Translational regulation in the persistence and drug susceptibility of Mycobacterium tuberculosis

Project Information

MtbTransReg

Grant agreement ID: 637730

DOI 10.3030/637730

Project closed

EC signature date 21 May 2015

Start date 1 June 2015

End date 30 November 2021

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 495 625,00

EU contribution € 1 495 625,00

Coordinated by

LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE ROYAL CHARTER
United Kingdom

Publications

Peer reviewed articles (7)

Transcriptomic Characterization of Tuberculous Sputum Reveals a Host Warburg Effect and Microbial Cholesterol Catabolism

Author(s): Rachel P. J. Lai, Teresa Cortes, Suzaan Marais, Neesha Rockwood, Melissa L. Burke, Acely Garza-Garcia, Stuart Horswell, Abdul K. Sesay, Anne O’Garra, Douglas B. Young, Robert J. Wilkinson
Published in: mBio, 2021, ISSN 2150-7511
Publisher: ASM Journals
DOI: 10.1128/mbio.01766-21

Translation of a Leaderless Reporter Is Robust During Exponential Growth and Well Sustained During Stress Conditions in Mycobacterium tuberculosis

Author(s): Anna D. Grabowska, Nuria Andreu, Teresa Cortes,
Published in: Frontiers in Microbiology, Issue 12:746320, 2021, ISSN 2693-5015
Publisher: Frontiers
DOI: 10.3389/fmicb.2021.746320

Translational regulation in mycobacteria and its implications for pathogenicity

Author(s): Elizabeth B Sawyer, Anna D Grabowska, Teresa Cortes
Published in: Nucleic Acids Research, Issue 46/14, 2018, Page(s) 6950-6961, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gky574

Delayed effects of transcriptional responses in Mycobacterium tuberculosis exposed to nitric oxide suggest other mechanisms involved in survival

Author(s): Teresa Cortes, Olga T. Schubert, Amir Banaei-Esfahani, Ben C. Collins, Ruedi Aebersold, Douglas B. Young
Published in: Scientific Reports, Issue 7/1, 2017, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-017-08306-1

Genome-wide mutational biases fuel transcriptional diversity in the Mycobacterium tuberculosis complex

Author(s): Álvaro Chiner-Oms, Michael Berney, Christine Boinett, Fernando González-Candelas, Douglas B. Young, Sebastien Gagneux, William R. Jacobs, Julian Parkhill, Teresa Cortes, Iñaki Comas
Published in: Nature Communications, Issue 10/1, 2019, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-019-11948-6

Comparative fitness analysis of D-cycloserine resistant mutants reveals both fitness-neutral and high-fitness cost genotypes

Author(s): Dimitrios Evangelopoulos, Gareth A. Prosser, Angela Rodgers, Belinda M. Dagg, Bhagwati Khatri, Mei Mei Ho, Maximiliano G. Gutierrez, Teresa Cortes, Luiz Pedro S. de Carvalho
Published in: Nature Communications, Issue 10/1, 2019, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-019-12074-z

A snapshot of translation in Mycobacterium tuberculosis during exponential growth and nutrient starvation revealed by ribosome profiling

Author(s): Elizabeth B. Sawyer, Jody E. Phelan, Taane G. Clark, Teresa Cortes
Published in: Cell Reports, Issue 34/5, 2021, Page(s) 108695, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2021.108695