Frontier research in arterial fibre remodelling for vascular disease diagnosis and tissue engineering

An in-silico Investigation Into the Role of Strain and Structure on Vascular Smooth Muscle Cell Growth

Author(s): Orla M. McGee, David R. Nolan, Pattie S. Mathieu, Caitriona Lally
Published in: Frontiers in Bioengineering and Biotechnology, Issue 9, 2021, Page(s) 1-13, ISSN 2296-4185
Publisher: Frontiers Media S.A.
DOI: 10.3389/fbioe.2021.641794

Exploring arterial tissue microstructural organization using non-Gaussian diffusion magnetic resonance schemes

Author(s): Syed Salman Shahid, Robert D. Johnston, Celine Smekens, Christian Kerskens, Robert Gaul, Brooke Tornifoglio, Alan J. Stone, Caitriona Lally
Published in: Scientific Reports, Issue 11, 2021, Page(s) 1-13, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-021-01476-z

Native extracellular matrix orientation determines multipotent vascular stem cell proliferation in response to cyclic uniaxial tensile strain and simulated stent indentation

Author(s): Pattie Mathieu, Emma Fitzpatrick, Mariana Di Luca, Paul A. Cahill, Caitriona Lally
Published in: Biochemistry and Biophysics Reports, Issue 29, 2022, Page(s) 1-7, ISSN 2405-5808
Publisher: Elsevier B.V.
DOI: 10.1016/j.bbrep.2021.101183

Diffusion tensor imaging and arterial tissue: establishing the influence of arterial tissue microstructure on fractional anisotropy, mean diffusivity and tractography

Author(s): Brooke Tornifoglio; Alan J. Stone; Robert D. Johnston; Syed Salman Shahid; Christian Kerskens; Caitríona Lally; Caitríona Lally
Published in: Scientific Reports, Issue 3, 2020, Page(s) 1-12, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1101/2020.05.20.104711

Development of a Collagen Fibre Remodelling Rupture Risk Metric for Potentially Vulnerable Carotid Artery Atherosclerotic Plaques

Author(s): Milad Ghasemi, Robert D. Johnston, Caitriona Lally
Published in: Frontiers in Bioengineering and Biotechnology, Issue 12, 2021, Page(s) 1-17, ISSN 2296-4185
Publisher: Frontiers Media S.A.
DOI: 10.3389/fphys.2021.718470

Collagen fibre characterisation in arterial tissue under load using SALS

Author(s): R.T. Gaul, D.R. Nolan, C. Lally
Published in: Journal of the Mechanical Behavior of Biomedical Materials, Issue 75, 2017, Page(s) 359-368, ISSN 1751-6161
Publisher: Elsevier BV
DOI: 10.1016/j.jmbbm.2017.07.036

Quantifying the ultrastructure of carotid artery using high-resolution micro-diffusion tensor imaging – comparison of intact vs. open cut tissue

Author(s): Syed Salman Shahid, Robert Gaul, Christian M Kerskens, Vittoria Flamini, Caitriona Lally
Published in: Physics in Medicine and Biology, 2017, ISSN 0031-9155
Publisher: Institute of Physics Publishing
DOI: 10.1088/1361-6560/aa9159

An investigation into the role of different constituents in damage accumulation in arterial tissue and constitutive model development

Author(s): Milad Ghasemi, David R. Nolan, Caitríona Lally
Published in: Biomechanics and Modeling in Mechanobiology, 2018, ISSN 1617-7959
Publisher: Springer Verlag
DOI: 10.1007/s10237-018-1054-3

The use of small angle light scattering in assessing strain induced collagen degradation in arterial tissue ex vivo

Author(s): R.T. Gaul, D.R. Nolan, C. Lally
Published in: Journal of Biomechanics, 2018, ISSN 0021-9290
Publisher: Elsevier BV
DOI: 10.1016/j.jbiomech.2018.10.006

Strain mediated enzymatic degradation of arterial tissue: Insights into the role of the non-collagenous tissue matrix and collagen crimp

Author(s): R.T. Gaul, D.R. Nolan, T. Ristori, C.V.C. Bouten, S. Loerakker, C. Lally
Published in: Acta Biomaterialia, Issue 77, 2018, Page(s) 301-310, ISSN 1742-7061
Publisher: Elsevier BV
DOI: 10.1016/j.actbio.2018.06.037

Assessment of mechanical indicators of carotid plaque vulnerability: Geometrical curvature metric, plaque stresses and damage in tissue fibres

