Organ-specific mechanisms of lymphatic vascular development and specialisation

Project Information

LYMPHORG

Grant agreement ID: 646849

DOI

10.3030/646849

Project closed

EC signature date 23 April 2015

Start date 1 May 2015

End date 30 April 2020

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 368 439,00

EU contribution

€ 2 368 439,00

Coordinated by

UPPSALA UNIVERSITET
Sweden

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (10)

Smooth muscle cell recruitment to lymphatic vessels requires PDGFB and impacts vessel size but not identity

Author(s): Yixin Wang, Yi Jin, Maarja Andaloussi Mäe, Yang Zhang, Henrik Ortsäter, Christer Betsholtz, Taija Mäkinen, Lars Jakobsson
Published in: Development, Issue 144/19, 2017, Page(s) 3590-3601, ISSN 0950-1991
Publisher: The Company of Biologists Ltd.
DOI: 10.1242/dev.147967

Vascular heterogeneity and specialization in development and disease

Author(s): Michael Potente, Taija Mäkinen
Published in: Nature Reviews Molecular Cell Biology, Issue 18/8, 2017, Page(s) 477-494, ISSN 1471-0072
Publisher: Nature Publishing Group
DOI: 10.1038/nrm.2017.36

Heterogeneity in VEGFR3 levels drives lymphatic vessel hyperplasia through cell-autonomous and non-cell-autonomous mechanisms

Author(s): Yan Zhang, Maria H. Ulvmar, Lukas Stanczuk, Ines Martinez-Corral, Maike Frye, Kari Alitalo, Taija Mäkinen
Published in: Nature Communications, Issue 9/1, 2018, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-018-03692-0

Matrix stiffness controls lymphatic vessel formation through regulation of a GATA2-dependent transcriptional program

Author(s): Maike Frye, Andrea Taddei, Cathrin Dierkes, Ines Martinez-Corral, Matthew Fielden, Henrik Ortsäter, Jan Kazenwadel, Dinis P. Calado, Pia Ostergaard, Marjo Salminen, Liqun He, Natasha L. Harvey, Friedemann Kiefer, Taija Mäkinen
Published in: Nature Communications, Issue 9/1, 2018, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-018-03959-6

Transient loss of venous integrity during developmental vascular remodeling leads to red blood cell extravasation and clearance by lymphatic vessels

Author(s): Yang Zhang, Nina Daubel, Simon Stritt, Taija Mäkinen
Published in: Development, Issue 145/3, 2018, Page(s) dev156745, ISSN 0950-1991
Publisher: The Company of Biologists Ltd.
DOI: 10.1242/dev.156745

Heterogeneity in the lymphatic vascular system and its origin

Author(s): Maria H. Ulvmar, Taija Mäkinen
Published in: Cardiovascular Research, Issue 111/4, 2016, Page(s) 310-321, ISSN 0008-6363
Publisher: Elsevier BV
DOI: 10.1093/cvr/cvw175

Pdgfrb-Cre targets lymphatic endothelial cells of both venous and non-venous origins

Author(s): Maria H. Ulvmar, Ines Martinez-Corral, Lukas Stanczuk, Taija Mäkinen
Published in: genesis, Issue 54/6, 2016, Page(s) 350-358, ISSN 1526-954X
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/dvg.22939

Vegfr3-CreER T2 mouse, a new genetic tool for targeting the lymphatic system

Author(s): Ines Martinez-Corral, Lukas Stanczuk, Maike Frye, Maria Helena Ulvmar, Rodrigo Diéguez-Hurtado, David Olmeda, Taija Makinen, Sagrario Ortega
Published in: Angiogenesis, Issue 19/3, 2016, Page(s) 433-445, ISSN 0969-6970
Publisher: Kluwer Academic Publishers
DOI: 10.1007/s10456-016-9505-x

Tamoxifen-independent recombination of reporter genes limits lineage tracing and mosaic analysis using CreERT2 lines

Author(s): A. Álvarez-Aznar, I. Martínez-Corral, N. Daubel, C. Betsholtz, T. Mäkinen, K. Gaengel
Published in: Transgenic Research, 2019, ISSN 0962-8819
Publisher: Chapman & Hall
DOI: 10.1007/s11248-019-00177-8

Blockade of VEGF-C signaling inhibits lymphatic malformations driven by oncogenic PIK3CA mutation

Author(s): Ines Martinez-Corral, Yan Zhang, Milena Petkova, Henrik Ortsäter, Sofie Sjöberg, Sandra D. Castillo, Pascal Brouillard, Louis Libbrecht, Dieter Saur, Mariona Graupera, Kari Alitalo, Laurence Boon, Miikka Vikkula, Taija Mäkinen
Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-16496-y