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Commitment, maturation and infectivity of sexual stage malaria parasites in natural infections

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Bead-based assays to simultaneously detect multiple human inherited blood disorders associated with malaria

Author(s): Lynn Grignard, Catherine Mair, Jonathan Curry, Laleta Mahey, Guide J. H. Bastiaens, Alfred B. Tiono, Joseph Okebe, Sam A. Coulibaly, Bronner P. Gonçalves, Muna Affara, Alphonse Ouédraogo, Edith C. Bougouma, Guillaume S. Sanou, Issa Nébié, Kjerstin H. W. Lanke, Sodiomon B. Sirima, Umberto d’Alessandro, Taane G. Clark, Susana Campino, Teun Bousema, Chris Drakeley
Published in: Malaria Journal, Issue 18/1, 2019, ISSN 1475-2875
DOI: 10.1186/s12936-019-2648-7

A multiplex assay for the sensitive detection and quantification of male and female Plasmodium falciparum gametocytes

Author(s): Meerstein-Kessel, Lisette; Andolina, Chiara; Carrio, Elvira; Mahamar, Almahamoudou; Sawa, Patrick; Diawara, Halimatou; van de Vegte-Bolmer, Marga; Stone, Will; Collins, Katharine A.; Schneider, Petra; Dicko, Alassane; Drakeley, Chris; Felger, Ingrid; Voss, Till; Lanke, Kjerstin; Bousema, Teun
Published in: Malaria Journal, 2018, ISSN 1475-2875
DOI: 10.1186/s12936-018-2584-y

Functional antibodies against Plasmodium falciparum sporozoites are associated with a longer time to qPCR-detected infection among schoolchildren in Burkina Faso

Author(s): Aissata Barry, Marije C. Behet, Issa Nébié, Kjerstin Lanke, Lynn Grignard, Alphonse Ouedraogo, Issiaka Soulama, Chris Drakeley, Robert Sauerwein, Judith M. Bolscher, Koen J. Dechering, Teun Bousema, Alfred B. Tiono, Bronner P. Gonçalves
Published in: Wellcome Open Research, Issue 3, 2018, Page(s) 159, ISSN 2398-502X
DOI: 10.12688/wellcomeopenres.14932.1

CYP2D6 Polymorphisms and the Safety and Gametocytocidal Activity of Single-Dose Primaquine for Plasmodium falciparum

Author(s): Helmi Pett, John Bradley, Joseph Okebe, Alassane Dicko, Alfred B. Tiono, Bronner P. Gonçalves, Will Stone, Ingrid Chen, Kjerstin Lanke, Mikko Neuvonen, Anna-Liina Mustaniemi, Alice C. Eziefula, Roly Gosling, Umberto D’Alessandro, Chris Drakeley, Mikko Niemi, Teun Bousema
Published in: Antimicrobial Agents and Chemotherapy, Issue 63/10, 2019, ISSN 0066-4804
DOI: 10.1128/AAC.00538-19

Plasmodium falciparum Gametocyte Enrichment in Peripheral Blood Samples by Magnetic Fractionation: Gametocyte Yields and Possibilities to Reuse Columns

Author(s): Wouter Graumans, Chiara Andolina, Shehu S. Awandu, Lynn Grignard, Kjerstin Lanke, Teun Bousema
Published in: The American Journal of Tropical Medicine and Hygiene, Issue 100/3, 2019, Page(s) 572-577, ISSN 0002-9637
DOI: 10.4269/ajtmh.18-0773

Transmission-blocking Effects of Primaquine and Methylene Blue Suggest Plasmodium falciparum Gametocyte Sterilization Rather Than Effects on Sex Ratio

Author(s): John Bradley, Harouna M Soumaré, Almahamoudou Mahamar, Halimatou Diawara, Michelle Roh, Michael Delves, Chris Drakeley, Thomas S Churcher, Alassane Dicko, Roly Gosling, Teun Bousema
Published in: Clinical Infectious Diseases, Issue 69/8, 2019, Page(s) 1436-1439, ISSN 1058-4838
DOI: 10.1093/cid/ciz134

The Gametocytocidal Efficacy of Different Single Doses of Primaquine with Dihydroartemisinin-piperaquine in Asymptomatic Parasite Carriers in The Gambia: A Randomized Controlled Trial

