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MEDICIS-produced radioisotope beams for medicine

Deliverables

Open training event (summer school)

Open training events (summer schools) in months 25 & 37 with the possibility of additional schools if deemed necessary.

Enrolment in PhD program

Enrolment of the ESRs in PhD programs

Public lecture

Public lecture on advancements in the field of radioisotopes and medical treatment.

Design of new containers for theranostic isotope pairs transportation

New shielded packaging container for nuclear medicine isotopes Objective: To obtain a new technology type B certified shipping container. Expected Results: The typical isotopes (149,152,155,161Tb, 177Lu, 47,48,49Sc, etc) and activities for shipment will first be defined. The European shipping regulations will then be studied in details. First dimensioning of the required shielding, mechanical resistance with be done by Monte-Carlo simulations and by Finite Element Model Mechanical codes. A first prototype will be constructed and checked for effective shielding capacity, leak tightness, shock resistance, etc. A second packaging will be constructed, learning from the prototype, and documentation will be filed to obtain its homologation. Specific innovations, such as direct transfer of the collected isotopes from the separator into the packaging are foreseen.

Summary of charge breeding investigations for a future 11C treatment facility

CO molecule fast gas injection and C-->C6+ and C-->C1+ -->Cn+ charge breeding investigations Objective: For different types of treatment ions explore the possibilities and limitations of the charge breeding stage linking the radioactive beam production and post-accelerator Expected Results: A. Ion throughput capability of the charge breeding system as is for different type of treatment ions and the means of increasing it., by e.g. implementing alternative cooling methods in the Penning trap or using continuous mode injection into the Electron-Beam Ion-Source (EBIS). B. In collaboration with ESR1 address the beam purity by 11C16O breakup efficiency inside the Penning trap and EBIS, and stable beam contamination. C. Establish the operational conditions such as injection repetition rate, extracted pulse length and mass-to-charge ratio.. D. Literature study on Electron Cyclotron Resonance Ion Source (ECRIS) alternative charge breeding in collaboration with MEDAUSTRON.

Personnalized 11C PET aided hadron therapy

Personalized 11Carbon PET aided hadron therapy Objective: to adapt the treatment plan according to PET response halfway through the course of hadron therapy, to investigate hypoxia tracers, fluorinated aminoacides or DNA synthesis markers and to validate PET for early response assessment. Expected Results: select most suitable PET tracers for adaptive hadron therapy and early response evaluation. New tracers will be investigated including hypoxia tracer (a non exhaustive list is: 18F-MISO, 18F-FAZA, 62Cu-ATSM) other fluorinated aminoacids (18F-FET, 18F-FACBC, etc.) or DNA synthesis markers (18- fluorothymidine). The tools developed for FLUKA will be verified at CNAO in a clinical scenario. Comparisons with the standard 12C treatment plans will be studied in terms of dose, biological effect and ß+-emitters distributions

Investigation of imaging probes for ovarian cancer in animal models

Technical leader: partner organization UNIGE (CH) Investigation of bimodal imaging probes for ovarian cancer in animal models Objective: Develop and validate preclinical imaging techniques for assessment of bio-distribution and performance of new tracers in animal models for prediction of therapeutic efficacy of new radio-labelled compounds at Institute of Translational Molecular Imaging (ITMI) Expected Results: Development of methodology and validation of preclinical techniques. The ESR will be responsible of seeking new methodological techniques and experimental protocols that are suitable for the new compounds that are being evaluated. It will also include the development and validation of biological models that allow quantitative assessment of the efficacy and performance of the tracers as well as their potential efficacy of treatment of the given tumours.

