Molecular mechanisms of autophagosome formation during selective autophagy

Publications

A PI3K-WIPI2 positive feedback loop allosterically activates LC3 lipidation in autophagy

Author(s): Dorotea Fracchiolla, Chunmei Chang, James H. Hurley, Sascha Martens
Published in: Journal of Cell Biology, Issue 219/7, 2020, ISSN 0021-9525
Publisher: Rockefeller University Press
DOI: 10.1083/jcb.201912098

Reconstitution of autophagosome nucleation defines Atg9 vesicles as seeds for membrane formation

Author(s): Justyna Sawa-Makarska, Verena Baumann, Nicolas Coudevylle, Sören von Bülow, Veronika Nogellova, Christine Abert, Martina Schuschnig, Martin Graef, Gerhard Hummer, Sascha Martens
Published in: Science, Issue 369/6508, 2020, Page(s) eaaz7714, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aaz7714

Activation and targeting of ATG8 protein lipidation

Author(s): Sascha Martens, Dorotea Fracchiolla
Published in: Cell Discovery, Issue 6/1, 2020, ISSN 2056-5968
Publisher: Springer
DOI: 10.1038/s41421-020-0155-1

Recruitment and Activation of the ULK1/Atg1 Kinase Complex in Selective Autophagy

Author(s): Eleonora Turco, Dorotea Fracchiolla, Sascha Martens
Published in: Journal of Molecular Biology, Issue 432/1, 2020, Page(s) 123-134, ISSN 0022-2836
Publisher: Academic Press
DOI: 10.1016/j.jmb.2019.07.027

A cross-kingdom conserved ER-phagy receptor maintains endoplasmic reticulum homeostasis during stress

Author(s): Madlen Stephani, Lorenzo Picchianti, Alexander Gajic, Rebecca Beveridge, Emilio Skarwan, Victor Sanchez de Medina Hernandez, Azadeh Mohseni, Marion Clavel, Yonglun Zeng, Christin Naumann, Mateusz Matuszkiewicz, Eleonora Turco, Christian Loefke, Baiying Li, Gerhard Dürnberger, Michael Schutzbier, Hsiao Tieh Chen, Alibek Abdrakhmanov, Adriana Savova, Khong-Sam Chia, Armin Djamei, Irene Schaffner, S
Published in: eLife, Issue 9, 2020, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.58396

p62 filaments capture and present ubiquitinated cargos for autophagy

Author(s): Gabriele Zaffagnini, Adriana Savova, Alberto Danieli, Julia Romanov, Shirley Tremel, Michael Ebner, Thomas Peterbauer, Martin Sztacho, Riccardo Trapannone, Abul K Tarafder, Carsten Sachse, Sascha Martens
Published in: The EMBO Journal, Issue 37/5, 2018, Page(s) e98308, ISSN 0261-4189
Publisher: Nature Publishing Group
DOI: 10.15252/embj.201798308

Conserved Atg8 recognition sites mediate Atg4 association with autophagosomal membranes and Atg8 deconjugation

Author(s): Susana Abreu, Franziska Kriegenburg, Rubén Gómez‐Sánchez, Muriel Mari, Jana Sánchez‐Wandelmer, Mads Skytte Rasmussen, Rodrigo Soares Guimarães, Bettina Zens, Martina Schuschnig, Ralph Hardenberg, Matthias Peter, Terje Johansen, Claudine Kraft, Sascha Martens, Fulvio Reggiori
Published in: EMBO reports, Issue 18/5, 2017, Page(s) 765-780, ISSN 1469-221X
Publisher: Nature Publishing Group
DOI: 10.15252/embr.201643146

Intrinsic lipid binding activity of ATG16L1 supports efficient membrane anchoring and autophagy

Author(s): Leo J Dudley, Ainara G Cabodevilla, Agata N Makar, Martin Sztacho, Tim Michelberger, Joseph A Marsh, Douglas R Houston, Sascha Martens, Xuejun Jiang, Noor Gammoh
Published in: The EMBO Journal, 2019, Page(s) e100554, ISSN 0261-4189
Publisher: Nature Publishing Group
DOI: 10.15252/embj.2018100554

p62-mediated phase separation at the intersection of the ubiquitin-proteasome system and autophagy

Author(s): Alberto Danieli, Sascha Martens
Published in: Journal of Cell Science, Issue 131/19, 2018, Page(s) jcs214304, ISSN 0021-9533
Publisher: The Company of Biologists Ltd.
DOI: 10.1242/jcs.214304

Atg4 proteolytic activity can be inhibited by Atg1 phosphorylation

Author(s): Jana Sánchez-Wandelmer, Franziska Kriegenburg, Sabrina Rohringer, Martina Schuschnig, Rubén Gómez-Sánchez, Bettina Zens, Susana Abreu, Ralph Hardenberg, David Hollenstein, Jieqiong Gao, Christian Ungermann, Sascha Martens, Claudine Kraft, Fulvio Reggiori
Published in: Nature Communications, Issue 8/1, 2017, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-017-00302-3

FIP200 Claw Domain Binding to p62 Promotes Autophagosome Formation at Ubiquitin Condensates

Author(s): Eleonora Turco, Marie Witt, Christine Abert, Tobias Bock-Bierbaum, Ming-Yuan Su, Riccardo Trapannone, Martin Sztacho, Alberto Danieli, Xiaoshan Shi, Gabriele Zaffagnini, Annamaria Gamper, Martina Schuschnig, Dorotea Fracchiolla, Daniel Bernklau, Julia Romanov, Markus Hartl, James H. Hurley, Oliver Daumke, Sascha Martens
Published in: Molecular Cell, 2019, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2019.01.035

Accessory Interaction Motifs in the Atg19 Cargo Receptor Enable Strong Binding to the Clustered Ubiquitin-related Atg8 Protein

Author(s): Christine Abert, Georg Kontaxis, Sascha Martens
Published in: Journal of Biological Chemistry, Issue 291/36, 2016, Page(s) 18799-18808, ISSN 0021-9258
Publisher: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.M116.736892

Insights into autophagosome biogenesis from in vitro reconstitutions

Author(s): Eleonora Turco, Sascha Martens
Published in: Journal of Structural Biology, Issue 196/1, 2016, Page(s) 29-36, ISSN 1047-8477
Publisher: Academic Press
DOI: 10.1016/j.jsb.2016.04.005

Phospholipids in Autophagosome Formation and Fusion

Author(s): Sascha Martens, Shuhei Nakamura, Tamotsu Yoshimori
Published in: Journal of Molecular Biology, Issue 428/24, 2016, Page(s) 4819-4827, ISSN 0022-2836
Publisher: Academic Press
DOI: 10.1016/j.jmb.2016.10.029

Mechanism of cargo-directed Atg8 conjugation during selective autophagy

Author(s): Dorotea Fracchiolla, Justyna Sawa-Makarska, Bettina Zens, Anita de Ruiter, Gabriele Zaffagnini, Andrea Brezovich, Julia Romanov, Kathrin Runggatscher, Claudine Kraft, Bojan Zagrovic, Sascha Martens
Published in: eLife, Issue 5, 2016, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/eLife.18544

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