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MEDICIS-produced radioisotope beams for medicine

Objective

Pure accelerated radioisotope beams have been used for 50 years in fundamental physics R&D, e.g. for nuclear structure studies (pear shaped exotic nuclei, Nature 2013); CERN-ISOLDE plays a central role in developing accelerator technologies and fostering collaborative approaches to advance this field of isotope mass separation online. Our most recent contribution was the use of nanomaterial targets for more intense and reliable beam production, and laser ion sources for their purification (discovery of yet unknown 233Francium).
Radioisotopes are widely used for functional imaging in medicine, based on 99mTechnetium or on 18Fluorine. This field is expected to rapidly expand, when coupling imaging with new cancer treatments, with isotopes emitting different type of radioactivity, e.g. alpha particles. This is shown with the recently introduced 223Radium chloride (Xofigo®) used as a treatment drug in advanced bone cancers. However, either shortage in the supply of 99mTechnetium or lack of access to new radioisotope with adequate properties is a severe treat to develop personalized treatment that combine functional imaging and therapy.
Ovarian cancers have poor prognosis, are the second most frequent cancer for women and one of the deadliest. They are difficult to treat, because of possible presence of metastasis, and because this region is difficult to irradiate without collateral damages.
MEDICIS-PROMED will train a new generation of scientists to develop systems for personalized Medicine combining functional imaging and treatments based on radioactive ion beam mass-separation. This will be done across a coherent intersectorial multidisciplinary network with world-leading scientists in their field.
Subsystems for the development of new radiopharmaceuticals, of isotope mass separators at medical cyclotrons, and of mass separated 11Carbon for PET-aided hadron therapy will be specifically developed to treat the ovarian cancer.

Call for proposal

H2020-MSCA-ITN-2014
See other projects for this call

Funding Scheme

MSCA-ITN-ETN - European Training Networks

Coordinator

EUROPEAN ORGANIZATION FOR NUCLEAR RESEARCH
Address
Esplanade Des Particules 1 Parcelle 11482 De Meyrin Batiment Cadastral 1046
1211 Geneva 23
Switzerland
Activity type
Research Organisations
EU contribution
€ 795 680,28

Participants (7)

THE UNIVERSITY OF MANCHESTER
United Kingdom
EU contribution
€ 273 287,88
Address
Oxford Road
M13 9PL Manchester
Activity type
Higher or Secondary Education Establishments
JOHANNES GUTENBERG-UNIVERSITAT MAINZ
Germany
EU contribution
€ 249 216,48
Address
Saarstrasse 21
55122 Mainz
Activity type
Higher or Secondary Education Establishments
Advanced Accelerator Applications
France
EU contribution
€ 262 875,60
Address
Rue Diesel 20
01630 Saint Genis Pouilly
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
INSTITUTO SUPERIOR TECNICO
Portugal
EU contribution
€ 476 712,72
Address
Avenida Rovisco Pais 1
1049-001 Lisboa
Activity type
Higher or Secondary Education Establishments
FONDAZIONE CENTRO NAZIONALE DI ADROTERAPIA ONCOLOGICA
Italy
EU contribution
€ 258 061,32
Address
Strada Campeggi 53
27100 Pavia Pv
Activity type
Research Organisations
KATHOLIEKE UNIVERSITEIT LEUVEN
Belgium
EU contribution
€ 250 560
Address
Oude Markt 13
3000 Leuven
Activity type
Higher or Secondary Education Establishments
LEMER PAX
France
EU contribution
€ 262 875,60
Address
3.Rue De L'europe
44472 Carquefou
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)

Partners (7)

CENTRE HOSPITALIER UNIVERSITAIRE VAUDOIS
Switzerland
Address
Rue Du Bugnon 21
1011 Lausanne
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
LES HOPITAUX UNIVERSITAIRES DE GENEVE
Switzerland
Address
Rue Gabrielle Perret Gentil 4
1205 Geneve 14
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
Switzerland
Address
Batiment Ce 3316 Station 1
1015 Lausanne
Activity type
Higher or Secondary Education Establishments
EBG (Entwicklungs- und Betriebsgesellschaft) MedAustron GmbH
Austria
Address
Marie Curie-strasse 5
2700 Wiener Neustadt
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
GROUPEMENT INTERET PUBLIC ARRONAX
France
Address
Rue Aronnax 1
44817 Saint Herblain
Activity type
Research Organisations
INSTITUT MAX VON LAUE - PAUL LANGEVIN
France
Address
71 Avenue Des Martyrs
38000 Grenoble
Activity type
Research Organisations
Isis Innovation Ltd
United Kingdom
Address

Oxford
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)