Skip to main content

GENOMIC, CELLULAR AND DEVELOPMENTAL RECONSTRUCTION OF INFANT MLL-AF4+ ACUTE LYMPHOBLASTIC LEUKEMIA

Searching for OpenAIRE data...

Publications

Aneuploidy in Cancer: Lessons from Acute Lymphoblastic Leukemia

Author(s): Oscar Molina, Maria Alba Abad, Francesc Solé, Pablo Menéndez
Published in: Trends in Cancer, 7/1, 2021, Page(s) 37-47, ISSN 2405-8033
Publisher: [Cambridge, MA] : Cell Press, [2015]
DOI: 10.1016/j.trecan.2020.08.008

In vivo CRISPR/Cas9 targeting of fusion oncogenes for selective elimination of cancer cells

Author(s): M. Martinez-Lage, R. Torres-Ruiz, P. Puig-Serra, P. Moreno-Gaona, M. C. Martin, F. J. Moya, O. Quintana-Bustamante, S. Garcia-Silva, A. M. Carcaboso, P. Petazzi, C. Bueno, J. Mora, H. Peinado, J. C. Segovia, P. Menendez, S. Rodriguez-Perales
Published in: Nature Communications, 11/1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-18875-x

Genetic Rescue of Mitochondrial and Skeletal Muscle Impairment in an Induced Pluripotent Stem Cells Model of Coenzyme Q 10 Deficiency

Author(s): Damià Romero-Moya, Carlos Santos-Ocaña, Julio Castaño, Gloria Garrabou, José A. Rodríguez-Gómez, Vanesa Ruiz-Bonilla, Clara Bueno, Patricia González-Rodríguez, Alessandra Giorgetti, Eusebio Perdiguero, Cristina Prieto, Constanza Moren-Nuñez, Daniel J. Fernández-Ayala, Maria Victoria Cascajo, Iván Velasco, Josep Maria Canals, Raquel Montero, Delia Yubero, Cristina Jou, José López-Barne
Published in: STEM CELLS, 35/7, 2017, Page(s) 1687-1703, ISSN 1066-5099
Publisher: AlphaMed Press Inc
DOI: 10.1002/stem.2634

Generation and characterization of a human iPSC cell line expressing inducible Cas9 in the “safe harbor” AAVS1 locus

Author(s): Julio Castaño, Clara Bueno, Senda Jiménez-Delgado, Heleia Roca-Ho, Mario F. Fraga, Agustín F. Fernandez, Mahito Nakanishi, Raúl Torres-Ruiz, Sandra Rodríguez-Perales, Pablo Menéndez
Published in: Stem Cell Research, 21, 2017, Page(s) 137-140, ISSN 1873-5061
Publisher: Elsevier
DOI: 10.1016/j.scr.2017.04.011

Detailed Characterization of Mesenchymal Stem/Stromal Cells from a Large Cohort of AML Patients Demonstrates a Definitive Link to Treatment Outcomes

Author(s): Rafael Diaz de la Guardia, Belen Lopez-Millan, Jessie R. Lavoie, Clara Bueno, Julio Castaño, Maite Gómez-Casares, Susana Vives, Laura Palomo, Manel Juan, Julio Delgado, Maria L. Blanco, Josep Nomdedeu, Alberto Chaparro, Jose Luis Fuster, Eduardo Anguita, Michael Rosu-Myles, Pablo Menéndez
Published in: Stem Cell Reports, 8/6, 2017, Page(s) 1573-1586, ISSN 2213-6711
Publisher: Cell Press
DOI: 10.1016/j.stemcr.2017.04.019

Chemical exposure and infant leukaemia: development of an adverse outcome pathway (AOP) for aetiology and risk assessment research

Author(s): Olavi Pelkonen, Andrea Terron, Antonio F. Hernandez, Pablo Menendez, Susanne Hougaard Bennekou
Published in: Archives of Toxicology, 91/8, 2017, Page(s) 2763-2780, ISSN 0340-5761
Publisher: Springer Verlag
DOI: 10.1007/s00204-017-1986-x

Modeling mixed-lineage-rearranged leukemia initiation in CD34 + cells: a “CRISPR” solution

