Integrating genomics, epidemiology and evolution to accelerate tuberculosis eradication

Mycobacterium tuberculosis associated with severe tuberculosis evades cytosolic surveillance systems and modulates IL-1β production

Autores: Jeremy Sousa, Baltazar Cá, Ana Raquel Maceiras, Luisa Simões-Costa, Kaori L. Fonseca, Ana Isabel Fernandes, Angélica Ramos, Teresa Carvalho, Leandro Barros, Carlos Magalhães, Álvaro Chiner-Oms, Henrique Machado, Maria Isabel Veiga, Albel Singh, Rui Pereira, António Amorim, Jorge Vieira, Cristina P. Vieira, Apoorva Bhatt, Fernando Rodrigues, Pedro N. S. Rodrigues, Sebastien Gagneux, António
Publicado en: Nature Communications, Edición 11/1, 2020, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-020-15832-6

Towards next generation diagnostics for tuberculosis: identification of novel molecular targets by large-scale comparative genomics

Autores: Galo A. Goig; Manuela Torres-Puente; Carla Mariner-Llicer; Luis M. Villamayor; Álvaro Chiner-Oms; Ana Gil-Brusola; Rafa Borrás; Iñaki Comas
Publicado en: Bioinformatics, Edición 3, 2019, ISSN 1759-6653
Editor: Oxford University Press
DOI: 10.1101/569384

Tuberculosis in Liberia: high multidrug-resistance burden, transmission and diversity modelled by multiple importation events

Autores: Mariana G. López, John B. Dogba, Manuela Torres-Puente, Galo A. Goig, Miguel Moreno-Molina, Luis M. Villamayor, Simeon Cadmus, Iñaki Comas
Publicado en: Microbial Genomics, Edición 6/1, 2020, ISSN 2057-5858
Editor: Microbiology Society
DOI: 10.1099/mgen.0.000325

Whole genome sequencing of Mycobacterium tuberculosis: current standards and open issues

Autores: Conor J. Meehan, Galo A. Goig, Thomas A. Kohl, Lennert Verboven, Anzaan Dippenaar, Matthew Ezewudo, Maha R. Farhat, Jennifer L. Guthrie, Kris Laukens, Paolo Miotto, Boatema Ofori-Anyinam, Viola Dreyer, Philip Supply, Anita Suresh, Christian Utpatel, Dick van Soolingen, Yang Zhou, Philip M. Ashton, Daniela Brites, Andrea M. Cabibbe, Bouke C. de Jong, Margaretha de Vos, Fabrizio Menardo, Sebastien G
Publicado en: Nature Reviews Microbiology, Edición 17/9, 2019, Página(s) 533-545, ISSN 1740-1526
Editor: Nature Publishing Group
DOI: 10.1038/s41579-019-0214-5

Genomic determinants of speciation and spread of the Mycobacterium tuberculosis complex

Autores: Á. Chiner-Oms, L. Sánchez-Busó, J. Corander, S. Gagneux, S. R. Harris, D. Young, F. González-Candelas, I. Comas
Publicado en: Science Advances, Edición 5/6, 2019, Página(s) eaaw3307, ISSN 2375-2548
Editor: AAAS
DOI: 10.1126/sciadv.aaw3307

Whole genome sequencing–based analysis of tuberculosis (TB) in migrants: rapid tools for cross-border surveillance and to distinguish between recent transmission in the host country and new importations

Autores: Estefanía Abascal, Laura Pérez-Lago, Miguel Martínez-Lirola, Álvaro Chiner-Oms, Marta Herranz, Imane Chaoui, Iñaki Comas, My Driss El Messaoudi, José Antonio Garrido Cárdenas, Sheila Santantón, Emilio Bouza, Darío García-de-Viedma
Publicado en: Eurosurveillance, Edición 24/4, 2019, ISSN 1560-7917
Editor: ECDC
DOI: 10.2807/1560-7917.es.2019.24.4.1800005

Cryptic Resistance Mutations Associated With Misdiagnoses of Multidrug-Resistant Tuberculosis

