Utilizing evolutionary interactions to limit multidrug resistance

Project Information

LimitMDR

Grant agreement ID: 638902

DOI 10.3030/638902

Project closed

EC signature date 29 April 2015

Start date 1 May 2015

End date 30 April 2020

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 492 453,00

EU contribution € 1 492 453,00

Coordinated by

DANMARKS TEKNISKE UNIVERSITET
Denmark

Publications

Peer reviewed articles (12)

Dominant resistance and negative epistasis can limit the co-selection of de novo resistance mutations and antibiotic resistance genes

Author(s): Andreas Porse, Leonie J. Jahn, Mostafa M. H. Ellabaan, Morten O. A. Sommer
Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-15080-8

Adaptive Laboratory Evolution of Antibiotic Resistance Using Different Selection Regimes Lead to Similar Phenotypes and Genotypes

Author(s): Leonie J. Jahn, Christian Munck, Mostafa M. H. Ellabaan, Morten O. A. Sommer
Published in: Frontiers in Microbiology, Issue 8, 2017, ISSN 1664-302X
Publisher: Frontiers Media
DOI: 10.3389/fmicb.2017.00816

Time-Resolved Tracking of Mutations Reveals Diverse Allele Dynamics during Escherichia coli Antimicrobial Adaptive Evolution to Single Drugs and Drug Pairs

Author(s): Rachel A. Hickman, Christian Munck, Morten O. A. Sommer
Published in: Frontiers in Microbiology, Issue 8, 2017, ISSN 1664-302X
Publisher: Frontiers Media
DOI: 10.3389/fmicb.2017.00893

Genome Dynamics of Escherichia coli during Antibiotic Treatment: Transfer, Loss, and Persistence of Genetic Elements In situ of the Infant Gut

Author(s): Andreas Porse, Heidi Gumpert, Jessica Z. Kubicek-Sutherland, Nahid Karami, Ingegerd Adlerberth, Agnes E. Wold, Dan I. Andersson, Morten O. A. Sommer
Published in: Frontiers in Cellular and Infection Microbiology, Issue 7, 2017, ISSN 2235-2988
Publisher: Frontiers Media S. A.
DOI: 10.3389/fcimb.2017.00126

Drug-Driven Phenotypic Convergence Supports Rational Treatment Strategies of Chronic Infections

Author(s): Lejla Imamovic, Mostafa Mostafa Hashim Ellabaan, Ana Manuel Dantas Machado, Linda Citterio, Tune Wulff, Soren Molin, Helle Krogh Johansen, Morten Otto Alexander Sommer
Published in: Cell, Issue 172/1-2, 2018, Page(s) 121-134.e14, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2017.12.012

Complete Genome Sequence of Escherichia coli Strain WG5

Author(s): Lejla Imamovic, Maria-Anna Misiakou, Eric van der Helm, Gianni Panagiotou, Maite Muniesa, Morten Otto Alexander Sommer
Published in: Genome Announcements, Issue 6/2, 2018, Page(s) e01403-17, ISSN 2169-8287
Publisher: American Society for Microbiology
DOI: 10.1128/genomeA.01403-17

Transient overexpression of DNA adenine methylase enables efficient and mobile genome engineering with reduced off-target effects

Author(s): Rebecca M. Lennen, Annika I. Nilsson Wallin, Margit Pedersen, Mads Bonde, Hao Luo, Markus J. Herrgård, Morten O. A. Sommer
Published in: Nucleic Acids Research, Issue 44/4, 2016, Page(s) e36-e36, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkv1090

Biochemical mechanisms determine the functional compatibility of heterologous genes

Author(s): Andreas Porse, Thea S. Schou, Christian Munck, Mostafa M. H. Ellabaan, Morten O. A. Sommer
Published in: Nature Communications, Issue 9/1, 2018, Page(s) 522, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-018-02944-3

Collateral sensitivity constrains resistance evolution of the CTX-M-15 β-lactamase

Author(s): Carola E. H. Rosenkilde, Christian Munck, Andreas Porse, Marius Linkevicius, Dan I. Andersson, Morten O. A. Sommer
Published in: Nature Communications, Issue 10/1, 2019, Page(s) 618, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-019-08529-y

Chromosomal barcoding as a tool for multiplexed phenotypic characterization of laboratory evolved lineages

Author(s): Leonie Johanna Jahn, Andreas Porse, Christian Munck, Daniel Simon, Svetlana Volkova, Morten Otto Alexander Sommer
Published in: Scientific Reports, Issue 8/1, 2018, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-018-25201-5

Prediction of antibiotic resistance: time for a new preclinical paradigm?

Author(s): Morten O. A. Sommer, Christian Munck, Rasmus Vendler Toft-Kehler, Dan I. Andersson
Published in: Nature Reviews Microbiology, Issue 15/11, 2017, Page(s) 689-696, ISSN 1740-1526
Publisher: Nature Publishing Group
DOI: 10.1038/nrmicro.2017.75

A versatile one-step CRISPR-Cas9 based approach to plasmid-curing

Author(s): Ida Lauritsen, Andreas Porse, Morten O. A. Sommer, Morten H. H. Nørholm
Published in: Microbial Cell Factories, Issue 16/1, 2017, ISSN 1475-2859
Publisher: BioMed Central
DOI: 10.1186/s12934-017-0748-z