Analysis, Design and Experimental Evolution of Novel Carbon Fixation Pathways

Project Information

NOVCARBFIX

Grant agreement ID: 646827

DOI 10.3030/646827

Project closed

EC signature date 20 May 2015

Start date 1 January 2016

End date 31 December 2020

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 999 843,00

EU contribution € 1 999 843,00

Coordinated by

WEIZMANN INSTITUTE OF SCIENCE
Israel

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (15)

Revisiting Trade-offs between Rubisco Kinetic Parameters

Author(s): Avi I. Flamholz, Noam Prywes, Uri Moran, Dan Davidi, Yinon M. Bar-On, Luke M. Oltrogge, Rui Alves, David Savage, Ron Milo
Published in: Biochemistry, Issue 58/31, 2019, Page(s) 3365-3376, ISSN 0006-2960
Publisher: American Chemical Society
DOI: 10.1021/acs.biochem.9b00237

The Biomass Composition of the Oceans: A Blueprint of Our Blue Planet

Author(s): Yinon M. Bar-On, Ron Milo
Published in: Cell, Issue 179/7, 2019, Page(s) 1451-1454, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2019.11.018

Functional reconstitution of a bacterial CO2 concentrating mechanism in Escherichia coli

Author(s): Avi I Flamholz, Eli Dugan, Cecilia Blikstad, Shmuel Gleizer, Roee Ben-Nissan, Shira Amram, Niv Antonovsky, Sumedha Ravishankar, Elad Noor, Arren Bar-Even, Ron Milo, David F Savage
Published in: eLife, Issue 9, 2020, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.59882

A Bird’s-Eye View of Enzyme Evolution: Chemical, Physicochemical, and Physiological Considerations

Author(s): Dan Davidi, Liam M. Longo, Jagoda Jabłońska, Ron Milo, Dan S. Tawfik
Published in: Chemical Reviews, Issue 118/18, 2018, Page(s) 8786-8797, ISSN 0009-2665
Publisher: American Chemical Society
DOI: 10.1021/acs.chemrev.8b00039

Engineering Microbes to Produce Fuel, Commodities, and Food from CO2

Author(s): Shmuel Gleizer, Yinon M. Bar-On, Roee Ben-Nissan, Ron Milo
Published in: Cell Reports Physical Science, Issue 1/10, 2020, Page(s) 100223, ISSN 2666-3864
Publisher: Cell Reports Physical Science
DOI: 10.1016/j.xcrp.2020.100223

pH determines the energetic efficiency of the cyanobacterial CO 2 concentrating mechanism

Author(s): Niall M. Mangan, Avi Flamholz, Rachel D. Hood, Ron Milo, David F. Savage
Published in: Proceedings of the National Academy of Sciences, Issue 113/36, 2016, Page(s) E5354-E5362, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.1525145113

The opportunity cost of animal based diets exceeds all food losses

Author(s): Alon Shepon, Gidon Eshel, Elad Noor, Ron Milo
Published in: Proceedings of the National Academy of Sciences, Issue 115/15, 2018, Page(s) 3804-3809, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.1713820115

The genetic basis for the adaptation of E. coli to sugar synthesis from CO2

Author(s): Elad Herz, Niv Antonovsky, Yinon Bar-On, Dan Davidi, Shmuel Gleizer, Noam Prywes, Lianet Noda-Garcia, Keren Lyn Frisch, Yehudit Zohar, David G. Wernick, Alon Savidor, Uri Barenholz, Ron Milo
Published in: Nature Communications, Issue 8/1, 2017, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-017-01835-3

Design principles of autocatalytic cycles constrain enzyme kinetics and force low substrate saturation at flux branch points

Author(s): Uri Barenholz, Dan Davidi, Ed Reznik, Yinon Bar-On, Niv Antonovsky, Elad Noor, Ron Milo
Published in: eLife, Issue 6, 2017, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/eLife.20667

Revised Estimates for the Number of Human and Bacteria Cells in the Body

Author(s): Ron Sender, Shai Fuchs, Ron Milo
Published in: PLOS Biology, Issue 14/8, 2016, Page(s) e1002533, ISSN 1545-7885
Publisher: PLOS
DOI: 10.1371/journal.pbio.1002533

A Minimalistic Resource Allocation Model to Explain Ubiquitous Increase in Protein Expression with Growth Rate

Author(s): Uri Barenholz, Leeat Keren, Eran Segal, Ron Milo
Published in: PLOS ONE, Issue 11/4, 2016, Page(s) e0153344, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0153344

Sugar Synthesis from CO2 in Escherichia coli

Author(s): Niv Antonovsky, Shmuel Gleizer, Elad Noor, Yehudit Zohar, Elad Herz, Uri Barenholz, Lior Zelcbuch, Shira Amram, Aryeh Wides, Naama Tepper, Dan Davidi, Yinon Bar-On, Tasneem Bareia, David G. Wernick, Ido Shani, Sergey Malitsky, Ghil Jona, Arren Bar-Even, Ron Milo
Published in: Cell, Issue 166/1, 2016, Page(s) 115-125, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2016.05.064

Conversion of Escherichia coli to Generate All Biomass Carbon from CO2.

Author(s): Gleizer, Shmuel; Ben-Nissan, Roee; Bar-On, Yinon M.; Antonovsky, Niv; Noor, Elad; id_orcid0000-0001-8776-4799; Zohar, Yehudit; Jona, Ghil; Krieger, Eyal; Shamshoum, Melina; Bar-Even, Arren; Milo, Ron
Published in: Cell, 179 (6), Issue 1, 2019, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.3929/ethz-b-000384652

Highly active rubiscos discovered by systematic interrogation of natural sequence diversity

Author(s): Dan Davidi, Melina Shamshoum, Zhijun Guo, Yinon M Bar‐On, Noam Prywes, Aia Oz, Jagoda Jablonska, Avi Flamholz, David G Wernick, Niv Antonovsky, Benoit Pins, Lior Shachar, Dina Hochhauser, Yoav Peleg, Shira Albeck, Itai Sharon, Oliver Mueller‐Cajar, Ron Milo
Published in: The EMBO Journal, Issue 39/18, 2020, ISSN 0261-4189
Publisher: Nature Publishing Group
DOI: 10.15252/embj.2019104081

Point mutations in topoisomerase I alter the mutation spectrum in E. coli and impact the emergence of drug resistance genotypes

Author(s): Amit Bachar, Elad Itzhaki, Shmuel Gleizer, Melina Shamshoom, Ron Milo, Niv Antonovsky
Published in: Nucleic Acids Research, Issue 48/2, 2019, Page(s) 761-769, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkz1100