mechanics of Materials Conference, Issue Yearly, 2018

Exploring the influence of damage accumulation on collagen fibre remodelling in arteries under supra-physiological loads

Author(s): Ghasemi, M, Nolan, D, Lally, C.
Published in: Proceedings of the European Mechanics of Materials Conference, Issue Yearly, 2018

PARAMETRIC MAPPING OF PORCINE CAROTID ARTERY MODELS FOR QUANTIFYING CELLULARITY IN DISEASED MODELS OF ARTERIAL TISSUE

Author(s): Smekens, C. J.1,2, Shahid, S. S.3, Kerskens, C.4, Lally, C1,2
Published in: Proceedings of the World Congress of Biomechanics, Issue Every 4 years, 2018

A constituent specific study of damage accumulation in arterial tissue

Author(s): Ghasemi,M., Nolan, D., Lally, C.
Published in: Proceedings of the World Congress of Biomechanics 2018, Issue Every 4 years, 2018

VASCULAR SMOOTH MUSCLE CELLS AND MULTIPOTENT VASCULAR STEM CELLS DIFFER IN THEIR RESPONSE TO CYCLIC TENSILE STRAIN

Author(s): Mathieu, P.S., Fitzpatrick, E., Cahill, P.A., Lally, C.
Published in: Proceedings of World Congress of Biomechanics 2018, Issue Every 4 years, 2018

OPTIMIZATED PATIENT SPECIFIC FINITE ELEMENT MODELS AT THE CAROTID BIFURCATION

Author(s): Johnston, R., Nolan, D., Ghasemi, M., Kerskens, C., Lally, C.
Published in: Proceedings of the World Congress of Biomechanics 2018, Issue Every 4 years, 2018

Degradation of arterial collagen with applied strain: critical influence of matrix content and collagen crimp

Author(s): Gaul, R.T., Nolan, D.R., Ristori, T., Loerakker S., Lally, C.
Published in: Proceedings of the World Congress of Biomechanics, Issue Every 4 years, 2018

Changes in the collagen fibre architecture within stented arterial tissue may play a critical role in directing the vascular cell response post stenting

Author(s): C. Lally, D.R. Nolan, P.S. Mathieu, A. McMahon, P.A. Cahill, E. Fitzpatrick
Published in: Issue Every four years, 2018

TOWARD THE DEVELOPMENT OF A CONSTITUTIVE MODEL TO CAPTURE ARTERIAL COLLAGEN FIBRE REMODELLING AND DAMAGE

Author(s): Milad Ghasemi, David.R.Nolan, Caitríona Lally
Published in: Proceedings of the European Society of Biomechanics Congress July 2017, 2017

Quantification of extracellular matrix components in arterial tissue using high-resolution micro diffusion tensor imaging

Author(s): Shahid, S.S., Kerskens, C., Gaul, R., Lally, C
Published in: Proceedings of the European Molecular Imaging Meeting April 5-7, Cologne, Germany, Issue April 2016 (yearly), 2017

Collagen fibre remodelling in arterial soft tissue

Author(s): Ghasemi, M., Nolan, D.R., Lally, C
Published in: Bioengineering in Ireland 23 Conference, Issue January 2017 (yearly), 2017

A review of arterial tissue remodelling

Author(s): Ghasemi, M., Nolan, D.R., Lally, C
Published in: Bioengineering in Ireland 22 Conference, Issue January 2016 (yearly), 2016

Assessment of clinically relevant measure for identifying vulnerable carotid plaque

Author(s): Nolan, D.R., Ghasemi, M, Lally, C
Published in: Bioengineering in Ireland 23 Conference, Issue January 2017 (yearly), 2017

Ex-vivo arterial collagen fibre tractography using micro-diffusion tensor imaging

Author(s): Shahid, S.S., Kerskens, C., Gaul, R. Flamini, V., Lally, C.
Published in: Proceedings of the European Society for Magnetic Resonance in Medicine and Biology, September 29-October 1, Vienna, Austria., Issue September 2016 (yearly), 2016

Use of high-resolution micro-diffusion tensor imaging to estimate the ultra-structure of the arterial wall

Author(s): Shahid, S.S., Kerskens, C., Lally, C.
Published in: Bioengineering in Ireland 23 Conference, Issue January 2017 (yearly), 2017

Understanding the critical role of strain and structure in vascular remodelling, regeneration and disease.

