Multiscale Modelling of the Neuromuscular System for Closed Loop Deep Brain Stimulation

Project Information

DBSModel

Grant agreement ID: 646923

DOI

10.3030/646923

Project closed

EC signature date 29 May 2015

Start date 1 August 2015

End date 31 July 2021

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 999 474,00

EU contribution

€ 1 999 474,00

Coordinated by

UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN
Ireland

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (25)

The Active Electrode in the Living Brain: The Response of the Brain Parenchyma to Chronically Implanted Deep Brain Stimulation Electrodes

Author(s): Judith Evers, Madeleine Lowery
Published in: Operative Neurosurgery, 2020, Page(s) 131-140, ISSN 2332-4252
Publisher: Oxford Academic
DOI: 10.1093/ons/opaa326

Consensus for experimental design in electromyography (CEDE) project: Amplitude normalization matrix

Author(s): Manuela Besomi, Paul W. Hodges, Edward A. Clancy, Jaap Van Dieën, François Hug, Madeleine Lowery, Roberto Merletti, Karen Søgaard, Tim Wrigley, Thor Besier, Richard G. Carson, Catherine Disselhorst-Klug, Roger M. Enoka, Deborah Falla, Dario Farina, Simon Gandevia, Aleš Holobar, Matthew C. Kiernan, Kevin McGill, Eric Perreault, John C. Rothwell, Kylie Tucker
Published in: Journal of Electromyography and Kinesiology, Issue 53, 2020, Page(s) 102438, ISSN 1050-6411
Publisher: Elsevier BV
DOI: 10.1016/j.jelekin.2020.102438

Consensus for experimental design in electromyography (CEDE) project: Terminology matrix

Author(s): Lara McManus, Madeleine Lowery, Roberto Merletti, Karen Søgaard, Manuela Besomi, Edward A. Clancy, Jaap H. van Dieën, François Hug, Tim Wrigley, Thor Besier, Richard G. Carson, Catherine Disselhorst-Klug, Roger M. Enoka, Deborah Falla, Dario Farina, Simon Gandevia, Aleš Holobar, Matthew C. Kiernan, Kevin McGill, Eric Perreault, John C. Rothwell, Kylie Tucker, Paul W. Hodges
Published in: Journal of Electromyography and Kinesiology, Issue 59, 2021, Page(s) 102565, ISSN 1050-6411
Publisher: Elsevier BV
DOI: 10.1016/j.jelekin.2021.102565

Altered supraspinal motor networks in survivors of poliomyelitis: A cortico-muscular coherence study

Author(s): Amina Coffey, Saroj Bista, Antonio Fasano, Teresa Buxo, Matthew Mitchell, Eileen Rose Giglia, Stefan Dukic, Matthew Fenech, Megan Barry, Andrew Wade, Mark Heverin, Muthuraman Muthuraman, Richard G. Carson, Madeleine Lowery, Orla Hardiman, Bahman Nasseroleslami
Published in: Clinical Neurophysiology, Issue 132/1, 2021, Page(s) 106-113, ISSN 1388-2457
Publisher: Elsevier BV
DOI: 10.1016/j.clinph.2020.10.011

Methods for Lowering the Power Consumption of OS-Based Adaptive Deep Brain Stimulation Controllers

Author(s): Roberto Rodriguez-Zurrunero, Alvaro Araujo, Madeleine M. Lowery
Published in: Sensors, Issue 21/7, 2021, Page(s) 2349, ISSN 1424-8220
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/s21072349

Cortical network effects of subthalamic deep brain stimulation in a thalamo-cortical microcircuit model

Author(s): AmirAli Farokhniaee, Madeleine M Lowery
Published in: Journal of Neural Engineering, Issue 18/5, 2021, Page(s) 056006, ISSN 1741-2560
Publisher: Institute of Physics Publishing
DOI: 10.1088/1741-2552/abee50

Self-Tuning Deep Brain Stimulation Controller for Suppression of Beta Oscillations: Analytical Derivation and Numerical Validation

Author(s): John E. Fleming, Jakub Orłowski, Madeleine M. Lowery, Antoine Chaillet
Published in: Frontiers in Neuroscience, Issue 14, 2020, ISSN 1662-453X
Publisher: Frontiers
DOI: 10.3389/fnins.2020.00639

Uncertainty Quantification of Oscillation Suppression During DBS in a Coupled Finite Element and Network Model

Author(s): Christian Schmidt, Eleanor Dunn, Madeleine Lowery, Ursula van Rienen
Published in: IEEE Transactions on Neural Systems and Rehabilitation Engineering, Issue 26/2, 2018, Page(s) 281-290, ISSN 1534-4320
Publisher: Institute of Electrical and Electronics Engineers
DOI: 10.1109/TNSRE.2016.2608925

