Nanomethods to understand what makes an endogenous protein immunogenic

Project Information

PredicTOOL

Grant agreement ID: 637877

DOI

10.3030/637877

Project closed

EC signature date 17 March 2015

Start date 1 April 2015

End date 30 September 2020

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 491 250,00

EU contribution

€ 1 491 250,00

Coordinated by

UNIVERSITAET GREIFSWALD
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (8)

Interaction of fibrinogen–magnetic nanoparticle bioconjugates with integrin reconstituted into artificial membranes

Author(s): Ulrike Martens, Una Janke, Sophie Möller, Delphine Talbot, Ali Abou-Hassan, Mihaela Delcea
Published in: Nanoscale, Issue 12/38, 2020, Page(s) 19918-19930, ISSN 2040-3364
Publisher: Royal Society of Chemistry
DOI: 10.1039/d0nr04181e

Specific domain V reduction of beta-2-glycoprotein I induces protein flexibility and alters pathogenic antibody binding

Author(s): Ina Buchholz, Thomas McDonnell, Peter Nestler, Sudarat Tharad, Martin Kulke, Anna Radziszewska, Vera M. Ripoll, Frank Schmidt, Elke Hammer, Jose L. Toca-Herrera, Anisur Rahman, Mihaela Delcea
Published in: Scientific Reports, Issue 11/1, 2021, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-021-84021-2

Lysine residues control the conformational dynamics of beta 2-glycoprotein I

Author(s): Ina Buchholz, Peter Nestler, Susan Köppen, Mihaela Delcea
Published in: Physical Chemistry Chemical Physics, Issue 20/42, 2018, Page(s) 26819-26829, ISSN 1463-9076
Publisher: Royal Society of Chemistry
DOI: 10.1039/c8cp03234c

Rupture Forces among Human Blood Platelets at different Degrees of Activation

Author(s): Thi-Huong Nguyen, Raghavendra Palankar, Van-Chien Bui, Nikolay Medvedev, Andreas Greinacher, Mihaela Delcea
Published in: Scientific Reports, Issue 6, 2016, Page(s) 25402, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/srep25402

Anti-platelet factor 4/polyanion antibodies mediate a new mechanism of autoimmunity

Author(s): Thi-Huong Nguyen, Nikolay Medvedev, Mihaela Delcea, Andreas Greinacher
Published in: Nature Communications, Issue 8, 2017, Page(s) 14945, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/ncomms14945

Biophysical tools to assess the interaction of PF4 with polyanions

Author(s): M. Delcea, A. Greinacher
Published in: Thrombosis and Haemostasis, Issue 116/5, 2016, ISSN 0340-6245
Publisher: Schattauer
DOI: 10.1160/TH16-04-0258

The impact of physiological stress conditions on protein structure and trypsin inhibition of serine protease inhibitor Kazal type 1 (SPINK1) and its N34S variant

Author(s): Ina Buchholz, Felix Nagel, Annelie Klein, Preshit R. Wagh, Ujjwal M. Mahajan, Andreas Greinacher, Markus M. Lerch, Julia Mayerle, Mihaela Delcea
Published in: Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2019, Page(s) 140281, ISSN 1570-9639
Publisher: Elsevier BV
DOI: 10.1016/j.bbapap.2019.140281

Drug-induced activation of integrin alpha IIb beta 3 leads to minor localized structural changes

Author(s): Una Janke, Martin Kulke, Ina Buchholz, Norman Geist, Walter Langel, Mihaela Delcea
Published in: PLOS ONE, Issue 14/4, 2019, Page(s) e0214969, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0214969