Author(s): Raúl Torres-Ruiz, Sandra Rodriguez-Perales, Clara Bueno, Pablo Menendez
Published in: Haematologica, 102/9, 2017, Page(s) 1467-1468, ISSN 0390-6078
Publisher: Ferrata Storti Foundation
DOI: 10.3324/haematol.2017.173740

RUNX1c Regulates Hematopoietic Differentiation of Human Pluripotent Stem Cells Possibly in Cooperation with Proinflammatory Signaling

Author(s): Oscar Navarro-Montero, Veronica Ayllon, Mar Lamolda, Lourdes López-Onieva, Rosa Montes, Clara Bueno, Elizabeth Ng, Xiomara Guerrero-Carreno, Tamara Romero, Damià Romero-Moya, Ed Stanley, Andrew Elefanty, Verónica Ramos-Mejia, Pablo Menendez, Pedro J. Real
Published in: STEM CELLS, 35/11, 2017, Page(s) 2253-2266, ISSN 1066-5099
Publisher: AlphaMed Press Inc
DOI: 10.1002/stem.2700

NG2 antigen is involved in leukemia invasiveness and central nervous system infiltration in MLL-rearranged infant B-ALL

Author(s): C Prieto, B López-Millán, H Roca-Ho, R W Stam, D Romero-Moya, F J Rodríguez-Baena, A Sanjuan-Pla, V Ayllón, M Ramírez, M Bardini, P De Lorenzo, M G Valsecchi, M Stanulla, M Iglesias, P Ballerini, Á M Carcaboso, J Mora, F Locatelli, A Bertaina, L Padilla, J Carlos Rodríguez-Manzaneque, C Bueno, P Menéndez
Published in: Leukemia, 32/3, 2017, Page(s) 633-644, ISSN 0887-6924
Publisher: Nature Publishing Group
DOI: 10.1038/leu.2017.294

Cellular Ontogeny and Hierarchy Influence the Reprogramming Efficiency of Human B Cells into Induced Pluripotent Stem Cells

Author(s): Álvaro Muñoz-López, Eddy. H.J. van Roon, Damià Romero-Moya, Belén López-Millan, Ronald W. Stam, Dolors Colomer, Mahito Nakanishi, Clara Bueno, Pablo Menendez
Published in: STEM CELLS, 34/3, 2016, Page(s) 581-587, ISSN 1066-5099
Publisher: AlphaMed Press Inc
DOI: 10.1002/stem.2303

Proinflammatory signals are insufficient to drive definitive hematopoietic specification of human HSCs in vitro

Author(s): Alessandra Giorgetti, Julio Castaño, Clara Bueno, Rafael Díaz de la Guardia, Mario Delgado, Anna Bigas, Lluis Espinosa, Pablo Menendez
Published in: Experimental Hematology, 45, 2017, Page(s) 85-93.e2, ISSN 0301-472X
Publisher: Elsevier BV
DOI: 10.1016/j.exphem.2016.09.007

Generation, genome edition and characterization of iPSC lines from a patient with coenzyme Q 10 deficiency harboring a heterozygous mutation in COQ4 gene

Author(s): Damià Romero-Moya, Julio Castaño, Carlos Santos-Ocaña, Plácido Navas, Pablo Menendez
Published in: Stem Cell Research, 24, 2017, Page(s) 144-147, ISSN 1873-5061
Publisher: Elsevier
DOI: 10.1016/j.scr.2016.09.007

Development Refractoriness of MLL-Rearranged Human B Cell Acute Leukemias to Reprogramming into Pluripotency

Author(s): Alvaro Muñoz-López, Damià Romero-Moya, Cristina Prieto, Verónica Ramos-Mejía, Antonio Agraz-Doblas, Ignacio Varela, Marcus Buschbeck, Anna Palau, Xonia Carvajal-Vergara, Alessandra Giorgetti, Anthony Ford, Majlinda Lako, Isabel Granada, Neus Ruiz-Xivillé, Sandra Rodríguez-Perales, Raul Torres-Ruíz, Ronald W. Stam, Jose Luis Fuster, Mario F. Fraga, Mahito Nakanishi, Gianni Cazzaniga, Mic
Published in: Stem Cell Reports, 7/4, 2016, Page(s) 602-618, ISSN 2213-6711
Publisher: Cell Press
DOI: 10.1016/j.stemcr.2016.08.013

