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Localization in biomechanics and mechanobiology of aneurysms: Towards personalized medicine

Objective

Rupture of Aortic Aneurysms (AA), which kills more than 30 000 persons every year in Europe and the USA, is a complex phenomenon that occurs when the wall stress exceeds the local strength of the aorta due to degraded properties of the tissue. The state of the art in AA biomechanics and mechanobiology reveals that major scientific challenges still have to be addressed to permit patient-specific computational predictions of AA rupture and enable localized repair of the structure with targeted pharmacologic treatment. A first challenge relates to ensuring an objective prediction of localized mechanisms preceding rupture. A second challenge relates to modelling the patient-specific evolutions of material properties leading to the localized mechanisms preceding rupture. Addressing these challenges is the aim of the BIOLOCHANICS proposal. We will take into account internal length-scales controlling localization mechanisms preceding AA rupture by implementing an enriched, also named nonlocal, continuum damage theory in the computational models of AA biomechanics and mechanobiology. We will also develop very advanced experiments, based on full-field optical measurements, aimed at characterizing localization mechanisms occurring in aortic tissues and at identifying local distributions of material properties at different stages of AA progression. A first in vivo application will be performed on genetic and pharmacological models of mice and rat AA. Eventually, a retrospective clinical study involving more than 100 patients at the Saint-Etienne University hospital will permit calibrating estimations of AA rupture risk thanks to our novel approaches and infuse them into future clinical practice. Through the achievements of BIOLOCHANICS, nonlocal mechanics will be possibly extended to other soft tissues for applications in orthopaedics, oncology, sport biomechanics, interventional surgery, human safety, cell biology, etc.

Field of science

  • /medical and health sciences/clinical medicine/orthopaedics
  • /natural sciences/computer and information sciences/software
  • /medical and health sciences/clinical medicine/angiology/vascular diseases
  • /medical and health sciences/clinical medicine/surgery
  • /medical and health sciences/clinical medicine/critical care medicine
  • /natural sciences/biological sciences/cell biology
  • /natural sciences/biological sciences/biophysics

Call for proposal

ERC-2014-CoG
See other projects for this call

Funding Scheme

ERC-COG - Consolidator Grant

Host institution

ASSOCIATION POUR LA RECHERCHE ET LE DEVELOPPEMENT DES METHODES ET PROCESSUS INDUSTRIELS
Address
Boulevard Saint Michel 60
75272 Paris
France
Activity type
Research Organisations
EU contribution
€ 1 920 003

Beneficiaries (2)

ASSOCIATION POUR LA RECHERCHE ET LE DEVELOPPEMENT DES METHODES ET PROCESSUS INDUSTRIELS
France
EU contribution
€ 1 920 003
Address
Boulevard Saint Michel 60
75272 Paris
Activity type
Research Organisations
CENTRE HOSPITALIER UNIVERSITAIRE SAINT ETIENNE - CHU
France
EU contribution
€ 79 393
Address

42055 Saint Etienne
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)