Structural studies of mammalian Cys-loop receptors

Project Information

PentaBrain

Grant agreement ID: 637733

DOI 10.3030/637733

Project closed

EC signature date 22 April 2015

Start date 1 June 2015

End date 30 November 2021

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 500 000,00

EU contribution € 1 500 000,00

Coordinated by

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France

Publications

Thesis and dissertations (1)

Etudes Structurales du récepteur 5-HT3

Author(s): Lucie Polovinkin
Published in: 2019
Publisher: N/A

Peer reviewed articles (5)

International Union of Basic and Clinical Pharmacology. CX. Classification of Receptors for 5-hydroxytryptamine; Pharmacology and Function

Author(s): Barnes NM, Ahern GP, Becamel C, Bockaert J, Camilleri M,Chaumont-Dubel S,Claeysen S,Cunningham KA,Fone KC,Gershon M,Di Giovanni G,Goodfellow NM,Halberstadt AL,Hartley RM,Hassaine G,Herrick-Davis K,Hovius R,Lacivita E,Lambe EK,Leopoldo M,Levy FO,Lummis SCR,Marin P,Maroteaux L,McCreary AC,Nelson DL,Neumaier JF,Newman-Tancredi A, Nury H, Roberts A,Roth BL,Roumier A,Sanger GJ,Teitler M,Sharp T,Villal
Published in: Pharmacol. Rev., 2021, ISSN 0031-6997
Publisher: American Society for Pharmacology and Experimental Therapeutics
DOI: 10.1124/pr.118.015552

Megabodies expand the nanobody toolkit for protein structure determination by single-particle cryo-EM

Author(s): Uchański T,Masiulis S,Fischer B,Kalichuk V, López-Sánchez U, Zarkadas E, Weckener M,Sente A,Ward P,Wohlkönig A,Zögg T,Remaut H,Naismith JH,Nury H,Vranken W,Aricescu AR,Pardon E,Steyaert J
Published in: Nature Methods, 2021, ISSN 1548-7091
Publisher: Nature Publishing Group
DOI: 10.1038/s41592-020-01001-6

The Binding of Palonosetron and Other Antiemetic Drugs to the Serotonin 5-HT3 Receptor

Author(s): Zarkadas E,Zhang H,Cai W,Effantin G,Perot J,Neyton J,Chipot C,Schoehn G,Dehez F,Nury H
Published in: Structure, 2020, ISSN 0969-2126
Publisher: Cell Press
DOI: 10.1016/j.str.2020.07.004

Conformational transitions of the serotonin 5-HT3 receptor

Author(s): Lucie Polovinkin, Ghérici Hassaine, Jonathan Perot, Emmanuelle Neumann, Anders A. Jensen, Solène N. Lefebvre, Pierre-Jean Corringer, Jacques Neyton, Christophe Chipot, Francois Dehez, Guy Schoehn, Hugues Nury
Published in: Nature, Issue 563/7730, 2018, Page(s) 275-279, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-018-0672-3

A lipid site shapes the agonist response of a pentameric ligand-gated ion channel

Author(s): Hénault CM,Govaerts C,Spurny R,Brams M,Estrada-Mondragon A,Lynch J,Bertrand D,Pardon E,Evans GL,Woods K,Elberson BW,Cuello LG,Brannigan G,Nury H,Steyaert J,Baenziger JE,Ulens C
Published in: Nat. Chem. Biol., 2019, ISSN 1552-4450
Publisher: Nature Publishing Group
DOI: 10.1038/s41589-019-0369-4

Book chapters (1)

Expression, Biochemistry, and Stabilization with Camel Antibodies of Membrane Proteins: Case Study of the Mouse 5-HT3 Receptor

Author(s): Ghérici Hassaïne, Cédric Deluz, Luigino Grasso, Romain Wyss, Ruud Hovius, Henning Stahlberg, Takashi Tomizaki, Aline Desmyter, Christophe Moreau, Lucie Peclinovska, Sonja Minniberger, Lamia Mebarki, Xiao-Dan Li, Horst Vogel, Hugues Nury
Published in: Methods in Molecular Biology, Membrane Protein Structure and Function Characterization, 2017, Page(s) 139-168
Publisher: Springer New York
DOI: 10.1007/978-1-4939-7151-0_8