Deliverables
Final RENALTRACT event, organised by the ESRs and largely open. To be held during the last month of presence of all ESRs, i.e between months 40 and 42 most probably.
Two “Young Researcher Training Workshops”Dissemination & training events to be held on months 8 and 20
Positions’ advertisementESRs position largely advertised on various channels.
Outreach activitiesDissemination, public contact, communication to be implemented by the ESRs.
Compulsory Deliverable
List of RTM-related peptide biomarkers in urineScreen for biomarkers
Award of doctoral degreesExpected 36 months after the ESRs recruitment, by the end of the project at the latest.
Establishment of bioinformatic model of kidney developmentIntegration of information on developmental network components; validation by genotype-phenotype pre-diction testing.
Characterization of the regulatory network required for the different steps of the ureteric myogenic programAnalysis and compilation of NGS data.
Phenotypic characterisation of urofacial syndrome mutant mouse renal tracts and hindgutsMolecular and electrophysiological characterrisation of mutant mice.
List of genes involved in regulation of nephrogenesis inductionModel genes depicted from the microarayed renal genes
Supervisory Board of Networkcompulsory deliverable
Identification of target genes of Tgfrb-, Pdgfra and/or retinoic acid-signalling in the ureterMicroarray and expression analysis
List of novel genetic vari-ants causing maldevelopment of human lower urinary tractCollation of information from human genetic studies.
Functional characterisation of novel genes for kidney and ureter developmentList of novel genes for kidney and ureter development
Characterization of the regulatory network required for the progression of the ureteric myogenic programCombined molecular and genetic approaches.
Role of pax8 targets in the Xenopus kidneyFunctionnal analysis of pax8 target genes
Periodic reportcompulsory deliverable
Phenotypic characterisation of Phf19 knockout miceMice carrying Phf19 mutations will be characterized
Screen and metabolomics analysis for genes for nephrolithiasis and IEM diseasesNovel genes for nephrolithiasis and IEM diseases.
Progress ReportCompulsory deliverable
In vivo functional characterisation of selected miRNAs and the identification of mRNA-feedback loopsmiRNA/mRNA transcriptomics & functional assays achieved.
Ethicscompulsory deliverable
Publications
Author(s):
Pedro Magalhães, Harald Mischak, Petra Zürbig
Published in:
Current Opinion in Nephrology and Hypertension, Issue 25/6, 2016, Page(s) 494-501, ISSN 1062-4821
Publisher:
Lippincott Williams & Wilkins Ltd.
DOI:
10.1097/MNH.0000000000000278
Author(s):
Pedro Magalhães, Joost P. Schanstra, Emma Carrick, Harald Mischak, Petra Zürbig
Published in:
Expert Review of Proteomics, Issue 13/12, 2016, Page(s) 1121-1129, ISSN 1478-9450
Publisher:
Future Drugs Ltd.
DOI:
10.1080/14789450.2016.1254555
Author(s):
Pierbruno Ricci, Pedro Magalhães, Magdalena Krochmal, Martin Pejchinovski, Erica Daina, Maria Rosa Caruso, Laura Goea, Iwona Belczacka, Giuseppe Remuzzi, Muriel Umbhauer, Jens Drube, Lars Pape, Harald Mischak, Stéphane Decramer, Franz Schaefer, Joost P. Schanstra, Silvia Cereghini, Petra Zürbig
Published in:
Scientific Reports, Issue 9/1, 2019, ISSN 2045-2322
Publisher:
Nature Publishing Group
DOI:
10.1038/s41598-019-38713-5
Author(s):
Gunjan Pandey, Jens Westhoff, Franz Schaefer, Jochen Gehrig
Published in:
International Journal of Molecular Sciences, Issue 20/6, 2019, Page(s) 1290, ISSN 1422-0067
Publisher:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/ijms20061290
Author(s):
Yasmine Neirijnck, Antoine Reginensi, Kirsten Y. Renkema, Filippo Massa, Vladimir M. Kozlov, Haroun Dhib, Ernie M.H.F. Bongers, Wout F. Feitz, Albertien M. van Eerde, Veronique Lefebvre, Nine V.A.M. Knoers, Mansoureh Tabatabaei, Herbert Schulz, Helen McNeill, Franz Schaefer, Michael Wegner, Elisabeth Sock, Andreas Schedl
Published in:
Kidney International, Issue 93/5, 2018, Page(s) 1142-1153, ISSN 0085-2538
Publisher:
Blackwell Publishing Inc.
