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Organ-specific mechanisms of lymphatic vascular development and specialisation

Publications

Smooth muscle cell recruitment to lymphatic vessels requires PDGFB and impacts vessel size but not identity

Author(s): Yixin Wang, Yi Jin, Maarja Andaloussi Mäe, Yang Zhang, Henrik Ortsäter, Christer Betsholtz, Taija Mäkinen, Lars Jakobsson
Published in: Development, Issue 144/19, 2017, Page(s) 3590-3601, ISSN 0950-1991
DOI: 10.1242/dev.147967

Vascular heterogeneity and specialization in development and disease

Author(s): Michael Potente, Taija Mäkinen
Published in: Nature Reviews Molecular Cell Biology, Issue 18/8, 2017, Page(s) 477-494, ISSN 1471-0072
DOI: 10.1038/nrm.2017.36

Heterogeneity in VEGFR3 levels drives lymphatic vessel hyperplasia through cell-autonomous and non-cell-autonomous mechanisms

Author(s): Yan Zhang, Maria H. Ulvmar, Lukas Stanczuk, Ines Martinez-Corral, Maike Frye, Kari Alitalo, Taija Mäkinen
Published in: Nature Communications, Issue 9/1, 2018, ISSN 2041-1723
DOI: 10.1038/s41467-018-03692-0

Matrix stiffness controls lymphatic vessel formation through regulation of a GATA2-dependent transcriptional program

Author(s): Maike Frye, Andrea Taddei, Cathrin Dierkes, Ines Martinez-Corral, Matthew Fielden, Henrik Ortsäter, Jan Kazenwadel, Dinis P. Calado, Pia Ostergaard, Marjo Salminen, Liqun He, Natasha L. Harvey, Friedemann Kiefer, Taija Mäkinen
Published in: Nature Communications, Issue 9/1, 2018, ISSN 2041-1723
DOI: 10.1038/s41467-018-03959-6

Transient loss of venous integrity during developmental vascular remodeling leads to red blood cell extravasation and clearance by lymphatic vessels

Author(s): Yang Zhang, Nina Daubel, Simon Stritt, Taija Mäkinen
Published in: Development, Issue 145/3, 2018, Page(s) dev156745, ISSN 0950-1991
DOI: 10.1242/dev.156745

Heterogeneity in the lymphatic vascular system and its origin

Author(s): Maria H. Ulvmar, Taija Mäkinen
Published in: Cardiovascular Research, Issue 111/4, 2016, Page(s) 310-321, ISSN 0008-6363
DOI: 10.1093/cvr/cvw175

Vegfr3-CreER T2 mouse, a new genetic tool for targeting the lymphatic system

Author(s): Ines Martinez-Corral, Lukas Stanczuk, Maike Frye, Maria Helena Ulvmar, Rodrigo Diéguez-Hurtado, David Olmeda, Taija Makinen, Sagrario Ortega
Published in: Angiogenesis, Issue 19/3, 2016, Page(s) 433-445, ISSN 0969-6970
DOI: 10.1007/s10456-016-9505-x

Blockade of VEGF-C signaling inhibits lymphatic malformations driven by oncogenic PIK3CA mutation

Author(s): Ines Martinez-Corral, Yan Zhang, Milena Petkova, Henrik Ortsäter, Sofie Sjöberg, Sandra D. Castillo, Pascal Brouillard, Louis Libbrecht, Dieter Saur, Mariona Graupera, Kari Alitalo, Laurence Boon, Miikka Vikkula, Taija Mäkinen
Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
DOI: 10.1038/s41467-020-16496-y