Rebuilding the human thymus to create a tolerising system for allogeneic tissue and organ transplantation

Project Information

Rethyming

Grant agreement ID: 639429

DOI

10.3030/639429

Project closed

EC signature date 4 May 2015

Start date 1 July 2015

End date 31 December 2021

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 480 416,00

EU contribution

€ 1 480 416,00

Coordinated by

UNIVERSITY COLLEGE LONDON
United Kingdom

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (10)

Evolution of enhanced innate immune evasion by the SARS-CoV-2 Alpha variant

Author(s): Thorne LG, Bouhaddou M, Reuschl AK, Alvarez Z, Polacco B, Pelin A, Batra J, Whelan MVX, Hosmillo M, Fossati A, Ragazzini R, Jungreis I, Ummadi M, Rojc A, Turner J, Bischof ML, Obernier K, Braberg H, Soucheray M, Richards A, Chen KH, Harjai B, Memon D, Hiatt J, Jahun A, Fabius JM, Goodfellow IG, Takeuchi Y, Bonfanti P, Shokat J, Jura N,, Klim Verba K, Noursadeghi M, Beltrao P, Kellis M, Swaney DL,
Published in: Nature, 2022, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-021-04352-y

In utero transplantation of in vitro expanded autologous amniotic fluid stem cells results in efficient long-term hematopoietic engraftment

Author(s): Loukogeorgakis SP, Shangaris P, Bertin E, Chiara Franzin C, Martina Piccoli M, Michela Pozzobon M, Subramaniam S, Tedeschi A, Kim AG, Li H, Fachin CG, Dias AIBS, Stratigis JD, Ahn NJ, Thrasher AJ, Bonfanti P, Peranteau WH, David A, Flake AW, and De Coppi P
Published in: Stem Cells, Issue 10665099, 2019, ISSN 1066-5099
Publisher: AlphaMed Press Inc
DOI: 10.1002/stem.3039

Engineering transplantable mucosal grafts using primary jejunal organoids derived from children with intestinal failure.

Author(s): Meran L, Massie I, Campinoti S, Weston A, Gaifulina R, Faull P, Orford M, Kucharska A, Baulies A, Hirst E, Konig J, Pellegata A, Snijders B, Collinson L, Thapar N, Thomas G, Eaton S, Bonfanti P, De Coppi P, and Li V.S.W.
Published in: Nature Medicine, Issue 10788956, 2020, ISSN 1078-8956
Publisher: Nature Publishing Group
DOI: 10.1038/s41591-020-1024-z

A cell atlas of human thymic development defines T cell repertoire formation

Author(s): Park JE, Botting RA, Conde CD, Popescu DM, Lavaert M, Kunz DJ, Stephenson E, Ragazzini R, Tuck E, Wilbrey-Clark A, Ferdinand JR, Webb S, Maunder D, Vandamme N, Mahbubani K, Polanski K, Mamanova L, Fuller A, Filby A, Reynolds G, Dixon D, Saeb-Parsy K, Lisgo S, Henderson D, Vento-Tormo R, Meyer KB, Saeys Y, Bonfanti P, Behjati S, Clatworthy MR, Taghon T, Haniffa M, Teichmann SA
Published in: Science, 2020, Page(s) Vol 367, Issue 6480, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aay3224

Reconstitution of a functional human thymus by postnatal progenitor cells and natural whole organ scaffolds.

Author(s): Campinoti S, Gjinovci A, Ragazzini R, Zanieri L, Ariza-McNaughton L, Catucci M, Boeing S, Park JE, Hutchinson JC, Munoz-Ruiz M, Manti PG, Vozza G, Villa CE, Phylactopoulos DE, Maurer C, Testa G, Stauss HJ, Teichmann SA, Sebire NJ, Hayday AC, Bonnet D, and Bonfanti P
Published in: Nature Communications, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-20082-7

Current and future therapeutic approaches for thymic stromal cell defects

Author(s): Kreins AY, Bonfanti P, Davies EG
Published in: Frontiers in Immunology, 2021, ISSN 1664-3224
Publisher: Frontiers Media S.A
DOI: 10.3389/fimmu.2021.655354

Extracellular matrix hydrogel derived from decellularized tissues enables endoderm organoids culture

Author(s): Giobbe GG, Crowley C, Luni C, Campinoti S, Khedr M, De Santis M, Zambaiti E, Kretzschmar K, Li V, Clevers H, Bonfanti P, Elvassore N, and De Coppi P
Published in: Nature Communications, Issue 20411723, 2019, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-019-13605-4

HGF-MET signaling causes tyrosine 641 STAT6 phosphorylation without transcriptional activation in human lung epithelial cells

Author(s): Hynds RE, Gowers KHC, Butler CR, Bonfanti P, Giangreco A, Prêle CM and Janes SM
Published in: Plos one, 2018, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0197129

Regenerating human epithelia with cultured stem cells: feeder cells, organoids and beyond

Author(s): Hynds RE, Bonfanti P*, Janes SM*
Published in: EMBO Molecular Medicine, Issue 17574676, 2018, ISSN 1757-4676
Publisher: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.201708213

Multi-stage bioengineering of a layered oesophagus with in vitro expanded muscle and epithelial adult progenitor

Author(s): Urbani L, Camilli C, Phylactopoulos DE, Crowley C, Natarajan D, Scottoni F, Maghsoudlou P, McCann CJ, Pellegata AF, Urciuolo A, Aruta S, Signorelli MC, Kiely D, Hannon E, Deguchi K, Trevisan M, Wong R, Baradez MO, Moulding D, Khalaf S, Virasami A, Gjinovci A, Loukogeorgakis S, Mantero S, Thapar N, Sebire N, Eaton S, Lowdell M, Cossu G, Bonfanti P* and De Coppi P
Published in: Nature Communications, Issue 20411723, 2018, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-018-06385-w