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Targeting Cartilage Regeneration in joint and intervertebral disc diseases

Objetivo

Mobility, important for well-being, is seriously impaired by chronic low back pain and osteoarthritis in many people due to degeneration of cartilaginous tissue of the intervertebral disc and joint. To develop a treatment for these diseases this ETN aims to combine expertise in novel highly advanced drug delivery carriers with dedicated targeting tools, state of the art imaging techniques and expertise in stem cell and joint biology by training 15 young scientists in 12 partner institutes located in 5 different countries.
We aim to achieve regeneration of damaged and degenerated tissues by employing targeting strategies tailored both to the pathology and the tissues involved. Regeneration of diseased tissues will be achieved by loading biologically active agents in state-of-the-art nanocarriers. The biologically active agents will stimulate the body’s own capacity to regenerate by attracting local stem cells or inhibit degeneration. Targeting will be achieved by A] injection with synthetic or natural hydrogels loaded with the nanocarriers or B] coupling diseased tissue-specific antibodies and specific hyaluronic acid moieties to the nanocarriers. Delivery and retention will be monitored by advanced in vivo and molecular imaging techniques to monitor distribution of the delivered compounds at the tissue level, as well as detect biological markers of regeneration.

Major objectives:
1] To establish a network of scientists skilled in the use of smart nanocarriers, unique approach of targeting by disease-specific molecules and application of innovative imaging tools. Supported by generic scientific and training in economical and clinical valorisation, these researchers can further implement these technologies in the musculoskeletal or other areas, both in academia and industry.
2] To develop strategies exclusively targeting diseased tissues with controlled doses of bio-actives, circumventing the disadvantages of the current shotgun approaches in regenerative medicine.

Convocatoria de propuestas

H2020-MSCA-ITN-2014
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Coordinador

ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Dirección
Dr Molewaterplein 40
3015 GD Rotterdam
Países Bajos
Tipo de actividad
Higher or Secondary Education Establishments
Aportación de la UE
€ 510 748,56

Participantes (10)

IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
United Kingdom
Aportación de la UE
€ 546 575,76
Dirección
South Kensington Campus Exhibition Road
SW7 2AZ London
Tipo de actividad
Higher or Secondary Education Establishments
PERCUROS BV
Países Bajos
Aportación de la UE
€ 255 374,28
Dirección
Eerbeeklaan 42
2573 HT 'S-gravenhage
Tipo de actividad
Private for-profit entities (excluding Higher or Secondary Education Establishments)
THE UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEEN
United Kingdom
Aportación de la UE
€ 273 287,88
Dirección
King's College Regent Walk
AB24 3FX Aberdeen
Tipo de actividad
Higher or Secondary Education Establishments
TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY
Israel
Aportación de la UE
€ 520 601,04
Dirección
Senate Building Technion City
32000 Haifa
Tipo de actividad
Higher or Secondary Education Establishments
CARDIFF UNIVERSITY
United Kingdom
Aportación de la UE
€ 273 287,88
Dirección
Newport Road 30-36
CF24 ODE Cardiff
Tipo de actividad
Higher or Secondary Education Establishments
UNIVERSITAIR MEDISCH CENTRUM UTRECHT
Países Bajos
Aportación de la UE
€ 255 374,28
Dirección
Heidelberglaan 100
3584 CX Utrecht
Tipo de actividad
Higher or Secondary Education Establishments
AO-FORSCHUNGSINSTITUT DAVOS
Suiza
Aportación de la UE
€ 530 453,52
Dirección
Clavadelerstrasse 8
7270 Davos Platz
Tipo de actividad
Research Organisations
AARHUS UNIVERSITET
Dinamarca
Aportación de la UE
€ 290 081,88
Dirección
Nordre Ringgade 1
8000 Aarhus C
Tipo de actividad
Higher or Secondary Education Establishments
PROCORE LTD
Israel
Aportación de la UE
€ 260 300,52
Dirección
Golda Meir 7 Weizmann Science Park 7
70400 Nes Ziona
Tipo de actividad
Private for-profit entities (excluding Higher or Secondary Education Establishments)
UNIVERSITEIT MAASTRICHT
Países Bajos
Aportación de la UE
€ 255 374,28
Dirección
Minderbroedersberg 4
6200 MD Maastricht
Tipo de actividad
Higher or Secondary Education Establishments

Socios (2)

Omics2Image
Países Bajos
Dirección
Science Park 105
1098 XG Amsterdam
Tipo de actividad
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Stichting ReumaNederland
Países Bajos
Dirección
Dr J Van Breemenstraat 4
1056 AB Amsterdam
Tipo de actividad
Other