Author(s): Joseph Okebe, Teun Bousema, Muna Affara, Gian Luca Di Tanna, Edgard Dabira, Abdoulaye Gaye, Frank Sanya-Isijola, Henry Badji, Simon Correa, Davis Nwakanma, Jean-Pierre Van Geertruyden, Chris Drakeley, Umberto D'Alessandro
Published in: EBioMedicine, Issue 13, 2016, Page(s) 348-355, ISSN 2352-3964
DOI: 10.1016/j.ebiom.2016.10.032

Age, Weight, and CYP2D6 Genotype Are Major Determinants of Primaquine Pharmacokinetics in African Children

Author(s): Bronner P. Gonçalves, Helmi Pett, Alfred B. Tiono, Daryl Murry, Sodiomon B. Sirima, Mikko Niemi, Teun Bousema, Chris Drakeley, Rob ter Heine
Published in: Antimicrobial Agents and Chemotherapy, Issue 61/5, 2017, Page(s) e02590-16, ISSN 0066-4804
DOI: 10.1128/AAC.02590-16

Concentration of Plasmodium falciparum gametocytes in whole blood samples by magnetic cell sorting enhances parasite infection rates in mosquito feeding assays

Author(s): Isaie J. Reuling, Will J. R. Stone, Marga van de Vegte-Bolmer, Geert-Jan van Gemert, Rianne Siebelink-Stoter, Wouter Graumans, Kjerstin Lanke, Teun Bousema, Robert W. Sauerwein
Published in: Malaria Journal, Issue 16/1, 2017, ISSN 1475-2875
DOI: 10.1186/s12936-017-1959-9

Molecular Markers for Sensitive Detection of Plasmodium falciparum Asexual Stage Parasites and their Application in a Malaria Clinical Trial

Author(s): Fitsum G. Tadesse, Jodie A. Schildkraut, Teun Bousema, Alfred B. Tiono, Kjerstin Lanke, Chris Drakeley, Sanna R. Rijpma, Bronner P. Gonçalves, Robert Sauerwein, Issa Nebie
Published in: The American Journal of Tropical Medicine and Hygiene, Issue 97/1, 2017, Page(s) 188-198, ISSN 0002-9637
DOI: 10.4269/ajtmh.16-0893

The shape of the iceberg: quantification of submicroscopic Plasmodium falciparum and Plasmodium vivax parasitaemia and gametocytaemia in five low endemic settings in Ethiopia

Author(s): Fitsum G. Tadesse, Lotus van den Hoogen, Kjerstin Lanke, Jodie Schildkraut, Kevin Tetteh, Abraham Aseffa, Hassen Mamo, Robert Sauerwein, Ingrid Felger, Chris Drakeley, Endalamaw Gadissa, Teun Bousema
Published in: Malaria Journal, Issue 16/1, 2017, ISSN 1475-2875
DOI: 10.1186/s12936-017-1749-4

Safety of single low-dose primaquine in glucose-6-phosphate dehydrogenase deficient falciparum-infected African males: Two open-label, randomized, safety trials

Author(s): Guido J. H. Bastiaens, Alfred B. Tiono, Joseph Okebe, Helmi E. Pett, Sam A. Coulibaly, Bronner P. Gonçalves, Muna Affara, Alphonse Ouédraogo, Edith C. Bougouma, Guillaume S. Sanou, Issa Nébié, John Bradley, Kjerstin H. W. Lanke, Mikko Niemi, Sodiomon B. Sirima, Umberto d’Alessandro, Teun Bousema, Chris Drakeley
Published in: PLOS ONE, Issue 13/1, 2018, Page(s) e0190272, ISSN 1932-6203
DOI: 10.1371/journal.pone.0190272

The relative contribution of symptomatic and asymptomatic Plasmodium vivax and Plasmodium falciparum infections to the infectious reservoir in a low-endemic setting in Ethiopia

Author(s): Fitsum G Tadesse, Hannah C Slater, Wakweya Chali, Karina Teelen, Kjerstin Lanke, Mulualem Belachew, Temesgen Menberu, Girma Shumie, Getasew Shitaye, Lucy C Okell, Wouter Graumans, Geert-Jan van Gemert, Soriya Kedir, Addisu Tesfaye, Feleke Belachew, Wake Abebe, Hassen Mamo, Robert Sauerwein, Taye Balcha, Abraham Aseffa, Delenasaw Yewhalaw, Endalamaw Gadisa, Chris Drakeley, Teun Bousema
Published in: Clinical Infectious Diseases, 2018, ISSN 1058-4838
DOI: 10.1093/cid/cix1123

