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Mechanistic and functional studies of Bacillus biofilms assembly on plants, and their impact in sustainable agriculture and food safety

Objective

Sustainable agriculture is an ambitious concept conceived to improve productivity but minimizing side effects. Why the efficiency of a biocontrol agent is so variable? How can different therapies be efficiently exploited in a combined way to combat microbial diseases? These are questions that need investigation to convey with criteria of sustainability. What I present is an integral proposal aim to study the microbial ecology and specifically bacterial biofilms as a central axis of two differential but likely interconnected scenarios in plant health: i) the beneficial interaction of the biocontrol agent (BCA) Bacillus subtilis, and ii) the non-conventional interaction of the food-borne pathogen Bacillus cereus.
I will start working with B. subtilis, and reasons are: 1) Different isolates are promising BCAs and are commercialized for such purpose, 2) There exist vast information of the genetics circuitries that govern important aspects of B. subtilis physiology as antibiotic production, cell differentiation, and biofilm formation. In parallel I propose to study the way B. cereus, a food-borne pathogenic bacterium interacts with vegetables. I am planning to set up a multidisciplinary approach that will combine genetics, biochemistry, proteomics, cell biology and molecular biology to visualize how these bacterial population interacts, communicates with plants and other microorganisms, or how all these factors trigger or inhibit the developmental program ending in biofilm formation. I am also interested on knowing if structural components of the bacterial extracellular matrix (exopolysaccharides or amyloid proteins) are important for bacterial fitness. If this were the case, I will also investigate which external factors affect their expression and assembly in functional biofilms. The insights get on these studies are committed to impulse our knowledge on microbial ecology and their biotechnological applicability to sustainable agriculture and food safety.

Field of science

  • /natural sciences/chemical sciences/analytical chemistry
  • /engineering and technology/materials engineering/fibers
  • /natural sciences/biological sciences/molecular biology
  • /medical and health sciences/health sciences/public and environmental health
  • /natural sciences/biological sciences/genetics and heredity
  • /natural sciences/biological sciences/microbiology/bacteriology
  • /natural sciences/biological sciences/biochemistry/biomolecules/proteins
  • /agricultural sciences/agriculture, forestry, and fisheries/agriculture/horticulture/fruit growing
  • /engineering and technology/other engineering and technologies/food and beverages/food safety
  • /natural sciences/biological sciences/cell biology
  • /natural sciences/biological sciences/biophysics
  • /agricultural sciences/agriculture, forestry, and fisheries/agriculture/sustainable agriculture
  • /natural sciences/biological sciences/ecology
  • /medical and health sciences/basic medicine/immunology
  • /medical and health sciences/basic medicine/physiology
  • /agricultural sciences/agriculture, forestry, and fisheries/agriculture/horticulture/vegetable growing

Call for proposal

ERC-2014-STG
See other projects for this call

Funding Scheme

ERC-STG - Starting Grant

Host institution

UNIVERSIDAD DE MALAGA
Address
Avda Cervantes, Num. 2
29016 Malaga
Spain
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 453 562,50

Beneficiaries (1)

UNIVERSIDAD DE MALAGA
Spain
EU contribution
€ 1 453 562,50
Address
Avda Cervantes, Num. 2
29016 Malaga
Activity type
Higher or Secondary Education Establishments