Deliverables
Publication of sequenced and annotated metagenomes obtained with already available and new bioinformatics tools. Publication of metagenome data banks.
Improved bioinformatics toolsPublication of new pipelines to assist genome annotation of unknown sequences.On-line open source softwares.
patenting and industrial applicationsPatents and preliminary tests of newly characterized enzymes and new metabolic pathways in industrial application
reports on new biocatalistsPublications on new characterized biocatalists and their potential applications
Joint publications concerning WP1-WP5"Joint publications concerning WP1-WP5. The editor of ""Computational biology and chemistry"" (impact factor 1.7), Wentian Li, invited dr. Pietro Liò (Cambridge) to organize a special issues on this matter."
proposals for new projectsNew proposals for EU projects.
Web page ,Twitter and Facebook account"Publlished web pages ,Twitter and Facebook accounts. Participation to the followung workshops for dissemination: http://www3.unil.ch/wpmu/eseb2015/ http://sbg.org.br/Evolution2015/ http://www.smbe.org/ eccsb/icsb http://www.iscb.org/about-ismb masamb https://twitter.com/theosysbio/status/454249905088114688 cmsb http://cmsb2015.sciencesconf.org/ http://www.physoc.org/suggest-symposium#Physiology_2015 We would like to apply to EMBO (http://applications.embo.org/01/register.php?reg=L06Q). for the organization of a workshop. "
E. focardii genome database and identification of sequences encoding molecules of interest for industrial applications.Publication of an E. focardii genome database. Identified genomic sequences encoding molecules of interest for industrial applications
New insight on the molecular mechanisms responsible for cold-adaptation and/or environmental adaptationPublications on the characterized new insights on the molecular mechanisms responsible for cold and/or environmental adaptation. The coordinator the project has been invited to organize a special issue on Frontiers in Bioengineering and Biotechnology , that will focus on this topic.
New rules for system biologyPubblications of improved bionformatic competence and that defines new rules for system biology.
Annotated genome to be analysed for discovering biomolecules of interest. Publications of data banks.
Characterized new metabolic pathwaysCharacterized new metabolic pathways that may be of interest for bioremediation processes and industrial application
characterization of biocatalysts of interestcharacterized new biocatalysts from extreme microorganisms that may be of interest for industrial applications
Optimized biomoleculesproduction of biomolecules with optimized properties at extreme conditions, such as improved catalytic activity, catalytic specificity, thermostability and many others.
Isolation of microbes that can survive to extreme environments for cultivation when possible that can survive to extreme environments for cultivation when possiblesIsolated and cultivated microbes able to survive to extreme environments, in particular psychrophilic microbes. These microbes can be the source of new enzymes and/or metabolic pathways that can be exploited in industrial applications and for bioremediation.
trained researchers on bioinformaticsTrained ESR on bioinformatics able to analyse genomic and metagenomic sequences.
optimized molecules for bioremediationOptimized molecules for bioremediation with improved degradation activity of pollutants.
Characterized new biocatalistsCharacterizaed biomolecules that may be involved in adaptation to cold and/or extreme environment able to produce compound at low temperatures (with saving of energy) and other extreme conditions (high salt concentration, extreme pH conditions), that may be of interest for industrial applications.
patent on optimized biomolecules that can be provided for industrial applications
PatentsPatent of new softwares, tools and algorithms for system biology.
Publications
Author(s):
Claudio Angione, Pietro Liò, Sandra Pucciarelli, Basarbatu Can, Maxwell Conway, Marina Lotti, Habib Bokhari, Alessio Mancini, Ugur Sezerman, Andrea Telatin
Published in:
Computational Intelligence Methods for Bioinformatics and Biostatistics, Issue 9874, 2016, Page(s) 205-219, ISBN 978-3-319-44331-7
Publisher:
Springer International Publishing
DOI:
10.1007/978-3-319-44332-4_16
Author(s):
Marco Mangiagalli, Guy Sarusi, Aleksei Kaleda, Maya Bar Dolev, Valentina Nardone, Vittoria Federica Vena, Ido Braslavsky, Marina Lotti, Marco Nardini
Published in:
The FEBS Journal, Issue 285/9, 2018, Page(s) 1653-1666, ISSN 1742-464X
Publisher:
Blackwell Publishing Inc.
DOI:
10.1111/febs.14434
Author(s):
Alessandro Pischedda, Kesava Priyan Ramasamy, Marco Mangiagalli, Federica Chiappori, Luciano Milanesi, Cristina Miceli, Sandra Pucciarelli, Marina Lotti
Published in:
Scientific Reports, Issue 8/1, 2018, ISSN 2045-2322
Publisher:
Nature Publishing Group
DOI:
10.1038/s41598-018-33127-1
Author(s):
Alessio Mancini, Sandra Pucciarelli
Published in:
Natural Product Research, 2018, Page(s) 1-6, ISSN 1478-6419
Publisher:
Taylor & Francis
DOI:
10.1080/14786419.2018.1517344
Author(s):
Alessio Mancini, Filmon Eyassu, Maxwell Conway, Annalisa Occhipinti, Pietro Liò, Claudio Angione, Sandra Pucciarelli
Published in:
BMC Bioinformatics, Issue 19/S15, 2018, Page(s) 1-11, ISSN 1471-2105
Publisher:
BioMed Central
DOI:
10.1186/s12859-018-2422-9
Author(s):
M. Lotti, S. Brocca, M. Mangiagalli, A. Pischedda, M. Orlando, S. Maione, D. De Pascale, S. Pucciarelli, M. Nardini, I. Braslavsky
Published in:
New Biotechnology, Issue 44, 2018, Page(s) S43-S44, ISSN 1871-6784
Publisher:
Elsevier BV
DOI:
10.1016/j.nbt.2018.05.091
Author(s):
Aleksei Kaleda, Lotem Haleva, Guy Sarusi, Tova Pinsky, Marco Mangiagalli, Maya Bar Dolev, Marina Lotti, Marco Nardini, Ido Braslavsky
Published in:
Langmuir, 2018, ISSN 0743-7463
Publisher:
American Chemical Society
DOI:
10.1021/acs.langmuir.8b01914
Author(s):
Katre Juganson, Monika Mortimer, Angela Ivask, Sandra Pucciarelli, Cristina Miceli, Kaja Orupõld, Anne Kahru
Published in:
Environmental Pollution, 2017, ISSN 0269-7491
Publisher:
Pergamon Press Ltd.
DOI:
10.1016/j.envpol.2017.03.013
Author(s):
Guang Yang, Hua Yao, Matteo Mozzicafreddo, Patrizia Ballarini, Sandra Pucciarelli, Cristina Miceli
Published in:
Applied and Environmental Microbiology, 2017, Page(s) AEM.00449-17, ISSN 0099-2240
Publisher:
American Society for Microbiology
DOI:
10.1128/AEM.00449-17
Author(s):
Tyler D.R. Vance, Maddalena Bayer-Giraldi, Peter L. Davies, Marco Mangiagalli
Published in:
The FEBS Journal, 2019, ISSN 1742-464X
Publisher:
Blackwell Publishing Inc.
DOI:
10.1111/febs.14764
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