Analysis, Design and Experimental Evolution of Novel Carbon Fixation Pathways

Informazioni relative al progetto

NOVCARBFIX

ID dell’accordo di sovvenzione: 646827

DOI 10.3030/646827

Progetto chiuso

Data della firma CE 20 Maggio 2015

Data di avvio 1 Gennaio 2016

Data di completamento 31 Dicembre 2020

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale € 1 999 843,00

Contributo UE € 1 999 843,00

Coordinato da

WEIZMANN INSTITUTE OF SCIENCE
Israel

Pubblicazioni

Peer reviewed articles (15)

Revisiting Trade-offs between Rubisco Kinetic Parameters

Autori: Avi I. Flamholz, Noam Prywes, Uri Moran, Dan Davidi, Yinon M. Bar-On, Luke M. Oltrogge, Rui Alves, David Savage, Ron Milo
Pubblicato in: Biochemistry, Numero 58/31, 2019, Pagina/e 3365-3376, ISSN 0006-2960
Editore: American Chemical Society
DOI: 10.1021/acs.biochem.9b00237

The Biomass Composition of the Oceans: A Blueprint of Our Blue Planet

Autori: Yinon M. Bar-On, Ron Milo
Pubblicato in: Cell, Numero 179/7, 2019, Pagina/e 1451-1454, ISSN 0092-8674
Editore: Cell Press
DOI: 10.1016/j.cell.2019.11.018

Functional reconstitution of a bacterial CO2 concentrating mechanism in Escherichia coli

Autori: Avi I Flamholz, Eli Dugan, Cecilia Blikstad, Shmuel Gleizer, Roee Ben-Nissan, Shira Amram, Niv Antonovsky, Sumedha Ravishankar, Elad Noor, Arren Bar-Even, Ron Milo, David F Savage
Pubblicato in: eLife, Numero 9, 2020, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/elife.59882

A Bird’s-Eye View of Enzyme Evolution: Chemical, Physicochemical, and Physiological Considerations

Autori: Dan Davidi, Liam M. Longo, Jagoda Jabłońska, Ron Milo, Dan S. Tawfik
Pubblicato in: Chemical Reviews, Numero 118/18, 2018, Pagina/e 8786-8797, ISSN 0009-2665
Editore: American Chemical Society
DOI: 10.1021/acs.chemrev.8b00039

Engineering Microbes to Produce Fuel, Commodities, and Food from CO2

Autori: Shmuel Gleizer, Yinon M. Bar-On, Roee Ben-Nissan, Ron Milo
Pubblicato in: Cell Reports Physical Science, Numero 1/10, 2020, Pagina/e 100223, ISSN 2666-3864
Editore: Cell Reports Physical Science
DOI: 10.1016/j.xcrp.2020.100223

pH determines the energetic efficiency of the cyanobacterial CO 2 concentrating mechanism

Autori: Niall M. Mangan, Avi Flamholz, Rachel D. Hood, Ron Milo, David F. Savage
Pubblicato in: Proceedings of the National Academy of Sciences, Numero 113/36, 2016, Pagina/e E5354-E5362, ISSN 0027-8424
Editore: National Academy of Sciences
DOI: 10.1073/pnas.1525145113

The opportunity cost of animal based diets exceeds all food losses

Autori: Alon Shepon, Gidon Eshel, Elad Noor, Ron Milo
Pubblicato in: Proceedings of the National Academy of Sciences, Numero 115/15, 2018, Pagina/e 3804-3809, ISSN 0027-8424
Editore: National Academy of Sciences
DOI: 10.1073/pnas.1713820115

The genetic basis for the adaptation of E. coli to sugar synthesis from CO2

Autori: Elad Herz, Niv Antonovsky, Yinon Bar-On, Dan Davidi, Shmuel Gleizer, Noam Prywes, Lianet Noda-Garcia, Keren Lyn Frisch, Yehudit Zohar, David G. Wernick, Alon Savidor, Uri Barenholz, Ron Milo
Pubblicato in: Nature Communications, Numero 8/1, 2017, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-017-01835-3

Design principles of autocatalytic cycles constrain enzyme kinetics and force low substrate saturation at flux branch points

Autori: Uri Barenholz, Dan Davidi, Ed Reznik, Yinon Bar-On, Niv Antonovsky, Elad Noor, Ron Milo
Pubblicato in: eLife, Numero 6, 2017, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/eLife.20667

Revised Estimates for the Number of Human and Bacteria Cells in the Body

Autori: Ron Sender, Shai Fuchs, Ron Milo
Pubblicato in: PLOS Biology, Numero 14/8, 2016, Pagina/e e1002533, ISSN 1545-7885
Editore: PLOS
DOI: 10.1371/journal.pbio.1002533

A Minimalistic Resource Allocation Model to Explain Ubiquitous Increase in Protein Expression with Growth Rate

Autori: Uri Barenholz, Leeat Keren, Eran Segal, Ron Milo
Pubblicato in: PLOS ONE, Numero 11/4, 2016, Pagina/e e0153344, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0153344

Sugar Synthesis from CO2 in Escherichia coli

Autori: Niv Antonovsky, Shmuel Gleizer, Elad Noor, Yehudit Zohar, Elad Herz, Uri Barenholz, Lior Zelcbuch, Shira Amram, Aryeh Wides, Naama Tepper, Dan Davidi, Yinon Bar-On, Tasneem Bareia, David G. Wernick, Ido Shani, Sergey Malitsky, Ghil Jona, Arren Bar-Even, Ron Milo
Pubblicato in: Cell, Numero 166/1, 2016, Pagina/e 115-125, ISSN 0092-8674
Editore: Cell Press
DOI: 10.1016/j.cell.2016.05.064

Conversion of Escherichia coli to Generate All Biomass Carbon from CO2.

Autori: Gleizer, Shmuel; Ben-Nissan, Roee; Bar-On, Yinon M.; Antonovsky, Niv; Noor, Elad; id_orcid0000-0001-8776-4799; Zohar, Yehudit; Jona, Ghil; Krieger, Eyal; Shamshoum, Melina; Bar-Even, Arren; Milo, Ron
Pubblicato in: Cell, 179 (6), Numero 1, 2019, ISSN 0092-8674
Editore: Cell Press
DOI: 10.3929/ethz-b-000384652

Highly active rubiscos discovered by systematic interrogation of natural sequence diversity

Autori: Dan Davidi, Melina Shamshoum, Zhijun Guo, Yinon M Bar‐On, Noam Prywes, Aia Oz, Jagoda Jablonska, Avi Flamholz, David G Wernick, Niv Antonovsky, Benoit Pins, Lior Shachar, Dina Hochhauser, Yoav Peleg, Shira Albeck, Itai Sharon, Oliver Mueller‐Cajar, Ron Milo
Pubblicato in: The EMBO Journal, Numero 39/18, 2020, ISSN 0261-4189
Editore: Nature Publishing Group
DOI: 10.15252/embj.2019104081

Point mutations in topoisomerase I alter the mutation spectrum in E. coli and impact the emergence of drug resistance genotypes

Autori: Amit Bachar, Elad Itzhaki, Shmuel Gleizer, Melina Shamshoom, Ron Milo, Niv Antonovsky
Pubblicato in: Nucleic Acids Research, Numero 48/2, 2019, Pagina/e 761-769, ISSN 0305-1048
Editore: Oxford University Press
DOI: 10.1093/nar/gkz1100