Viruses, Immune stimulation and RNA Interference in Oncology Network

Deliverables

Set-up publically accessible dedicated webpage for the consortium research program with a layman summary of the program.

Communication

Include information of consortium and program on beneficiaries’ individual website.

Doctorate

PhD enabling thesis.

Supervisory board of the network

Supervisory board of the network will be created and the specific roles of the members will be defined as per the original Annex I part B.

Presentation

Present consortium results at international scientific meeting.

Recruitment

Advertise ESR vacancies VIRION consortium

Publications

Adenoviral production of interleukin-2 at the tumor site removes the need for systemic postconditioning in adoptive cell therapy

Author(s): Joao Manuel Santos, Riikka Havunen, Mikko Siurala, Víctor Cervera-Carrascon, Siri Tähtinen, Suvi Sorsa, Marjukka Anttila, Pauliina Karell, Anna Kanerva, Akseli Hemminki
Published in: International Journal of Cancer, Issue 141/7, 2017, Page(s) 1458-1468, ISSN 0020-7136
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/ijc.30839

Adenovirus Coding for Interleukin-2 and Tumor Necrosis Factor Alpha Replaces Lymphodepleting Chemotherapy in Adoptive T Cell Therapy

Author(s): João Manuel Santos, Víctor Cervera-Carrascon, Riikka Havunen, Sadia Zafar, Mikko Siurala, Suvi Sorsa, Marjukka Anttila, Anna Kanerva, Akseli Hemminki
Published in: Molecular Therapy, Issue 26/9, 2018, Page(s) 2243-2254, ISSN 1525-0016
Publisher: Nature Publishing Group
DOI: 10.1016/j.ymthe.2018.06.001

CD40L coding oncolytic adenovirus allows long-term survival of humanized mice receiving dendritic cell therapy

Author(s): Sadia Zafar, Suvi Sorsa, Mikko Siurala, Otto Hemminki, Riikka Havunen, Victor Cervera-Carrascon, João Manuel Santos, Hongjie Wang, Andre Lieber, Tanja De Gruijl, Anna Kanerva, Akseli Hemminki
Published in: OncoImmunology, Issue 7/10, 2018, Page(s) e1490856, ISSN 2162-402X
Publisher: Cell press
DOI: 10.1080/2162402x.2018.1490856

Unleashing the Full Potential of Oncolytic Adenoviruses against Cancer by Applying RNA Interference: The Force Awakens

Author(s): Tereza Brachtlova, Victor van Beusechem
Published in: Cells, Issue 7/12, 2018, Page(s) 228, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells7120228

TNFa and IL-2 armed adenoviruses enable complete responses by anti-PD-1 checkpoint blockade

Author(s): V. Cervera-Carrascon, M. Siurala, J. M. Santos, R. Havunen, S. Tähtinen, P. Karell, S. Sorsa, A. Kanerva, A. Hemminki
Published in: OncoImmunology, Issue 7/5, 2018, Page(s) e1412902, ISSN 2162-402X
Publisher: Landes Bioscience
DOI: 10.1080/2162402x.2017.1412902

Abscopal Effect in Non-injected Tumors Achieved with Cytokine-Armed Oncolytic Adenovirus

Author(s): Riikka Havunen, João M. Santos, Suvi Sorsa, Tommi Rantapero, Dave Lumen, Mikko Siurala, Anu J. Airaksinen, Victor Cervera-Carrascon, Siri Tähtinen, Anna Kanerva, Akseli Hemminki
Published in: Molecular Therapy - Oncolytics, Issue 11, 2018, Page(s) 109-121, ISSN 2372-7705
Publisher: Cell press
DOI: 10.1016/j.omto.2018.10.005

Constitutively active GSK3β as a means to bolster dendritic cell functionality in the face of tumour-mediated immune suppression

Author(s): Marta López González, Dinja Oosterhoff, Jelle J. Lindenberg, Ioanna Milenova, Sinead M. Lougheed, Tania Martiáñez, Henk Dekker, Dafne Carolina Alves Quixabeira, Basav Hangalapura, Jos Joore, Sander R. Piersma, Victor Cervera-Carrascon, Joao Manuel Santos, Rik J. Scheper, Henk M.W. Verheul, Connie R. Jiménez, Rieneke Van De Ven, Akseli Hemminki, Victor W. Van Beusechem, Tanja D. De Gruijl
Published in: OncoImmunology, Issue 8/10, 2019, Page(s) e1631119, ISSN 2162-402X
Publisher: landes Bioscience
DOI: 10.1080/2162402x.2019.1631119

Deliverables

Publications

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