Periodic Reporting for period 4 - REGENETHER (Modeling and treating retinal degenerative disease)
Reporting period: 2020-06-01 to 2020-11-30
We created new AAV capsids adapted to human retina using and ex vivo selection paradigm. We have generated a large amount of data on the selection process thanks to the implementation of next generation sequencing. These new datasets allowed us to better understand the process and the numerical aspects of the experimental parameters. We hope this data will allow machine learning backed models for this type of selection after the end of the project. We thus need to await further, in order to fully measure the impact the project will have at the higher levels. However on a smaller scale, the progress has been up to our expectations and we have met the technical milestones that pave the way to achieve the broader objectives
The bioengineering strategy using human samples can also be applied to other organs and can be a brilliant alternative to the state of the art xenograft models.