MicroRNA determinants of the balance between effector and regulatory T cells in vivo

Project Information

DevoTed_miR

Grant agreement ID: 646701

DOI 10.3030/646701

Project closed

EC signature date 23 June 2015

Start date 1 July 2015

End date 28 February 2021

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 2 000 000,00

EU contribution € 2 000 000,00

Coordinated by

INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES
Portugal

Publications

Peer reviewed articles (23)

A population of proinflammatory T cells coexpresses αβ and γδ T cell receptors in mice and humans

Author(s): Sarah C. Edwards, Caroline E. Sutton, Kristin Ladell, Emma J. Grant, James E. McLaren, Fiona Roche, Pradyot Dash, Nopporn Apiwattanakul, Walid Awad, Kelly L. Miners, Stephen J. Lalor, Julie C. Ribot, Song Baik, Barry Moran, Aoife McGinley, Valerie Pivorunas, Lori Dowding, Michael Macoritto, Jesus Paez-Cortez, Anthony Slavin, Graham Anderson, Bruno Silva-Santos, Karsten Hokamp, David A. Price, Paul
Published in: Journal of Experimental Medicine, Issue 217/5, 2020, ISSN 0022-1007
Publisher: Rockefeller University Press
DOI: 10.1084/jem.20190834

From thymus to periphery: Molecular basis of effector γδ‐T cell differentiation

Author(s): Gina J. Fiala, Anita Q. Gomes, Bruno Silva‐Santos
Published in: Immunological Reviews, Issue 298/1, 2020, Page(s) 47-60, ISSN 0105-2896
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/imr.12918

γδ T cells in malaria: a double‐edged sword

Author(s): Ana Pamplona, Bruno Silva‐Santos
Published in: The FEBS Journal, Issue 288/4, 2021, Page(s) 1118-1129, ISSN 1742-464X
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/febs.15494

IL‐23 drives differentiation of peripheral γδ17 T cells from adult bone marrow‐derived precursors

Author(s): Pedro H Papotto, Natacha Gonçalves‐Sousa, Nina Schmolka, Andrea Iseppon, Sofia Mensurado, Brigitta Stockinger, Julie C Ribot, Bruno Silva‐Santos
Published in: EMBO reports, Issue 18/11, 2017, Page(s) 1957-1967, ISSN 1469-221X
Publisher: Nature Publishing Group
DOI: 10.15252/embr.201744200

IL-17+ γδ T cells as kick-starters of inflammation

Author(s): Pedro H Papotto, Julie C Ribot, Bruno Silva-Santos
Published in: Nature Immunology, Issue 18/6, 2017, Page(s) 604-611, ISSN 1529-2908
Publisher: Nature Publishing Group
DOI: 10.1038/ni.3726

Strong TCRγδ Signaling Prohibits Thymic Development of IL-17A-Secreting γδ T Cells

Author(s): Nital Sumaria, Capucine L. Grandjean, Bruno Silva-Santos, Daniel J. Pennington
Published in: Cell Reports, Issue 19/12, 2017, Page(s) 2469-2476, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2017.05.071

Primary Tumors Limit Metastasis Formation through Induction of IL15-Mediated Cross-Talk between Patrolling Monocytes and NK Cells

Author(s): Hiroshi Kubo, Sofia Mensurado, Natacha Gonçalves-Sousa, Karine Serre, Bruno Silva-Santos
Published in: Cancer Immunology Research, Issue 5/9, 2017, Page(s) 812-820, ISSN 2326-6066
Publisher: American Association for Cancer Research Inc.
DOI: 10.1158/2326-6066.CIR-17-0082

Innately versatile: γδ17 T cells in inflammatory and autoimmune diseases

Author(s): Pedro H. Papotto, Annika Reinhardt, Immo Prinz, Bruno Silva-Santos
Published in: Journal of Autoimmunity, Issue 87, 2018, Page(s) 26-37, ISSN 0896-8411
Publisher: Academic Press
DOI: 10.1016/j.jaut.2017.11.006

