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Modeling and treating retinal degenerative disease

Publications

Towards optogenetic vision restoration with high resolution

Author(s): Ulisse Ferrari, Stéphane Deny, Abhishek Sengupta, Romain Caplette, Francesco Trapani, José-Alain Sahel, Deniz Dalkara, Serge Picaud, Jens Duebel, Olivier Marre
Published in: PLOS Computational Biology, Issue 16/7, 2020, Page(s) e1007857, ISSN 1553-7358
Publisher: PLOS
DOI: 10.1371/journal.pcbi.1007857

The primate model for understanding and restoring vision

Author(s): Serge Picaud, Deniz Dalkara, Katia Marazova, Olivier Goureau, Botond Roska, José-Alain Sahel
Published in: Proceedings of the National Academy of Sciences, Issue 116/52, 2019, Page(s) 26280-26287, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.1902292116

Noninvasive gene delivery to foveal cones for vision restoration

Author(s): Hanen Khabou, Marcela Garita-Hernandez, Antoine Chaffiol, Sacha Reichman, Céline Jaillard, Elena Brazhnikova, Stéphane Bertin, Valérie Forster, Mélissa Desrosiers, Céline Winckler, Olivier Goureau, Serge Picaud, Jens Duebel, José-Alain Sahel, Deniz Dalkara
Published in: JCI Insight, Issue 3/2, 2018, ISSN 2379-3708
Publisher: Dr. Howard Rockman
DOI: 10.1172/jci.insight.96029

Optogenetic Light Sensors in Human Retinal Organoids

Author(s): Marcela Garita-Hernandez, Laure Guibbal, Lyes Toualbi, Fiona Routet, Antoine Chaffiol, Celine Winckler, Marylin Harinquet, Camille Robert, Stephane Fouquet, Sebastien Bellow, José-Alain Sahel, Olivier Goureau, Jens Duebel, Deniz Dalkara
Published in: Frontiers in Neuroscience, Issue 12, 2018, ISSN 1662-453X
Publisher: Frontiers
DOI: 10.3389/fnins.2018.00789

Restoration of visual function by transplantation of optogenetically engineered photoreceptors

Author(s): Marcela Garita-Hernandez, Maruša Lampič, Antoine Chaffiol, Laure Guibbal, Fiona Routet, Tiago Santos-Ferreira, Sylvia Gasparini, Oliver Borsch, Giuliana Gagliardi, Sacha Reichman, Serge Picaud, José-Alain Sahel, Olivier Goureau, Marius Ader, Deniz Dalkara, Jens Duebel
Published in: Nature Communications, Issue 10/1, 2019, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-019-12330-2

AAV-Mediated Gene Delivery to 3D Retinal Organoids Derived from Human Induced Pluripotent Stem Cells

Author(s): Marcela Garita-Hernandez, Fiona Routet, Laure Guibbal, Hanen Khabou, Lyes Toualbi, Luisa Riancho, Sacha Reichman, Jens Duebel, Jose-Alain Sahel, Olivier Goureau, Deniz Dalkara
Published in: International Journal of Molecular Sciences, Issue 21/3, 2020, Page(s) 994, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21030994

Vectors and Gene Delivery to the Retina

Author(s): Arthur Planul, Deniz Dalkara
Published in: Annual Review of Vision Science, Issue 3/1, 2017, Page(s) 121-140, ISSN 2374-4642
Publisher: J. Anthony Movshon
DOI: 10.1146/annurev-vision-102016-061413

Intellectual Property Rights

OPTOGENETICALLY TRANSFORMED PHOTORECEPTOR PRECURSOR CELLS FOR THE USE IN THE TREATMENT OF RETINAL DEGENERATIVE DISEASES

Application/Publication number: 20 17074125
Date: 2017-09-22
Applicant(s): UNIVERSITE PIERRE ET MARIE CURIE - PARIS 6