Cyclotron production and mass-separation of 47/48/49Sc

Large scale production of a beta-/gamma emitter radioisotope for therapy using a middle sized high-current cyclotron and the CERN-MEDICIS mass separation system Objectives: feasibility study for a large scale production of selected isotopes using a middle sized high current cyclotron and the CERN-MEDICIS mass separation system Expected Results: Perform a explorative study based on theoretical analysis and Monte Carlo simulations in order to identify radioisotopes with favourable characteristics, namely: β- spectrum for therapy; γ emission for SPECT imaging; half-life for logistics and clinical use, corresponding β+ (positron) emitting isotope to be used as companion diagnostic agent; favourable chemistry for targeted radiometabolic therapy suitability; effective production yield, for 30-70 MeV protons, target feasibility, effective extraction yield with the CERN-MEDICIS mass separation system.)

Laser molecular break-up in RFQ cooler for beam purification

Molecular break-up by laser in RFQ cooler Objective : To study the impact of the chemical nature of the molecules on their break up in a RFQ-Cooler device before or after mass separation of molecular isotope beams Expected Results: A :Different types of molecular ions will be injected in a RFQ Cooler, such as LnF+, CO+, CH4+. B The efficiencies of transmission, time of residence will be investigated by varying the cooling gas pressure, its nature (He, H2, H2O). C The molecular break-up by UV laser light excitation will be investigated. The precise required repetition rate, wavelength, plasma induction will be investigated. D The presence of other beam components on the results, such as alkali metals, will be investigated, to decide if the purification step must take place before or after mass-separation.

Collection of mass separated 11CO/CO2/CH4 at high efficiency

Mass separated beams of CO+, CO2+ and CH4+ with high efficiency Objective: develop compact and turn-key mass separator systems for medical radioisotope production Expected Results: The program aims to liaise the development on innovative medical RIB ongoing in Belgium (e.g. the ISOL@MYRRHA project and the University Hospital research groups on medical RIB) with CERN-MEDICIS. Different mass separators are currently operational or under the development at KUL. A new off-line mass separator to study resonance laser ionization of gas-jet based radioactive isotopes and a new laser laboratory are under construction, part of the HELIOS project. The outcome of the program will be 1) an operational MEDICIS mass separator (based on the LISOL system), 2) ion simulation packages to optimize the beam transport with respect to efficiency and mass resolution in order to limit isotope contamination, 3) trained scientists to operate and optimize the RIB production of certain interesting isotopes and 4) active participation in the long-term development of compact and turnkey mass separator systems.

Radiometal and 11C –based bioligands synthesis for target receptors of ovarian cancer

Lead beneficiary: EPFL (CH) Bifunctional fluorescent and PET/treatment bioligand for ovarian cancer Objective: Develop and validate new bifunctional fluorescent and radioactive bioligand for ovarian cancer Expected Results: These reagents will consist of three major parts – 1) a bioligand for targeting of ovarian cancer; 2) a fluorophore for optical readout; 3) and a chelator for radiolanthanide such as Terbium (Tb). The first application of these probes would be to study their specific binding to ovarian cancer cells first in cell culture followed by biodistribution studies in animal models of ovarian cancer. The initial studies will be focused on folate receptor-alpha targeting moiety because several studies revealed that it is increased in 90–95% of patients with epithelial ovarian cancer. Moreover, the absence of folate receptor-alpha on healthy cells provides high tumor-to-normal ratios making this targeting moiety a good target for both imaging and therapeutic. Indocyanine green (ICG) will be a first choice of fluorescent reagent because of its extensive use in clinic. Terbium is known to possess excellent chelation properties to diethylene triamine pentaacetic acid (DTPA) and therefore this compound will be used in the construction of the final conjugates. In some biodistribution studies the chelate will be replaced with 11C isotope.

