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Tailored Elastin-like Recombinamers as Advanced Systems for Cell Therapies in Diabetes Mellitus: a Synthetic Biology Approach towards a Bioeffective and Immunoisolated Biosimilar Islet/Cell Niche

Objective

ELASTISLET aims to create a breakthrough development in encapsulation technology and its use in cell and tissue therapies for the treatment of type 1 and 2 diabetes. ELASTISLET will combine leading technologies in biomaterial design, production and processing, cross-linking/grafting technology and cell therapy, to synergistically integrate them into a new immune-isolation and biomimetic scaffolding approach for islet and cell transplantation in diabetes treatment. ELASTISLET’s starting point is a highly innovative and versatile family of superior biomaterials, the Elastin-like Recombinamers (ELRs). Those innovative materials will be combined with the most cutting-edge encapsulation technologies, such as reactive LbL. ELASTISLET relies on the most innovative ideas taken from synthetic biology, nanobiotechnology and molecular and cellular biology to build the ideal niche for islet/cell encapsulation and transplantation.
ELASTISLET main objective is to achieve a functional coating that fulfils, first, the basic requirements of optimal biocompatibility and physical properties (permselectivity) but, second, generate a capsule that can promote an intense and directed cross talk through all cell-material interfaces involved: the implant-surrounding tissue (outer) interface and cargo cells-capsule (inner) interface. At the end, a capsule that is able not only to cloak its content and isolate it from the immune rejection but that it is able to biologically interact with the surrounding tissues and its cargo simultaneously in a way that the implanted capsule will immediately interact and fuse with the surrounding tissues creating a real continuity of the extracellular matrix from the core of the capsule to the surrounding hosts tissues and procuring adequate nutrient supply. That will provide a physiologically ideal biomimetic environment for the implanted islets/cells to survive and function in the long term without perceiving a foreign, unusual or hostile environment.

Field of science

  • /engineering and technology/materials engineering/coating and films
  • /medical and health sciences/clinical medicine/transplantation
  • /natural sciences/biological sciences/synthetic biology
  • /engineering and technology/industrial biotechnology/biomaterials
  • /medical and health sciences/clinical medicine/endocrinology/diabetes

Call for proposal

H2020-NMP-2014-two-stage
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

UNIVERSIDAD DE VALLADOLID
Address
Plaza Santa Cruz 8 Palacio De Santa Cruz
47002 Valladolid
Spain
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 773 555,97

Participants (11)

UNIVERSIDADE DO MINHO
Portugal
EU contribution
€ 301 121,88
Address
Largo Do Paco
4704 553 Braga
Activity type
Higher or Secondary Education Establishments
THE HEBREW UNIVERSITY OF JERUSALEM
Israel
EU contribution
€ 303 125
Address
Edmond J Safra Campus Givat Ram
91904 Jerusalem
Activity type
Higher or Secondary Education Establishments
MEDIZINISCHE UNIVERSITAET WIEN
Austria
EU contribution
€ 645 750
Address
Spitalgasse 23
1090 Wien
Activity type
Higher or Secondary Education Establishments
UNIVERSITAT BASEL
Switzerland
EU contribution
€ 0
Address
Petersplatz 1
4051 Basel
Activity type
Higher or Secondary Education Establishments
UNIVERSITA DEGLI STUDI DI PERUGIA
Italy
EU contribution
€ 688 579,01
Address
Piazza Dell Universita 1
06123 Perugia
Activity type
Higher or Secondary Education Establishments
Promoscience srl
Italy
EU contribution
€ 262 450
Address
Localita Padriciano 99
34012 Trieste
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
TECHNICAL PROTEINS NANOBIOTECHNOLOGY SL
Spain
EU contribution
€ 489 000
Address
Paseo De Belen 11
47011 Valladolid
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
NCARDIA AG
Germany
EU contribution
€ 341 875
Address
Nattermannallee 1
50829 Koln
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
ASPHALION SL
Spain
EU contribution
€ 222 500
Address
Calle Tarragona, Numeros 151-157, Planta 10, Bloqu
08014 Barcelona
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
UPPSALA UNIVERSITET
Sweden
EU contribution
€ 831 597,51
Address
Von Kraemers Alle 4
751 05 Uppsala
Activity type
Higher or Secondary Education Establishments
UNIVERSIDADE DE AVEIRO
Portugal
EU contribution
€ 354 940,63
Address
Campus Universitário De Santiago
3810-193 Aveiro
Activity type
Higher or Secondary Education Establishments