Functional and Molecular Analyses of the Interplay between Hematopoietic and Mesenchymal Niche Cells in Human Myelodysplastic Syndromes.

Project Information

HemNichMDS

Grant agreement ID: 639795

DOI

10.3030/639795

Project closed

EC signature date 8 July 2015

Start date 1 August 2015

End date 31 January 2022

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 500 000,00

EU contribution

€ 1 500 000,00

Coordinated by

CHEMOTHERAPEUTISCHES FORSCHUNGSINSTITUT GEORG-SPEYER-HAUS STIFTUNG
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (4)

AXL inhibition in macrophages stimulates host-versus-leukemia immunity and eradicates naive and treatment resistant leukemia

Author(s): Irene Tirado-Gonzalez, Arnaud Descot, Devona Soetopo, Aleksandra Nevmerzhitskaya, Alexander Schaffer, Ivan-Maximiliano Kur, Ewelina Czlonka, Carolin Wachtel, Ioanna Tsoukala, Luise Muller, Anna-Lena Schafer, Maresa Weitmann, Petra Dinse, Emily Alberto, Michele C Buck, Jonathan J M Landry, Bianka Baying, Julia Slotta-Huspenina, Jenny Roesler, Patrick N Harter, Anne-Sophie Kubasch, Jörn Meinel, Eim
Published in: Cancer Discovery, 2021, Page(s) candisc.1378.2020, ISSN 2159-8274
Publisher: American Association for Cancer Research Inc.
DOI: 10.1158/2159-8290.cd-20-1378

Mutational hierarchies in myelodysplastic syndromes dynamically adapt and evolve upon therapy response and failure

Author(s): M. Mossner, J.-C. Jann, J. Wittig, F. Nolte, S. Fey, V. Nowak, J. Oblander, J. Pressler, I. Palme, C. Xanthopoulos, T. Boch, G. Metzgeroth, H. Rohl, S. H. Witt, H. Dukal, C. Klein, S. Schmitt, P. Gelss, U. Platzbecker, E. Balaian, A. Fabarius, H. Blum, T. J. Schulze, M. Meggendorfer, C. Haferlach, A. Trumpp, W.-K. Hofmann, H. Medyouf, D. Nowak
Published in: Blood, Issue 128/9, 2016, Page(s) 1246-1259, ISSN 0006-4971
Publisher: American Society of Hematology
DOI: 10.1182/blood-2015-11-679167

The microenvironment in human myeloid malignancies: emerging concepts and therapeutic implications

Author(s): Hind Medyouf
Published in: Blood, Issue 129/12, 2017, Page(s) 1617-1626, ISSN 0006-4971
Publisher: American Society of Hematology
DOI: 10.1182/blood-2016-11-696070

CRISPR/Cas9-edited NSG mice as PDX models of human leukemia to address the role of niche-derived SPARC

Author(s): I Tirado-Gonzalez, E Czlonka, A Nevmerzhitskaya, D Soetopo, E Bergonzani, A Mahmoud, A Contreras, I Jeremias, U Platzbecker, J P Bourquin, U Kloz, F Van der Hoeven, H Medyouf
Published in: Leukemia, Issue 32/4, 2017, Page(s) 1049-1052, ISSN 0887-6924
Publisher: Nature Publishing Group
DOI: 10.1038/leu.2017.346