Autores: Irving Cancino-Muñoz, Miguel Moreno-Molina, Victoria Furió, Galo A Goig, Manuela Torres-Puente, Álvaro Chiner-Oms, Luis M Villamayor, Francisco Sanz, María Remedio Guna-Serrano, Iñaki Comas
Publicado en: The Journal of Infectious Diseases, Edición 220/2, 2019, Página(s) 316-320, ISSN 0022-1899
Editor: University of Chicago Press
DOI: 10.1093/infdis/jiz104

Development and application of affordable SNP typing approaches to genotype Mycobacterium tuberculosis complex strains in low and high burden countries

Autores: Irving Cancino-Muñoz, Ana Gil-Brusola, Manuela Torres-Puente, Carla Mariner-Llicer, John Dogba, Victor Akinseye, Kehinde Adesokan, Ayi Kwaghe, Francis Ejeh, Simeon Cadmus, Iñaki Comas
Publicado en: Scientific Reports, Edición 9/1, 2019, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-019-51326-2

Specificity and mutagenesis bias of the mycobacterial alternative mismatch repair analyzed by mutation accumulation studies

Autores: A. Castañeda-García, I. Martín-Blecua, E. Cebrián-Sastre, A. Chiner-Oms, M. Torres-Puente, I. Comas, J. Blázquez
Publicado en: Science Advances, Edición 6/7, 2020, Página(s) eaay4453, ISSN 2375-2548
Editor: Nature Publishing Group
DOI: 10.1126/sciadv.aay4453

Population Genomics of Mycobacterium tuberculosis in Ethiopia Contradicts the Virgin Soil Hypothesis for Human Tuberculosis in Sub-Saharan Africa

Autores: Iñaki Comas, Elena Hailu, Teklu Kiros, Shiferaw Bekele, Wondale Mekonnen, Balako Gumi, Rea Tschopp, Gobena Ameni, R. Glyn Hewinson, Brian D. Robertson, Galo A. Goig, David Stucki, Sebastien Gagneux, Abraham Aseffa, Douglas Young, Stefan Berg
Publicado en: Current Biology, Edición 25/24, 2015, Página(s) 3260-3266, ISSN 0960-9822
Editor: Cell Press
DOI: 10.1016/j.cub.2015.10.061

Draft Genome Sequence of Mycobacterium brumae ATCC 51384

Autores: Giuseppe D'Auria, Eduard Torrents, Marina Luquin, Iñaki Comas, Esther Julián
Publicado en: Genome Announcements, Edición 4/2, 2016, Página(s) e00237-16, ISSN 2169-8287
Editor: American Society for Microbiology
DOI: 10.1128/genomeA.00237-16

Mycobacterium tuberculosis lineage 4 comprises globally distributed and geographically restricted sublineages

Autores: David Stucki, Daniela Brites, Leïla Jeljeli, Mireia Coscolla, Qingyun Liu, Andrej Trauner, Lukas Fenner, Liliana Rutaihwa, Sonia Borrell, Tao Luo, Qian Gao, Midori Kato-Maeda, Marie Ballif, Matthias Egger, Rita Macedo, Helmi Mardassi, Milagros Moreno, Griselda Tudo Vilanova, Janet Fyfe, Maria Globan, Jackson Thomas, Frances Jamieson, Jennifer L Guthrie, Adwoa Asante-Poku, Dorothy Yeboah-Manu, Edd
Publicado en: Nature Genetics, Edición 48/12, 2016, Página(s) 1535-1543, ISSN 1061-4036
Editor: Nature Publishing Group
DOI: 10.1038/ng.3704

Urgent Implementation in a Hospital Setting of a Strategy To Rule Out Secondary Cases Caused by Imported Extensively Drug-Resistant Mycobacterium tuberculosis Strains at Diagnosis

Autores: Laura Pérez-Lago, Miguel Martínez-Lirola, Sergio García, Marta Herranz, Igor Mokrousov, Iñaki Comas, Llúcia Martínez-Priego, Emilio Bouza, Darío García-de-Viedma
Publicado en: Journal of Clinical Microbiology, Edición 54/12, 2016, Página(s) 2969-2974, ISSN 0095-1137
Editor: American Society for Microbiology
DOI: 10.1128/JCM.01718-16

A standardised method for interpreting the association between mutations and phenotypic drug resistance in Mycobacterium tuberculosis

