The design and development of efficient biocatalytic cascades and biosynthetic pathways for the sustainable production of amines

Project Information

BIOSUSAMIN

Grant agreement ID: 638271

DOI

10.3030/638271

Project closed

EC signature date 12 March 2015

Start date 1 May 2015

End date 31 October 2020

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 497 270,00

EU contribution

€ 1 497 270,00

Coordinated by

UNIVERSITEIT VAN AMSTERDAM
Netherlands

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (16)

Generation of Oxidoreductases with Dual Alcohol Dehydrogenase and Amine Dehydrogenase Activity

Author(s): Vasilis Tseliou, Don Schilder, Marcelo F. Masman, Tanja Knaus, Francesco G. Mutti
Published in: Chemistry – A European Journal, Issue Vol. 27, Issue 10, 2021, Page(s) in press, ISSN 0947-6539
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/chem.202003140

Parallel Interconnected Kinetic Asymmetric Transformation (PIKAT) with an Immobilized ω-Transaminase in Neat Organic Solvent

Author(s): Wesley Böhmer, Lucien Koenekoop, Timothée Simon, Francesco G. Mutti
Published in: Molecules, Issue 25/9, 2020, Page(s) 2140, ISSN 1420-3049
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules25092140

Kinetic Resolution of Racemic Primary Amines Using Geobacillus stearothermophilus Amine Dehydrogenase Variant

Author(s): Vasilis Tseliou, Tanja Knaus, Jan Vilím, Marcelo F. Masman, Francesco G. Mutti
Published in: ChemCatChem, Issue 12/8, 2020, Page(s) 2184-2188, ISSN 1867-3880
Publisher: Wiley - VCH Verlag GmbH & CO. KGaA
DOI: 10.1002/cctc.201902085

Highly efficient production of chiral amines in batch and continuous flow by immobilized ω-transaminases on controlled porosity glass metal-ion affinity carrier

Author(s): Wesley Böhmer, Tanja Knaus, Alexey Volkov, Thierry K. Slot, N. Raveendran Shiju, Karim Engelmark Cassimjee, Francesco G. Mutti
Published in: Journal of Biotechnology, Issue 291, 2019, Page(s) 52-60, ISSN 0168-1656
Publisher: Elsevier BV
DOI: 10.1016/j.jbiotec.2018.12.001

Efficient synthesis of enantiopure amines from alcohols using resting E. coli cells and ammonia

Author(s): Joseline A. Houwman, Tanja Knaus, Magda Costa, Francesco G. Mutti
Published in: Green Chemistry, Issue 21/14, 2019, Page(s) 3846-3857, ISSN 1463-9262
Publisher: Royal Society of Chemistry
DOI: 10.1039/c9gc01059a

Generation of amine dehydrogenases with increased catalytic performance and substrate scope from ε-deaminating L-Lysine dehydrogenase

Author(s): Vasilis Tseliou, Tanja Knaus, Marcelo F. Masman, Maria L. Corrado, Francesco G. Mutti
Published in: Nature Communications, Issue 10/1, 2019, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-019-11509-x

In vitro biocatalytic pathway design: orthogonal network for the quantitative and stereospecific amination of alcohols

Author(s): Tanja Knaus, Luca Cariati, Marcelo F. Masman, Francesco G. Mutti
Published in: Organic & Biomolecular Chemistry, Issue 15/39, 2017, Page(s) 8313-8325, ISSN 1477-0520
Publisher: Royal Society of Chemistry
DOI: 10.1039/C7OB01927K

Biocatalytic hydrogen-borrowing cascades

Author(s): Tanja Knaus, Francesco G. Mutti
Published in: Chimica Oggi - Chemistry Today, Issue 6 times per year, 2017, Page(s) 34-37, ISSN 0392-839X
Publisher: Teknoscienze s.r.l.

Hydrogen-Borrowing Alcohol Bioamination with Coimmobilized Dehydrogenases

Author(s): Wesley Böhmer, Tanja Knaus, Francesco G. Mutti
Published in: ChemCatChem, Issue 10/4, 2018, Page(s) 731-735, ISSN 1867-3880
Publisher: Wiley - VCH Verlag GmbH & CO. KGaA
DOI: 10.1002/cctc.201701366

A Chimeric Styrene Monooxygenase with Increased Efficiency in Asymmetric Biocatalytic Epoxidation

Author(s): Maria L. Corrado, Tanja Knaus, Francesco G. Mutti
Published in: ChemBioChem, Issue 19/7, 2018, Page(s) 679-686, ISSN 1439-4227
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.201700653

Catalytic Promiscuity of Galactose Oxidase: A Mild Synthesis of Nitriles from Alcohols, Air, and Ammonia

Author(s): Jan Vilím, Tanja Knaus, Francesco G. Mutti
Published in: Angewandte Chemie International Edition, Issue 57/43, 2018, Page(s) 14240-14244, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201809411

Conversion of alcohols to enantiopure amines through dual-enzyme hydrogen-borrowing cascades

Author(s): F. G. Mutti, T. Knaus, N. S. Scrutton, M. Breuer, N. J. Turner
Published in: Science, Issue 349/6255, 2015, Page(s) 1525-1529, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aac9283

Amine dehydrogenases: efficient biocatalysts for the reductive amination of carbonyl compounds

Author(s): Tanja Knaus, Wesley B?hmer, Francesco G. Mutti
Published in: Green Chem., Issue 19/2, 2017, Page(s) 453-463, ISSN 1463-9262
Publisher: Royal Society of Chemistry
DOI: 10.1039/C6GC01987K

Continuous Flow Bioamination of Ketones in Organic Solvents at Controlled Water Activity using Immobilized ω‐Transaminases

Author(s): Wesley Böhmer, Alexey Volkov, Karim Engelmark Cassimjee, Francesco G. Mutti
Published in: Advanced Synthesis & Catalysis, Issue 362/9, 2020, Page(s) 1858-1867, ISSN 1615-4150
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/adsc.201901274

Mechanistic Insight into the Catalytic Promiscuity of Amine Dehydrogenases: Asymmetric Synthesis of Secondary and Primary Amines

Author(s): Vasilis Tseliou, Marcelo F. Masman, Wesley Böhmer, Tanja Knaus, Francesco G. Mutti
Published in: ChemBioChem, Issue 20/6, 2019, Page(s) 800-812, ISSN 1439-4227
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.201800626

Regio- and stereoselective multi-enzymatic aminohydroxylation of β-methylstyrene using dioxygen, ammonia and formate

Author(s): Maria L. Corrado, Tanja Knaus, Francesco G. Mutti
Published in: Green Chemistry, Issue 21/23, 2019, Page(s) 6246-6251, ISSN 1463-9262
Publisher: Royal Society of Chemistry
DOI: 10.1039/c9gc03161h

Intellectual Property Rights

Patent (3)

Redox self-sufficient biocatalytic amination of alcohols

Application/Publication number: EP 14175632
Date: 2014-07-03
Applicant(s): THE UNIVERSITY OF MANCHESTER

PROCESS FOR THE MANUFACTURE OF NITRILE COMPOUNDS

Application/Publication number: 20 19069715
Date: 2019-07-22
Applicant(s): UNIVERSITEIT VAN AMSTERDAM

L-LYSINE EPSILON-DEHYDROGENASE VARIANTS AND USES THEREOF

Application/Publication number: 20 20053918
Date: 2020-02-14
Applicant(s): UNIVERSITEIT VAN AMSTERDAM