Motor Unit Activity during Fatiguing Isometric Muscle Contraction in Hemispheric Stroke Survivors

Author(s): Lara McManus, Xiaogang Hu, William Z. Rymer, Nina L. Suresh, Madeleine M. Lowery
Published in: Frontiers in Human Neuroscience, Issue 11, 2017, ISSN 1662-5161
Publisher: Frontiers Research Foundation
DOI: 10.3389/fnhum.2017.00569

Muscle fatigue increases beta-band coherence between the firing times of simultaneously active motor units in the first dorsal interosseous muscle

Author(s): Lara McManus, Xiaogang Hu, William Z. Rymer, Nina L. Suresh, Madeleine M. Lowery
Published in: Journal of Neurophysiology, Issue 115/6, 2016, Page(s) 2830-2839, ISSN 0022-3077
Publisher: American Physiological Society
DOI: 10.1152/jn.00097.2016

Numerical Identification of Motor Units using an Optimal Control Approach

Author(s): Tobias Sproll, Anton Schiela, Madeleine Lowery
Published in: IFAC-PapersOnLine, Issue 51/2, 2018, Page(s) 174-179, ISSN 2405-8963
Publisher: Elsevier
DOI: 10.1016/j.ifacol.2018.03.030

Analysis of Oscillatory Neural Activity in Series Network Models of Parkinson's Disease During Deep Brain Stimulation

Author(s): Davidson CM, de Paor AM, Cagnan H, Lowery MM.
Published in: IEEE Transactions on Biomedical Engineering, 2016, Page(s) 86-96, ISSN 0018-9294
Publisher: Institute of Electrical and Electronics Engineers
DOI: 10.1109/TBME.2015.2475166

Gait Event Detection from Accelerometry using the Teager-Kaiser Energy Operator

Author(s): Matthew William Flood, Ben O'Callaghan, Madeleine Lowery
Published in: IEEE Transactions on Biomedical Engineering, 2019, Page(s) 1-1, ISSN 0018-9294
Publisher: Institute of Electrical and Electronics Engineers
DOI: 10.1109/tbme.2019.2919394

Beta-band motor unit coherence and nonlinear surface EMG features of the first dorsal interosseous muscle vary with force

Author(s): Lara McManus, Matthew W. Flood, Madeleine M. Lowery
Published in: Journal of Neurophysiology, Issue 122/3, 2019, Page(s) 1147-1162, ISSN 0022-3077
Publisher: American Physiological Society
DOI: 10.1152/jn.00228.2019

Anatomically accurate model of EMG during index finger flexion and abduction derived from diffusion tensor imaging

Author(s): Diego Pereira Botelho, Kathleen Curran, Madeleine M. Lowery
Published in: PLOS Computational Biology, Issue 15/8, 2019, Page(s) e1007267, ISSN 1553-7358
Publisher: PLOS
DOI: 10.1371/journal.pcbi.1007267

Beta-Band Resonance and Intrinsic Oscillations in a Biophysically Detailed Model of the Subthalamic Nucleus-Globus Pallidus Network

Author(s): Lucas A. Koelman, Madeleine M. Lowery
Published in: Frontiers in Computational Neuroscience, Issue 13, 2019, ISSN 1662-5188
Publisher: Frontiers Research Foundation
DOI: 10.3389/fncom.2019.00077

Increased EMG intermuscular coherence and reduced signal complexity in Parkinson’s disease

Author(s): Matthew W. Flood, Bente Rona Jensen, Anne-Sofie Malling, Madeleine M. Lowery
Published in: Clinical Neurophysiology, Issue 130/2, 2019, Page(s) 259-269, ISSN 1388-2457
Publisher: Elsevier BV
DOI: 10.1016/j.clinph.2018.10.023

Feature-based evaluation of a wearable surface EMG sensor against laboratory standard EMG during force-varying and fatiguing contractions.