Autores: Paolo Miotto, Belay Tessema, Elisa Tagliani, Leonid Chindelevitch, Angela M. Starks, Claudia Emerson, Debra Hanna, Peter S. Kim, Richard Liwski, Matteo Zignol, Christopher Gilpin, Stefan Niemann, Claudia M. Denkinger, Joy Fleming, Robin M. Warren, Derrick Crook, James Posey, Sebastien Gagneux, Sven Hoffner, Camilla Rodrigues, Iñaki Comas, David M. Engelthaler, Megan Murray, David Alland, Leen Ri
Publicado en: European Respiratory Journal, Edición 50/6, 2017, Página(s) 1701354, ISSN 0903-1936
Editor: European Respiratory Society
DOI: 10.1183/13993003.01354-2017

A novel strategy based on genomics and specific PCR reveals how a multidrug-resistant Mycobacterium tuberculosis strain became prevalent in Equatorial Guinea 15 years after its emergence

Autores: L. Pérez-Lago, S. Izco, M. Herranz, G. Tudó, M. Carcelén, I. Comas, O. Sierra, J. González-Martín, M.J. Ruiz-Serrano, J. Eyene, E. Bouza, D. García de Viedma
Publicado en: Clinical Microbiology and Infection, Edición 23/2, 2017, Página(s) 92-97, ISSN 1198-743X
Editor: Blackwell Publishing Inc.
DOI: 10.1016/j.cmi.2016.10.006

The Troika Host–Pathogen–Extrinsic Factors in Tuberculosis: Modulating Inflammation and Clinical Outcomes

Autores: Helder Novais Bastos, Nuno S. Osório, Sebastien Gagneux, Iñaki Comas, Margarida Saraiva
Publicado en: Frontiers in Immunology, Edición 8, 2018, ISSN 1664-3224
Editor: Frontiers
DOI: 10.3389/fimmu.2017.01948

Prediction of Susceptibility to First-Line Tuberculosis Drugs by DNA Sequencing

Autores: CRyPTIC Consortium and the 100,000 Genomes Project, Allix-Béguec C, Arandjelovic I, Bi L, Beckert P, Bonnet M, Bradley P, Cabibbe AM, Cancino-Muñoz I, Caulfield MJ, Chaiprasert A, Cirillo DM, Clifton DA, Comas I, Crook DW, De Filippo MR, de Neeling H, Diel R, Drobniewski FA, Faksri K, Farhat MR, Fleming J, Fowler P, Fowler TA, Gao Q, Gardy J, Gascoyne-Binzi D, Gibertoni-Cruz AL, Gil-Brusola A, G
Publicado en: New England Journal of Medicine, Edición 379/15, 2018, Página(s) 1403-1415, ISSN 0028-4793
Editor: Massachusetts Medical Society
DOI: 10.1056/NEJMoa1800474

Mycobacterium tuberculosis Acquires Limited Genetic Diversity in Prolonged Infections, Reactivations and Transmissions Involving Multiple Hosts

Autores: Marta Herranz, Ilva Pole, Iveta Ozere, Álvaro Chiner-Oms, Miguel Martínez-Lirola, Felipe Pérez-García, Paloma Gijón, María Jesús Ruiz Serrano, Laura Clotet Romero, Oscar Cuevas, Iñaki Comas, Emilio Bouza, Laura Pérez-Lago, Darío García-de-Viedma
Publicado en: Frontiers in Microbiology, Edición 8, 2018, ISSN 1664-302X
Editor: Frontiers Media
DOI: 10.3389/fmicb.2017.02661

Gene expression models based on a reference laboratory strain are poor predictors of Mycobacterium tuberculosis complex transcriptional diversity

Autores: Álvaro Chiner-Oms, Fernando González-Candelas, Iñaki Comas
Publicado en: Scientific Reports, Edición 8/1, 2018, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-018-22237-5

Integrating standardized whole genome sequence analysis with a global Mycobacterium tuberculosis antibiotic resistance knowledgebase

