Deliverables
Analysis of proteomic and post-translational data sets and development of cellular systems models including secretion and glycosylation.
Determination of the role of long non-coding RNA in CHO and application to models.
Manipulation of key target genes to generate new CHO chassis validated under industrial conditions
Final Report delivered to EC
Large omics datasets published and available to the scientific community
Establishment of CHO cell lines with enhanced translational and protein synthesis capacity
At least 2 peer reviewed publications from each ESR
Meeting with fellows, members of consortium and REA representative to assess the work progress and achievements
Determination of gene copy number variation/mutations and models describing transcriptional regulation and control.
All NTA courses held at each hosting university partner
Supervisory Board committee members selected
Searching for OpenAIRE data...
Publications
Author(s): Sara Pereira, Helene Faustrup Kildegaard, Mikael Rørdam Andersen
Published in: Biotechnology Journal, 13/3, 2018, Page(s) 1700499, ISSN 1860-6768
Publisher: Wiley - VCH Verlag GmbH & CO. KGaA
DOI: 10.1002/biot.201700499
Author(s): Thomas Amann, Anders Holmgaard Hansen, Stefan Kol, Gyun Min Lee, Mikael Rørdam Andersen, Helene Faustrup Kildegaard
Published in: Biotechnology Journal, 2018, Page(s) 1800111, ISSN 1860-6768
Publisher: Wiley - VCH Verlag GmbH & CO. KGaA
DOI: 10.1002/biot.201800111
Author(s): Nuša Pristovšek, Henning Gram Hansen, Daria Sergeeva, Nicole Borth, Gyun Min Lee, Mikael Rørdam Andersen, Helene Faustrup Kildegaard
Published in: Biotechnology Journal, 13/3, 2018, Page(s) 1700216, ISSN 1860-6768
Publisher: Wiley - VCH Verlag GmbH & CO. KGaA
DOI: 10.1002/biot.201700216
Author(s): Ankita Singh, Helene F. Kildegaard, Mikael R. Andersen
Published in: Biotechnology Journal, 2018, Page(s) 1800070, ISSN 1860-6768
Publisher: Wiley - VCH Verlag GmbH & CO. KGaA
DOI: 10.1002/biot.201800070
Author(s): Nicolas Marx, Clemens Grünwald-Gruber, Nina Bydlinski, Heena Dhiman, Ly Ngoc Nguyen, Gerald Klanert, Nicole Borth
Published in: Biotechnology Journal, 2018, Page(s) 1700217, ISSN 1860-6768
Publisher: Wiley - VCH Verlag GmbH & CO. KGaA
DOI: 10.1002/biot.201700217
Author(s): Valerie Schmieder, Nina Bydlinski, Richard Strasser, Martina Baumann, Helene Faustrup Kildegaard, Vaibhav Jadhav, Nicole Borth
Published in: Biotechnology Journal, 13/3, 2018, Page(s) 1700211, ISSN 1860-6768
Publisher: Wiley - VCH Verlag GmbH & CO. KGaA
DOI: 10.1002/biot.201700211
Author(s): Oliver Rupp, Madolyn L. MacDonald, Shangzhong Li, Heena Dhiman, Shawn Polson, Sven Griep, Kelley Heffner, Inmaculada Hernandez, Karina Brinkrolf, Vaibhav Jadhav, Mojtaba Samoudi, Haiping Hao, Brewster Kingham, Alexander Goesmann, Michael J. Betenbaugh, Nathan E. Lewis, Nicole Borth, Kelvin H. Lee
Published in: Biotechnology and Bioengineering, 2018, ISSN 0006-3592
Publisher: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/bit.26722
Author(s): Davide Vito, Christopher Mark Smales
Published in: Biotechnology Journal, 2018, Page(s) 1800122, ISSN 1860-6768
Publisher: Wiley - VCH Verlag GmbH & CO. KGaA
DOI: 10.1002/biot.201800122
Author(s): Ricardo Valdés-Bango Curell, Niall Barron
Published in: Biotechnology Journal, 2018, Page(s) 1700220, ISSN 1860-6768
Publisher: Wiley - VCH Verlag GmbH & CO. KGaA
DOI: 10.1002/biot.201700220
Author(s): Linas Tamošaitis, Christopher Mark Smales
Published in: Biotechnology Journal, 2018, Page(s) 1800066, ISSN 1860-6768
Publisher: Wiley - VCH Verlag GmbH & CO. KGaA
DOI: 10.1002/biot.201800066
