Nanomethods to understand what makes an endogenous protein immunogenic

Información del proyecto

PredicTOOL

Identificador del acuerdo de subvención: 637877

DOI 10.3030/637877

Proyecto cerrado

Fecha de la firma de la CE 17 Marzo 2015

Fecha de inicio 1 Abril 2015

Fecha de finalización 30 Septiembre 2020

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total € 1 491 250,00

Aportación de la UE € 1 491 250,00

Coordinado por

UNIVERSITAET GREIFSWALD
Germany

Publicaciones

Peer reviewed articles (8)

Interaction of fibrinogen–magnetic nanoparticle bioconjugates with integrin reconstituted into artificial membranes

Autores: Ulrike Martens, Una Janke, Sophie Möller, Delphine Talbot, Ali Abou-Hassan, Mihaela Delcea
Publicado en: Nanoscale, Edición 12/38, 2020, Página(s) 19918-19930, ISSN 2040-3364
Editor: Royal Society of Chemistry
DOI: 10.1039/d0nr04181e

Specific domain V reduction of beta-2-glycoprotein I induces protein flexibility and alters pathogenic antibody binding

Autores: Ina Buchholz, Thomas McDonnell, Peter Nestler, Sudarat Tharad, Martin Kulke, Anna Radziszewska, Vera M. Ripoll, Frank Schmidt, Elke Hammer, Jose L. Toca-Herrera, Anisur Rahman, Mihaela Delcea
Publicado en: Scientific Reports, Edición 11/1, 2021, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-021-84021-2

Lysine residues control the conformational dynamics of beta 2-glycoprotein I

Autores: Ina Buchholz, Peter Nestler, Susan Köppen, Mihaela Delcea
Publicado en: Physical Chemistry Chemical Physics, Edición 20/42, 2018, Página(s) 26819-26829, ISSN 1463-9076
Editor: Royal Society of Chemistry
DOI: 10.1039/c8cp03234c

Rupture Forces among Human Blood Platelets at different Degrees of Activation

Autores: Thi-Huong Nguyen, Raghavendra Palankar, Van-Chien Bui, Nikolay Medvedev, Andreas Greinacher, Mihaela Delcea
Publicado en: Scientific Reports, Edición 6, 2016, Página(s) 25402, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/srep25402

Anti-platelet factor 4/polyanion antibodies mediate a new mechanism of autoimmunity

Autores: Thi-Huong Nguyen, Nikolay Medvedev, Mihaela Delcea, Andreas Greinacher
Publicado en: Nature Communications, Edición 8, 2017, Página(s) 14945, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/ncomms14945

Biophysical tools to assess the interaction of PF4 with polyanions

Autores: M. Delcea, A. Greinacher
Publicado en: Thrombosis and Haemostasis, Edición 116/5, 2016, ISSN 0340-6245
Editor: Schattauer
DOI: 10.1160/TH16-04-0258

The impact of physiological stress conditions on protein structure and trypsin inhibition of serine protease inhibitor Kazal type 1 (SPINK1) and its N34S variant

Autores: Ina Buchholz, Felix Nagel, Annelie Klein, Preshit R. Wagh, Ujjwal M. Mahajan, Andreas Greinacher, Markus M. Lerch, Julia Mayerle, Mihaela Delcea
Publicado en: Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2019, Página(s) 140281, ISSN 1570-9639
Editor: Elsevier BV
DOI: 10.1016/j.bbapap.2019.140281

Drug-induced activation of integrin alpha IIb beta 3 leads to minor localized structural changes

Autores: Una Janke, Martin Kulke, Ina Buchholz, Norman Geist, Walter Langel, Mihaela Delcea
Publicado en: PLOS ONE, Edición 14/4, 2019, Página(s) e0214969, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0214969