Autores: Matthew Ezewudo, Amanda Borens, Álvaro Chiner-Oms, Paolo Miotto, Leonid Chindelevitch, Angela M. Starks, Debra Hanna, Richard Liwski, Matteo Zignol, Christopher Gilpin, Stefan Niemann, Thomas Andreas Kohl, Robin M. Warren, Derrick Crook, Sebastien Gagneux, Sven Hoffner, Camilla Rodrigues, Iñaki Comas, David M. Engelthaler, David Alland, Leen Rigouts, Christoph Lange, Keertan Dheda, Rumina Hasan,
Publicado en: Scientific Reports, Edición 8/1, 2018, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-018-33731-1

In-Depth Characterization and Functional Analysis of Clonal Variants in a Mycobacterium tuberculosis Strain Prone to Microevolution

Autores: Yurena Navarro, Laura Pérez-Lago, Marta Herranz, Olalla Sierra, Iñaki Comas, Javier Sicilia, Emilio Bouza, Darío García de Viedma
Publicado en: Frontiers in Microbiology, Edición 8, 2017, ISSN 1664-302X
Editor: Frontiers Media
DOI: 10.3389/fmicb.2017.00694

New Genome-Wide Algorithm Identifies Novel In-Vivo Expressed Mycobacterium Tuberculosis Antigens Inducing Human T-Cell Responses with Classical and Unconventional Cytokine Profiles

Autores: Mariateresa Coppola, Krista E. van Meijgaarden, Kees L. M. C. Franken, Susanna Commandeur, Gregory Dolganov, Igor Kramnik, Gary K. Schoolnik, Inaki Comas, Ole Lund, Corine Prins, Susan J. F. van den Eeden, Gro E. Korsvold, Fredrik Oftung, Annemieke Geluk, Tom H. M. Ottenhoff
Publicado en: Scientific Reports, Edición 6/1, 2016, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/srep37793

Contaminant DNA in bacterial sequencing experiments is a major source of false genetic variability

Autores: Galo A. Goig, Silvia Blanco, Alberto L. Garcia-Basteiro, Iñaki Comas
Publicado en: BMC Biology, Edición 18/1, 2020, ISSN 1741-7007
Editor: BioMed Central
DOI: 10.1186/s12915-020-0748-z

Mycobacterium tuberculosis clinical isolates carry mutational signatures of host immune environments

Autores: Qingyun Liu, Jianhao Wei, Yawei Li, Mei Wang, Jun Su, Yonghui Lu, Mariana G. López, Xueqin Qian, Zhaoqin Zhu, Haiying Wang, Mingyun Gan, Qi Jiang, Yun-Xin Fu, Howard E. Takiff, Iñaki Comas, Feng Li, Xuemei Lu, Sarah M. Fortune, Qian Gao
Publicado en: Science Advances, Edición 6/22, 2020, Página(s) eaba4901, ISSN 2375-2548
Editor: Nature Pubclishing Group
DOI: 10.1126/sciadv.aba4901

High-resolution mapping of tuberculosis transmission: Whole genome sequencing and phylogenetic modelling of a cohort from Valencia Region, Spain

Autores: Yuanwei Xu, Irving Cancino-Muñoz, Manuela Torres-Puente, Luis M. Villamayor, Rafael Borrás, María Borrás-Máñez, Montserrat Bosque, Juan J. Camarena, Ester Colomer-Roig, Javier Colomina, Isabel Escribano, Oscar Esparcia-Rodríguez, Ana Gil-Brusola, Concepción Gimeno, Adelina Gimeno-Gascón, Bárbara Gomila-Sard, Damiana González-Granda, Nieves Gonzalo-Jiménez, María Remedio Guna-Serrano,
Publicado en: PLOS Medicine, Edición 16/10, 2019, Página(s) e1002961, ISSN 1549-1676
Editor: Public Library of Sciences
DOI: 10.1371/journal.pmed.1002961

Genomic epidemiology of tuberculosis

Autores: Iñaki Comas
Publicado en: 2017, Página(s) 79-93
Editor: Springer International Publishing
DOI: 10.1007/978-3-319-64371-7_4

Evolutionary Biology

Autores: Pierre Pontarotti
Publicado en: 2016, ISBN 978-3-319-41324-2
Editor: Springer International Publishing
DOI: 10.1007/978-3-319-41324-2

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