Author(s): Thomas Amann, Anders Holmgaard Hansen, Stefan Kol, Henning Gram Hansen, Johnny Arnsdorf, Saranya Nallapareddy, Bjørn Voldborg, Gyun Min Lee, Mikael Rørdam Andersen, Helene Faustrup Kildegaard
Published in: Metabolic Engineering, 52, 2019, Page(s) 143-152, ISSN 1096-7176
Publisher: Academic Press
DOI: 10.1016/j.ymben.2018.11.014
Author(s): Davide Vito, C Mark Smales
Published in: Current Opinion in Chemical Engineering, 22, 2018, Page(s) 199-208, ISSN 2211-3398
Publisher: Elsevier BV
DOI: 10.1016/j.coche.2018.11.002
Author(s): Cyrielle Calmels, Andréa McCann, Laetitia Malphettes, Mikael Rørdam Andersen
Published in: Metabolic Engineering, 51, 2019, Page(s) 9-19, ISSN 1096-7176
Publisher: Academic Press
DOI: 10.1016/j.ymben.2018.09.009
Author(s): Prashant Kaushik, Michael Henry, Martin Clynes, Paula Meleady
Published in: Biotechnology Journal, 13/10, 2018, Page(s) 1700221, ISSN 1860-6768
Publisher: Wiley - VCH Verlag GmbH & CO. KGaA
DOI: 10.1002/biot.201700221
Author(s): Michael Henry, Martin Power, Prashant Kaushik, Orla Coleman, Martin Clynes, Paula Meleady
Published in: Journal of Proteome Research, 16/7, 2017, Page(s) 2339-2358, ISSN 1535-3893
Publisher: American Chemical Society
DOI: 10.1021/acs.jproteome.6b00868
Author(s): Inmaculada Hernandez, Heena Dhiman, Gerald Klanert, Vaibhav Jadhav, Norbert Auer, Michael Hanscho, Martina Baumann, Anna Esteve-Codina, Marc Dabad, Jessica Gómez, Tyler Alioto, Angelika Merkel, Emanuele Raineri, Simon Heath, Daniel Rico, Nicole Borth
Published in: Biotechnology and Bioengineering, 116/3, 2019, Page(s) 677-692, ISSN 0006-3592
Publisher: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/bit.26891
Author(s): Amandine Bastide, Diego Peretti, John R.P. Knight, Stefano Grosso, Ruth V. Spriggs, Xavier Pichon, Thomas Sbarrato, Anne Roobol, Jo Roobol, Davide Vito, Martin Bushell, Tobias von der Haar, C. Mark Smales, Giovanna R. Mallucci, Anne E. Willis
Published in: Current Biology, 2017, ISSN 0960-9822
Publisher: Cell Press
DOI: 10.1016/j.cub.2017.01.047
Author(s): Henning Gram Hansen, Nuša Pristovšek, Helene Faustrup Kildegaard, Gyun Min Lee
Published in: Biotechnology Advances, 35/1, 2017, Page(s) 64-76, ISSN 0734-9750
Publisher: Elsevier BV
DOI: 10.1016/j.biotechadv.2016.11.008
Author(s): Paul S. Kelly, Colin Clarke, Alan Costello, Craig Monger, Justine Meiller, Heena Dhiman, Nicole Borth, Michael J. Betenbaugh, Martin Clynes, Niall Barron
Published in: Metabolic Engineering, 2017, ISSN 1096-7176
Publisher: Academic Press
DOI: 10.1016/j.ymben.2017.02.001
Author(s): Heena Dhiman, Matthias P. Gerstl, David Ruckerbauer, Michael Hanscho, Heinz Himmelbauer, Colin Clarke, Niall Barron, Jürgen Zanghellini, Nicole Borth
Published in: Biotechnology Journal, 2019, Page(s) 1800681, ISSN 1860-6768
Publisher: Wiley - VCH Verlag GmbH & CO. KGaA
DOI: 10.1002/biot.201800681
Author(s): Nuša Pristovšek, Saranya Nallapareddy, Lise Marie Grav, Hooman Hefzi, Nathan E. Lewis, Peter Rugbjerg, Henning Gram Hansen, Gyun Min Lee, Mikael Rørdam Andersen, Helene Faustrup Kildegaard
Published in: ACS Synthetic Biology, 8/4, 2019, Page(s) 758-774, ISSN 2161-5063
Publisher: American Chemical Society
DOI: 10.1021/acssynbio.8b00453
Author(s): Craig Monger, Krishna Motheramgari, John McSharry, Niall Barron, Colin Clarke
Published in: Heterologous Protein Production in CHO Cells, 1603, 2017, Page(s) 169-186, ISBN 978-1-4939-6971-5
Publisher: Springer New York
DOI: 10.1007/978-1-4939-6972-2_11
Author(s): Michael Henry, Orla Coleman, Prashant, Martin Clynes, Paula Meleady
Published in: Heterologous Protein Production in CHO Cells, 1603, 2017, Page(s) 195-208, ISBN 978-1-4939-6971-5
Publisher: Springer New York
DOI: 10.1007/978-1-4939-6972-2_13