Author(s): Milad Ghasemi, David R. Nolan, Caitríona Lally
Published in: Journal of the Mechanical Behavior of Biomedical Materials, Issue 103, 2020, Page(s) 103573, ISSN 1751-6161
Publisher: Elsevier BV
DOI: 10.1016/j.jmbbm.2019.103573

Pressure-induced collagen degradation in arterial tissue as a potential mechanism for degenerative arterial disease progression

Author(s): R.T. Gaul, D.R. Nolan, T. Ristori, C.V.C. Bouten, S. Loerakker, C. Lally
Published in: Journal of the Mechanical Behavior of Biomedical Materials, 2020, Page(s) 103771, ISSN 1751-6161
Publisher: Elsevier BV
DOI: 10.1016/j.jmbbm.2020.103771

Resident multipotent vascular stem cells exhibit amplitude dependent strain avoidance similar to that of vascular smooth muscle cells

Author(s): Pattie S. Mathieu, Emma Fitzpatrick, Mariana Di Luca, Paul A. Cahill, Caitríona Lally
Published in: Biochemical and Biophysical Research Communications, Issue 521/3, 2020, Page(s) 762-768, ISSN 0006-291X
Publisher: Academic Press
DOI: 10.1016/j.bbrc.2019.10.185

Quantitative susceptibility mapping of carotid arterial tissue ex vivo: Assessing sensitivity to vessel microstructural composition

Author(s): Alan J. Stone, Brooke Tornifoglio, Robert D. Johnston, Karin Shmueli, Christian Kerskens, Caitriona Lally
Published in: Magnetic Resonance in Medicine, Issue 86, 2021, Page(s) 2512-2527, ISSN 1522-2594
Publisher: Wiley
DOI: 10.1002/mrm.28893

An investigation into the critical role of fibre orientation in the ultimate tensile strength and stiffness of human carotid plaque caps

Author(s): Robert D. Johnston, Robert T. Gaul, Caitriona Lally
Published in: Acta Biomaterialia, Issue 124, 2021, Page(s) 291-300, ISSN 1742-7061
Publisher: Elsevier BV
DOI: 10.1016/j.actbio.2021.02.008

Fundamental insights into the biomechanics of atherosclerotic plaque tissue: Determining possible new diagnostic measures of plaque vulnerability

Author(s): Robert Daniel Johnston, Caitriona Lally
Published in: 2022
Publisher: Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng

Mechanical Assessment of the Risk of Atherosclerotic Plaque Rupture in Carotid Arteries with a Focus on Damage Accumulation

Author(s): Milad Ghasemi, Caitriona Lally
Published in: 2019
Publisher: Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng

INVESTIGATING THE POTENTIAL OF IN-VIVO MRI STRAIN MEASUREMENTS TO IDENTIFY CAROTID PLAQUES AT RISK OF RUPTURE

Author(s): Johnston, R., Gaul, R., Ghasemi, M., Tornifoglio, B., Lally, C.
Published in: 26th Congress of the European Society of Biomechanics, 2021
Publisher: Politecnico Milano

INVESTIGATING THE POTENTIAL OF IN-VIVO MRI STRAIN MEASUREMENTS TO IDENTIFY CAROTID PLAQUES AT RISK OF RUPTURE

Author(s): Johnston, R., Gaul, R., Ghasemi, M., Tornifoglio, B., Lally, C.
Published in: Bioengineering in Ireland 2021, 2021
Publisher: BinI

Ex vivo diffusion tensor imaging to investigate atherosclerosis in human carotid arteries

Author(s): Brooke Tornifoglio, Alan J. Stone, Christian Kerskens, Caitríona Lally
Published in: 11th European Solid Mechanics Conference, 2022
Publisher: ESMC

Diffusion tensor imaging (DTI)-derived metrics as non-invasive biomarkers for plaque stability and tissue engineering –Investigating microstructure and mechanics

Author(s): Tornifoglio, B., Johnston, R., Stone, A.J., Kerskens, C., Lally, C.
Published in: Bioengineering in Ireland 2022, 2022
Publisher: BinI

Investigating the potential of DTI-derived metrics to characterise human atherosclerotic plaques

Author(s): Brooke Tornifoglio, Robert D. Johnston, Alan J. Stone, Christian Kerskens, Caitríona Lally
Published in: 9th World Congress of Biomechanics 2022, 2022
Publisher: WCB

Using DTI-derived metrics to non-invasively track recellularisation in vascular tissue engineering

Author(s): Brooke Tornifoglio, Alan J. Stone, Pattie Mathieu, Emma Fitzpatrick, Christian Kerskens, Caitríona Lally
Published in: 17th international symposium on Biomechanics in Vascular Biology and Cardiovascular Disease, 2022
Publisher: BVBCD