Intra-Bone Marrow Transplantation Confers Superior Multilineage Engraftment of Murine Aorta-Gonad Mesonephros Cells Over Intravenous Transplantation

Author(s): Alejandra Sanjuan-Pla, Damia Romero-Moya, Cristina Prieto, Clara Bueno, Anna Bigas, Pablo Menendez
Published in: Stem Cells and Development, 25/3, 2016, Page(s) 259-265, ISSN 1547-3287
Publisher: Mary Ann Liebert Inc.
DOI: 10.1089/scd.2015.0309

Engineered LINE-1 retrotransposition in nondividing human neurons

Author(s): Angela Macia, Thomas J. Widmann, Sara R. Heras, Veronica Ayllon, Laura Sanchez, Meriem Benkaddour-Boumzaouad, Martin Muñoz-Lopez, Alejandro Rubio, Suyapa Amador-Cubero, Eva Blanco-Jimenez, Javier Garcia-Castro, Pablo Menendez, Philip Ng, Alysson R. Muotri, John L. Goodier, Jose L. Garcia-Perez
Published in: Genome Research, 27/3, 2017, Page(s) 335-348, ISSN 1088-9051
Publisher: Cold Spring Harbor Laboratory Press
DOI: 10.1101/gr.206805.116

The European Hematology Association Roadmap for European Hematology Research: a consensus document

Author(s): A. Engert, C. Balduini, A. Brand, B. Coiffier, C. Cordonnier, H. Dohner, T. D. de Wit, S. Eichinger, W. Fibbe, T. Green, F. de Haas, A. Iolascon, T. Jaffredo, F. Rodeghiero, G. Salles, J. J. Schuringa, J. J. Schuringa, T. Jaffredo, B. Coiffier, G. Salles, H. Dohner, A. Iolascon, C. Balduini, S. Eichinger, A. Brand, C. Cordonnier, W. Fibbe
Published in: Haematologica, 101/2, 2016, Page(s) 115-208, ISSN 0390-6078
Publisher: Ferrata Storti Foundation
DOI: 10.3324/haematol.2015.136739

Human acute leukemia induced pluripotent stem cells: a unique model for investigating disease development and pathogenesis

Author(s): Clara Bueno, Pablo Menendez
Published in: Stem Cell Investigation, 4/7, 2017, Page(s) 55-55, ISSN 2313-0792
Publisher: Stem Cell Investigation
DOI: 10.21037/sci.2017.05.12

The AF4-MLL fusion transiently augments multilineage hematopoietic engraftment but is not sufficient to initiate leukemia in cord blood CD34<sup>+</sup> cells

Author(s): Cristina Prieto, Rolf Marschalek, Alessa Kühn, Adelheid Bursen, Clara Bueno, Pablo Menéndez
Published in: Oncotarget, 8/47, 2017, ISSN 1949-2553
Publisher: Impact Journals
DOI: 10.18632/oncotarget.19567

The “Never-Ending” Mouse Models for MLL-Rearranged Acute Leukemia Are Still Teaching Us

Author(s): Katrin Ottersbach, Alejandra Sanjuan-Pla, Raúl Torres-Ruíz, Clara Bueno, Talia Velasco-Hernández, Pablo Menendez
Published in: HemaSphere, 2/4, 2018, Page(s) e57, ISSN 2572-9241
Publisher: Wolters Kluwer Health Inc
DOI: 10.1097/HS9.0000000000000057

Activated KRAS Cooperates with MLL-AF4 to Promote Extramedullary Engraftment and Migration of Cord Blood CD34 + HSPC But Is Insufficient to Initiate Leukemia

Author(s): Cristina Prieto, Ronald W. Stam, Antonio Agraz-Doblas, Paola Ballerini, Mireia Camos, Julio Castaño, Rolf Marschalek, Aldeheid Bursen, Ignacio Varela, Clara Bueno, Pablo Menendez
Published in: Cancer Research, 76/8, 2016, Page(s) 2478-2489, ISSN 0008-5472
Publisher: American Association for Cancer Research
DOI: 10.1158/0008-5472.CAN-15-2769