Safety of Single-Dose Primaquine in G6PD-Deficient and G6PD-Normal Males in Mali Without Malaria: An Open-Label, Phase 1, Dose-Adjustment Trial

Author(s): Ingrid Chen, Halimatou Diawara, Almahamoudou Mahamar, Koualy Sanogo, Sekouba Keita, Daouda Kone, Kalifa Diarra, Moussa Djimde, Mohamed Keita, Joelle Brown, Michelle E Roh, Jimee Hwang, Helmi Pett, Maxwell Murphy, Mikko Niemi, Bryan Greenhouse, Teun Bousema, Roly Gosling, Alassane Dicko
Published in: The Journal of Infectious Diseases, 2018, ISSN 0022-1899
DOI: 10.1093/infdis/jiy014

A Molecular Assay to Quantify Male and Female Plasmodium falciparum Gametocytes: Results From 2 Randomized Controlled Trials Using Primaquine for Gametocyte Clearance

Author(s): Will Stone, Patrick Sawa, Kjerstin Lanke, Sanna Rijpma, Robin Oriango, Maureen Nyaurah, Paul Osodo, Victor Osoti, Almahamoudou Mahamar, Halimatou Diawara, Rob Woestenenk, Wouter Graumans, Marga van de Vegte-Bolmer, John Bradley, Ingrid Chen, Joelle Brown, Giulia Siciliano, Pietro Alano, Roly Gosling, Alassane Dicko, Chris Drakeley, Teun Bousema
Published in: The Journal of Infectious Diseases, Issue 216/4, 2017, Page(s) 457-467, ISSN 0022-1899
DOI: 10.1093/infdis/jix237

Efficacy and safety of primaquine and methylene blue for prevention of Plasmodium falciparum transmission in Mali: a phase 2, single-blind, randomised controlled trial

Author(s): Alassane Dicko, Michelle E Roh, Halimatou Diawara, Almahamoudou Mahamar, Harouna M Soumare, Kjerstin Lanke, John Bradley, Koualy Sanogo, Daouda T Kone, Kalifa Diarra, Sekouba Keita, Djibrilla Issiaka, Sekou F Traore, Charles McCulloch, Will J R Stone, Jimee Hwang, Olaf Müller, Joelle M Brown, Vinay Srinivasan, Chris Drakeley, Roly Gosling, Ingrid Chen, Teun Bousema
Published in: The Lancet Infectious Diseases, 2018, ISSN 1473-3099
DOI: 10.1016/S1473-3099(18)30044-6

Assessing the impact of next-generation rapid diagnostic tests on Plasmodium falciparum malaria elimination strategies

Author(s): Hannah C. Slater, Amanda Ross, André Lin Ouédraogo, Lisa J. White, Chea Nguon, Patrick G.T. Walker, Pengby Ngor, Ricardo Aguas, Sheetal P. Silal, Arjen M. Dondorp, Paul La Barre, Robert Burton, Robert W. Sauerwein, Chris Drakeley, Thomas A. Smith, Teun Bousema, Azra C. Ghani
Published in: Nature, Issue 528/7580, 2015, Page(s) S94-S101, ISSN 0028-0836
DOI: 10.1038/nature16040

Single low dose primaquine to reduce gametocyte carriage and Plasmodium falciparum transmission after artemether-lumefantrine in children with asymptomatic infection: a randomised, double-blind, placebo-controlled trial

Author(s): Bronner P. Gonçalves, Alfred B. Tiono, Alphonse Ouédraogo, Wamdaogo M. Guelbéogo, John Bradley, Issa Nebie, Débé Siaka, Kjerstin Lanke, Alice C. Eziefula, Amidou Diarra, Helmi Pett, Edith C. Bougouma, Sodiomon B. Sirima, Chris Drakeley, Teun Bousema
Published in: BMC Medicine, Issue 14/1, 2016, ISSN 1741-7015
DOI: 10.1186/s12916-016-0581-y