Investigating the potential of diffusion tensor imaging metrics to inform atherosclerotic plaque mechanical integrity

Author(s): Brooke Tornifoglio, Robert D. Johnston, Alan J. Stone, Mike Bourke, Lucian Iacob, Prakash Madhavan, Zenia Martin, Adrian O’Callaghan, Sean O’Neill, Christian Kerskens, Caitríona Lally
Published in: 18th European Mechanics of Materials Conference (EMMC18), 2022
Publisher: EMMC

Strain Mediated Enzyme Degradation of Arterial Tissue; Implications in Disease and Medical Device Design

Author(s): Robert Gaul, Caitríona Lally
Published in: Summer Biomechanics, Bioengineering and Biotransport Conference, 2017
Publisher: TARA (Trinity College Dublin Repository)

Non-Destructive Characterisation of Arterial Structure using High-Resolution Diffusion MRI

Author(s): Caitríona Lally, Syed S. Shahid, Christian Kerskens, Céline Smekens, Robert Johnston,
Published in: Proceedings of the Matrix Biology Ireland Conference 2017, Issue Yearly, 2017
Publisher: Matrix Biology Ireland

STRAIN MEDIATED ARTERIAL DEGRADATION IS CRITICALLY INFLUENCED BY MATRIX CONTENT AND COLLAGEN CRIMP

Author(s): Gaul, R T; Nolan, D R; Ristori, T; Loerakker, S; Lally, C.
Published in: 24th Bioengineering in Ireland Conference, Issue yearly, 2018
Publisher: Royal Academy of Medicine

PARAMETRIC MAPPING OF PORCINE CAROTID ARTERY MODELS FOR QUANTIFYING CELLULARITY IN DISEASED MODELS OF ARTERIAL TISSUE

Author(s): Smekens, C J; Shahid, S S; Kerskens, C; Lally C.
Published in: 24th Bioengineering in Ireland Conference, Issue Yearly, 2018
Publisher: Royal Academy of Medicine

AN IN-VIVO STUDY ON THE IMPACT OF AXIAL RESOLUTION ON PEAK STRESSES AT THE CAROTID BIFURCATION

Author(s): Johnston, R; Nolan, D; Ghasemi, M; Kerskens, C; Lally, C.
Published in: 24th Bioengineering in Ireland Conference, Issue Yearly, 2018
Publisher: Royal Academy of Medicine

DAMAGE ACCUMULATION IN ARTERIAL TISSUE; EXPERIMENTAL OBSERVATIONS ON THE ROLE OF MATRIX AND FIBRES AND CONSTITUTIVE MODEL DEVELOPMENT

Author(s): Ghasemi, M; Nolan, D R; Lally, C.
Published in: 24th Bioengineering in Ireland Conference, Issue Yearly, 2018
Publisher: Royal Academy of Medicine

Optimization of Magnetic Resonance Imaging (MRI) based Patient Specific Models with mechanical property estimation from inverse finite element analysis

Author(s): Robert Johnston, David Nolan, Dorian Botella-Barriot, Milad Ghasemi, Christian Kerskens, Caitriona Lally
Published in: Proceedings of the European Mechanics of Materials Conference, Issue Yearly, 2018
Publisher: European Mechanics Society

Exploring the influence of damage accumulation on collagen fibre remodelling in arteries under supra-physiological loads

Author(s): Ghasemi, M, Nolan, D, Lally, C.
Published in: Proceedings of the European Mechanics of Materials Conference, Issue Yearly, 2018
Publisher: European Mechanics Society

PARAMETRIC MAPPING OF PORCINE CAROTID ARTERY MODELS FOR QUANTIFYING CELLULARITY IN DISEASED MODELS OF ARTERIAL TISSUE

Author(s): Smekens, C. J.1,2, Shahid, S. S.3, Kerskens, C.4, Lally, C1,2
Published in: Proceedings of the World Congress of Biomechanics, Issue Every 4 years, 2018
Publisher: World Congress of Biomechanics

A constituent specific study of damage accumulation in arterial tissue

Author(s): Ghasemi,M., Nolan, D., Lally, C.
Published in: Proceedings of the World Congress of Biomechanics 2018, Issue Every 4 years, 2018
Publisher: World Congress of Biomechanics

VASCULAR SMOOTH MUSCLE CELLS AND MULTIPOTENT VASCULAR STEM CELLS DIFFER IN THEIR RESPONSE TO CYCLIC TENSILE STRAIN

Author(s): Mathieu, P.S., Fitzpatrick, E., Cahill, P.A., Lally, C.
Published in: Proceedings of World Congress of Biomechanics 2018, Issue Every 4 years, 2018
Publisher: World Congress of Biomechanics