Intratumoral heterogeneity and clonal evolution in blood malignancies and solid tumors

Author(s): Ignacio Varela, Pablo Menendez, Alejandra Sanjuan-Pla
Published in: Oncotarget, 8/39, 2017, ISSN 1949-2553
Publisher: Impact Journals
DOI: 10.18632/oncotarget.20279

IMiDs mobilize acute myeloid leukemia blasts to peripheral blood through downregulation of CXCR4 but fail to potentiate AraC/Idarubicin activity in preclinical models of non del5q/5q- AML

Author(s): Belen Lopez-Millan, Rafael Diaz de la Guardia, Heleia Roca-Ho, Eduardo Anguita, Abul B. M. M. K. Islam, Damia Romero-Moya, Cristina Prieto, Francisco Gutierrez-Agüera, Jose Antonio Bejarano-Garcia, Jose Antonio Perez-Simon, Paula Costales, Montse Rovira, Pedro Marín, Silvia Menendez, Mar Iglesias, Jose Luis Fuster, Alvaro Urbano-Ispizua, Fernando Anjos-Afonso, Clara Bueno, Pablo Menendez
Published in: OncoImmunology, 2018, Page(s) 1-14, ISSN 2162-402X
Publisher: Taylor & Francis
DOI: 10.1080/2162402x.2018.1477460

BM-Mscs From Risk-Stratified AML Patients Support Normal Hematopoiesis and are Anti-Inflammatory in in Vivo Preclinical Models of Hematopoietic Reconstitution and Severe Colitis

Author(s): Pablo Menendez, Rafael Diaz de la Guardia, Belen Lopez-Millan
Published in: Experimental Hematology, 64, 2018, Page(s) S85, ISSN 0301-472X
Publisher: Elsevier BV
DOI: 10.1016/j.exphem.2018.06.091

Expression of MLL-AF4 or AF4-MLL fusions does not impact the efficiency of DNA damage repair

Author(s): Julio Castaño, Ana B. Herrero, Aldeheid Bursen, Federico González, Rolf Marschalek, Norma C. Gutiérrez, Pablo Menendez
Published in: Oncotarget, 7/21, 2016, ISSN 1949-2553
Publisher: Impact Journals
DOI: 10.18632/oncotarget.8938

Bone Marrow Clonogenic Myeloid Progenitors from NPM1-Mutated AML Patients Do Not Harbor the NPM1 Mutation: Implication for the Cell-Of-Origin of NPM1+ AML

Author(s): Rafael Diaz de la Guardia, Laura González-Silva, Belén López-Millán, Juan José Rodríguez-Sevilla, Matteo L. Baroni, Clara Bueno, Eduardo Anguita, Susana Vives, Laura Palomo, Helene Lapillonne, Ignacio Varela, Pablo Menendez
Published in: Genes, 11/1, 2020, Page(s) 73, ISSN 2073-4425
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/genes11010073

GATA2 Promotes Hematopoietic Development and Represses Cardiac Differentiation of Human Mesoderm

Author(s): Julio Castaño, Sergi Aranda, Clara Bueno, Fernando J. Calero-Nieto, Eva Mejia-Ramirez, Jose Luis Mosquera, Enrique Blanco, Xiaonan Wang, Cristina Prieto, Lorea Zabaleta, Elisabetta Mereu, Meritxell Rovira, Senda Jiménez-Delgado, Daniel R. Matson, Holger Heyn, Emery H. Bresnick, Berthold Göttgens, Luciano Di Croce, Pablo Menendez, Angel Raya, Alessandra Giorgetti
Published in: Stem Cell Reports, 13/3, 2019, Page(s) 515-529, ISSN 2213-6711
Publisher: Cell Press
DOI: 10.1016/j.stemcr.2019.07.009

Unraveling the cellular origin and clinical prognostic markers of infant B-cell acute lymphoblastic leukemia using genome-wide analysis

Author(s): Antonio Agraz-Doblas, Clara Bueno, Rachael Bashford-Rogers, Anindita Roy, Pauline Schneider, Michela Bardini, Paola Ballerini, Gianni Cazzaniga, Thaidy Moreno, Carlos Revilla, Marta Gut, Maria G. Valsecchi, Irene Roberts, Rob Pieters, Paola De Lorenzo, Ignacio Varela, Pablo Menendez, Ronald W. Stam
Published in: Haematologica, 104/6, 2019, Page(s) 1176-1188, ISSN 0390-6078
Publisher: Ferrata Storti Foundation
DOI: 10.3324/haematol.2018.206375

