Deliverables Documents, reports (10) metagenome sequence and annotation Publication of sequenced and annotated metagenomes obtained with already available and new bioinformatics tools. Publication of metagenome data banks. Improved bioinformatics tools Publication of new pipelines to assist genome annotation of unknown sequences.On-line open source softwares. patenting and industrial applications Patents and preliminary tests of newly characterized enzymes and new metabolic pathways in industrial application reports on new biocatalists Publications on new characterized biocatalists and their potential applications Joint publications concerning WP1-WP5 "Joint publications concerning WP1-WP5. The editor of ""Computational biology and chemistry"" (impact factor 1.7), Wentian Li, invited dr. Pietro Liò (Cambridge) to organize a special issues on this matter." proposals for new projects New proposals for EU projects. Web page ,Twitter and Facebook account "Publlished web pages ,Twitter and Facebook accounts. Participation to the followung workshops for dissemination: http://www3.unil.ch/wpmu/eseb2015/ http://sbg.org.br/Evolution2015/ http://www.smbe.org/ eccsb/icsb http://www.iscb.org/about-ismb masamb https://twitter.com/theosysbio/status/454249905088114688 cmsb http://cmsb2015.sciencesconf.org/ http://www.physoc.org/suggest-symposium#Physiology_2015 We would like to apply to EMBO (http://applications.embo.org/01/register.php?reg=L06Q). for the organization of a workshop. " E. focardii genome database and identification of sequences encoding molecules of interest for industrial applications. Publication of an E. focardii genome database. Identified genomic sequences encoding molecules of interest for industrial applications New insight on the molecular mechanisms responsible for cold-adaptation and/or environmental adaptation Publications on the characterized new insights on the molecular mechanisms responsible for cold and/or environmental adaptation. The coordinator the project has been invited to organize a special issue on Frontiers in Bioengineering and Biotechnology , that will focus on this topic. New rules for system biology Pubblications of improved bionformatic competence and that defines new rules for system biology. Other (8) genome annotations Annotated genome to be analysed for discovering biomolecules of interest. Publications of data banks. Characterized new metabolic pathways Characterized new metabolic pathways that may be of interest for bioremediation processes and industrial application characterization of biocatalysts of interest characterized new biocatalysts from extreme microorganisms that may be of interest for industrial applications Optimized biomolecules production of biomolecules with optimized properties at extreme conditions, such as improved catalytic activity, catalytic specificity, thermostability and many others. Isolation of microbes that can survive to extreme environments for cultivation when possible that can survive to extreme environments for cultivation when possibles Isolated and cultivated microbes able to survive to extreme environments, in particular psychrophilic microbes. These microbes can be the source of new enzymes and/or metabolic pathways that can be exploited in industrial applications and for bioremediation. trained researchers on bioinformatics Trained ESR on bioinformatics able to analyse genomic and metagenomic sequences. optimized molecules for bioremediation Optimized molecules for bioremediation with improved degradation activity of pollutants. Characterized new biocatalists Characterizaed biomolecules that may be involved in adaptation to cold and/or extreme environment able to produce compound at low temperatures (with saving of energy) and other extreme conditions (high salt concentration, extreme pH conditions), that may be of interest for industrial applications. Websites, patent fillings, videos etc. (2) patent on optimized biomolecules patent on optimized biomolecules that can be provided for industrial applications Patents