99Mo/Tc production with metal uranium/graphene targets at CERN-MEDICIS

Metallic foil targets with protective graphene layers to produce innovative isotopes Objective: To study the possibility and mechanisms of graphene growth on uranium, thorium and other metals to form a protective layer. To characterised the grown graphene layer and its ageing in difficult environments Expected Results: It has been demonstrated recently, that graphene can serve as a completely impermeable membrane on a surface of a metal. Furthermore, as graphene can be grown conformal on a piece of metal of any shape, it can be used as a corrosion protection. We would like to use graphene as a corrosion protection on uranium, thorium and other metals. Different metals allow for different mechanisms of graphene growth. We will investigate a possibility of graphene growth on uranium, thorium and other metals, the mechanisms of such growth and will optimise the process. Growth on Tantalum will first be investigated. The student will get familiar with the basic methods of graphene characterisation (AFM, SEM, Raman, etc). and develop new methods to characterise graphene on uranium.

Preclinical Imaging and Animal Models – Clinical Translation on ovarian cancer

Technical leader: partner organization CHUV (CH) Preclinical Imaging and Animal Models – Clinical Translation on ovarian cancer Objective: Develop translational imaging and therapy with monoclonal antibodies for ovarian cancer Expected Results: The ESR will be in charge of performing the translation from a successful preclinical model for diagnosis to a first study in humans, firstly from a diagnostic point of view, and secondarily, as a preclinical therapeutic radioimmunotherapy and then, if feasible into a therapy in humans; His supervisor, Dr. Melita Irving, (Ludwig Center for Cancer Research, University of Lausanne, Biopôle III ) will train him performing molecular biology and preclinical antibody research on ovarian cancer in mice. At CHUV, preclinical imaging will be done in nuclear medicine with μPET/SPECT/CT, and for clinical trials, PET/CT and SPECT/CT clinical scanners and radiation shielded beds for clinical therapy.

Cell-nucleus targeting with bioligands for Auger-thera

Design, synthesis and pre-clinical evaluation of multifunctional 161Tb complexes for cell specific targeting of DNA Objective: 161Terbium Auger-emitting radiopharmaceuticals for the eradication of large tumor masses or small metastases for ovarian cancers Expected Results: A Synthesis and characterization of macrocyclic bifunctional chelators (e.g. 1,4,7,10-tetraazacyclododecane DOTA) bearing a tumor-specific MAb fragment targeting moiety and a DNA-binding moiety). B Synthesis of cold Tb complexes and characterization by spectroscopic techniques. C biological evaluation of Tb-161 complexes (Damage in plasmid DNA, Cell uptake using human tumor cell lines, Radiotoxicity and mechanisms of cell death, Biodistribution and SPECT imaging in tumor-bearing mice)

Remote laser ion source operation system for installation at medical cyclotrons

Remotely operated Laser Ion Source for radiolanthanide purification at medical cyclotrons Objectives: efficient mono-isobaric ion beam production via elemental selective laser ionization Expected Results: Each chemical element needs a defined 2 or 3 –steps laser ionization scheme. Terbium, Lutetium and Erbium isotopes will first be considered, using solid-state diode lasers that are better suited for remote operation. The ion source cavity (length, material, temperature) at the mass separator will afterward be developed to increase the ionization efficiencies. Finally a fully automated control software and monitoring will be implemented fo foresee its transfer at a medical cyclotron.

New robot-assisted instruments and delivery methods for brachytherapy

Technical leader: partner organization UNIGE (CH) New robot-assisted instruments and delivery methods for brachytherapy Objective: Develop and validate new delivery techniques for brachytherapy in computerized and large animal models Expected Results: The aim of this project is to establish new instruments and delivery methods for brachytherapy using stereotactic, endoscopic ultrasonographic-guided or robotic-assisted surgery for the treatment of non-resectable brain, ovarian and pancreatic cancers. New isotopes with specific types of emission, tissue penetration and half-life will be developed at CERN-MEDICIS. For brain tumors, we will use stereotactic and/or image-guided placement of coated particles, based on magnetic resonance imaging. For ovarian and pancreatic cancers, we will evaluate endoscopic ultrasonographic guided delivery of seeds and will establish the Da Vinci robot-assisted system for intra-organ placement of seeds.