Daratumumab displays in vitro and in vivo anti-tumor activity in models of B cell non-Hodgkin lymphoma and improves responses to standard chemo-immunotherapy regimens

Author(s): Anna Vidal-Crespo, Alba Matas-Céspedes, Vanina Rodriguez, Cédric Rossi, Juan G. Valero, Neus Serrat, Alejandra Sanjuan Pla, Pablo Menéndez, Gaël Roué, Armando López-Guillermo, Eva Giné, Elías Campo, Dolors Colomer, Christine Bezombes, Jeroen Lammerts van Bueren, Christopher Chiu, Parul Doshi, Patricia Pérez-Galán
Published in: Haematologica, 11th July 2019, 2019, Page(s) haematol.2018.211904, ISSN 0390-6078
Publisher: Ferrata Storti Foundation
DOI: 10.3324/haematol.2018.211904

Natural history and cell of origin of TCF3-ZNF384 and PTPN11 mutations in monozygotic twins with concordant BCP-ALL

Author(s): Clara Bueno, J. Ramón Tejedor, Rachael Bashford-Rogers, Laura González-Silva, Rafael Valdés-Mas, Antonio Agraz-Doblás, Rafael Díaz de la Guardia, Jordi Ribera, Lurdes Zamora, Chrystele Bilhou-Nabera, Nassera Abermil, Hélène Guermouche, Elodie Gouache, Guy Leverger, Mario F. Fraga, Agustín F. Fernández, Paola Ballerini, Ignacio Varela, Pablo Menendez
Published in: Blood, 134/11, 2019, Page(s) 900-905, ISSN 0006-4971
Publisher: American Society of Hematology
DOI: 10.1182/blood.2019000893

Fratricide-resistant CD1a-specific CAR T cells for the treatment of cortical T-cell acute lymphoblastic leukemia

Author(s): Diego Sánchez-Martínez, Matteo L. Baroni, Francisco Gutierrez-Agüera, Heleia Roca-Ho, Oscar Blanch-Lombarte, Sara González-García, Montserrat Torrebadell, Jordi Junca, Manuel Ramírez-Orellana, Talía Velasco-Hernández, Clara Bueno, José Luís Fuster, Julia G. Prado, Julien Calvo, Benjamin Uzan, Jan Cools, Mireia Camos, Françoise Pflumio, María Luisa Toribio, Pablo Menéndez
Published in: Blood, 133/21, 2019, Page(s) 2291-2304, ISSN 0006-4971
Publisher: American Society of Hematology
DOI: 10.1182/blood-2018-10-882944

Discovery of a CD10-negative B-progenitor in human fetal life identifies unique ontogeny-related developmental programs

Author(s): Sorcha O’Byrne, Natalina Elliott, Siobhan Rice, Gemma Buck, Nicholas Fordham, Catherine Garnett, Laura Godfrey, Nicholas T. Crump, Gary Wright, Sarah Inglott, Peng Hua, Bethan Psaila, Benjamin Povinelli, David J. H. F. Knapp, Antonio Agraz-Doblas, Clara Bueno, Ignacio Varela, Phillip Bennett, Hashem Koohy, Suzanne M. Watt, Anastasios Karadimitris, Adam J. Mead, Phillip Ancliff, Paresh Vyas, Pabl
Published in: Blood, 134/13, 2019, Page(s) 1059-1071, ISSN 0006-4971
Publisher: American Society of Hematology
DOI: 10.1182/blood.2019001289

Enhanced hemato-endothelial specification during human embryonic differentiation through developmental cooperation between AF4-MLL and MLL-AF4 fusions

