Mastering skills in the training Network for attention deficit hyperactivity and autism spectrum Disorders

Informations projet

MiND

N° de convention de subvention: 643051

DOI 10.3030/643051

Projet clôturé

Date de signature de la CE 19 Decembre 2014

Date de début 1 Janvier 2015

Date de fin 31 Decembre 2018

Financé au titre de

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Coût total € 3 913 940,43

Contribution de l’UE € 3 913 940,43

Coordonné par

STICHTING RADBOUD UNIVERSITEIT
Netherlands

Livrables

Documents, reports (16)

Disease genes and candidates in Drosophila

Manipulation and characterization of 12 ADHD/ASD models for (hyper)activity, cognitive and (sub)synaptic defects

Population-registry research

Papers on how ADHD and ASD are associated with academic, occupational, and social outcomes, and on the societal costs associated with ADHD and ASD comorbidity

Papers on how ADHD and ASD are associated with academic, occupational, and social outcomes, and on the societal costs associated with ADHD and ASD comorbidity

Publication(s) on novel assessments in patients

Non-pharmacological treatment

Paper(s) on effects of mindfulness on child self-control and ADHD or ASD symptoms

Data protection officers overview

A full list of data protection officers/national protection authorities and data controllers for all sites will be sent to the EU Commission

Hypothesis-free analysis of GWAS data

Paper of cross-disorder meta-analysis of existing GWAS in ADHD and ASD

Biological chaperones

Paper(s) on effects of novel com-pounds on ADHD candidate protein(s)

Biomarkers for outcome

Paper on predictors of ADHD outcome

progress report

progress report MiND

Doctorates

Awarding of doctorates to all ESRs complete

Integrative analysis of risk genes

Paper of integration of rare and common variants for ADHD / ASD and bioinformatic analysis

Cross-species validation

Paper on comparison of findings between models

Epigenetics of mouse models and validation in humans

Publications of behavioural characterisation, gene expression and DNA methylation profiling of ADHD/ASD-like phenotypes in mouse and man

ADHD/ASD microbiome

Paper(s) on identification of ADHD / ASD microbiome profiles

Cellular phenotyping

Characterization of two genetic variants in iPSCs from patients

Disease genes in human imaging

Papers on effects of disease risk genes on different forms of brain connectivity

Other (2)

Supervisory Board

installment of Supervisory Board

Whole-genome sequencing

Complete analysis of whole genome sequencing (WGS) data with validation

Demonstrators, pilots, prototypes (1)

e-biostatistics module

E-learning module developed & applied

Websites, patent fillings, videos etc. (1)

website

project website

Publications

Peer reviewed articles (16)

The familial co-aggregation of ASD and ADHD: a register-based cohort study

Auteurs: L Ghirardi, I Brikell, R Kuja-Halkola, C M Freitag, B Franke, P Asherson, P Lichtenstein, H Larsson
Publié dans: Molecular Psychiatry, 2017, ISSN 1359-4184
Éditeur: Nature Publishing Group
DOI: 10.1038/mp.2017.17

Tyrosine and tryptophan hydroxylases as therapeutic targets in human disease

Auteurs: Kai Waløen, Rune Kleppe, Aurora Martinez, Jan Haavik
Publié dans: Expert Opinion on Therapeutic Targets, Numéro 21/2, 2017, Page(s) 167-180, ISSN 1472-8222
Éditeur: Ashley Publications Ltd.
DOI: 10.1080/14728222.2017.1272581

Generation of human induced pluripotent stem cell lines (hiPSC) from one bipolar disorder patient carrier of a DGKH risk haplotype and one non-risk-variant-carrier bipolar disorder patient

Auteurs: Viola Stella Palladino, Nadia Omega Cipta Subrata, Andreas Geburtig-Chiocchetti, Rhiannon McNeill, Per Hoffmann, Andreas Reif, Sarah Kittel-Schneider
Publié dans: Stem Cell Research, Numéro 32, 2018, Page(s) 104-109, ISSN 1873-5061
Éditeur: Elsevier
DOI: 10.1016/j.scr.2018.09.008

Mindfulness for children with ADHD and Mindful Parenting (MindChamp): Protocol of a randomised controlled trial comparing a family Mindfulness-Based Intervention as an add-on to care-as-usual with care-as-usual only

Auteurs: Nienke M. Siebelink, Susan M. Bögels, Lisanne M. Boerboom, Noor de Waal, Jan K. Buitelaar, Anne E. Speckens, Corina U. Greven
Publié dans: BMC Psychiatry, Numéro 18/1, 2018, ISSN 1471-244X
Éditeur: BioMed Central
DOI: 10.1186/s12888-018-1811-y

Genetic risk factors and gene–environment interactions in adult and childhood attention-deficit/hyperactivity disorder

Auteurs: Viola S. Palladino, Rhiannon McNeill, Andreas Reif, Sarah Kittel-Schneider
Publié dans: Psychiatric Genetics, 2019, Page(s) 1, ISSN 0955-8829
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/ypg.0000000000000220

Attention profiles in autism spectrum disorder and subtypes of attention-deficit/hyperactivity disorder

Auteurs: Sara Boxhoorn, Eva Lopez, Catharina Schmidt, Diana Schulze, Susann Hänig, Christine M. Freitag
Publié dans: European Child & Adolescent Psychiatry, Numéro 27/11, 2018, Page(s) 1433-1447, ISSN 1018-8827
Éditeur: Dr. Dietrich Steinkopff Verlag
DOI: 10.1007/s00787-018-1138-8

