A systematic characterization of human regulatory architectures and their determinants of regulatory activity

Project Information

SCORA

Grant agreement ID: 638273

DOI 10.3030/638273

Project closed

EC signature date 15 April 2015

Start date 1 May 2015

End date 31 January 2021

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 436 292,50

EU contribution € 1 436 292,50

Coordinated by

KOBENHAVNS UNIVERSITET
Denmark

Publications

Peer reviewed articles (12)

Determinants of enhancer and promoter activities of regulatory elements

Author(s): Robin Andersson, Albin Sandelin
Published in: Nature Reviews Genetics, Issue 21/2, 2020, Page(s) 71-87, ISSN 1471-0056
Publisher: Nature Publishing Group
DOI: 10.1038/s41576-019-0173-8

Transcriptional decomposition reveals active chromatin architectures and cell specific regulatory interactions

Author(s): Sarah Rennie, Maria Dalby, Lucas van Duin, Robin Andersson
Published in: Nature Communications, Issue 9/1, 2018, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-017-02798-1

Regulating retrotransposon activity through the use of alternative transcription start sites

Author(s): Jenna Persson, Babett Steglich, Agata Smialowska, Mette Boyd, Jette Bornholdt, Robin Andersson, Catherine Schurra, Benoit Arcangioli, Albin Sandelin, Olaf Nielsen, Karl Ekwall
Published in: EMBO reports, Issue 17/5, 2016, Page(s) 753-768, ISSN 1469-221X
Publisher: Nature Publishing Group
DOI: 10.15252/embr.201541866

Loss-of-function variants in ADCY3 increase risk of obesity and type 2 diabetes

Author(s): Niels Grarup, Ida Moltke, Mette K. Andersen, Maria Dalby, Kristoffer Vitting-Seerup, Timo Kern, Yuvaraj Mahendran, Emil Jørsboe, Christina V. L. Larsen, Inger K. Dahl-Petersen, Arthur Gilly, Daniel Suveges, George Dedoussis, Eleftheria Zeggini, Oluf Pedersen, Robin Andersson, Peter Bjerregaard, Marit E. Jørgensen, Anders Albrechtsen, Torben Hansen
Published in: Nature Genetics, Issue 50/2, 2018, Page(s) 172-174, ISSN 1061-4036
Publisher: Nature Publishing Group
DOI: 10.1038/s41588-017-0022-7

Shared activity patterns arising at genetic susceptibility loci reveal underlying genomic and cellular architecture of human disease

Author(s): J. Kenneth Baillie, Andrew Bretherick, Christopher S. Haley, Sara Clohisey, Alan Gray, Lucile P. A. Neyton, Jeffrey Barrett, Eli A. Stahl, Albert Tenesa, Robin Andersson, J. Ben Brown, Geoffrey J. Faulkner, Marina Lizio, Ulf Schaefer, Carsten Daub, Masayoshi Itoh, Naoto Kondo, Timo Lassmann, Jun Kawai, Damian Mole, Vladimir B. Bajic, Peter Heutink, Michael Rehli, Hideya Kawaji, Albin Sandelin, Har
Published in: PLOS Computational Biology, Issue 14/3, 2018, Page(s) e1005934, ISSN 1553-7358
Publisher: Public Library of Science
DOI: 10.1371/journal.pcbi.1005934

Transcription start site analysis reveals widespread divergent transcription in D. melanogaster and core promoter-encoded enhancer activities

Author(s): Sarah Rennie, Maria Dalby, Marta Lloret-Llinares, Stylianos Bakoulis, Christian Dalager Vaagensø, Torben Heick Jensen, Robin Andersson
Published in: Nucleic Acids Research, 2018, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gky244

Characterization of the enhancer and promoter landscape of inflammatory bowel disease from human colon biopsies

Author(s): Mette Boyd, Malte Thodberg, Morana Vitezic, Jette Bornholdt, Kristoffer Vitting-Seerup, Yun Chen, Mehmet Coskun, Yuan Li, Bobby Zhao Sheng Lo, Pia Klausen, Pawel Jan Schweiger, Anders Gorm Pedersen, Nicolas Rapin, Kerstin Skovgaard, Katja Dahlgaard, Robin Andersson, Thilde Bagger Terkelsen, Berit Lilje, Jesper Thorvald Troelsen, Andreas Munk Petersen, Kim Bak Jensen, Ismail Gögenur, Peter Thielse
Published in: Nature Communications, Issue 9/1, 2018, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-018-03766-z

A unified architecture of transcriptional regulatory elements

Author(s): Robin Andersson, Albin Sandelin, Charles G. Danko
Published in: Trends in Genetics, Issue 31/8, 2015, Page(s) 426-433, ISSN 0168-9525
Publisher: Elsevier BV
DOI: 10.1016/j.tig.2015.05.007

Principles for RNA metabolism and alternative transcription initiation within closely spaced promoters

Author(s): Yun Chen, Athma A Pai, Jan Herudek, Michal Lubas, Nicola Meola, Aino I Järvelin, Robin Andersson, Vicent Pelechano, Lars M Steinmetz, Torben Heick Jensen, Albin Sandelin
Published in: Nature Genetics, Issue 48/9, 2016, Page(s) 984-994, ISSN 1061-4036
Publisher: Nature Publishing Group
DOI: 10.1038/ng.3616

Human Gene Promoters Are Intrinsically Bidirectional

Author(s): Robin Andersson, Yun Chen, Leighton Core, John T. Lis, Albin Sandelin, Torben Heick Jensen
Published in: Molecular Cell, Issue 60/3, 2015, Page(s) 346-347, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2015.10.015

MCM2 promotes symmetric inheritance of modified histones during DNA replication

Author(s): Nataliya Petryk, Maria Dalby, Alice Wenger, Caroline B. Stromme, Anne Strandsby, Robin Andersson, Anja Groth
Published in: Science, Issue 361/6409, 2018, Page(s) 1389-1392, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aau0294

The Transcriptional Network That Controls Growth Arrest and Macrophage Differentiation in the Human Myeloid Leukemia Cell Line THP-1

Author(s): Iveta Gažová, Lucas Lefevre, Stephen J. Bush, Sara Clohisey, Erik Arner, Michiel de Hoon, Jessica Severin, Lucas van Duin, Robin Andersson, Andreas Lengeling, David A. Hume, Kim M. Summers
Published in: Frontiers in Cell and Developmental Biology, Issue 8, 2020, ISSN 2296-634X
Publisher: Frontiers Media S.A.
DOI: 10.3389/fcell.2020.00498