Author(s): Emer P. Doheny, Cathy Goulding, Matthew W. Flood, Lara McManus, Madeleine M. Lowery
Published in: IEEE Sensors Journal, 2019, Page(s) 1-1, ISSN 1530-437X
Publisher: Institute of Electrical and Electronics Engineers
DOI: 10.1109/jsen.2019.2953354

Simplified parametric models of the dielectric properties of brain and muscle tissue during electrical stimulation

Author(s): Peadar F. Grant, Madeleine M. Lowery
Published in: Medical Engineering & Physics, Issue 65, 2019, Page(s) 61-67, ISSN 1350-4533
Publisher: Elsevier BV
DOI: 10.1016/j.medengphy.2018.12.018

Simulation of Closed-Loop Deep Brain Stimulation Control Schemes for Suppression of Pathological Beta Oscillations in Parkinson’s Disease

Author(s): John E. Fleming, Eleanor Dunn, Madeleine M. Lowery
Published in: Frontiers in Neuroscience, Issue 14, 2020, ISSN 1662-453X
Publisher: Frontiers in Neuroscience
DOI: 10.3389/fnins.2020.00166

Simple and customizable method for fabrication of high-aspect ratio microneedle molds using low-cost 3D printing

Author(s): Kevin J. Krieger, Nicky Bertollo, Manita Dangol, John T. Sheridan, Madeleine M. Lowery, Eoin D. O’Cearbhaill
Published in: Microsystems & Nanoengineering, Issue 5/1, 2019, ISSN 2055-7434
Publisher: Springer Nature Limited
DOI: 10.1038/s41378-019-0088-8

Consensus for experimental design in electromyography (CEDE) project: Electrode selection matrix

Author(s): Manuela Besomi, Paul W. Hodges, Jaap Van Dieën, Richard G. Carson, Edward A. Clancy, Catherine Disselhorst-Klug, Aleš Holobar, François Hug, Matthew C. Kiernan, Madeleine Lowery, Kevin McGill, Roberto Merletti, Eric Perreault, Karen Søgaard, Kylie Tucker, Thor Besier, Roger Enoka, Deborah Falla, Dario Farina, Simon Gandevia, John C. Rothwell, Bill Vicenzino, Tim Wrigley
Published in: Journal of Electromyography and Kinesiology, Issue 48, 2019, Page(s) 128-144, ISSN 1050-6411
Publisher: Elsevier BV
DOI: 10.1016/j.jelekin.2019.07.008

Analysis and Biophysics of Surface EMG for Physiotherapists and Kinesiologists: Toward a Common Language With Rehabilitation Engineers

Author(s): Lara McManus, Giuseppe De Vito, Madeleine M. Lowery
Published in: Frontiers in Neurology, Issue 11, 2020, ISSN 1664-2295
Publisher: Frontiers Research Foundation
DOI: 10.3389/fneur.2020.576729

Effects of extracellular potassium on calcium handling and force generation in a model of excitation-contraction coupling in skeletal muscle

Author(s): Sageanne Senneff, Madeleine M. Lowery
Published in: Journal of Theoretical Biology, Issue 519, 2021, Page(s) 110656, ISSN 0022-5193
Publisher: Academic Press
DOI: 10.1016/j.jtbi.2021.110656

Quantitative clinical assessment of motor function during and following LSVT-BIG® therapy

Author(s): Matthew W. Flood, Ben P. F. O’Callaghan, Paul Diamond, Jérémy Liegey, Graham Hughes, Madeleine M. Lowery
Published in: Journal of NeuroEngineering and Rehabilitation, Issue 17/1, 2020, ISSN 1743-0003
Publisher: BioMed Central
DOI: 10.1186/s12984-020-00729-8

Conference proceedings (10)

Estimation of respiration rate and sleeping position using a wearable accelerometer

Author(s): Emer P. Doheny, Madeleine M. Lowery, Audrey Russell, Silke Ryan
Published in: 2020 42nd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC), 2020, Page(s) 4668-4671, ISBN 978-1-7281-1990-8
Publisher: IEEE
DOI: 10.1109/embc44109.2020.9176573

The Influence of Force Level and Motor Unit Coherence on Nonlinear Surface EMG Features Examined Using Model Simulation

Author(s): Lara McManus, Diego Pereira Botelho, Matthew W. Flood, Madeleine M. Lowery
Published in: 2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), 2019, Page(s) 6616-6619, ISBN 978-1-5386-1311-5
Publisher: IEEE
DOI: 10.1109/embc.2019.8857299

Adaptive gait segmentation algorithm for walking bout detection using tri-axial accelerometers

Author(s): Ben P. F. O'Callaghan, Emer P. Doheny, Cathy Goulding, Emma Fortune, Madeleine M. Lowery
Published in: 2020 42nd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC), 2020, Page(s) 4592-4595, ISBN 978-1-7281-1990-8
Publisher: IEEE
DOI: 10.1109/embc44109.2020.9176460

Effect of oral glucose supplementation on surface EMG during fatiguing dynamic exercise