Production of theranostics 149/152Tb at CERN-MEDICIS and shipping

Production of 149/152Terbium theranostics isotopes at CERN-MEDICIS and shipping Objective : to define the proper operational conditions and safety boundaries for the production and shipping of radioisotopes from radioactive ion beams Expected Results: The CERN-MEDICIS facility is the first facility to start operation for the production of medical istope batches by mass separation. The necessary engineering validation and documentation steps will be elaborated for its safety file. This includes the procedure and design of isotope batch collection chambers, coupling of radiochemical purification modules to the isotope mass separator. The efficiencies for the collection of 149/152Terbium will be determined, and different engineering systems, such as targets and ion sources will be selected and optimized to achieve the best figures.

Website

Creation of project website for internal and external use.

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Publications

Enhancing the extraction of laser-ionized beams from an arc discharge ion source volume

Author(s): Y. Martinez Palenzuela, B.A. Marsh, J. Ballof, R. Catherall, K. Chrysalidis, T.E. Cocolios, B. Crepieux, T. Day Goodacre, V.N. Fedosseev, M.H. Huyse, P.B. Larmonier, J.P. Ramos, S. Rothe, J.D.A. Smith, T. Stora, P. Van Duppen, S. Wilkins
Published in: Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, Issue 431, 2018, Page(s) 59-66, ISSN 0168-583X
DOI: 10.1016/j.nimb.2018.06.006

Time-of-Flight study of molecular beams extracted from the ISOLDE RFQ cooler and buncher

Author(s): A. Ringvall Moberg, S. Warren, C. Muñoz Pequeño, J. Cruikshank, T. Giles, D. Hanstorp
Published in: Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 2019, ISSN 0168-583X
DOI: 10.1016/j.nimb.2019.03.014

Upgrades of the GANDALPH photodetachment detector towards the determination of the electron affinity of astatine

Author(s): D. Leimbach, S. Rothe, L. Bengtsson, A. Ringvall-Moberg, J. Sundberg, K. Wendt, D. Hanstorp
Published in: Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 2019, ISSN 0168-583X
DOI: 10.1016/j.nimb.2019.05.015

Challenges in 11C charge breeding

Author(s): J. Pitters, M. Breitenfeldt, H. Pahl, A. Pikin, F. Wenander
Published in: Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 2019, ISSN 0168-583X
DOI: 10.1016/j.nimb.2019.05.046

Pepperpot emittance measurements of ion beams from an electron beam ion source

Author(s): J. Pitters, M. Breitenfeldt, S. Duarte Pinto, H. Pahl, A. Pikin, A. Shornikov, F. Wenander
Published in: Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, Issue 922, 2019, Page(s) 28-35, ISSN 0168-9002
DOI: 10.1016/j.nima.2018.12.072

A low energy ion beamline for TwinEBIS

Author(s): H. Pahl, V. Bencini, M. Breitenfeldt, A.R. Granadeiro Costa, A. Pikin, J. Pitters, F. Wenander
Published in: Journal of Instrumentation, Issue 13/08, 2018, Page(s) P08012-P08012, ISSN 1748-0221
DOI: 10.1088/1748-0221/13/08/p08012

Growth of graphene on tantalum and its protective properties

Author(s): M. Nazarova, T. Stora, A.A. Zhukov, K. Huang, R.R. Nair, Y.B. Wang, J. Yin, M. Holwill, Z. Wang, A. Mishchenko, K.S. Novoselov
Published in: Carbon, Issue 139, 2018, Page(s) 29-34, ISSN 0008-6223
DOI: 10.1016/j.carbon.2018.06.027

MELISSA: Laser ion source setup at CERN-MEDICIS facility. Blueprint

Author(s): V.M. Gadelshin, V. Barozier, T.E. Cocolios, V.N. Fedosseev, R. Formento-Cavaier, F. Haddad, B. Marsh, S. Marzari, S. Rothe, T. Stora, D. Studer, F. Weber, K. Wendt
Published in: Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 2019, ISSN 0168-583X
DOI: 10.1016/j.nimb.2019.04.024