OPTIMIZATED PATIENT SPECIFIC FINITE ELEMENT MODELS AT THE CAROTID BIFURCATION

Author(s): Johnston, R., Nolan, D., Ghasemi, M., Kerskens, C., Lally, C.
Published in: Proceedings of the World Congress of Biomechanics 2018, Issue Every 4 years, 2018
Publisher: World Congress of Biomechanics

Degradation of arterial collagen with applied strain: critical influence of matrix content and collagen crimp

Author(s): Gaul, R.T., Nolan, D.R., Ristori, T., Loerakker S., Lally, C.
Published in: Proceedings of the World Congress of Biomechanics, Issue Every 4 years, 2018
Publisher: World Congress of Biomechanics

Changes in the collagen fibre architecture within stented arterial tissue may play a critical role in directing the vascular cell response post stenting

Author(s): C. Lally, D.R. Nolan, P.S. Mathieu, A. McMahon, P.A. Cahill, E. Fitzpatrick
Published in: Issue Every four years, 2018
Publisher: Proceedings of the World Congress of Biomechanics 2018

TOWARD THE DEVELOPMENT OF A CONSTITUTIVE MODEL TO CAPTURE ARTERIAL COLLAGEN FIBRE REMODELLING AND DAMAGE

Author(s): Milad Ghasemi, David.R.Nolan, Caitríona Lally
Published in: Proceedings of the European Society of Biomechanics Congress July 2017, 2017
Publisher: ESB

Quantification of extracellular matrix components in arterial tissue using high-resolution micro diffusion tensor imaging

Author(s): Shahid, S.S., Kerskens, C., Gaul, R., Lally, C
Published in: Proceedings of the European Molecular Imaging Meeting April 5-7, Cologne, Germany, Issue April 2016 (yearly), 2017
Publisher: EMIM

Collagen fibre remodelling in arterial soft tissue

Author(s): Ghasemi, M., Nolan, D.R., Lally, C
Published in: Bioengineering in Ireland 23 Conference, Issue January 2017 (yearly), 2017
Publisher: Royal Academy of Medicine in Ireland

A review of arterial tissue remodelling

Author(s): Ghasemi, M., Nolan, D.R., Lally, C
Published in: Bioengineering in Ireland 22 Conference, Issue January 2016 (yearly), 2016
Publisher: Royal Academy of Medicine in Ireland

Assessment of clinically relevant measure for identifying vulnerable carotid plaque

Author(s): Nolan, D.R., Ghasemi, M, Lally, C
Published in: Bioengineering in Ireland 23 Conference, Issue January 2017 (yearly), 2017
Publisher: Royal Academy of Medicine in Ireland

Ex-vivo arterial collagen fibre tractography using micro-diffusion tensor imaging

Author(s): Shahid, S.S., Kerskens, C., Gaul, R. Flamini, V., Lally, C.
Published in: Proceedings of the European Society for Magnetic Resonance in Medicine and Biology, September 29-October 1, Vienna, Austria., Issue September 2016 (yearly), 2016
Publisher: European Society for Magnetic Resonance in Medicine and Biology

Use of high-resolution micro-diffusion tensor imaging to estimate the ultra-structure of the arterial wall

Author(s): Shahid, S.S., Kerskens, C., Lally, C.
Published in: Bioengineering in Ireland 23 Conference, Issue January 2017 (yearly), 2017
Publisher: Royal Academy of Medicine in Ireland

Understanding the critical role of strain and structure in vascular remodelling, regeneration and disease.

Author(s): Lally C., Dunphy, S., Mathieu, P., Nolan, D., Cahill, P.
Published in: Matrix Biology Ireland Abstract Proceedings, Issue November 2016 (Yearly), 2016
Publisher: Matrix Biology Ireland

Diffusion tensor imaging of carotid arteries and atherosclerotic plaques to determine vessel health

Author(s): Brooke Tornifoglio, Alan Stone, Salman Shahid, C. Kerskens, C. Lally
Published in: Bioengineering in Ireland Conference, Issue Yearly, 2019
Publisher: Royal Academy of Medicine

Investigation of ex-vivo carotid atherosclerotic plaques through diffusion MRI and histology

Author(s): Tornifoglio, B., Stone, A. J., Bourke, M., Iacob, L., Clarke, J., Madhavan, P., Martin, Z., O’Callaghan, A., O’Neill, S., Kerskens, C., Lally, C.
Published in: Virtual Physiological Human Workshop 2019, Issue Yearly, 2019
Publisher: Virtual Physiological Human

