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Chromatin Dynamics in Development and Disease

Informations projet

N° de convention de subvention: 642934

  • Date de début

    1 Janvier 2015

  • Date de fin

    31 Decembre 2018

Financé au titre de:

H2020-EU.1.3.1.

  • Budget total:

    € 3 782 583,36

  • Contribution de l’UE

    € 3 782 583,36

Coordonné par:

IDRYMA TECHNOLOGIAS KAI EREVNAS

Grèce

Objectif

The cell nucleus is organized and compartmentalized into a highly ordered structure that contains DNA, RNA, chromosomal and histone proteins which make up a structure called chromatin. The dynamics associated with these various components are responsible for regulating physiological processes and the overall stability of the genome. The destabilization of such regulatory mechanisms that act on the chromatin structure are implicated in pathologies such as cancer. Higher order organization of chromatin results in chromosomes which occupy discrete territories within the cell nucleus. Most nuclear processes occur or at least being initiated onto the chromosomes which makes them the main organizing factors in the nucleus. Several proteins that are involved in the replication of DNA, gene transcription and the processing of RNA are found enriched in discrete focal structures. An emerging question is how these structures assemble and are maintained in the absence of membranes and moreover what are the kinetics of stable binding and/or rapid exchange of their components. The dynamic assembly and modification of chromatin during developmental processes as well as the deregulation of such chromatin dynamics during the onset of disease lacks mechanistic insights at present. To address these questions we have put forward a multidisciplinary approach which involves molecular, cellular and systems level approaches by assembling a group of scientists from academia and industry with cross disciplinary expertise and capabilities.

Coordinateur

IDRYMA TECHNOLOGIAS KAI EREVNAS

Adresse

N Plastira Str 100
70013 Irakleio

Grèce

Type d’activité

Research Organisations

Contribution de l’UE

€ 969 547,68

Participants (12)

LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN

Allemagne

Contribution de l’UE

€ 249 216,48

BIOMEDICAL SCIENCES RESEARCH CENTER ALEXANDER FLEMING

Grèce

FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA

Italie

Contribution de l’UE

€ 164 872,51

THE UNIVERSITY OF EDINBURGH

Royaume-Uni

Contribution de l’UE

€ 273 287,88

FUNDACIO INSTITUT D'INVESTIGACIO BIOMEDICA DE BELLVITGE

Espagne

Contribution de l’UE

€ 247 872,96

KAROLINSKA INSTITUTET

Suède

Contribution de l’UE

€ 527 318,64

WEIZMANN INSTITUTE OF SCIENCE

Israël

Contribution de l’UE

€ 260 300,52

DIAGENODE

Belgique

Contribution de l’UE

€ 250 560

UD-GENOMED MEDICAL GENOMIC TECHNOLOGIES KUTATAS-FEJLESZTESI ES SZOLGALTATO KFT

Hongrie

Contribution de l’UE

€ 223 913,52

MOSAIQUES DIAGNOSTICS GMBH

Allemagne

Contribution de l’UE

€ 249 216,48

AvantiCell Science Ltd

Royaume-Uni

Contribution de l’UE

€ 273 287,88

ISTITUTO EUROPEO DI ONCOLOGIA SRL

Italie

Contribution de l’UE

€ 93 188,81

Partenaires (4)

EXIQON AS

Danemark

LIFEGLIMMER GMBH

Allemagne

YELLOW RESEARCH

Pays-Bas

SB SCIENCE MANAGEMENT UG

Allemagne

Informations projet

N° de convention de subvention: 642934

  • Date de début

    1 Janvier 2015

  • Date de fin

    31 Decembre 2018

Financé au titre de:

H2020-EU.1.3.1.

  • Budget total:

    € 3 782 583,36

  • Contribution de l’UE

    € 3 782 583,36

Coordonné par:

IDRYMA TECHNOLOGIAS KAI EREVNAS

Grèce