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Utilizing evolutionary interactions to limit multidrug resistance

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Dominant resistance and negative epistasis can limit the co-selection of de novo resistance mutations and antibiotic resistance genes (opens in new window)

Author(s): Andreas Porse, Leonie J. Jahn, Mostafa M. H. Ellabaan, Morten O. A. Sommer
Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-15080-8

Adaptive Laboratory Evolution of Antibiotic Resistance Using Different Selection Regimes Lead to Similar Phenotypes and Genotypes (opens in new window)

Author(s): Leonie J. Jahn, Christian Munck, Mostafa M. H. Ellabaan, Morten O. A. Sommer
Published in: Frontiers in Microbiology, Issue 8, 2017, ISSN 1664-302X
Publisher: Frontiers Media
DOI: 10.3389/fmicb.2017.00816

Time-Resolved Tracking of Mutations Reveals Diverse Allele Dynamics during Escherichia coli Antimicrobial Adaptive Evolution to Single Drugs and Drug Pairs (opens in new window)

Author(s): Rachel A. Hickman, Christian Munck, Morten O. A. Sommer
Published in: Frontiers in Microbiology, Issue 8, 2017, ISSN 1664-302X
Publisher: Frontiers Media
DOI: 10.3389/fmicb.2017.00893

Genome Dynamics of Escherichia coli during Antibiotic Treatment: Transfer, Loss, and Persistence of Genetic Elements In situ of the Infant Gut (opens in new window)

Author(s): Andreas Porse, Heidi Gumpert, Jessica Z. Kubicek-Sutherland, Nahid Karami, Ingegerd Adlerberth, Agnes E. Wold, Dan I. Andersson, Morten O. A. Sommer
Published in: Frontiers in Cellular and Infection Microbiology, Issue 7, 2017, ISSN 2235-2988
Publisher: Frontiers Media S. A.
DOI: 10.3389/fcimb.2017.00126

Drug-Driven Phenotypic Convergence Supports Rational Treatment Strategies of Chronic Infections (opens in new window)

Author(s): Lejla Imamovic, Mostafa Mostafa Hashim Ellabaan, Ana Manuel Dantas Machado, Linda Citterio, Tune Wulff, Soren Molin, Helle Krogh Johansen, Morten Otto Alexander Sommer
Published in: Cell, Issue 172/1-2, 2018, Page(s) 121-134.e14, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2017.12.012

Complete Genome Sequence of Escherichia coli Strain WG5 (opens in new window)

Author(s): Lejla Imamovic, Maria-Anna Misiakou, Eric van der Helm, Gianni Panagiotou, Maite Muniesa, Morten Otto Alexander Sommer
Published in: Genome Announcements, Issue 6/2, 2018, Page(s) e01403-17, ISSN 2169-8287
Publisher: American Society for Microbiology
DOI: 10.1128/genomeA.01403-17

Transient overexpression of DNA adenine methylase enables efficient and mobile genome engineering with reduced off-target effects (opens in new window)

Author(s): Rebecca M. Lennen, Annika I. Nilsson Wallin, Margit Pedersen, Mads Bonde, Hao Luo, Markus J. Herrgård, Morten O. A. Sommer
Published in: Nucleic Acids Research, Issue 44/4, 2016, Page(s) e36-e36, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkv1090

Biochemical mechanisms determine the functional compatibility of heterologous genes (opens in new window)

Author(s): Andreas Porse, Thea S. Schou, Christian Munck, Mostafa M. H. Ellabaan, Morten O. A. Sommer
Published in: Nature Communications, Issue 9/1, 2018, Page(s) 522, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-018-02944-3

Collateral sensitivity constrains resistance evolution of the CTX-M-15 β-lactamase (opens in new window)

Author(s): Carola E. H. Rosenkilde, Christian Munck, Andreas Porse, Marius Linkevicius, Dan I. Andersson, Morten O. A. Sommer
Published in: Nature Communications, Issue 10/1, 2019, Page(s) 618, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-019-08529-y

Chromosomal barcoding as a tool for multiplexed phenotypic characterization of laboratory evolved lineages (opens in new window)

Author(s): Leonie Johanna Jahn, Andreas Porse, Christian Munck, Daniel Simon, Svetlana Volkova, Morten Otto Alexander Sommer
Published in: Scientific Reports, Issue 8/1, 2018, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-018-25201-5

Prediction of antibiotic resistance: time for a new preclinical paradigm? (opens in new window)

Author(s): Morten O. A. Sommer, Christian Munck, Rasmus Vendler Toft-Kehler, Dan I. Andersson
Published in: Nature Reviews Microbiology, Issue 15/11, 2017, Page(s) 689-696, ISSN 1740-1526
Publisher: Nature Publishing Group
DOI: 10.1038/nrmicro.2017.75

A versatile one-step CRISPR-Cas9 based approach to plasmid-curing (opens in new window)

Author(s): Ida Lauritsen, Andreas Porse, Morten O. A. Sommer, Morten H. H. Nørholm
Published in: Microbial Cell Factories, Issue 16/1, 2017, ISSN 1475-2859
Publisher: BioMed Central
DOI: 10.1186/s12934-017-0748-z

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