Gametocyte carriage in uncomplicated Plasmodium falciparum malaria following treatment with artemisinin combination therapy: a systematic review and meta-analysis of individual patient data

Author(s): Abdulla S, Achan J, Adam I, Alemayehu BH, Allan R, Allen EN, Anvikar AR, Arinaitwe E, Ashley EA, Sot M, Asih PB, Awab GR, Barnes KI, Bassat Q, de Manhiça S, Baudin E, Björkman A, Bompart F, Bonnet M, Borrmann S, Bousema T, Carrara VI, Sot M, Cenci F, Tau S, Checchi F, Cot M, Dahal P, D'Alessandro U, Deloron P, Djimde A, Dondorp A, Dorsey G, Doumbo OK, Drakeley CJ, Duparc S, Espie E, Faiz A, Fal
Published in: BMC Medicine, Issue 14/1, 2016, ISSN 1741-7015
DOI: 10.1186/s12916-016-0621-7

Persistence of Plasmodium falciparum parasitemia after artemisinin combination therapy: evidence from a randomized trial in Uganda

Author(s): Hsiao-Han Chang, Elamaran Meibalan, Justin Zelin, Rachel Daniels, Alice C. Eziefula, Evan C. Meyer, Fitsum Tadesse, Lynn Grignard, Regina C. Joice, Chris Drakeley, Dyann F. Wirth, Sarah K. Volkman, Caroline Buckee, Teun Bousema, Matthias Marti
Published in: Scientific Reports, Issue 6, 2016, Page(s) 26330, ISSN 2045-2322
DOI: 10.1038/srep26330

Infectivity of Microscopic and Submicroscopic Malaria Parasite Infections in Areas of Low Malaria Endemicity

Author(s): Bronner P. Gonçalves, Chris Drakeley, Teun Bousema
Published in: Journal of Infectious Diseases, Issue 213/9, 2016, Page(s) 1516-1517, ISSN 0022-1899
DOI: 10.1093/infdis/jiw044

Primaquine to reduce transmission of Plasmodium falciparum malaria in Mali: a single-blind, dose-ranging, adaptive randomised phase 2 trial

Author(s): Alassane Dicko, Joelle M Brown, Halimatou Diawara, Ibrahima Baber, Almahamoudou Mahamar, Harouna M Soumare, Koualy Sanogo, Fanta Koita, Sekouba Keita, Sekou F Traore, Ingrid Chen, Eugenie Poirot, Jimee Hwang, Charles McCulloch, Kjerstin Lanke, Helmi Pett, Mikko Niemi, François Nosten, Teun Bousema, Roly Gosling
Published in: The Lancet Infectious Diseases, Issue 16/6, 2016, Page(s) 674-684, ISSN 1473-3099
DOI: 10.1016/S1473-3099(15)00479-X

A controlled human malaria infection model enabling evaluation of transmission-blocking interventions

Author(s): Katharine A. Collins, Claire Y.T. Wang, Matthew Adams, Hayley Mitchell, Melanie Rampton, Suzanne Elliott, Isaie J. Reuling, Teun Bousema, Robert Sauerwein, Stephan Chalon, Jörg J. Möhrle, James S. McCarthy
Published in: Journal of Clinical Investigation, Issue 128/4, 2018, Page(s) 1551-1562, ISSN 0021-9738
DOI: 10.1172/JCI98012

Haemolysis and haem oxygenase-1 induction during persistent “asymptomatic” malaria infection in Burkinabé children

Author(s): Jason P. Mooney, Aissata Barry, Bronner P. Gonçalves, Alfred B. Tiono, Shehu S. Awandu, Lynn Grignard, Chris J. Drakeley, Christian Bottomley, Teun Bousema, Eleanor M. Riley
Published in: Malaria Journal, Issue 17/1, 2018, ISSN 1475-2875
DOI: 10.1186/s12936-018-2402-6

A randomized feasibility trial comparing four antimalarial drug regimens to induce Plasmodium falciparum gametocytemia in the controlled human malaria infection model

