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Scalable, point-of-care and label free microarray platform for rapid detection of Sepsis

Objective

The diagnosis and management of acute Sepsis is a critical area where fast and accurate results can translate into life changing health outcomes for individuals. The overall aim of RAIS is to develop a new point-of-care label-free microarray platform and validate it for quantifying levels of specific Sepsis’ biomarkers. The approach uses a novel interferometric technique ultimately capable of providing very large arrays of tests. Specific objectives and activities include: (i) an optical microarray reader based on a disruptive proprietary design combining interferometric lens-free microscopy and proximity CCD or CMOS image sensing; (ii) a microarray plate, in a proper microfluidic cartridge, consisting of a transparent slide with a novel nano-structured surface geometry to increase the detection sensitivity and covered by specific receptors to capture bio-markers; (iii) their integration in a portable and battery powered label free microarray platform potentially capable of measuring more than 1 million bio-targets simultaneously. The developed technology will be capable to detect micro-ribonucleic acids (microRNAs), interleukins and other specific proteins associated to Sepsis using a few microliters of blood or serum samples, in a concentration of a few pg/ml, within 30 minutes (sample to result) and at a cost per patient of less than 50€. In this way, patients will be put on the right treatment more rapidly, potentially reducing the Sepsis mortality rate of more than 70%, with estimated cost savings of more than €10 billion per year as a consequence of shorter hospital stays, reduced use of unnecessary drugs and lower associated insurance bills. The technical approach, targeted device, application and the addressed market sector are perfectly in line with the call H2020-ICT-2014-1 - Photonics KET - Biophotonics for screening of diseases: Mobile, low-cost point-of-care screening devices for reliable, fast and non- or minimally-invasive detection of diseases.

Call for proposal

H2020-ICT-2014-1
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Funding Scheme

RIA - Research and Innovation action

Coordinator

FUNDACIO INSTITUT DE CIENCIES FOTONIQUES
Address
Avinguda Carl Friedrich Gauss 3
08860 Castelldefels
Spain
Activity type
Research Organisations
EU contribution
€ 812 945

Participants (10)

ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
Switzerland
EU contribution
€ 0
Address
Batiment Ce 3316 Station 1
1015 Lausanne
Activity type
Higher or Secondary Education Establishments
AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS

Participation ended

Spain
EU contribution
€ 153 736,03
Address
Calle Serrano 117
28006 Madrid
Activity type
Research Organisations
MICROTEC GESELLSCHAFT FUR MIKROTECHNOLOGIE MBH
Germany
EU contribution
€ 298 750
Address
Bismarckstrasse 142B
47057 Duisburg
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
TRINEAN NV

Participation ended

Belgium
EU contribution
€ 416 660
Address
Dulle Grietlaan 17/3
9050 Gentbrugge
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
INSTITUT CATALA DE LA SALUT

Participation ended

Spain
EU contribution
€ 30 891,95
Address
Gran Via De Les Corts Catalanes 587
08007 Barcelona
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
BRAHMS GMBH
Germany
EU contribution
€ 144 000
Address
Neuendorfstrasse 25
16761 Hennigsdorf
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
IXSCIENT LIMITED
United Kingdom
EU contribution
€ 264 375
Address
Popes Grove 76
TW1 4JX Twickenham Middlesex
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
DIESSE DIAGNOSTICA SENESE SPA
Italy
EU contribution
€ 250 450
Address
Via Solari 19
20144 Milano
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
FUNDACIO INSTITUT CATALA DE NANOCIENCIA I NANOTECNOLOGIA
Spain
EU contribution
€ 246 406,47
Address
Campus De La Uab Edifici Q Icn2
08193 Bellaterra (Barcelona)
Activity type
Research Organisations
FUNDACIO HOSPITAL UNIVERSITARI VALL D'HEBRON - INSTITUT DE RECERCA
Spain
EU contribution
€ 370 358,05
Address
Passeig Vall D Hebron 119-129 Edificio De Recerca
08035 Barcelona
Activity type
Research Organisations