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Enhancing CHO by Mammalian Systems Biotechnology (eCHO systems)

Objective

Chinese hamster (CHO) ovary cells are the production host for a +50 billion €/yr biopharmaceuticals market. Current CHO production platforms dates to 1980 and are based primarily on media and process optimisation with little consideration to the optimization of the cellular machinery. Fortunately, with the recent sequencing of the CHO genome, an opportunity has opened to significantly advance the CHO platform. The benefit will be advanced production flexibility and a lower production cost.

This ITN graduate training programme - eCHO Systems - will blend conventional molecular, cellular, and synthetic biology with genome scale systems biology training in ‘omics data acquisition, biological network modeling, and genome engineering in three interdisciplinary topics:

1) Acquisition of large scale ‘omics data sets and their incorporation into genome-scale mathematical models
2) Development of genome engineering tools, enabling synthetic biology
3) Application of systems and synthetic biology and genome engineering to improve performance of CHO producers

The training projects are supported by 15 industrial participants, which will participate in the research and test the results. ESR training will include intense courses focused on computational systems biology, cell biology, business and entrepreneurship. The three universities bring unique complementary skills in systems and synthetic biology, ‘omics technologies, cytometry, and molecular cell biology which will provide depth and breadth to this training. The eCHO Systems will produce four major outputs: General knowledge to improve the productivity, quality, and efficiency of CHO platform cell lines, new systems models for CHO cells, new CHO cell line chassises generated through synthetic biology approaches, high quality education at the graduate level, and a cadre of interdisciplinary graduates poised to transform biopharmaceutical biotechnology.

Field of science

  • /natural sciences/biological sciences/cell biology
  • /social sciences/economics and business/business and management/commerce
  • /natural sciences/mathematics/applied mathematics/mathematical model
  • /natural sciences/biological sciences/synthetic biology
  • /social sciences/economics and business
  • /social sciences/economics and business/business and management/entrepreneurship
  • /natural sciences/biological sciences/genetics and heredity/genome
  • /social sciences/economics and business/economics/production economics/productivity

Call for proposal

H2020-MSCA-ITN-2014
See other projects for this call

Funding Scheme

MSCA-ITN-ETN - European Training Networks

Coordinator

DANMARKS TEKNISKE UNIVERSITET
Address
Anker Engelundsvej 1 Bygning 101 A
2800 Kgs Lyngby
Denmark
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 160 327,52

Participants (5)

UNIVERSITY OF KENT
United Kingdom
EU contribution
€ 819 863,64
Address
The Registry Canterbury
CT2 7NZ Canterbury, Kent
Activity type
Higher or Secondary Education Establishments
DUBLIN CITY UNIVERSITY
Ireland
EU contribution
€ 797 023,80
Address
Glasnevin
9 Dublin
Activity type
Higher or Secondary Education Establishments
ACIB GMBH
Austria
EU contribution
€ 1 017 018,72
Address
Krenngasse 37/2
8010 Graz
Activity type
Research Organisations
RENTSCHLER BIOTECHNOLOGIE GMBH

Participation ended

Germany
EU contribution
€ 0
Address
Erwin Rentschler Strasse 21
88471 Laupheim
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
UCB PHARMA SA
Belgium
EU contribution
€ 250 560
Address
Allee De La Recherche 60
1070 Bruxelles
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)

Partners (11)

UNIVERSITAET FUER BODENKULTUR WIEN
Austria
Address
Gregor Mendel Strasse 33
1180 Wien
Activity type
Higher or Secondary Education Establishments
Chorus GmbH
Austria
Address
Untergrafendorf 17
3071 Boheimkirchen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
BOEHRINGER INGELHEIM PHARMA GMBH &CO KG
Germany
Address
Binger Strasse 173
55218 Ingelheim
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
EVERCYTE GMBH
Austria
Address
Muthgasse 18
1190 Wien
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
FUJIFILM DIOSYNTH BIOTECHNOLOGIES UK LIMITED
United Kingdom
Address
Belasis Avenue
TS23 1LH Billingham
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Symphogen A/S
Denmark
Address
Elektrovej Byg. 375
2800 Lyngby
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
CMC BIOLOGICS AS
Denmark
Address
Vandtaarnsvej 83 B
2860 Soborg
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
BIONEER A/S
Denmark
Address
Kogle Alle 2
2970 Hoersholm
Activity type
Research Organisations
Eli Lilly and Company Limited
United Kingdom
Address
Lilly House, Priestley Road
RG24 9NL Basingstoke
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
ICOSAGEN AS
Estonia
Address
Nooruse 9
50411 Tartu
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Janssen Biologics
Netherlands
Address
Einsteinweg 101
2300AG Leiden
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)