Terbium Radionuclides for Theranostics Applications: A Focus On MEDICIS-PROMED

Author(s): R. Formento Cavaier, F. Haddad, T. Sounalet, T. Stora, I. Zahi
Published in: Physics Procedia, Issue 90, 2017, Page(s) 157-163, ISSN 1875-3892
DOI: 10.1016/j.phpro.2017.09.053

Very high specific activity erbium 169Er production for potential receptor-targeted radiotherapy

Author(s): R. Formento-Cavaier, U. Köster, B. Crepieux, V.M. Gadelshin, F. Haddad, T. Stora, K. Wendt
Published in: Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 2019, ISSN 0168-583X
DOI: 10.1016/j.nimb.2019.04.022

Measurement of spallation cross sections for the production of terbium radioisotopes for medical applications from tantalum targets

Author(s): H. Verhoeven, T.E. Cocolios, K. Dockx, G.J. Farooq-Smith, O. Felden, R. Formento-Cavaier, R. Gebel, U. Köster, B. Neumaier, B. Scholten, I. Spahn, S. Spellerberg, M.E. Stamati, S. Stegemann
Published in: Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 2019, ISSN 0168-583X
DOI: 10.1016/j.nimb.2019.04.071

First in-human radiation dosimetry of the gastrin-releasing peptide (GRP) receptor antagonist 68Ga-NODAGA-MJ9

Author(s): Silvano Gnesin, Francesco Cicone, Periklis Mitsakis, Axel Van der Gucht, Sébastien Baechler, Raymond Miralbell, Valentina Garibotto, Thomas Zilli, John O. Prior
Published in: EJNMMI Research, Issue 8/1, 2018, ISSN 2191-219X
DOI: 10.1186/s13550-018-0462-9

A Monte Carlo model for the internal dosimetry of choroid plexuses in nuclear medicine procedures

Author(s): Ernesto Amato, Francesco Cicone, Lucrezia Auditore, Sergio Baldari, John O. Prior, Silvano Gnesin
Published in: Physica Medica, Issue 49, 2018, Page(s) 52-57, ISSN 1120-1797
DOI: 10.1016/j.ejmp.2018.05.005

18 F-DOPA uptake parameters in glioma: effects of patients’ characteristics and prior treatment history

Author(s): Luciano Carideo, Giuseppe Minniti, Marcelo Mamede, Claudia Scaringi, Ivana Russo, Francesco Scopinaro, Francesco Cicone
Published in: The British Journal of Radiology, 2018, Page(s) 20170847, ISSN 0007-1285
DOI: 10.1259/bjr.20170847

Expression of large neutral amino acid transporters LAT1 and LAT2 in medulloblastoma

Author(s): Francesco Cicone, Giuseppe Minniti, Maria Antonietta Oliva, Luciano Carideo, John O. Prior, Francesco Scopinaro, Felice Giangaspero, Antonietta Arcella
Published in: Brain Tumor Pathology, Issue 34/4, 2017, Page(s) 179-181, ISSN 1433-7398
DOI: 10.1007/s10014-017-0296-6

Hyperhomocysteinemia in acute iatrogenic hypothyroidism: the relevance of thyroid autoimmunity

Author(s): F. Cicone, M. G. Santaguida, G. My, G. Mancuso, A. Papa, R. Persechino, C. Virili, N. Brusca, A. Tofani, F. Scopinaro, M. Centanni
Published in: Journal of Endocrinological Investigation, Issue 41/7, 2018, Page(s) 831-837, ISSN 1720-8386
DOI: 10.1007/s40618-017-0811-y

Dosimetry-based treatment planning for molecular radiotherapy: a summary of the 2017 report from the Internal Dosimetry Task Force

