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Advanced bioinformatics for genome and metagenome analyses and discovery of novel biocatalists from extremophiles: implications for improving industrial bioprocesses

Objective

The aim of this proposal is to acquire new insights about the mechanisms of environmental adaptation, particularly for cold-adapted organisms, and to discover novel metabolic pathways and enzymes with potential industrial value. We intend to accomplish this goal by establishing a collaboration and a knowledge-exchange network between industrial and academic partners aiming at developing bioinformatic tools for genomic analysis and biotechnology tools for directed evolution. The partners present high complementarity: UNICAM holds genomic sequences from psychrophilic and mesophilic ciliates that need to be annotated and analysed. Sabanci provides environmental samples for the isolation and characterization of new extremophiles. CAMBRIDGE provides the know-how for the discovery of new metabolic pathways valuable for understanding environmental adaptation. BMR Genomics and COMSATS possess all the facilities for genome sequencing and annotation and bioinformatic expertise with the purpose of developing new tools to analyse genomes of microorganisms from extreme environment. UNIMIB owns the facilities for the heterologous expression of gene sequences in bacteria and yeasts and technologies to assess and implement the properties of novel enzymes towards industrial application. We are confident that the establishment of the international research network proposed, with its synergistic effects, will significantly contribute to push all the involved laboratories to the top level in the field of production of active biomolecules and in the discovery of mechanisms of molecular adaptation under extreme environmental conditions. These discoveries may help the manufacturing of a new generation of ordinary facilities, as cleaning agents, biofuels, with a significant impact on the everyday life of European citizens.

Field of science

  • /engineering and technology/environmental engineering/energy and fuels/biofuels
  • /natural sciences/biological sciences/genetics and heredity/genome
  • /natural sciences/biological sciences/biochemistry/biomolecules
  • /natural sciences/biological sciences/biochemistry/biomolecules/proteins/enzymes

Call for proposal

H2020-MSCA-RISE-2014
See other projects for this call

Funding Scheme

MSCA-RISE - Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE)

Coordinator

UNIVERSITA DEGLI STUDI DI CAMERINO
Address
Piazza Cavour 19F
62032 Camerino
Italy
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 81 000

Participants (5)

THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE
United Kingdom
EU contribution
€ 22 500
Address
Trinity Lane The Old Schools
CB2 1TN Cambridge
Activity type
Higher or Secondary Education Establishments
BIOMOLECULAR RESEARCH GENOMICS SRL
Italy
EU contribution
€ 45 000
Address
Via Redipuglia 21A
35131 Padova
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
UNIVERSITA' DEGLI STUDI DI MILANO-BICOCCA
Italy
EU contribution
€ 58 500
Address
Piazza Dell'ateneo Nuovo 1
20126 Milano
Activity type
Higher or Secondary Education Establishments
EPIGENETIKS GENETIK BIYOINFORMATIK YAZILIM AS
Turkey
EU contribution
€ 130 500
Address
Teknopark Istanbul, Sanayi Mh. Teknopark Blv. No: 1/4A Kulucka Merkezi, Pendik
34906 Istanbul
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
ELVESYS
France
EU contribution
€ 0
Address
172 Rue De Charonne B2 2 Eme Etage
75011 Paris
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)

Partners (1)

COMSATS UNIVERSITY ISLAMABAD
Pakistan
Address
Park Road, Chak Shahzad
44000 Islamabad
Activity type
Higher or Secondary Education Establishments