Author(s): Clare M. Davidson, Giuseppe De Vito, Madeleine M. Lowery
Published in: 2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), 2016, Page(s) 3498-3502, ISBN 978-1-4577-0220-4
Publisher: IEEE
DOI: 10.1109/EMBC.2016.7591482

A Thalamo-Cortex Microcircuit Model of Beta Oscillations in the Parkinsonian Motor Cortex*

Author(s): AmirAli Farokhniaee, Madeleine M. Lowery
Published in: 2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), 2019, Page(s) 2145-2148, ISBN 978-1-5386-1311-5
Publisher: IEEE
DOI: 10.1109/embc.2019.8857790

Application of the Teagar-Kaiser energy operator and wavelet transform for detection of finger tapping contact and release times using accelerometery

Author(s): Ben P. F. O'Callaghan, Matthew W. Flood, Madeleine M. Lowery
Published in: 2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), 2019, Page(s) 4596-4599, ISBN 978-1-5386-1311-5
Publisher: IEEE
DOI: 10.1109/embc.2019.8857901

Changes in Neuronal Entropy in a Network Model of the Cortico-Basal Ganglia during Deep Brain Stimulation

Author(s): John E. Fleming, Madeleine M. Lowery
Published in: 2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), 2019, Page(s) 5172-5175, ISBN 978-1-5386-1311-5
Publisher: IEEE
DOI: 10.1109/embc.2019.8857440

Estimation of dispersive properties of encapsulation tissue surrounding deep brain stimulation electrodes in the rat

Author(s): Karthik Sridhar, Judith Evers, Diego Pereira Botelho, Madeleine M. Lowery
Published in: 2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), 2019, Page(s) 2973-2976, ISBN 978-1-5386-1311-5
Publisher: IEEE
DOI: 10.1109/embc.2019.8857062

Investigating the Effect of Persistent Inward Currents on Motor Unit Firing Rates and Beta-Band Coherence in a Model of the First Dorsal Interosseous Muscle *

Author(s): Sageanne Senneff, Lara McManus, Madeleine M. Lowery
Published in: 2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), 2019, Page(s) 2293-2296, ISBN 978-1-5386-1311-5
Publisher: IEEE
DOI: 10.1109/embc.2019.8857534

Regression-based analysis of front crawl swimming using upper-arm mounted accelerometers

Author(s): Emer P. Doheny, Cathy Goulding, Madeleine M. Lowery
Published in: 2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), 2019, Page(s) 6409-6412, ISBN 978-1-5386-1311-5
Publisher: IEEE
DOI: 10.1109/embc.2019.8857026

Thesis and dissertations (4)

Control Strategies for Closed-Loop Deep Brain Stimulation in Network Models of Parkinson’s Disease

Author(s): John Fleming
Published in: 2021
Publisher: UCD

Multiscale Modelling of the Neuromuscular System: Central and Peripheral Mechanisms Influencing Force

Author(s): Sageanne Senneff
Published in: 2021
Publisher: UCD

Instrumentation of Clinical Motor Tests to Examine the LSVT BIG Rehabilitation Protocol in Parkinson’s Disease

Author(s): Paul Diamond
Published in: 2019
Publisher: UCD

Investigation of Pathophysiology of Parkinson's Disease and Mechanisms of Deep Brain Stimulation using Biophysically Detailed Neuron Models

Author(s): Lucas Koelman
Published in: 2020
Publisher: UCD

Book chapters (3)

Electromyography Modeling and Simulation

Author(s): M. M. Lowery
Published in: Surface Electromyography: Physiology, Engineering and Applications, 2016, Page(s) 210-246
Publisher: John Wiley & Sons, Inc.
DOI: 10.1002/9781119082934.ch08

Modeling Deep Brain Stimulation for Parkinson's Disease

Author(s): Madeleine M. Lowery
Published in: Computational Models of Brain and Behavior, 1, 2017, Page(s) 109-123
Publisher: John Wiley & Sons, Ltd
DOI: 10.1002/9781119159193.ch9

7.32 Engineering the Neural Interface

Author(s): A. Kelly, L. Ballerini, M. Lowery, M. Biggs
Published in: Comprehensive Biomaterials II, 2017, Page(s) 642-660, ISBN 9780-081006924
Publisher: Elsevier
DOI: 10.1016/b978-0-12-803581-8.09322-x

Intellectual Property Rights

Other (2)

Remote Monitoring of Respiration

Application/Publication number: UKIPO UKIPO
Date: 2021-07-21
Applicant(s): UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN

Handalysis - Motor Function

Application/Publication number: PCT/ EP2020/070706
Date: 2019-07-22
Applicant(s): UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN