CORDIS - EU research results

ToWards Immunisations that Last: the Immunology and Gerontology of Helper T cells


Human blood T fr cells are indicators of ongoing humoral activity not fully licensed with suppressive function

Author(s): Valter R. Fonseca, Ana Agua-Doce, Ana Raquel Maceiras, Wim Pierson, Filipa Ribeiro, Vasco C. Romão, Ana Rita Pires, Susana Lopes da Silva, João Eurico Fonseca, Ana E. Sousa, Michelle A. Linterman, Luis Graca
Published in: Science Immunology, Issue 2/14, 2017, Page(s) eaan1487, ISSN 2470-9468
Publisher: AAAs
DOI: 10.1126/sciimmunol.aan1487

Signals that drive T follicular helper cell formation

Author(s): Louise M. C. Webb, Michelle A. Linterman
Published in: Immunology, Issue 152/2, 2017, Page(s) 185-194, ISSN 0019-2805
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/imm.12778

Follicular regulatory T cells can be specific for the immunizing antigen and derive from naive T cells

Author(s): Meryem Aloulou, Edward J. Carr, Mylène Gador, Alexandre Bignon, Roland S. Liblau, Nicolas Fazilleau, Michelle A. Linterman
Published in: Nature Communications, Issue 7, 2016, Page(s) 10579, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/ncomms10579

The cellular composition of the human immune system is shaped by age and cohabitation

Author(s): Edward J Carr, James Dooley, Josselyn E Garcia-Perez, Vasiliki Lagou, James C Lee, Carine Wouters, Isabelle Meyts, An Goris, Guy Boeckxstaens, Michelle A Linterman, Adrian Liston
Published in: Nature Immunology, Issue 17/4, 2016, Page(s) 461-468, ISSN 1529-2908
Publisher: Nature Publishing Group
DOI: 10.1038/ni.3371

Can follicular helper T cells be targeted to improve vaccine efficacy?

Author(s): Michelle A. Linterman, Danika L. Hill
Published in: F1000Research, 2016, ISSN 2046-1402
Publisher: F1000 Research Ltd.
DOI: 10.12688/f1000research.7388.1

Heterochronic faecal transplantation boosts gut germinal centres in aged mice

Author(s): Marisa Stebegg, Alyssa Silva-Cayetano, Silvia Innocentin, Timothy P. Jenkins, Cinzia Cantacessi, Colin Gilbert, Michelle A. Linterman
Published in: Nature Communications, Issue 10/1, 2019, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-019-10430-7

The adjuvant GLA-SE promotes human Tfh cell expansion and emergence of public TCRβ clonotypes

Author(s): Danika L. Hill, Wim Pierson, Daniel J. Bolland, Catherine Mkindi, Edward J. Carr, Jiong Wang, Sophie Houard, Steven W. Wingett, Regine Audran, Elizabeth F. Wallin, Said A. Jongo, Kassim Kamaka, Martin Zand, Francois Spertini, Claudia Daubenberger, Anne E. Corcoran, Michelle A. Linterman
Published in: The Journal of Experimental Medicine, Issue 216/8, 2019, Page(s) 1857-1873, ISSN 0022-1007
Publisher: Rockefeller University Press
DOI: 10.1084/jem.20190301

Follicular Regulatory T Cells Can Access the Germinal Center Independently of CXCR5

Author(s): Ine Vanderleyden, Sigrid C. Fra-Bido, Silvia Innocentin, Marisa Stebegg, Hanneke Okkenhaug, Nicola Evans-Bailey, Wim Pierson, Alice E. Denton, Michelle A. Linterman
Published in: Cell Reports, Issue 30/3, 2020, Page(s) 611-619.e4, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2019.12.076

Rejuvenating conventional dendritic cells and T follicular helper cell formation after vaccination

Author(s): Marisa Stebegg, Alexandre Bignon, Danika Lea Hill, Alyssa Silva-Cayetano, Christel Krueger, Ine Vanderleyden, Silvia Innocentin, Louis Boon, Jiong Wang, Martin S Zand, James Dooley, Jonathan Clark, Adrian Liston, Edward Carr, Michelle A Linterman
Published in: eLife, Issue 9, 2020, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.52473

Intrinsic defects in lymph node stromal cells underpin poor germinal center responses during aging

Author(s): Alice E Denton, Alyssa Silva-Cayetano, James Dooley, Danika L Hill, Edward J Carr, Philippe A Robert, Michael Meyer-Hermann, Adrian Liston, Michelle A Linterman
Published in: 2020
Publisher: bioRxiv preprint
DOI: 10.1101/2020.05.07.082255

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