Inclusion of residual stresses in patient specific finite element simulations

Author(s): Robert Johnston, David Nolan, Milad Ghasemi, Christian Kerskens, Caitríona Lally
Published in: Bioengineering in Ireland Conference, Issue Yearly, 2019
Publisher: Royal Academy of Medicine in Ireland

Exploring remodelling and damage in arterial tissue using in vitro testing techniques and computational modelling

Author(s): C. Lally
Published in: Virtual Physiological Human Workshop 2019, Issue Yearly, 2019
Publisher: Virtual Physiological Human

Investigation of carotid atherosclerotic plaques through diffusion tensor imaging

Author(s): Tornifoglio, B., Stone, A.J., Shahid, S., Iacob, L., Clarke, J., O’Callaghan, A., O’Neill, S., Kerskens, C., Lally, C.
Published in: Proceedings of 36th Annual Scientific Meeting of ESMRMB, Issue Yearly, 2019
Publisher: ESMRMB

Elucidating the role of strain and scaffold structure in vascular tissue engineering applications using in vitro and in silico experiments

Author(s): C. Lally
Published in: Proceedings of the Euromech Symposium 604, 2019
Publisher: Euromech Symposium 604

Diffusion MRI of carotid arteries and atherosclerotic plaques: insight into microstructural alterations

Author(s): Tornifoglio, B., Stone, A.J., Shahid, S., Iacob, L., Clarke, J., O’Callaghan, A., O’Neill, S., Kerskens, C., Lally, C.
Published in: Bioengineering in Ireland Conference, Issue Yearly, 2020
Publisher: Royal Academy of Medicine in Ireland

Collagen fibre orientation, not content determines the ultimate tensile strength and strain of atherosclerotic plaque caps

Author(s): R. Johnston, R. Gaul, C. Lally
Published in: Bioengineering in Ireland Conference, Issue Yearly, 2020
Publisher: Royal Academy of Medicine in Ireland

The Critical Role of Seeding Density on the Growth Response of Porcine Bone Marrow MSCs to Cyclic Strain and Substrate Structure

Author(s): E. Fitzpatrick, P. Mathieu, C. Lally
Published in: Bioengineering in Ireland Conference, Issue Yearly, 2019
Publisher: Royal Academy of Medicine in Ireland

An investigation into microstructural changes in human atherosclerotic carotid arteries using diffusion tensor imaging

Author(s): Tornifoglio, B., Stone, A. J., Kerskens, C., Lally C.
Published in: British and Irish Chapter of ISMRMB, 2021, 2021
Publisher: BICISMRMB

CHARACTERISATION OF HEALTHY AND DISEASED HUMAN CAROTID ARTERIES USING DIFFUSION TENSOR MAGNETIC RESONANCE IMAGING

Author(s): Brooke Tornifoglio, Alan J. Stone, Christian Kerskens, Caitriona Lally
Published in: 26th Congress of the European Society of Biomechanics, 2021
Publisher: Politecnico Milano

Characterisation of arterial tissue microstructure by ex vivo diffusion MRI

Author(s): Tornifoglio, B., Stone, A.J., Shahid, S., Iacob, L., Clarke, J., O’Callaghan, A., O’Neill, S., Kerskens, C., Lally, C.
Published in: British and Irish chapter of ISMRMB, 2020, 2020
Publisher: BICISMRMB

Inverse Material Parameter Estimation of Patient Specific Finite Element Models at the Carotid Bifurcation: The Impact of Excluding the Zero Pressure Configuration and Residual Stress

Author(s): Robert D. Johnston, Milad Ghasemi, Caitriona Lally
Published in: bioRxiv, 2022
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2022.04.12.487823

ESMRMB 2019, 36th Annual Scientific Meeting, Rotterdam, NL, October 3–October 5: Abstracts, Thursday

Author(s): A. Stone, R. Johnston, B.Tornifoglio, C.Kerskens, C. Lally
Published in: Magnetic Resonance Materials in Physics, Biology and Medicine, Issue 32/S1, 2019, Page(s) 1-105, ISSN 0968-5243
Publisher: Springer Verlag
DOI: 10.1007/s10334-019-00753-3

ESMRMB 2019, 36th Annual Scientific Meeting, Rotterdam, NL, October 3–October 5: Abstracts, Friday

Author(s): R Johnston, A. Stone, M. Bourke , P. Madhavan, Z. Martin, C. Kerskens, C. Lally
Published in: Magnetic Resonance Materials in Physics, Biology and Medicine, Issue 32/S1, 2019, Page(s) 107-233, ISSN 0968-5243
Publisher: Springer Verlag
DOI: 10.1007/s10334-019-00754-2

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