Periodic Reporting for period 4 - NOVA (Non-coding RNA in Vascular Ageing)
Reporting period: 2019-10-01 to 2021-03-31
To identify novel therapeutic possibilities, we studied a special class of molecules: The so-called non-coding RNAs, which, in contrast to coding RNAs, do not contain instructions on how to form proteins, but rather function as active regulator themselves. We first wanted to know which of these non-coding RNAs are increased or decreased by ageing in endothelial cells. We identified several of these molecules that are either increased or decreased when comparing old and young endothelial cells. Importantly, we then found that altering the levels of these molecules changed the health of the endothelial cells. These molecules can therefore potentially be used as a therapeutic to improve endothelial cell and cardiovascular health in the elderly.
The main findings are summarized here:
1. LncRNA Meg3 controls endothelial cell aging, published in Journal of the American College of Cardiology, 68(23), 2016, 2589-2591.
2. LncRNA H19 regulates endothelial cell aging, published in Cardiovasc Res. 2019 115(1):230-242.
3. LncRNA Lassie (linc00520) regulates endothelial barrier function, published in Commun Biol. 2020 3(1):265
4. Long Non-coding RNA Aerrie Controls DNA Damage Repair via YBX1 to Maintain Endothelial Cell Function, Front Cell Dev Biol. 2021 8:619079