Objective
Chinese hamster (CHO) ovary cells are the production host for a +50 billion €/yr biopharmaceuticals market. Current CHO production platforms dates to 1980 and are based primarily on media and process optimisation with little consideration to the optimization of the cellular machinery. Fortunately, with the recent sequencing of the CHO genome, an opportunity has opened to significantly advance the CHO platform. The benefit will be advanced production flexibility and a lower production cost.
This ITN graduate training programme - eCHO Systems - will blend conventional molecular, cellular, and synthetic biology with genome scale systems biology training in ‘omics data acquisition, biological network modeling, and genome engineering in three interdisciplinary topics:
1) Acquisition of large scale ‘omics data sets and their incorporation into genome-scale mathematical models
2) Development of genome engineering tools, enabling synthetic biology
3) Application of systems and synthetic biology and genome engineering to improve performance of CHO producers
The training projects are supported by 15 industrial participants, which will participate in the research and test the results. ESR training will include intense courses focused on computational systems biology, cell biology, business and entrepreneurship. The three universities bring unique complementary skills in systems and synthetic biology, ‘omics technologies, cytometry, and molecular cell biology which will provide depth and breadth to this training. The eCHO Systems will produce four major outputs: General knowledge to improve the productivity, quality, and efficiency of CHO platform cell lines, new systems models for CHO cells, new CHO cell line chassises generated through synthetic biology approaches, high quality education at the graduate level, and a cadre of interdisciplinary graduates poised to transform biopharmaceutical biotechnology.
Fields of science
- natural sciencesbiological sciencesgenetics and hereditygenome
- social scienceseconomics and businesseconomicsproduction economicsproductivity
- natural sciencesbiological sciencessynthetic biology
- natural sciencesbiological sciencescell biology
- natural sciencesmathematicsapplied mathematicsmathematical model
- social scienceseconomics and businessbusiness and managemententrepreneurship
Programme(s)
Call for proposal
H2020-MSCA-ITN-2014
See other projects for this call
Funding Scheme
MSCA-ITN-ETN - European Training NetworksCoordinator
2800 Kgs Lyngby
Denmark
Participants (5)
CT2 7NZ Canterbury, Kent
9 Dublin
8010 Graz
Participation ended
88471 Laupheim
1070 Bruxelles
Partners (11)
1180 Wien
3071 Boheimkirchen
55218 Ingelheim
1110 Wien
TS23 1LH Billingham
2800 Lyngby
2860 Soborg
2970 Hoersholm
RG21 4FA Basingstoke
50411 Tartu
2300AG Leiden