A new class of microtubules in the spindle exerting forces on kinetochores

Project Information

NewSpindleForce

Grant agreement ID: 647077

DOI 10.3030/647077

Project closed

EC signature date 20 March 2015

Start date 1 April 2015

End date 31 March 2020

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 2 150 000,00

EU contribution € 2 150 000,00

Coordinated by

RUDER BOSKOVIC INSTITUTE
Croatia

Publications

Peer reviewed articles (13)

Mitotic Spindle Assembly: Building the Bridge between Sister K-Fibers

Author(s): Juraj Simunić, Iva M. Tolić
Published in: Trends in Biochemical Sciences, Issue 41/10, 2016, Page(s) 824-833, ISSN 0968-0004
Publisher: Elsevier BV
DOI: 10.1016/j.tibs.2016.07.004

PRC1‐labeled microtubule bundles and kinetochore pairs show one‐to‐one association in metaphase

Author(s): Bruno Polak, Patrik Risteski, Sonja Lesjak, Iva M Tolić
Published in: EMBO reports, Issue 18/2, 2017, Page(s) 217-230, ISSN 1469-221X
Publisher: Nature Publishing Group
DOI: 10.15252/embr.201642650

Microtubule Sliding within the Bridging Fiber Pushes Kinetochore Fibers Apart to Segregate Chromosomes

Author(s): Kruno Vukušić, Renata Buđa, Agneza Bosilj, Ana Milas, Nenad Pavin, Iva M. Tolić
Published in: Developmental Cell, Issue 43/1, 2017, Page(s) 11-23.e6, ISSN 1534-5807
Publisher: Cell Press
DOI: 10.1016/j.devcel.2017.09.010

Mitotic spindle: kinetochore fibers hold on tight to interpolar bundles

Author(s): Iva M. Tolić
Published in: European Biophysics Journal, 2017, ISSN 0175-7571
Publisher: Springer Verlag
DOI: 10.1007/s00249-017-1244-4

Relaxation of interkinetochore tension after severing of a k-fiber depends on the length of the k-fiber stub

Author(s): Ana Milas, Iva Tolić
Published in: Matters Select, Issue Mar 23rd, 2016, 2016, ISSN 2297-9239
Publisher: Matters Select
DOI: 10.19185/matters.201603000025

Helical Twist and Rotational Forces in the Mitotic Spindle

Author(s): Iva M. Tolić, Maja Novak, Nenad Pavin
Published in: Biomolecules, Issue 9/4, 2019, Page(s) 132, ISSN 2218-273X
Publisher: MDPI
DOI: 10.3390/biom9040132

The mitotic spindle is chiral due to torques within microtubule bundles

Author(s): Maja Novak, Bruno Polak, Juraj Simunić, Zvonimir Boban, Barbara Kuzmić, Andreas W. Thomae, Iva M. Tolić, Nenad Pavin
Published in: Nature Communications, Issue 9/1, 2018, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-018-06005-7

Overlap microtubules link sister k-fibres and balance the forces on bi-oriented kinetochores

Author(s): Janko Kajtez, Anastasia Solomatina, Maja Novak, Bruno Polak, Kruno Vukušić, Jonas Rüdiger, Gheorghe Cojoc, Ana Milas, Ivana Šumanovac Šestak, Patrik Risteski, Federica Tavano, Anna H. Klemm, Emanuele Roscioli, Julie Welburn, Daniela Cimini, Matko Glunčić, Nenad Pavin, Iva M. Tolić
Published in: Nature Communications, Issue 7, 2016, Page(s) 10298, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/ncomms10298

Self-Organization and Forces in the Mitotic Spindle

Author(s): Nenad Pavin, Iva M. Tolić
Published in: Annual Review of Biophysics, Issue 45/1, 2015, Page(s) 279-298, ISSN 1936-122X
Publisher: Annual Reviews, Inc.
DOI: 10.1146/annurev-biophys-062215-010934

Bridging the gap between sister kinetochores

Author(s): Iva M. Tolić, Nenad Pavin
Published in: Cell Cycle, Issue 15/9, 2016, Page(s) 1169-1170, ISSN 1538-4101
Publisher: Landes Bioscience
DOI: 10.1080/15384101.2016.1157976

Pivot-and-bond model explains microtubule bundle formation

Author(s): Marcel Prelogović, Lora Winters, Ana Milas, Iva M. Tolić, Nenad Pavin
Published in: Physical Review E, Issue 100/1, 2019, ISSN 2470-0045
Publisher: APS Physics
DOI: 10.1103/physreve.100.012403

Pivoting of microtubules driven by minus-end-directed motors leads to spindle assembly

Author(s): Lora Winters, Ivana Ban, Marcel Prelogović, Iana Kalinina, Nenad Pavin, Iva M. Tolić
Published in: BMC Biology, Issue 17/1, 2019, ISSN 1741-7007
Publisher: BioMed Central
DOI: 10.1186/s12915-019-0656-2

Force-generating mechanisms of anaphase in human cells

Author(s): Kruno Vukušić, Renata Buđa, Iva M. Tolić
Published in: Journal of Cell Science, Issue 132/18, 2019, Page(s) jcs231985, ISSN 0021-9533
Publisher: The Company of Biologists Ltd.
DOI: 10.1242/jcs.231985

Book chapters (3)

Dissection and characterization of microtubule bundles in the mitotic spindle using femtosecond laser ablation.

Author(s): R. Buđa, K. Vukušić, I.M. Tolić
Published in: Methods in Cell Biology, Issue 139: 81–101 (2017), 2017, Page(s) 81-101
Publisher: Elsevier
DOI: 10.1016/bs.mcb.2016.11.007

Optogenetic reversible knocksideways, laser ablation and photoactivation on the mitotic spindle in human cells.

Author(s): Ana Milas, Mihaela Jagrić, Jelena Martinčić, Iva M. Tolić
Published in: Methods in Cell Biology, Issue Volume 145, 2018, Page(s) 191-215
Publisher: Elsevier
DOI: 10.1016/bs.mcb.2018.03.024

Expansion microscopy of the mitotic spindle

Author(s): Ivana Ponjavić, Kruno Vukušić, Iva M. Tolić
Published in: Methods in Cell Biology, 2020
Publisher: Elsevier
DOI: 10.1016/bs.mcb.2020.04.014