The Physiology of Nutrient Sensing by mTOR

Project Information

NutrientSensingVivo

Grant agreement ID: 638891

DOI 10.3030/638891

Project closed

EC signature date 27 August 2015

Start date 1 January 2016

End date 31 December 2021

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 846 494,00

EU contribution € 1 846 494,00

Coordinated by

FUNDACION SECTOR PUBLICO ESTATAL CENTRO NACIONAL INVESTIGACIONES ONCOLOGICAS CARLOS III
Spain

Publications

Peer reviewed articles (8)

Inhibition of Rag GTPase signaling in mice suppresses B cell activation and lymphomagenesis without detrimental tradeoffs

Author(s): Ortega-Molina A, Lebrero-Fernández C, Deleyto-Seldas N, Sanz A, Menéndez C, Caleiras E, Efeyan A
Published in: Cell Reports, 2021, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2021.109372

Oncogenic Rag GTPase signaling enhances B cell activation and drives follicular lymphoma sensitive to pharmacological inhibition of mTOR

Author(s): Ortega-Molina A, Deleyto-Seldas N, Joaquim Carreras J, Sanz A, Lebrero-Fernández C, Menéndez C, Vandenberg A, Fernández-Ruiz B, Marín-Arraiza L, de la Calle Arregui C, Plata-Gómez AB, Caleiras E, de Martino A, Martínez-Martín N, Troulé K, Piñeiro-Yáñez E, Nakamura N, Araf S, Victora GD, Okosun J, Fitzgibbon J, Efeyan A
Published in: Nature Metabolism, 2019, ISSN 2522-5812
Publisher: Springer Berlin
DOI: 10.1038/s42255-019-0098-8

From mouse genetics to targeting the Rag GTPase pathway.

Author(s): Ortega-Molina A, Efeyan A
Published in: Molecular & Cellular Oncology, 2021, ISSN 2372-3556
Publisher: Taylor & Francis
DOI: 10.1080/23723556.2021.1979370

Limited survival and impaired hepatic fasting metabolism in mice with constitutive Rag GTPase signaling

Author(s): de la Calle Arregui C, Plata-Goméz AB, Deleyto-Seldas N, Ortega-Molina A, García F, Muñoz J, Abril-Garrido J, Rodriguez E, Nemazanyy I, de Martino A, Caleiras E, Mulero F, Pende M, Sabio G, Sabatini DM, Efeyan A.
Published in: Nature Communications, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-23857-8

mTORC1-dependent AMD1 regulation sustains polyamine metabolism in prostate cancer

Author(s): Amaia Zabala-Letona, Amaia Arruabarrena-Aristorena, Natalia Martín-Martín, Sonia Fernandez-Ruiz, James D. Sutherland, Michelle Clasquin, Julen Tomas-Cortazar, Jose Jimenez, Ines Torres, Phong Quang, Pilar Ximenez-Embun, Ruzica Bago, Aitziber Ugalde-Olano, Ana Loizaga-Iriarte, Isabel Lacasa-Viscasillas, Miguel Unda, Verónica Torrano, Diana Cabrera, Sebastiaan M. van Liempd, Ylenia Cendon, Elena
Published in: Nature, Issue 547/7661, 2017, Page(s) 109-113, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/nature22964

The mTOR–Autophagy Axis and the Control of Metabolism

Author(s): Deleyto-Seldas N, Efeyan A
Published in: Frontiers in Cell and Developmental Biology, 2021, ISSN 2296-634X
Publisher: Frontiers Media
DOI: 10.3389/fcell.2021.655731

Protocol for the assessment of mTOR activity in mouse primary hepatocytes

Author(s): Plata-Gómez AB, Crespo M, de la Calle Arregui C, de Prado-Rivas L, Sabio G, Efeyan A
Published in: STAR Protocols, 2021, ISSN 2666-1667
Publisher: Cell Press
DOI: 10.1016/j.xpro.2021.100918

Assessing kinetics and recruitment of DNA repair factors using high content screens

Author(s): Martinez-Pastor B, Silveira GG, Clarke TL, Chung D, Gu Y, Cosentino C, Davidow LS, Mata G, Hassanieh S, Salsman J, Ciccia A, Bae N, Bedford MT, Megias D, Rubin LL, Efeyan A, Dellaire G, Mostoslavsky R.
Published in: Cell Reports, 2021, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2021.110176