Thymic Determinants of γδ T Cell Differentiation

Author(s): Miguel Muñoz-Ruiz, Nital Sumaria, Daniel J. Pennington, Bruno Silva-Santos
Published in: Trends in Immunology, Issue 38/5, 2017, Page(s) 336-344, ISSN 1471-4906
Publisher: Elsevier BV
DOI: 10.1016/j.it.2017.01.007

γδ T cells get adaptive

Author(s): Bruno Silva-Santos, Jessica Strid
Published in: Nature Immunology, Issue 18/4, 2017, Page(s) 370-372, ISSN 1529-2908
Publisher: Nature Publishing Group
DOI: 10.1038/ni.3705

Control of T cell effector functions by miRNAs

Author(s): Daniel P. Inácio, Tiago Amado, Bruno Silva-Santos, Anita Q. Gomes
Published in: Cancer Letters, Issue 427, 2018, Page(s) 63-73, ISSN 0304-3835
Publisher: Elsevier BV
DOI: 10.1016/j.canlet.2018.04.011

Tumor-associated neutrophils suppress pro-tumoral IL-17+ γδ T cells through induction of oxidative stress

Author(s): Sofia Mensurado, Margarida Rei, Telma Lança, Marianna Ioannou, Natacha Gonçalves-Sousa, Hiroshi Kubo, Marie Malissen, Venizelos Papayannopoulos, Karine Serre, Bruno Silva-Santos
Published in: PLOS Biology, Issue 16/5, 2018, Page(s) e2004990, ISSN 1545-7885
Publisher: Public Library of Science
DOI: 10.1371/journal.pbio.2004990

The Emerging Complexity of γδT17 Cells

Author(s): Duncan R. McKenzie, Iain Comerford, Bruno Silva-Santos, Shaun R. McColl
Published in: Frontiers in Immunology, Issue 9, 2018, ISSN 1664-3224
Publisher: Frontiers
DOI: 10.3389/fimmu.2018.00796

MicroRNA-146a controls functional plasticity in γδ T cells by targeting NOD1

Author(s): Nina Schmolka, Pedro H. Papotto, Paula Vargas Romero, Tiago Amado, Francisco J. Enguita, Ana Amorim, Ana F. Rodrigues, Katrina E. Gordon, Ana S. Coroadinha, Mark Boldin, Karine Serre, Amy H. Buck, Anita Q. Gomes, Bruno Silva-Santos
Published in: Science Immunology, Issue 3/23, 2018, Page(s) eaao1392, ISSN 2470-9468
Publisher: AAAS
DOI: 10.1126/sciimmunol.aao1392

TCR signal strength controls thymic differentiation of discrete proinflammatory γδ T cell subsets

Author(s): Miguel Muñoz-Ruiz, Julie C Ribot, Ana R Grosso, Natacha Gonçalves-Sousa, Ana Pamplona, Daniel J Pennington, José R Regueiro, Edgar Fernández-Malavé, Bruno Silva-Santos
Published in: Nature Immunology, Issue 17/6, 2016, Page(s) 721-727, ISSN 1529-2908
Publisher: Nature Publishing Group
DOI: 10.1038/ni.3424

Casein kinase 2 controls the survival of normal thymic and leukemic γδ T cells via promotion of AKT signaling

Author(s): S T Ribeiro, M Tesio, J C Ribot, E Macintyre, J T Barata, B Silva-Santos
Published in: Leukemia, 2016, ISSN 0887-6924
Publisher: Nature Publishing Group
DOI: 10.1038/leu.2016.363

γδ T cells: pleiotropic immune effectors with therapeutic potential in cancer

Author(s): Bruno Silva-Santos, Sofia Mensurado, Seth B. Coffelt
Published in: Nature Reviews Cancer, Issue 19/7, 2019, Page(s) 392-404, ISSN 1474-175X
Publisher: Nature Publishing Group
DOI: 10.1038/s41568-019-0153-5

