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Peptide-Drug Conjugates for Targeted Delivery in Tumor Therapy

Objective

Many tumor cells are characterized by the overexpression of certain antigens. Molecules that specifically recognize these structures are suitable as homing devices in tumor therapy. Conjugates of anticancer drugs with such a delivery vector targeting tumors would be a “magic bullet” according to the Nobel laureate Paul Ehrlich. Three antibody-drug conjugates (ADC) have already been approved for anticancer therapy. However, ADC have e.g. limitations with respect to tumor penetration, high manufacturing costs, and require challenging conjugation chemistry. Peptide-drug conjugates can have a high drug loading, easily penetrate tissue, and can be easily prepared in a homogenous form with straightforward and well-defined conjugation chemistry.
The ETN MAGICBULLET will focus on chemistry-driven approaches toward conjugates between peptides (delivery vectors) that recognize tumors and anticancer drugs (payloads or warheads) in order to selectively fight cancer, a topic with a high demand of research activities. The ETN will develop and validate an array of new peptide-drug conjugates combining either known tumor-specific peptides or newly discovered tumor-homing peptides with potent cytotoxic drugs. The tumor-selective peptides are designed for cellular uptake mediated either by endocytosis or by cell-penetrating peptides. The consortium of the ETN MAGICBULLET covers tumor biology, biochemistry, pharmacology, synthetic chemistry, medicinal chemistry, spectroscopy, conformational analysis, and computational chemistry.
The training program focuses on multidisciplinary research to explore and validate molecular targets for innovative treatment or investigations on the molecular mechanisms in organ-specific metastatic growth processes. It aims at scientific multilingualism and relies e.g. on concerted learning, a combination of introductory training, hands-on learning “on the bench”, teaching by peers, and training in additional skills.

Field of science

  • /medical and health sciences/basic medicine/medicinal chemistry

Call for proposal

H2020-MSCA-ITN-2014
See other projects for this call

Funding Scheme

MSCA-ITN-ETN - European Training Networks

Coordinator

UNIVERSITAET BIELEFELD
Address
Universitaetsstrasse 25
33615 Bielefeld
Germany
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 498 432,96

Participants (8)

UNIVERSITA DEGLI STUDI DELL'INSUBRIA
Italy
EU contribution
€ 516 122,64
Address
Via Ravasi 2
21100 Varese
Activity type
Higher or Secondary Education Establishments
EOTVOS LORAND TUDOMANYEGYETEM
Hungary
EU contribution
€ 447 827,04
Address
Egyetem Ter 1-3
1053 Budapest
Activity type
Higher or Secondary Education Establishments
HELSINGIN YLIOPISTO
Finland
EU contribution
€ 538 290,72
Address
Yliopistonkatu 3
00014 Helsingin Yliopisto
Activity type
Higher or Secondary Education Establishments
UNIVERSITA DEGLI STUDI DI MILANO
Italy
EU contribution
€ 516 122,64
Address
Via Festa Del Perdono 7
20122 Milano
Activity type
Higher or Secondary Education Establishments
UNIVERSITAET ZU KOELN
Germany
EU contribution
€ 249 216,48
Address
Albertus Magnus Platz
50931 Koeln
Activity type
Higher or Secondary Education Establishments
Orszagos Onkologiai Intezet
Hungary
EU contribution
€ 223 913,52
Address
Rath Gyorgy Utca 7-9.
1122 Budapest
Activity type
Research Organisations
HEIDELBERG PHARMA RESEARCH GMBH
Germany
EU contribution
€ 498 432,96
Address
Schriesheimer Strasse 101
68526 Ladenburg
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
EXIRIS SRL
Italy
EU contribution
€ 258 061,32
Address
Via Savona Int 2 B 6
00182 Roma
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)

Partners (5)

Bayer Pharma AG
Germany
Address
Muellerstrasse 178
13353 Berlin
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
FRIEDRICH-ALEXANDER-UNIVERSITAET ERLANGEN-NUERNBERG
Germany
Address
Schlossplatz 4
91054 Erlangen
Activity type
Higher or Secondary Education Establishments
Kineto Lab Ltd.
Hungary
Address
Zápor U. 55.
H-1032 Budapest
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.
Germany
Address
Hansastrasse 27C
80686 Munchen
Activity type
Research Organisations
IRBM SCIENCE PARK SPA
Italy
Address
Via Pontina Km 30600
00040 Pomezia Rm
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)