Author(s): Lally C., Dunphy, S., Mathieu, P., Nolan, D., Cahill, P.
Published in: Matrix Biology Ireland Abstract Proceedings, Issue November 2016 (Yearly), 2016

Diffusion tensor imaging of carotid arteries and atherosclerotic plaques to determine vessel health

Author(s): Brooke Tornifoglio, Alan Stone, Salman Shahid, C. Kerskens, C. Lally
Published in: Bioengineering in Ireland Conference, Issue Yearly, 2019

Investigation of ex-vivo carotid atherosclerotic plaques through diffusion MRI and histology

Author(s): Tornifoglio, B., Stone, A. J., Bourke, M., Iacob, L., Clarke, J., Madhavan, P., Martin, Z., O’Callaghan, A., O’Neill, S., Kerskens, C., Lally, C.
Published in: Virtual Physiological Human Workshop 2019, Issue Yearly, 2019

Inclusion of residual stresses in patient specific finite element simulations

Author(s): Robert Johnston, David Nolan, Milad Ghasemi, Christian Kerskens, Caitríona Lally
Published in: Bioengineering in Ireland Conference, Issue Yearly, 2019

Exploring remodelling and damage in arterial tissue using in vitro testing techniques and computational modelling

Author(s): C. Lally
Published in: Virtual Physiological Human Workshop 2019, Issue Yearly, 2019

Investigation of carotid atherosclerotic plaques through diffusion tensor imaging

Author(s): Tornifoglio, B., Stone, A.J., Shahid, S., Iacob, L., Clarke, J., O’Callaghan, A., O’Neill, S., Kerskens, C., Lally, C.
Published in: Proceedings of 36th Annual Scientific Meeting of ESMRMB, Issue Yearly, 2019

Elucidating the role of strain and scaffold structure in vascular tissue engineering applications using in vitro and in silico experiments

Author(s): C. Lally
Published in: Proceedings of the Euromech Symposium 604, 2019

Diffusion MRI of carotid arteries and atherosclerotic plaques: insight into microstructural alterations

Author(s): Tornifoglio, B., Stone, A.J., Shahid, S., Iacob, L., Clarke, J., O’Callaghan, A., O’Neill, S., Kerskens, C., Lally, C.
Published in: Bioengineering in Ireland Conference, Issue Yearly, 2020

Collagen fibre orientation, not content determines the ultimate tensile strength and strain of atherosclerotic plaque caps

Author(s): R. Johnston, R. Gaul, C. Lally
Published in: Bioengineering in Ireland Conference, Issue Yearly, 2020

The Critical Role of Seeding Density on the Growth Response of Porcine Bone Marrow MSCs to Cyclic Strain and Substrate Structure​

Author(s): E. Fitzpatrick, P. Mathieu, C. Lally
Published in: Bioengineering in Ireland Conference, Issue Yearly, 2019

ESMRMB 2019, 36th Annual Scientific Meeting, Rotterdam, NL, October 3–October 5: Abstracts, Thursday

Author(s): A. Stone, R. Johnston, B.Tornifoglio, C.Kerskens, C. Lally
Published in: Magnetic Resonance Materials in Physics, Biology and Medicine, Issue 32/S1, 2019, Page(s) 1-105, ISSN 0968-5243
DOI: 10.1007/s10334-019-00753-3

ESMRMB 2019, 36th Annual Scientific Meeting, Rotterdam, NL, October 3–October 5: Abstracts, Friday

Author(s): R Johnston, A. Stone, M. Bourke , P. Madhavan, Z. Martin, C. Kerskens, C. Lally
Published in: Magnetic Resonance Materials in Physics, Biology and Medicine, Issue 32/S1, 2019, Page(s) 107-233, ISSN 0968-5243
DOI: 10.1007/s10334-019-00754-2