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Multiscale modelling of stimuli-responsive nanoreactors

Project description

Revolutionising the nanoparticle catalysis process

The advancement and refinement of nanoscience play a pivotal role in numerous industries and fields, offering solutions to existing problems and providing alternative options. Among these nanoscience fields, catalysis using metal nanoparticles holds significant potential for yielding substantial benefits, especially given the increasing demand for fuel, environmental remediation and climate change-related drugs. The ERC-funded NANOREACTOR project aims to drive innovation by pushing the boundaries of nanoparticle catalysis. To achieve this goal, the project will employ thermosensitive yolk-shell carrier systems, thereby enhancing the catalytic process with improved control and efficiency.


The catalysis by metal nanoparticles is one of the fastest growing areas in nanoscience due to our society's exploding need for fuels, drugs, and environmental remediation. However, the optimal control of catalytic activity and selectivity remains one of the grand challenges in the 21st century.

Here, I propose to theoretically derive design rules for the optimization of nanoparticle catalysis by means of thermosensitive yolk-shell carrier systems. In the latter, the nanoparticle is stabilized in solution by an encapsulating, thermosensitive hydrogel shell. The physicochemical properties of this polymeric 'nanogate' react to stimuli in the environment and thus permit the reactant transport and the diffusion-controlled part of the catalytic reaction to be switched and tuned, e.g. by the temperature or the pH. The novel hybrid character of these emerging 'nanoreactors' opens up unprecedented ways for the control of nanocatalysis due to new designable degrees of freedom.

The complex mechanisms behind stimuli-responsive nanocatalysis call for a concerted, interdisciplinary modelling approach that has converged in my group in the recent years. In particular, it can only be achieved by combining my expertise in multiscale computer simulations of solvated polymers with the statistical and continuum mechanics of soft matter structures and dynamics. The key challenge is to integrate the molecular solvation effects and our growing knowledge of hydrogel mechanics and thermodynamics into advanced reaction-diffusion equations for a quantitative rate prediction. In addition, I envision exciting novel phenomena such as a chemo-mechanical 'self-regulated catalysis' or an amplifying 'resonant catalysis', if hydrogel response and fluctuations couple to the chemical output signal.

The expected results and design principles will help our collaborators to synthesize tailor-made, superior nanocatalysts and will advance our understanding of their structure-reactivity relationship.



Net EU contribution
€ 558 437,50
79098 Freiburg

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Baden-Württemberg Freiburg Freiburg im Breisgau, Stadtkreis
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00

Beneficiaries (2)