Patent of new softwares, tools and algorithms for system biology. Publications Book chapters (1) Bioinformatics Challenges and Potentialities in Studying Extreme Environments Author(s): Claudio Angione, Pietro Liò, Sandra Pucciarelli, Basarbatu Can, Maxwell Conway, Marina Lotti, Habib Bokhari, Alessio Mancini, Ugur Sezerman, Andrea Telatin Published in: Computational Intelligence Methods for Bioinformatics and Biostatistics, Issue 9874, 2016, Page(s) 205-219, ISBN 978-3-319-44331-7 Publisher: Springer International Publishing DOI: 10.1007/978-3-319-44332-4_16 Peer reviewed articles (9) Structure of a bacterial ice binding protein with two faces of interaction with ice Author(s): Marco Mangiagalli, Guy Sarusi, Aleksei Kaleda, Maya Bar Dolev, Valentina Nardone, Vittoria Federica Vena, Ido Braslavsky, Marina Lotti, Marco Nardini Published in: The FEBS Journal, Issue 285/9, 2018, Page(s) 1653-1666, ISSN 1742-464X Publisher: Blackwell Publishing Inc. DOI: 10.1111/febs.14434 Antarctic marine ciliates under stress: superoxide dismutases from the psychrophilic Euplotes focardii are cold-active yet heat tolerant enzymes Author(s): Alessandro Pischedda, Kesava Priyan Ramasamy, Marco Mangiagalli, Federica Chiappori, Luciano Milanesi, Cristina Miceli, Sandra Pucciarelli, Marina Lotti Published in: Scientific Reports, Issue 8/1, 2018, ISSN 2045-2322 Publisher: Nature Publishing Group DOI: 10.1038/s41598-018-33127-1 Antibiotic activity of the antioxidant drink effective Microorganism-X (EM-X) extracts against common nosocomial pathogens: an in vitro study Author(s): Alessio Mancini, Sandra Pucciarelli Published in: Natural Product Research, 2018, Page(s) 1-6, ISSN 1478-6419 Publisher: Taylor & Francis DOI: 10.1080/14786419.2018.1517344 CiliateGEM: an open-project and a tool for predictions of ciliate metabolic variations and experimental condition design Author(s): Alessio Mancini, Filmon Eyassu, Maxwell Conway, Annalisa Occhipinti, Pietro Liò, Claudio Angione, Sandra Pucciarelli Published in: BMC Bioinformatics, Issue 19/S15, 2018, Page(s) 1-11, ISSN 1471-2105 Publisher: BioMed Central DOI: 10.1186/s12859-018-2422-9 Enzymes and ice binding proteins from Antarctic organisms Author(s): M. Lotti, S. Brocca, M. Mangiagalli, A. Pischedda, M. Orlando, S. Maione, D. De Pascale, S. Pucciarelli, M. Nardini, I. Braslavsky Published in: New Biotechnology, Issue 44, 2018, Page(s) S43-S44, ISSN 1871-6784 Publisher: Elsevier BV DOI: 10.1016/j.nbt.2018.05.091 Saturn-Shaped Ice Burst Pattern and Fast Basal Binding of an Ice-Binding Protein from an Antarctic Bacterial Consortium Author(s): Aleksei Kaleda, Lotem Haleva, Guy Sarusi, Tova Pinsky, Marco Mangiagalli, Maya Bar Dolev, Marina Lotti, Marco Nardini, Ido Braslavsky Published in: Langmuir, 2018, ISSN 0743-7463 Publisher: American Chemical Society DOI: 10.1021/acs.langmuir.8b01914 Mechanisms of toxic action of silver nanoparticles in the protozoan Tetrahymena thermophila : From gene expression to phenotypic events Author(s): Katre Juganson, Monika Mortimer, Angela Ivask, Sandra Pucciarelli, Cristina Miceli, Kaja Orupõld, Anne Kahru Published in: Environmental Pollution, 2017, ISSN 0269-7491 Publisher: Pergamon Press Ltd. DOI: 10.1016/j.envpol.2017.03.013 Rational engineering of a cold-adapted α-amylase from the Antarctic ciliate Euplotes focardii for simultaneous improvement of thermostability and catalytic activity Author(s): Guang Yang, Hua Yao, Matteo Mozzicafreddo, Patrizia Ballarini, Sandra Pucciarelli, Cristina Miceli Published in: Applied and Environmental Microbiology, 2017, Page(s) AEM.00449-17, ISSN 0099-2240 Publisher: American Society for Microbiology DOI: 10.1128/AEM.00449-17 Ice-binding proteins and the ‘domain of unknown function’ 3494 family Author(s): Tyler D.R. Vance, Maddalena Bayer-Giraldi, Peter L. Davies, Marco Mangiagalli Published in: The FEBS Journal, 2019, ISSN 1742-464X Publisher: Blackwell Publishing Inc. DOI: 10.1111/febs.14764 Searching for OpenAIRE data... There was an error trying to search data from OpenAIRE No results available