Author(s): Caroline Stokke, Pablo Minguez Gabiña, Pavel Solný, Francesco Cicone, Mattias Sandström, Katarina Sjögreen Gleisner, Carlo Chiesa, Emiliano Spezi, Maria Paphiti, Mark Konijnenberg, Matt Aldridge, Jill Tipping, Michael Wissmeyer, Boudewijn Brans, Klaus Bacher, Carsten Kobe, Glenn Flux
Published in: EJNMMI Physics, Issue 4/1, 2017, ISSN 2197-7364
DOI: 10.1186/s40658-017-0194-3

Variations in the practice of molecular radiotherapy and implementation of dosimetry: results from a European survey

Author(s): Katarina Sjögreen Gleisner, Emiliano Spezi, Pavel Solny, Pablo Minguez Gabina, Francesco Cicone, Caroline Stokke, Carlo Chiesa, Maria Paphiti, Boudewijn Brans, Mattias Sandström, Jill Tipping, Mark Konijnenberg, Glenn Flux
Published in: EJNMMI Physics, Issue 4/1, 2017, ISSN 2197-7364
DOI: 10.1186/s40658-017-0193-4

Amino acid PET and MR perfusion imaging in brain tumours

Author(s): Christian P. Filss, Francesco Cicone, Nadim Jon Shah, Norbert Galldiks, Karl-Josef Langen
Published in: Clinical and Translational Imaging, Issue 5/3, 2017, Page(s) 209-223, ISSN 2281-5872
DOI: 10.1007/s40336-017-0225-z

Outcomes of postoperative stereotactic radiosurgery to the resection cavity versus stereotactic radiosurgery alone for melanoma brain metastases

Author(s): Giuseppe Minniti, Sergio Paolini, Giancarlo D’Andrea, Gaetano Lanzetta, Francesco Cicone, Veronica Confaloni, Alessandro Bozzao, Vincenzo Esposito, Mattia Osti
Published in: Journal of Neuro-Oncology, Issue 132/3, 2017, Page(s) 455-462, ISSN 0167-594X
DOI: 10.1007/s11060-017-2394-z

Multiparametric evaluation of low grade gliomas at follow-up: comparison between diffusion and perfusion MR with 18 F-FDOPA PET

Author(s): Maria C Rossi Espagnet, Andrea Romano, Valeria Mancuso, Francesco Cicone, Antonio Napolitano, Claudia Scaringi, Giuseppe Minniti, Alessandro Bozzao
Published in: The British Journal of Radiology, Issue 89/1066, 2016, Page(s) 20160476, ISSN 0007-1285
DOI: 10.1259/bjr.20160476

“Comment on Hatzoglou et al.: Dynamic contrast-enhanced MRI perfusion vs 18FDG PET/CT in differentiating brain tumor progression from radiation injury”-Reply

Author(s): Robert J. Young, T. Jonathan Yang, Vaios Hatzoglou, Gary Ulaner, Antonio Omuro
Published in: Neuro-Oncology, 2017, Page(s) now286, ISSN 1522-8517
DOI: 10.1093/neuonc/now286

18F-DOPA Positron Emission Tomography in Medulloblastoma: 2 Case Reports

Author(s): Francesco Cicone, Anna Clerico, Giuseppe Minniti, Milena Paiano, Luciano Carideo, Claudia Scaringi, Karl-Josef Langen, Francesco Scopinaro
Published in: World Neurosurgery, Issue 93, 2016, Page(s) 490.e7-490.e11, ISSN 1878-8750
DOI: 10.1016/j.wneu.2016.06.058

Single-Fraction Versus Multifraction (3 × 9 Gy) Stereotactic Radiosurgery for Large (>2 cm) Brain Metastases: A Comparative Analysis of Local Control and Risk of Radiation-Induced Brain Necrosis

Author(s): Giuseppe Minniti, Claudia Scaringi, Sergio Paolini, Gaetano Lanzetta, Andrea Romano, Francesco Cicone, Mattia Osti, Riccardo Maurizi Enrici, Vincenzo Esposito
Published in: International Journal of Radiation Oncology*Biology*Physics, Issue 95/4, 2016, Page(s) 1142-1148, ISSN 0360-3016
DOI: 10.1016/j.ijrobp.2016.03.013