Author(s): Isaie J Reuling, Lisanne A van de Schans, Luc E Coffeng, Kjerstin Lanke, Lisette Meerstein-Kessel, Wouter Graumans, Geert-Jan van Gemert, Karina Teelen, Rianne Siebelink-Stoter, Marga van de Vegte-Bolmer, Quirijn de Mast, André J van der Ven, Karen Ivinson, Cornelus C Hermsen, Sake de Vlas, John Bradley, Katharine A Collins, Christian F Ockenhouse, James McCarthy, Robert W Sauerwein, Teun Bousema
Published in: eLife, Issue 7, 2018, ISSN 2050-084X
DOI: 10.7554/eLife.31549

Predicting the likelihood and intensity of mosquito infection from sex specific Plasmodium falciparum gametocyte density

Author(s): John Bradley, Will Stone, Dari F Da, Isabelle Morlais, Alassane Dicko, Anna Cohuet, Wamdaogo M Guelbeogo, Almahamoudou Mahamar, Sandrine Nsango, Harouna M Soumaré, Halimatou Diawara, Kjerstin Lanke, Wouter Graumans, Rianne Siebelink-Stoter, Marga van de Vegte-Bolmer, Ingrid Chen, Alfred Tiono, Bronner Pamplona Gonçalves, Roland Gosling, Robert W Sauerwein, Chris Drakeley, Thomas S Churcher, Teun
Published in: eLife, Issue 7, 2018, ISSN 2050-084X
DOI: 10.7554/eLife.34463

Transmission of molecularly undetectable circulating parasite clones leads to high infection complexity in mosquitoes post feeding

Author(s): Lynn Grignard, Bronner P. Gonçalves, Angela M. Early, Rachel F. Daniels, Alfred B. Tiono, Wamdaogo M. Guelbéogo, Alphonse Ouédraogo, Elke M. van Veen, Kjerstin Lanke, Amidou Diarra, Issa Nebie, Sodiomon B. Sirima, Geoff A. Targett, Sarah K. Volkman, Daniel E. Neafsey, Dyann F. Wirth, Teun Bousema, Chris Drakeley
Published in: International Journal for Parasitology, Issue 48/8, 2018, Page(s) 671-677, ISSN 0020-7519
DOI: 10.1016/j.ijpara.2018.02.005

Modeling the impact of Plasmodium falciparum sexual stage immunity on the composition and dynamics of the human infectious reservoir for malaria in natural settings

Author(s): André Lin Ouédraogo, Philip A. Eckhoff, Adrian J. F. Luty, Will Roeffen, Robert W. Sauerwein, Teun Bousema, Edward A. Wenger
Published in: PLOS Pathogens, Issue 14/5, 2018, Page(s) e1007034, ISSN 1553-7374
DOI: 10.1371/journal.ppat.1007034

Low and heterogeneous prevalence of glucose-6-phosphate dehydrogenase deficiency in different settings in Ethiopia using phenotyping and genotyping approaches

Author(s): Getasew Shitaye, Endalamaw Gadisa, Lynn Grignard, Girma Shumie, Wakweya Chali, Temesgen Menberu, Mulualem Belachew, Getaneh Tegegn, Sagni Challi, Jonathan Curry, Laleta Mahey, Tsegaye Hailu, Hassen Mamo, Menakath Menon, Taye Balcha, Abraham Aseffa, Chris Drakeley, Teun Bousema, Fitsum G. Tadesse
Published in: Malaria Journal, Issue 17/1, 2018, ISSN 1475-2875
DOI: 10.1186/s12936-018-2437-8

Plasmodium falciparum Gametocyte Density and Infectivity in Peripheral Blood and Skin Tissue of Naturally Infected Parasite Carriers in Burkina Faso

Author(s): Elamaran Meibalan, Aissata Barry, Matthew P Gibbins, Shehu Awandu, Lisette Meerstein-Kessel, Fiona Achcar, Selina Bopp, Christopher Moxon, Amidou Diarra, Siaka Debe, Nicolas Ouédraogo, Ines Barry-Some, Emilie S Badoum, Traoré Fagnima, Kjerstin Lanke, Bronner P Gonçalves, John Bradley, Dyann Wirth, Chris Drakeley, Wamdaogo Moussa Guelbeogo, Alfred B Tiono, Matthias Marti, Teun Bousema
Published in: The Journal of Infectious Diseases, 2019, ISSN 0022-1899
DOI: 10.1093/infdis/jiz680