DOI:
10.1016/j.kint.2017.11.026
Author(s):
Zenglai Tan, Jingdong Shan, Aleksandra Rak-Raszewska, Seppo J. Vainio
Published in:
Scientific Reports, Issue 8/1, 2018, ISSN 2045-2322
Publisher:
Nature Publishing Group
DOI:
10.1038/s41598-018-34995-3
Author(s):
Magdalena Krochmal, Georgia Kontostathi, Pedro Magalhães, Manousos Makridakis, Julie Klein, Holger Husi, Johannes Leierer, Gert Mayer, Jean-Loup Bascands, Colette Denis, Jerome Zoidakis, Petra Zürbig, Christian Delles, Joost P. Schanstra, Harald Mischak, Antonia Vlahou
Published in:
Scientific Reports, Issue 7/1, 2017, ISSN 2045-2322
Publisher:
Nature Publishing Group
DOI:
10.1038/s41598-017-15359-9
Author(s):
Pedro Magalhães, Claudia Pontillo, Martin Pejchinovski, Justyna Siwy, Magdalena Krochmal, Manousos Makridakis, Emma Carrick, Julie Klein, William Mullen, Joachim Jankowski, Antonia Vlahou, Harald Mischak, Joost P. Schanstra, Petra Zürbig, Lars Pape
Published in:
PROTEOMICS - Clinical Applications, Issue 12/5, 2018, Page(s) 1700163, ISSN 1862-8346
Publisher:
Wiley - VCH Verlag GmbH & CO. KGaA
DOI:
10.1002/prca.201700163
Author(s):
Pedro Magalhães, Martin Pejchinovski, Katerina Markoska, Miroslaw Banasik, Marian Klinger, Dominika Švec-Billá, Ivan Rychlík, Merita Rroji, Arianna Restivo, Giovambattista Capasso, Flaviu Bob, Adalbert Schiller, Alberto Ortiz, Maria Vanessa Perez-Gomez, Pablo Cannata, Maria Dolores Sanchez-Niño, Radomir Naumovic, Voin Brkovic, Momir Polenakovic, William Mullen, Antonia Vlahou, Petra Zürbig,
Published in:
Scientific Reports, Issue 7/1, 2017, ISSN 2045-2322
Publisher:
Nature Publishing Group
DOI:
10.1038/s41598-017-17083-w
Author(s):
L. Pelander, V. Brunchault, B. Buffin-Meyer, J. Klein, B. Breuil, P. Zürbig, P. Magalhães, W. Mullen, J. Elliott, H. Syme, J.P. Schanstra, J. Häggström, I. Ljungvall
Published in:
The Veterinary Journal, Issue 249, 2019, Page(s) 73-79, ISSN 1090-0233
Publisher:
W. B. Saunders Co., Ltd.
DOI:
10.1016/j.tvjl.2019.05.010
Author(s):
Caroline M. Kolvenbach, Gabriel C. Dworschak, Sandra Frese, Anna S. Japp, Peggy Schuster, Nina Wenzlitschke, Öznur Yilmaz, Filipa M. Lopes, Alexey Pryalukhin, Luca Schierbaum, Loes F.M. van der Zanden, Franziska Kause, Ronen Schneider, Katarzyna Taranta-Janusz, Maria Szczepańska, Krzysztof Pawlaczyk, William G. Newman, Glenda M. Beaman, Helen M. Stuart, Raimondo M. Cervellione, Wouter F.J. Feitz
Published in:
The American Journal of Human Genetics, Issue 104/5, 2019, Page(s) 994-1006, ISSN 0002-9297
Publisher:
University of Chicago Press
DOI:
10.1016/j.ajhg.2019.03.023
Author(s):
Neil A. Roberts, Emma N. Hilton, Filipa M. Lopes, Subir Singh, Michael J. Randles, Natalie J. Gardiner, Karl Chopra, Riccardo Coletta, Zunera Bajwa, Robert J. Hall, Wyatt W. Yue, Franz Schaefer, Stefanie Weber, Roger Henriksson, Helen M. Stuart, Håkan Hedman, William G. Newman, Adrian S. Woolf
Published in:
Kidney International, Issue 95/5, 2019, Page(s) 1138-1152, ISSN 0085-2538
Publisher:
Blackwell Publishing Inc.
DOI:
10.1016/j.kint.2018.11.040
Author(s):
Adrian S. Woolf, Filipa M. Lopes, Parisa Ranjzad, Neil A. Roberts
Published in:
Frontiers in Pediatrics, Issue 7, 2019, ISSN 2296-2360
Publisher:
Frontiers
DOI:
10.3389/fped.2019.00136
Author(s):
Jochen Gehrig, Gunjan Pandey, Jens H. Westhoff
Published in:
Frontiers in Pediatrics, Issue 6, 2018, ISSN 2296-2360
Publisher:
Frontiers
DOI:
10.3389/fped.2018.00183
Author(s):
Guillermo Martínez-Corrales, Pablo Cabrero, Julian A. T. Dow, Selim Terhzaz, Shireen-A. Davies
Published in:
Development, Issue 146/9, 2019, Page(s) dev178087, ISSN 0950-1991
Publisher:
The Company of Biologists Ltd.
DOI:
10.1242/dev.178087
Author(s):
Saurav Ghimire, Selim Terhzaz, Pablo Cabrero, Michael F. Romero, Shireen Davies, Julian A.T. Dow
Published in:
American Journal of Physiology-Renal Physiology, 2019, ISSN 1931-857X
Publisher:
American Physiological Society
DOI:
10.1152/ajprenal.00551.2018
Author(s):
Sunder Sims-Lucas, Misty Good, Seppo J. Vainio
Published in:
Frontiers in Cell and Developmental Biology, Issue 5, 2017, ISSN 2296-634X
Publisher:
Frontiers
DOI:
10.3389/fcell.2017.00085
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