Repeated stereotactic radiosurgery for patients with progressive brain metastases

Author(s): Giuseppe Minniti, Claudia Scaringi, Sergio Paolini, Enrico Clarke, Francesco Cicone, Vincenzo Esposito, Andrea Romano, Mattia Osti, Riccardo Maurizi Enrici
Published in: Journal of Neuro-Oncology, Issue 126/1, 2016, Page(s) 91-97, ISSN 0167-594X
DOI: 10.1007/s11060-015-1937-4

The TwinEBIS setup: Machine description

Author(s): M. Breitenfeldt, R. Mertzig, J. Pitters, A. Shornikov, F. Wenander
Published in: Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, Issue 856, 2017, Page(s) 139-146, ISSN 0168-9002
DOI: 10.1016/j.nima.2016.12.037

First in-human radiation dosimetry of 68Ga-NODAGA-RGDyK

Author(s): Silvano Gnesin, Periklis Mitsakis, Francesco Cicone, Emmanuel Deshayes, Vincent Dunet, Augusto F. Gallino, Marek Kosinski, Sébastien Baechler, Franz Buchegger, David Viertl, John O. Prior
Published in: EJNMMI Research, Issue 7/1, 2017, Page(s) 43, ISSN 2191-219X
DOI: 10.1186/s13550-017-0288-x

Laser resonance ionization spectroscopy on lutetium for the MEDICIS project

Author(s): V. Gadelshin, T. Cocolios, V. Fedoseev, R. Heinke, T. Kieck, B. Marsh, P. Naubereit, S. Rothe, T. Stora, D. Studer, P. Van Duppen, K. Wendt
Published in: Hyperfine Interactions, Issue 238/1, 2017, ISSN 0304-3843
DOI: 10.1007/s10751-017-1406-x

Cardiac Radionuclide Imaging in Rodents: A Review of Methods, Results, and Factors at Play

Author(s): Francesco Cicone, David Viertl, Ana Maria Quintela Pousa, Thibaut Denoël, Silvano Gnesin, Francesco Scopinaro, Marie-Catherine Vozenin, John O. Prior
Published in: Frontiers in Medicine, Issue 4, 2017, Page(s) 35, ISSN 2296-858X
DOI: 10.3389/fmed.2017.00035

A high-compression electron gun for C 6+ production: concept, simulations and mechanical design

Author(s): Robert Mertzig, M. Breitenfeldt, S. Mathot, J. Pitters, A. Shornikov, F. Wenander
Published in: Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, Issue 859, 2017, Page(s) 102-111, ISSN 0168-9002
DOI: 10.1016/j.nima.2016.12.036

The ISOLDE LEGO ® robot: building interest in frontier research

Author(s): Thomas Elias Cocolios, Kara M Lynch, Emma Nichols
Published in: Physics Education, Issue 52/4, 2017, Page(s) 044004, ISSN 0031-9120
DOI: 10.1088/1361-6552/aa71e4

Charge breeding of CO+ beams at REX-ISOLDE

Author(s): J. Pitters, M. Breitenfeldt, F. Wenander
Published in: AIP Conference Proceedings volume 2011, 2018, Page(s) 070012
DOI: 10.1063/1.5053354

MEDeGUN commissioning results

Author(s): M. Breitenfeldt, F. di Lorenzo, A. Pikin, J. Pitters, F. Wenander
Published in: AIP Conference Proceedings volume 2011, 2018, Page(s) 040004
DOI: 10.1063/1.5053278

MEDICIS-Promed: an Innovative Training Network for a new generation of professionals in nuclear medicine

Author(s): Thomas Elias Cocolios, Cristina Ferrari, Fiona Reid, Thierry Stora
Published in: IFMBE Proceedings, Issue 65, 2018, Page(s) 530-533
DOI: 10.1007/978-981-10-5122-7_133