Naturally acquired immunity against immature Plasmodium falciparum gametocytes

Author(s): Kathleen W. Dantzler, Siyuan Ma, Priscilla Ngotho, Will J. R. Stone, Dingyin Tao, Sanna Rijpma, Mariana De Niz, Sandra K. Nilsson Bark, Matthijs M. Jore, Tonke K. Raaijmakers, Angela M. Early, Ceereena Ubaida-Mohien, Leandro Lemgruber, Joseph J. Campo, Andy A. Teng, Timothy Q. Le, Cassidy L. Walker, Patricia Hermand, Philippe Deterre, D. Huw Davies, Phil Felgner, Isabelle Morlais, Dyann F. Wirth,
Published in: Science Translational Medicine, Issue 11/495, 2019, Page(s) eaav3963, ISSN 1946-6234
DOI: 10.1126/scitranslmed.aav3963

Is that a real oocyst? Insectary establishment and identification of Plasmodium falciparum oocysts in midguts of Anopheles mosquitoes fed on infected human blood in Tororo, Uganda

Author(s): Alex K. Musiime, Joseph Okoth, Melissa Conrad, Daniel Ayo, Ismail Onyige, John Rek, Joaniter I. Nankabirwa, Emmanuel Arinaitwe, Moses R. Kamya, Grant Dorsey, Geert-Jan van Gemert, Sarah G. Staedke, Chris Drakeley, Teun Bousema, Chiara Andolina
Published in: Malaria Journal, Issue 18/1, 2019, ISSN 1475-2875
DOI: 10.1186/s12936-019-2922-8

Immunity against sexual stage Plasmodium falciparum and Plasmodium vivax parasites

Author(s): Roos M. Jong, Surafel K. Tebeje, Lisette Meerstein‐Kessel, Fitsum G. Tadesse, Matthijs M. Jore, Will Stone, Teun Bousema
Published in: Immunological Reviews, Issue 293/1, 2019, Page(s) 190-215, ISSN 0105-2896
DOI: 10.1111/imr.12828

A Randomized Clinical Trial to Compare Plasmodium falciparum Gametocytemia and Infectivity After Blood-Stage or Mosquito Bite–Induced Controlled Malaria Infection

Author(s): Alkema M, Reuling IJ, de Jong GM, Lanke K, Coffeng LE, van Gemert GJ, van de Vegte-Bolmer M, de Mast Q, van Crevel R, Ivinson K, Ockenhouse CF, McCarthy JS, Sauerwein R, Collins KA, Bousema T.
Published in: Journal of Infectious Diseases, 2019, ISSN 0022-1899
DOI: 10.1093/infdis/jiaa428

Investigating the impact of enhanced community case management and monthly screening and treatment on the transmissibility of malaria infections in Burkina Faso: study protocol for a cluster-randomised trial

Author(s): Katharine A Collins, Alphonse Ouedraogo, Wamdaogo Moussa Guelbeogo, Shehu S Awandu, Will Stone, Issiaka Soulama, Maurice S Ouattara, Apollinaire Nombre, Amidou Diarra, John Bradley, Prashanth Selvaraj, Jaline Gerardin, Chris Drakeley, Teun Bousema, Alfred Tiono
Published in: BMJ Open, Issue 9/9, 2019, Page(s) e030598, ISSN 2044-6055
DOI: 10.1136/bmjopen-2019-030598

Determinants of Malaria Transmission at the Population Level

Author(s): Teun Bousema, Chris Drakeley
Published in: Cold Spring Harbor Perspectives in Medicine, Issue 7/12, 2017, Page(s) a025510, ISSN 2157-1422
DOI: 10.1101/cshperspect.a025510

Increased gametocyte production and mosquito infectivity in chronic versus incident Plasmodium falciparum infections

Author(s): Aissata Barry; John Bradley; Will Stone; Moussa W Guelbeogo; Kjerstin Lanke; Alphonse Ouedraogo; Issiaka Soulama; Issa N Ouedraogo; Samuel Serme; Lynn Grignard; Katie Patterson; Shehu S Awandu; Mireille Ouedraogo; Casimire W Tarama; Desire Kargougou; Zongo Zoumanaba; Sodiomon B Sirima; Matthias Marti; Chris Drakeley; Alfred B Tiono; Teun Bousema
Published in: medRxiv, Issue 1, 2020
DOI: 10.1101/2020.04.08.20057927