Meningeal γδ T cell–derived IL-17 controls synaptic plasticity and short-term memory

Author(s): Miguel Ribeiro, Helena C. Brigas, Mariana Temido-Ferreira, Paula A. Pousinha, Tommy Regen, Cátia Santa, Joana E. Coelho, Inês Marques-Morgado, Cláudia A. Valente, Sara Omenetti, Brigitta Stockinger, Ari Waisman, Bruno Manadas, Luísa V. Lopes, Bruno Silva-Santos, Julie C. Ribot
Published in: Science Immunology, Issue 4/40, 2019, Page(s) eaay5199, ISSN 2470-9468
Publisher: Science Immunology
DOI: 10.1126/sciimmunol.aay5199

γδ-T cells promote IFN-γ–dependent Plasmodium pathogenesis upon liver-stage infection

Author(s): Julie C. Ribot, Rita Neres, Vanessa Zuzarte-Luís, Anita Q. Gomes, Liliana Mancio-Silva, Sofia Mensurado, Daniel Pinto-Neves, Miguel M. Santos, Tânia Carvalho, Jonathan J. M. Landry, Eva A. Rolo, Ankita Malik, Daniel Varón Silva, Maria M. Mota, Bruno Silva-Santos, Ana Pamplona
Published in: Proceedings of the National Academy of Sciences, 2019, Page(s) 201814440, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.1814440116

Delta One T Cells for Immunotherapy of Chronic Lymphocytic Leukemia: Clinical-Grade Expansion/Differentiation and Preclinical Proof of Concept

Author(s): A. R. Almeida, D. V. Correia, A. Fernandes-Platzgummer, C. L. da Silva, M. G. da Silva, D. R. Anjos, B. Silva-Santos
Published in: Clinical Cancer Research, Issue 22/23, 2016, Page(s) 5795-5804, ISSN 1078-0432
Publisher: American Association for Cancer Research
DOI: 10.1158/1078-0432.ccr-16-0597

Lineage tracing of acute myeloid leukemia reveals the impact of hypomethylating agents on chemoresistance selection

Author(s): Francisco Caiado, Diogo Maia-Silva, Carolina Jardim, Nina Schmolka, Tânia Carvalho, Cláudia Reforço, Rita Faria, Branka Kolundzija, André E. Simões, Tuncay Baubec, Christopher R. Vakoc, Maria Gomes da Silva, Markus G. Manz, Ton N. Schumacher, Håkan Norell, Bruno Silva-Santos
Published in: Nature Communications, Issue 10/1, 2019, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-019-12983-z

Distinct metabolic programs established in the thymus control effector functions of γδ T cell subsets in tumor microenvironments

Author(s): Noella Lopes, Claire McIntyre, Stefania Martin, Mathilde Raverdeau, Nital Sumaria, Ayano C. Kohlgruber, Gina J. Fiala, Leandro Z. Agudelo, Lydia Dyck, Harry Kane, Aaron Douglas, Stephen Cunningham, Hannah Prendeville, Roisin Loftus, Colleen Carmody, Philippe Pierre, Manolis Kellis, Michael Brenner, Rafael J. Argüello, Bruno Silva-Santos, Daniel J. Pennington, Lydia Lynch
Published in: Nature Immunology, Issue 22/2, 2021, Page(s) 179-192, ISSN 1529-2908
Publisher: Nature Publishing Group
DOI: 10.1038/s41590-020-00848-3

MicroRNA-181a regulates IFN-γ expression in effector CD8+ T cell differentiation

Author(s): Tiago Amado, Ana Amorim, Francisco J. Enguita, Paula V. Romero, Daniel Inácio, Marta Pires de Miranda, Samantha J. Winter, J. Pedro Simas, Andreas Krueger, Nina Schmolka, Bruno Silva-Santos, Anita Q. Gomes
Published in: Journal of Molecular Medicine, Issue 98/2, 2020, Page(s) 309-320, ISSN 0946-2716
Publisher: Springer Verlag
DOI: 10.1007/s00109-019-01865-y