Author(s): Clara Bueno, Fernando J Calero-Nieto, Xiaonan Wang, Rafael Valdés-Mas, Francisco Gutiérrez-Agüera, Heleia Roca-Ho, Veronica Ayllon, Pedro J Real, David Arambilet, Lluis Espinosa, Raul Torres-Ruiz, Antonio Agraz-Doblas, Ignacio Varela, Jasper de Boer, Anna Bigas, Bertie Gottgens, Rolf Marschalek, Pablo Menendez
Published in: Haematologica, 104/6, 2019, Page(s) 1189-1201, ISSN 0390-6078
Publisher: Ferrata Storti Foundation
DOI: 10.3324/haematol.2018.202044

Chromatin regulation by Histone H4 acetylation at Lysine 16 during cell death and differentiation in the myeloid compartment

Author(s): Rocio G Urdinguio, Virginia Lopez, Gustavo F Bayón, Rafael Diaz de la Guardia, Marta I Sierra, Estela García-Toraño, Raúl F Perez, María G García, Antonella Carella, Patricia C Pruneda, Cristina Prieto, Marija Dmitrijeva, Pablo Santamarina, Thalía Belmonte, Cristina Mangas, Elena Diaconu, Cecilia Ferrero, Juan Ramón Tejedor, Juan Luis Fernandez-Morera, Cristina Bravo, Clara Bueno, Aleja
Published in: Nucleic Acids Research, 47/10, 2019, Page(s) 5016-5037, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkz195

Reprogramming human B cells into induced pluripotent stem cells and its enhancement by C/EBPα

Author(s): C Bueno, J L Sardina, B Di Stefano, D Romero-Moya, A Muñoz-López, L Ariza, M C Chillón, A Balanzategui, J Castaño, A Herreros, M F Fraga, A Fernández, I Granada, O Quintana-Bustamante, J C Segovia, K Nishimura, M Ohtaka, M Nakanishi, T Graf, P Menendez
Published in: Leukemia, 30/3, 2015, Page(s) 674-682, ISSN 0887-6924
Publisher: Nature Publishing Group
DOI: 10.1038/leu.2015.294

Immunophenotypic analysis and quantification of B-1 and B-2 B cells during human fetal hematopoietic development

Author(s): C Bueno, E H J van Roon, A Muñoz-López, A Sanjuan-Pla, M Juan, A Navarro, R W Stam, P Menendez
Published in: Leukemia, 30/7, 2015, Page(s) 1603-1606, ISSN 0887-6924
Publisher: Nature Publishing Group
DOI: 10.1038/leu.2015.362

Linking Pesticide Exposure with Pediatric Leukemia: Potential Underlying Mechanisms

Author(s): Antonio Hernández, Pablo Menéndez
Published in: International Journal of Molecular Sciences, 17/4, 2016, Page(s) 461, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms17040461

Enforced sialyl‐Lewis‐X (sLeX) display in E‐selectin ligands by exofucosylation is dispensable for CD19‐CAR T‐cell activity and bone marrow homing

Author(s): Diego Sánchez‐Martínez, Francisco Gutiérrez‐Agüera, Paola Romecin, Meritxell Vinyoles, Marta Palomo, Néstor Tirado, Samanta Romina Zanetti, Manel Juan, Michela Carlet, Irmela Jeremias, Pablo Menéndez
Published in: Clinical and Translational Medicine, 11/2, 2021, Page(s) e280, ISSN 2001-1326
Publisher: Springer Verlag
DOI: 10.1002/ctm2.280

Integrative methylome-transcriptome analysis unravels cancer cell vulnerabilities in infant MLL-rearranged B-cell acute lymphoblastic leukemia

Author(s): J. Ramon Tejedor, Clara Bueno, Meritxell Vinyoles, Paolo Petazzi, Antonio Agraz-Doblas, Isabel Cobo, Raúl Torres-Ruiz, Gustavo F. Bayón, Raúl F. Pérez, Sara López-Tamargo, Francisco Gutierrez-Agüera, Pablo Santamarina-Ojeda, Manuel Ramírez-Orellana, Michela Bardini, Giovanni Cazzaniga, Paola Ballerini, Pauline Schneider, Ronald W. Stam, Ignacio Varela, Mario F. Fraga, Agustín F. Fernández
Published in: Journal of Clinical Investigation, Twenty-four issues a year, 2021, 2021, Page(s) 138833, ISSN 1558-8238
Publisher: New Haven [etc.] American Society for Clinical Investigation.
DOI: 10.1172/jci138833