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Computational and functional annotation of genomic elements during development of the model vertebrate zebrafish

Objective

The recent explosion of next generation sequencing (NGS) data has caught Europe unprepared and led to a critical shortage of computational biology expertise. As NGS methods are expected to become pervasive from basic science to personalised medicine there is an urgent need for highly skilled young scientists trained in both computational biology and experimental wet lab biology. Our network addresses this important problem of the postgenomic era. We aim to provide multi-disciplinary skills for a solid foundation in computational biology and developmental genomics. Developmental genomics is central to understanding of ontogeny and many genetic and congenital anomalies, but was outside the scope of the landmark ENCODE and FANTOM projects. ENCODE highlighted the need for an in vivo vertebrate model that enables high throughput in vivo functional testing of hypotheses generated from genome scale annotation. Zebrafish is an ideal model for extending the scope of genomics to vertebrate development. We aim to comprehensively annotate functional elements, decipher genomic codes of transcription, as well as coding and non-coding gene function during development and enhance zebrafish as an attractive developmental, comparative and disease model. The participants include 7 non-academic members (2 of which are beneficiaries), major zebrafish genomics laboratories, eminent computational biologists and world class genomics technology experts active in FANTOM and ENCODE. The training program involves 15 ESRs, more than 40 intersectoral and interdisciplinary secondments totalling 19 months, 7 training courses and 2 workshops/conferences. The main outcome of this programme is a cohort of researchers with computational, experimental laboratory and transferable skills ready to further their career in academia, public health and the private sector.

Field of science

  • /medical and health sciences/health sciences/public and environmental health
  • /natural sciences/biological sciences/genetics and heredity/genome

Call for proposal

H2020-MSCA-ITN-2014
See other projects for this call

Funding Scheme

MSCA-ITN-ETN - European Training Networks

Coordinator

THE UNIVERSITY OF BIRMINGHAM
Address
Edgbaston
B15 2TT Birmingham
United Kingdom
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 546 575,76

Participants (10)

IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
United Kingdom
EU contribution
€ 273 287,88
Address
South Kensington Campus Exhibition Road
SW7 2AZ London
Activity type
Higher or Secondary Education Establishments
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Germany
EU contribution
€ 387 670,08
Address
Hofgartenstrasse 8
80539 Muenchen
Activity type
Research Organisations
KAROLINSKA INSTITUTET
Sweden
EU contribution
€ 769 006,35
Address
Nobels Vag 5
17177 Stockholm
Activity type
Higher or Secondary Education Establishments
KING'S COLLEGE LONDON
United Kingdom
EU contribution
€ 447 888,47
Address
Strand
WC2R 2LS London
Activity type
Higher or Secondary Education Establishments
UNIVERSITE DE LIEGE
Belgium
EU contribution
€ 501 120
Address
Place Du 20 Aout 7
4000 Liege
Activity type
Higher or Secondary Education Establishments
GENOME RESEARCH LIMITED

Participation ended

United Kingdom
EU contribution
€ 0
Address
The Gibbs Building, Euston Road 215
NW1 2BE London
Activity type
Research Organisations
KARLSRUHER INSTITUT FUER TECHNOLOGIE
Germany
EU contribution
€ 498 432,96
Address
Kaiserstrasse 12
76131 Karlsruhe
Activity type
Higher or Secondary Education Establishments
RIKEN THE INSTITUTE OF PHYSICAL ANDCHEMICAL RESEARCH

Participation ended

Japan
EU contribution
€ 52 181,43
Address
Hirosawa 2-1
351 0198 Wako Shi Saitama
Activity type
Research Organisations
CONSORCI INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER
Spain
EU contribution
€ 247 872,96
Address
Calle Rossello 149 Puerta Bjs
08036 Barcelona
Activity type
Other
BGI EUROPE INSTITUTE FOND

Participation ended

Denmark
EU contribution
€ 0
Address
Ole Maaloes Vej 3
2200 Kobenhavn N
Activity type
Other

Partners (4)

MicroDiscovery GmbH
Germany
Address
Marienburger Strasse 1
10405 Berlin
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
D Young & Co LLP
United Kingdom
Address

London
Activity type
Other
Skillstudio Limited
United Kingdom
Address

Chislehurst
Activity type
Other
Zebrafish Model Organism Database
United States
Address

Eugene
Activity type
Other