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The Extracellular Matrix in Epileptogenesis

Deliverables

New data on the mechanisms of epileptogenesis-2

Paper on the role of ECM molecules/ECM-associated glycans in epileptogenesis

New data on the mechanisms of epileptogenesis

Paper on phenotype of alfaV integrin deficient mice

Advanced training course 2

In vivo assessment of plasticity during epileptogenesis

Advanced training course 3

Monitoring epilepsy in humans and animals

Advanced training course 4

Topic to be defined by ESRs

Advanced Training course 1

The perisynaptic ECM implications for neural development and synaptic plasticity

Publications

Constitutive Inactivation of the PRRT2 Gene Alters Short-Term Synaptic Plasticity and Promotes Network Hyperexcitability in Hippocampal Neurons

Author(s): Pierluigi Valente, Alessandra Romei, Manuela Fadda, Bruno Sterlini, Davide Lonardoni, Nicola Forte, Floriana Fruscione, Enrico Castroflorio, Caterina Michetti, Giorgia Giansante, Flavia Valtorta, Jin-Wu Tsai, Federico Zara, Thierry Nieus, Anna Corradi, Anna Fassio, Pietro Baldelli, Fabio Benfenati
Published in: Cerebral Cortex, 2018, ISSN 1047-3211
Publisher: Oxford University Press
DOI: 10.1093/cercor/bhy079

Systematic review and meta-analysis of differentially expressed miRNAs in experimental and human temporal lobe epilepsy

Author(s): A. Korotkov, J. D. Mills, J. A. Gorter, E. A. van Vliet, E. Aronica
Published in: Scientific Reports, Issue 7/1, 2017, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-017-11510-8

Sushi repeat-containing protein X-linked 2: A novel phylogenetically conserved hypothalamo-pituitary protein

Author(s): Mehwish Anwer, Tamuna Bolkvadze, Xavier Ekolle Ndode-Ekane, Noora Puhakka, Tuomas Rauramaa, Ville Leinonen, Erwin A. van Vliet, Dick F. Swaab, Annakaisa Haapasalo, Stina Leskelä, Nea Bister, Tarja Malm, Synnöve Carlson, Eleonora Aronica, Asla Pitkänen
Published in: Journal of Comparative Neurology, Issue 526/11, 2018, Page(s) 1806-1819, ISSN 0021-9967
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/cne.24449

PRRT2 controls neuronal excitability by negatively modulating Na+ channel 1.2/1.6 activity

Author(s): Floriana Fruscione, Pierluigi Valente, Bruno Sterlini, Alessandra Romei, Simona Baldassari, Manuela Fadda, Cosimo Prestigio, Giorgia Giansante, Jacopo Sartorelli, Pia Rossi, Alicia Rubio, Antonio Gambardella, Thierry Nieus, Vania Broccoli, Anna Fassio, Pietro Baldelli, Anna Corradi, Federico Zara, Fabio Benfenati
Published in: Brain, Issue 141/4, 2018, Page(s) 1000-1016, ISSN 0006-8950
Publisher: Oxford University Press
DOI: 10.1093/brain/awy051

Increased expression of matrix metalloproteinase 3 can be attenuated by inhibition of microRNA-155 in cultured human astrocytes

Author(s): Anatoly Korotkov, Diede W. M. Broekaart, Jackelien van Scheppingen, Jasper J. Anink, Johannes C. Baayen, Sander Idema, Jan A. Gorter, Eleonora Aronica, Erwin A. van Vliet
Published in: Journal of Neuroinflammation, Issue 15/1, 2018, ISSN 1742-2094
Publisher: BioMed Central
DOI: 10.1186/s12974-018-1245-y

Heparin/heparan sulfates bind to and modulate neuronal L-type (Cav1.2) voltage-dependent Ca2+ channels

Author(s): Gianpiero Garau, Paola Magotti, Martin Heine, Svetlana Korotchenko, Patricia Marie-Jeanne Lievens, Vladimir Berezin, Alexander Dityatev
Published in: Experimental Neurology, Issue 274, 2015, Page(s) 156-165, ISSN 0014-4886
Publisher: Academic Press
DOI: 10.1016/j.expneurol.2015.08.006

Foamy Virus Vectors Transduce Visceral Organs and Hippocampal Structures following In Vivo Delivery to Neonatal Mice

Author(s): John R. Counsell, Rajvinder Karda, Juan Antinao Diaz, Louise Carey, Tatiana Wiktorowicz, Suzanne M.K. Buckley, Shima Ameri, Joanne Ng, Julien Baruteau, Filipa Almeida, Rohan de Silva, Roberto Simone, Eleonora Lugarà, Gabriele Lignani, Dirk Lindemann, Axel Rethwilm, Ahad A. Rahim, Simon N. Waddington, Steven J. Howe
Published in: Molecular Therapy - Nucleic Acids, Issue 12, 2018, Page(s) 626-634, ISSN 2162-2531
Publisher: Nature Publishing Group
DOI: 10.1016/j.omtn.2018.07.006

Workshop on neurobiology of epilepsy appraisal: Imaging biomarkers in epilepsy

Author(s): van Vliet, Erwin A; Potschka, Heidrun; Koepp, Matthias J; Immonen, Riikka; Federico, Paolo; Friedman, Alon; Pitkänen, Asla; Cole, Andrew J.; Dedeurwaerdere, Stefanie
Published in: Epilepsia, Issue 1, 2016, ISSN 1528-1167
Publisher: International League Against Epilepsy (ILAE)
DOI: 10.1111/epi.13621

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