Cross-species models of attention-deficit/hyperactivity disorder and autism spectrum disorder

Auteurs: Elisa Dalla Vecchia, Niall Mortimer, Viola S. Palladino, Sarah Kittel-Schneider, Klaus-Peter Lesch, Andreas Reif, Annette Schenck, William H.J. Norton
Publié dans: Psychiatric Genetics, Numéro 29/1, 2019, Page(s) 1-17, ISSN 0955-8829
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/ypg.0000000000000211

An emotion recognition subtyping approach to studying the heterogeneity and comorbidity of autism spectrum disorders and attention-deficit/hyperactivity disorder

Auteurs: Francesca Waddington, Catharina Hartman, Yvette de Bruijn, Martijn Lappenschaar, Anoek Oerlemans, Jan Buitelaar, Barbara Franke, Nanda Rommelse
Publié dans: Journal of Neurodevelopmental Disorders, Numéro 10/1, 2018, ISSN 1866-1947
Éditeur: Springer Verlag
DOI: 10.1186/s11689-018-9249-6

Visual and auditory emotion recognition problems as familial cross-disorder phenomenon in ASD and ADHD

Auteurs: Francesca Waddington, Catharina Hartman, Yvette de Bruijn, Martijn Lappenschaar, Anoek Oerlemans, Jan Buitelaar, Barbara Franke, Nanda Rommelse
Publié dans: European Neuropsychopharmacology, Numéro 28/9, 2018, Page(s) 994-1005, ISSN 0924-977X
Éditeur: Elsevier BV
DOI: 10.1016/j.euroneuro.2018.06.009

The effects of emotional lability, mind wandering and sleep quality on ADHD symptom severity in adults with ADHD

Auteurs: Bartosz Helfer, Ruth E. Cooper, Natali Bozhilova, Stefanos Maltezos, Jonna Kuntsi, Philip Asherson
Publié dans: European Psychiatry, Numéro 55, 2019, Page(s) 45-51, ISSN 0924-9338
Éditeur: Elsevier Masson
DOI: 10.1016/j.eurpsy.2018.09.006

Genetic and environmental contribution to the overlap between ADHD and ASD trait dimensions in young adults: a twin study

Auteurs: Laura Ghirardi, Erik Pettersson, Mark J. Taylor, Christine M. Freitag, Barbara Franke, Philip Asherson, Henrik Larsson, Ralf Kuja-Halkola
Publié dans: Psychological Medicine, 2018, Page(s) 1-9, ISSN 0033-2917
Éditeur: Cambridge University Press
DOI: 10.1017/s003329171800243x

A Genetic Investigation of Sex Bias in the Prevalence of Attention-Deficit/Hyperactivity Disorder

Auteurs: Joanna Martin, Raymond K. Walters, Ditte Demontis, Manuel Mattheisen, S. Hong Lee, Elise Robinson, Isabell Brikell, Laura Ghirardi, Henrik Larsson, Paul Lichtenstein, Nicholas Eriksson, Thomas Werge, Preben Bo Mortensen, Marianne Giørtz Pedersen, Ole Mors, Merete Nordentoft, David M. Hougaard, Jonas Bybjerg-Grauholm, Naomi R. Wray, Barbara Franke, Stephen V. Faraone, Michael C. O’Donovan, Anita
Publié dans: Biological Psychiatry, Numéro 83/12, 2018, Page(s) 1044-1053, ISSN 0006-3223
Éditeur: Elsevier BV
DOI: 10.1016/j.biopsych.2017.11.026

Moderating effect of mode of delivery on the genetics of intelligence: Explorative genome-wide analyses in ALSPAC

Auteurs: Dinka Smajlagić, Kaya Kvarme Jacobsen, Craig Myrum, Jan Haavik, Stefan Johansson, Tetyana Zayats
Publié dans: Brain and Behavior, Numéro 8/12, 2018, Page(s) e01144, ISSN 2162-3279
Éditeur: Brain and Behavior
DOI: 10.1002/brb3.1144

Reliability of a participant-friendly fecal collection method for microbiome analyses: a step towards large sample size investigation

Auteurs: Joanna W. Szopinska, Raphaële Gresse, Saskia van der Marel, Jos Boekhorst, Sabina Lukovac, Iris van Swam, Barbara Franke, Harro Timmerman, Clara Belzer, Alejandro Arias Vasquez
Publié dans: BMC Microbiology, Numéro 18/1, 2018, ISSN 1471-2180
Éditeur: BioMed Central
DOI: 10.1186/s12866-018-1249-x

Ex-Gaussian, Frequency and Reward Analyses Reveal Specificity of Reaction Time Fluctuations to ADHD and Not Autism Traits

Auteurs: Nicoletta Adamo, John Hodsoll, Philip Asherson, Jan K. Buitelaar, Jonna Kuntsi
Publié dans: Journal of Abnormal Child Psychology, Numéro 47/3, 2019, Page(s) 557-567, ISSN 0091-0627
Éditeur: Kluwer Academic/Plenum Publishers
DOI: 10.1007/s10802-018-0457-z

Genetic and environmental aetiologies of associations between dispositional mindfulness and ADHD traits: a population-based twin study

Auteurs: Nienke M. Siebelink, Philip Asherson, Elena Antonova, Susan M. Bögels, Anne E. Speckens, Jan K. Buitelaar, Corina U. Greven
Publié dans: European Child & Adolescent Psychiatry, 2019, ISSN 1018-8827
Éditeur: Dr. Dietrich Steinkopff Verlag
DOI: 10.1007/s00787-019-01279-8