METHODS OF EXPRESSING A POLYNUCLEOTIDE OF INTEREST IN THE CONE PHOTORECEPTORS

Application/Publication number: 20 18050925
Date: 2018-01-16

METHODS OF EXPRESSING A POLYNUCLEOTIDE OF INTEREST IN THE CONE PHOTORECEPTORS OF A SUBJECT COMPRISING THE SUBRETINAL DELIVERY OF A THERAPEUTICALLY EFFECTIVE AMOUNT OF A RECOMBINANT AAV9-DERIVED VECTOR

Application/Publication number: 20 18078856
Date: 2018-10-22

OPTOGENETICALLY TRANSFORMED PHOTORECEPTOR PRECURSOR CELLS FOR THE USE IN THE TREATMENT OF RETINAL DEGENERATIVE DISEASES

Application/Publication number: 20 17074125
Date: 2017-09-22
Applicant(s): UNIVERSITE PIERRE ET MARIE CURIE - PARIS 6

METHODS OF EXPRESSING A POLYNUCLEOTIDE OF INTEREST IN THE CONE PHOTORECEPTORS

Application/Publication number: 20 18050925
Date: 2018-01-16
Applicant(s): UNIVERSITE PIERRE ET MARIE CURIE - PARIS 6

OPTOGENETIC VISUAL RESTORATION USING CHRIMSON

Application/Publication number: 17 734136
Date: 2017-04-28
Applicant(s): INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

METHODS OF EXPRESSING A POLYNUCLEOTIDE OF INTEREST IN THE CONE PHOTORECEPTORS OF A SUBJECT COMPRISING THE SUBRETINAL DELIVERY OF A THERAPEUTICALLY EFFECTIVE AMOUNT OF A RECOMBINANT AAV9-DERIVED VECTOR

Application/Publication number: 20 18078856
Date: 2018-10-22

OPTOGENETIC VISUAL RESTORATION USING CHRIMSON

Application/Publication number: 17 734136
Date: 2017-04-28

METHODS OF EXPRESSING A POLYNUCLEOTIDE OF INTEREST IN THE CONE PHOTORECEPTORS

Application/Publication number: 20 18050925
Date: 2018-01-16
Applicant(s): INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

PROMOTERS AND USES THEREOF

Application/Publication number: 20 16079755
Date: 2016-12-05
Applicant(s): UNIVERSITE PIERRE ET MARIE CURIE - PARIS 6

PROMOTERS AND USES THEREOF

Application/Publication number: 20 16079755
Date: 2016-12-05
Applicant(s): UNIVERSITE PIERRE ET MARIE CURIE - PARIS 6

METHODS OF EXPRESSING A POLYNUCLEOTIDE OF INTEREST IN THE CONE PHOTORECEPTORS OF A SUBJECT COMPRISING THE SUBRETINAL DELIVERY OF A THERAPEUTICALLY EFFECTIVE AMOUNT OF A RECOMBINANT AAV9-DERIVED VECTOR

Application/Publication number: 20 18078856
Date: 2018-10-22

OPTOGENETIC VISUAL RESTORATION USING CHRIMSON

Application/Publication number: 17 734136
Date: 2017-04-28

OPTOGENETIC VISUAL RESTORATION USING CHRIMSON

Application/Publication number: 17 734136
Date: 2017-04-28

METHODS OF EXPRESSING A POLYNUCLEOTIDE OF INTEREST IN THE CONE PHOTORECEPTORS

Application/Publication number: 20 18050925
Date: 2018-01-16
Applicant(s): UNIVERSITE PIERRE ET MARIE CURIE - PARIS 6

METHODS OF EXPRESSING A POLYNUCLEOTIDE OF INTEREST IN THE CONE PHOTORECEPTORS OF A SUBJECT COMPRISING THE SUBRETINAL DELIVERY OF A THERAPEUTICALLY EFFECTIVE AMOUNT OF A RECOMBINANT AAV9-DERIVED VECTOR

Application/Publication number: 20 18078856
Date: 2018-10-22
Applicant(s): INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

PROMOTERS AND USES THEREOF

Application/Publication number: 20 16079755
Date: 2016-12-05

PROMOTERS AND USES THEREOF

Application/Publication number: 20 16079755
Date: 2016-12-05
Applicant(s): INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

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